Xuejun Wang, PhD, MBBS

Professor

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 10308 Citations
  • 47 h-Index
19962019
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Research Output 1996 2019

1996
4 Citations (Scopus)

Measurement of regional myocardial blood flow in rats by unlabeled microspheres and Coulter Channelyzer

Wang, X., Li, F., Said, S., Capasso, J. M. & Gerdes, A. M., Oct 1 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 271, 4 40-4, p. H1656-H1665

Research output: Contribution to journalArticle

Regional Blood Flow
Microspheres
Catheterization
Myocardium
71 Citations (Scopus)

Myocyte remodeling during the progression to failure in rats with hypertension

Gerdes, A. M., Onodera, T., Wang, X. & McCune, S. A., Oct 1996, In : Hypertension. 28, 4, p. 609-614 6 p.

Research output: Contribution to journalArticle

Muscle Cells
Hypertension
Hypertrophy
Heart Failure
Growth
524 Citations (Scopus)

Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development

Li, F., Wang, X., Capasso, J. M. & Gerdes, A. M., Aug 1996, In : Journal of Molecular and Cellular Cardiology. 28, 8, p. 1737-1746 10 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Muscle Cells
Hypertrophy
Hyperplasia
Bromodeoxyuridine
1997
55 Citations (Scopus)

Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation

Li, F., Wang, X. & Gerdes, A. M., Jun 1997, In : Journal of Molecular and Cellular Cardiology. 29, 6, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Actinin
Cytoplasm
Vinculin
Muscle Cells
72 Citations (Scopus)

Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring

Li, F., Wang, X., Bunger, P. C. & Gerdes, A. M., Jun 1997, In : Journal of Molecular and Cellular Cardiology. 29, 6, p. 1541-1551 11 p.

Research output: Contribution to journalArticle

Myosins
Cardiac Myocytes
Actins
Muscle Cells
Connectin
1999
86 Citations (Scopus)

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

Wang, X. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 333-343 11 p.

Research output: Contribution to journalArticle

Cardiomegaly
Muscle Cells
Catenins
Guinea Pigs
Heart Failure
23 Citations (Scopus)

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

Wang, X., Li, F. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 307-317 11 p.

Research output: Contribution to journalArticle

Cardiomegaly
Muscle Cells
Guinea Pigs
Heart Failure
Hemodynamics
72 Citations (Scopus)

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

Wang, X., Faqian, L., Campbell, S. E. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

Cardiomegaly
Muscle Cells
Guinea Pigs
Heart Failure
Pressure
126 Citations (Scopus)

The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function

Milner, D. J., Taffet, G. E., Wang, X., Pham, T., Tamura, T., Hartley, C., Gerdes, M. A. & Capetanaki, Y., Nov 1999, In : Journal of Molecular and Cellular Cardiology. 31, 11, p. 2063-2076 14 p.

Research output: Contribution to journalArticle

Desmin
Cardiomegaly
Cardiac Myocytes
Dilatation
Muscle Cells
2000
37 Citations (Scopus)

In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy

Sanbe, A., Nelson, D., Gulick, J., Setser, E., Osinska, H., Wang, X., Hewett, T. E., Klevitsky, R., Hayes, E., Warshaw, D. M. & Robbins, J., Aug 18 2000, In : Circulation Research. 87, 4, p. 296-302 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Myosin Light Chains
Myofibrils
Hypertrophic Cardiomyopathy
Hypertrophy
2001
229 Citations (Scopus)

Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice

Wang, X., Osinska, H., Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, T. & Robbins, J., Jul 6 2001, In : Circulation Research. 89, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
Crystallins
Desmin
Cardiomyopathies
Mutation
Cardiac Myocytes
59 Citations (Scopus)

Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy

Wu, G., Yussman, M. G., Barrett, T. J., Hahn, H. S., Osinska, H., Hilliard, G. M., Wang, X., Toyokawa, T., Yatani, A., Lynch, R. A., Robbins, J. & Dorn, G. W., Dec 7 2001, In : Circulation Research. 89, 12, p. 1130-1137 8 p.

Research output: Contribution to journalArticle

Open Access
rab GTP-Binding Proteins
Transport Vesicles
Cardiomegaly
Cardiomyopathies
Muscle Cells
160 Citations (Scopus)

Mouse model of desmin-related cardiomyopathy

Wang, X., Osinska, H., Dorn, G. W., Nieman, M., Lorenz, J. N., Gerdes, A. M., Witt, S., Kimball, T., Gulick, J. & Robbins, J., May 15 2001, In : Circulation. 103, 19, p. 2402-2407 6 p.

Research output: Contribution to journalArticle

Desmin
Cardiomyopathies
Mutation
Transgenic Mice
Up-Regulation
17 Citations (Scopus)

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

Yang, Q., Hewett, T. E., Klevitsky, R., Sanbe, A., Wang, X. & Robbins, J., Jun 21 2001, In : Cardiovascular research. 51, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Cyclic AMP-Dependent Protein Kinases
Transgenic Mice
Phosphorylation
Exercise
2002
42 Citations (Scopus)

Desmin filaments and cardiac disease: Establishing causality

Wang, X., Osinska, H., Gerdes, A. M. & Robbins, J., Dec 2002, In : Journal of Cardiac Failure. 8, 6 SUPPL., p. S287-S292

Research output: Contribution to journalArticle

Desmin
Causality
Heart Diseases
Cardiomegaly
Dilatation
2003
1 Citation (Scopus)

Expression and distribution of desmosomal proteins in a transgenic mouse model of desmin-related cardiomyopathy

Huang, W., Ma, W. Z. & Wang, X. J., Jul 1 2003, In : Chinese Journal of Clinical Rehabilitation. 7, 15, p. 2152-2154 3 p.

Research output: Contribution to journalArticle

Desmin
Cardiomyopathies
Transgenic Mice
Desmoplakins
Proteins
31 Citations (Scopus)

Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium

Yi, X. P., Wang, X., Gerdes, A. M. & Li, F., Jun 1 2003, In : Hypertension. 41, 6, p. 1317-1323 7 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Myocardium
Serine
Cardiac Myocytes
Heart Ventricles
92 Citations (Scopus)

αB-Crystallin Modulates Protein Aggregation of Abnormal Desmin

Wang, X., Klevitsky, R., Huang, W., Glasford, J., Li, F. & Robbins, J., Nov 14 2003, In : Circulation Research. 93, