Xuejun Wang, PhD, MBBS

Professor

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 10579 Citations
  • 48 h-Index
19962019

Research output per year

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Research Output

2014

Defense Against Proteotoxic Stress in the Heart: Role of p62, Autophagy, and Ubiquitin-Proteasome System. Role of p62, Autophagy, and Ubiquitin-Proteasome System.

Su, H. & Wang, X., Jan 31 2014, Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Elsevier Inc., Vol. 3. p. 187-210 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent bcr-abl downregulation AC

Shi, X., Chen, X., Li, X., Lan, X., Zhao, C., Liu, S., Huang, H., Liu, N., Liao, S., Song, W., Zhou, P., Wang, S., Xu, L., Wang, X., Dou, Q. P. & Liu, J., Jan 1 2014, In : Clinical Cancer Research. 20, 1, p. 151-163 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T. & Molkentin, J. D., Aug 2014, In : Cell Death and Differentiation. 21, 8, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M. J., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Apr 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Proteasomal and lysosomal protein degradation and heart disease

Wang, X. & Robbins, J., Jun 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 16-24 9 p.

Research output: Contribution to journalReview article

68 Scopus citations

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., May 2014, In : Journal of Neurochemistry. 129, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

Gupta, M. K., Gulick, J., Liu, R., Wang, X., Molkentin, J. D. & Robbins, J., Jan 1 2014, In : Circulation Research. 115, 8, p. 721-729 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., Apr 2014, In : Cellular and molecular neurobiology. 34, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice

Liu, Y., Lü, L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X. & Wang, H., Feb 25 2014, In : Journal of Neuroscience. 34, 8, p. 2813-2821 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

Rajagopalan, V., Zhao, M., Reddy, S., Fajardo, G., Wang, X., Dewey, S., Gomes, A. V. & Bernstein, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H551-H562

Research output: Contribution to journalArticle

23 Scopus citations

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats.

Li, S., Wang, X., Li, Y., Kost, C. K. & Martin, D. S., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

Liu, C., Guo, L. Q., Menon, S., Jin, D., Pick, E., Wang, X., Deng, X. W. & Wei, N., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Li, X., Liu, S., Huang, H., Liu, N., Zhao, C., Liao, S., Yang, C., Liu, Y., Zhao, C., Li, S., Lu, X., Liu, C., Guan, L., Zhao, K., Shi, X., Song, W., Zhou, P., Dong, X., Guo, H., Wen, G. & 9 others, Zhang, C., Jiang, L., Ma, N., Li, B., Wang, S., Tan, H., Wang, X., Dou, Q. P. & Liu, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 211-222 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

Lei, D., Li, F., Su, H., Liu, J., Wei, N. & Wang, X., Jul 1 2013, In : PloS one. 8, 7, e67793.

Research output: Contribution to journalArticle

6 Scopus citations

Posttranslational modification and quality control

Wang, X., Pattison, J. S. & Su, H., Jan 18 2013, In : Circulation Research. 112, 2, p. 367-381 15 p.

Research output: Contribution to journalReview article

45 Scopus citations

Protein kinase G positively regulates proteasome-mediated degradation of misfolded proteins

Ranek, M. J., Terpstra, E. J. M., Li, J., Kass, D. A. & Wang, X., Jul 23 2013, In : Circulation. 128, 4, p. 365-376 12 p.

Research output: Contribution to journalArticle

57 Scopus citations
3 Scopus citations

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice

Su, H., Li, J., Osinska, H., Li, F., Robbins, J., Liu, J., Wei, N. & Wang, X., Sep 1 2013, In : Circulation: Heart Failure. 6, 5, p. 1049-1057 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Ubiquitin receptors and protein quality control

Wang, X. & Terpstra, E. J. M., Feb 1 2013, In : Journal of Molecular and Cellular Cardiology. 55, 1, p. 73-84 12 p.

Research output: Contribution to journalReview article

39 Scopus citations
2012

Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in Mice

Tian, Z., Zheng, H., Li, J., Li, Y., Su, H. & Wang, X., Aug 17 2012, In : Circulation Research. 111, 5, p. 532-542 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco-Cruz, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B., Il Kang, K., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H., Kim, J. C., Kim, J. K., Kim, P. K., Kim, S. W., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H., Koike, M., Komatsu, M., Kominami, E., Kong, H. J., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovács, A. L., Kraft, C., Krainc, D., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Krüger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., László, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J. X., Lee, B. W., Lee, G. M., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., Levenson, V. V., Levine, B., Levy, E., Li, F., Li, J. L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., López-Otín, C., Lossi, L., Lotze, M. T., Lõw, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C., Malagoli, D., Malicdan, M. C. V., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Mariño, G., Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Meléndez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A. M., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. N., Mora, R., Moreau, K., Moreira, P. I., Moriyasu, Y., Moscat, J., Mostowy, S., Mottram, J. C., Motyl, T., Moussa, C. E. H., Müller, S., Muller, S., Münger, K., Münz, C., Murphy, L. O., Murphy, M. E., Musarò, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nair, U., Nakagawa, T., Nakahira, K., Nakano, H., Nakatogawa, H., Nanjundan, M., Naqvi, N. I., Narendra, D. P., Narita, M., Navarro, M., Nawrocki, S. T., Nazarko, T. Y., Nemchenko, A., Netea, M. G., Neufeld, T. P., Ney, P. A., Nezis, I. P., Nguyen, H. P., Nie, D., Nishino, I., Nislow, C., Nixon, R. A., Noda, T., Noegel, A. A., Nogalska, A., Noguchi, S., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nürnberger, T., Nyfeler, B., Obara, K., Oberley, T. D., Oddo, S., Ogawa, M., Ohashi, T., Okamoto, K., Oleinick, N. L., Oliver, F. J., Olsen, L. J., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Ou, J. H. J., Ouimet, M., Overholtzer, M., Ozpolat, B., Paganetti, P., Pagnini, U., Pallet, N., Palmer, G. E., Palumbo, C., Pan, T., Panaretakis, T., Pandey, U. B., Papackova, Z., Papassideri, I., Paris, I., Park, J., Park, O. K., Parys, J. B., Parzych, K. R., Patschan, S., Patterson, C., Pattingre, S., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Pervaiz, S., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Phang, J. M., Piacentini, M., Pierre, P., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Pöggeler, S., Poirot, M., Poletti, A., Poüs, C., Pozuelo-Rubio, M., Prætorius-Ibba, M., Prasad, A., Prescott, M., Priault, M., Produit-Zengaffinen, N., Progulske-Fox, A., Proikas-Cezanne, T., Przedborski, S., Przyklenk, K., Puertollano, R., Puyal, J., Qian, S. B., Qin, L., Qin, Z. H., Quaggin, S. E., Raben, N., Rabinowich, H., Rabkin, S. W., Rahman, I., Rami, A., Ramm, G., Randall, G., Randow, F., Rao, V. A., Rathmell, J. C., Ravikumar, B., Ray, S. K., Reed, B. H., Reed, J. C., Reggiori, F., Régnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., De Córdoba, S. R., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M. J., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H. V., Scharl, M., Schätzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schüller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Silva-Zacarin, E. C. M., Simmons, A., Simon, A. K., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stenmark, H., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Strålfors, P., Subauste, C. S., Sui, X., Sulzer, D., Sun, J., Sun, S. Y., Sun, Z. J., Sung, J. J. Y., Suzuki, K., Suzuki, T., Swanson, M. S., Swanton, C., Sweeney, S. T., Sy, L. K., Szabadkai, G., Tabas, I., Taegtmeyer, H., Tafani, M., Takács-Vellai, K., Takano, Y., Takegawa, K., Takemura, G., Takeshita, F., Talbot, N. J., Tan, K. S. W., Tanaka, K., Tanaka, K., Tang, D., Tang, D., Tanida, I., Tannous, B. A., Tavernarakis, N., Taylor, G. S., Taylor, G. A., Taylor, J. P., Terada, A. S., Terman, A., Tettamanti, G., Thevissen, K., Thompson, C. B., Thorburn, A., Thumm, M., Tian, F., Tian, Y., Tocchini-Valentini, G., Tolkovsky, A. M., Tomino, Y., Tönges, L., Tooze, S. A., Tournier, C., Tower, J., Towns, R., Trajkovic, V., Travassos, L. H., Tsai, T. F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M., Van Den Berghe, G., Van Der Klei, I. J., Van Doorn, W. G., Van Dyk, L. F., Van Egmond, M., Van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T., Voitsekhovskaja, O. V., Von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y., Yang, W., Yang, W. Y., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., David Zacks, E., Zacksenhaus, L., Zaffaroni, N., Zakeri, Z., Zeh, H. J., Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 1 2012, In : Autophagy. 8, 4, p. 445-544 100 p.

Research output: Contribution to journalReview article

2429 Scopus citations

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

Huang, H., Liu, N., Guo, H., Liao, S., Li, X., Yang, C., Liu, S., Song, W., Liu, C., Guan, L., Li, B., Xu, L., Zhang, C., Wang, X., Dou, Q. P. & Liu, J., Nov 5 2012, In : PloS one. 7, 11, e49062.

Research output: Contribution to journalArticle

53 Scopus citations

Protein quality control in cardiomyocytes

Wang, X. & Patterson, C., Dec 1 2012, Muscle. Elsevier Inc., Vol. 1. p. 353-367 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The ubiquitin-proteasome system and cardiovascular disease

Powell, S. R., Herrmann, J., Lerman, A., Patterson, C. & Wang, X., 2012, Progress in Molecular Biology and Translational Science. Elsevier B.V., p. 295-346 52 p. (Progress in Molecular Biology and Translational Science; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter

49 Scopus citations
2011

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. J. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

115 Scopus citations

Autophagy and p62 in cardiac protein quality control

Su, H. & Wang, X., Nov 2011, In : Autophagy. 7, 11, p. 1382-1383 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M. J., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation

Lei, D., Li, F., Su, H., Tian, Z., Ye, B., Wei, N. & Wang, X., Feb 1 2011, In : Cell Death and Differentiation. 18, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J. & Wang, X., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3689-3700 12 p.

Research output: Contribution to journalArticle

120 Scopus citations

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress

Li, J., Powell, S. R. & Wang, X., Mar 1 2011, In : FASEB Journal. 25, 3, p. 883-893 11 p.

Research output: Contribution to journalArticle

90 Scopus citations

FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice

Wang, X. & Su, H., Sep 1 2011, In : Cardiovascular research. 91, 4, p. 561-562 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
44 Scopus citations

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice

Su, H., Li, J., Menon, S., Liu, J., Kumarapeli, A. R., Wei, N. & Wang, X., Jan 7 2011, In : Circulation Research. 108, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Proteasome functional insufficiency in cardiac pathogenesis

Wang, X., Li, J., Zheng, H., Su, H. & Powell, S. R., Dec 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 6, p. 2207-2219 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Sanggenon C decreases tumor cell viability associated with proteasome inhibition

Huang, H., Liu, N., Zhao, K., Zhu, C., Lu, X., Li, S., Lian, W., Zhou, P., Dong, X., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Lu, L., Li, X., Guan, L., Liu, C., Wang, X., Dou, Q. P. & 1 others, Liu, J., Jan 6 2011, In : Frontiers in Bioscience - Elite. 3 E, 4, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

Lu, L., Qin, A., Huang, H., Zhou, P., Zhang, C., Liu, N., Li, S., Wen, G., Zhang, C., Dong, W., Wang, X., Dou, Q. P. & Liu, J., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 242-247 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

The role of the proteasome in heart disease

Li, Y. F. & Wang, X., Feb 1 2011, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1809, 2, p. 141-149 9 p.

Research output: Contribution to journalReview article

32 Scopus citations
2010

Autophagy and the ubiquitin-proteasome system in cardiac dysfunction

Zheng, Q. & Wang, X., Mar 1 2010, In : Panminerva Medica. 52, 1, p. 9-25 17 p.

Research output: Contribution to journalReview article

32 Scopus citations

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Zheng, H., Tang, M., Zheng, Q., Kumarapeli, A. R. K., Horak, K. M., Tian, Z. & Wang, X., Oct 19 2010, In : Journal of the American College of Cardiology. 56, 17, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Physiological levels of ATP negatively regulate proteasome function

Huang, H., Zhang, X., Li, S., Liu, N., Lian, W., McDowell, E., Zhou, P., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Dong, X., Lu, L., Ma, N., Dong, W., Dou, Q. P., Wang, X. & Liu, J., Dec 1 2010, In : Cell Research. 20, 12, p. 1372-1385 14 p.

Research output: Contribution to journalArticle

80 Scopus citations

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

Tang, M., Li, J., Huang, W., Su, H., Liang, Q., Tian, Z., Horak, K. M., Molkentin, J. D. & Wang, X., Dec 1 2010, In : Cardiovascular research. 88, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Protein quality control in protection against systolic overload cardiomyopathy: The long term role of small heat shock proteins

Kumarapeli, A. R. K., Horak, K. & Wang, X., Oct 8 2010, In : American Journal of Translational Research. 2, 4, p. 390-401 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of the ubiquitin-proteasome pathway in cardiovascular disease

Depre, C., Powell, S. R. & Wang, X., Jan 1 2010, In : Cardiovascular research. 85, 2, p. 251-252 2 p.

Research output: Contribution to journalEditorial

20 Scopus citations

The ubiquitin-proteasome system in cardiac proteinopathy: A quality control perspective

Su, H. & Wang, X., Jan 1 2010, In : Cardiovascular research. 85, 2, p. 253-262 10 p.

Research output: Contribution to journalReview article

78 Scopus citations

Unraveling enigma in the z-disk

Wang, X. & Su, H., Aug 6 2010, In : Circulation Research. 107, 3, p. 321-323 3 p.

Research output: Contribution to journalEditorial

4 Scopus citations
2009

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy

Wang, X. & Ranek, M. J., Dec 1 2009, In : Current Hypertension Reports. 11, 6, p. 389-395 7 p.

Research output: Contribution to journalReview article

39 Scopus citations

Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies

Zheng, Q., Li, J. & Wang, X., Dec 1 2009, In : International Journal of Physiology, Pathophysiology and Pharmacology. 1, 2, p. 127-142 16 p.

Research output: Contribution to journalReview article

39 Scopus citations

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo

Yang, H., Zhou, P., Huang, H., Chen, D., Ma, N., Cui, Q. C., Shen, S., Dong, W., Zhang, X., Lian, W., Wang, X., Dou, Q. P. & Liu, J., May 15 2009, In : International Journal of Cancer. 124, 10, p. 2450-2459 10 p.

Research output: Contribution to journalArticle

127 Scopus citations

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription

Su, H., Huang, W. & Wang, X., Mar 1 2009, In : International Journal of Biochemistry and Cell Biology. 41, 3, p. 615-624 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008
56 Scopus citations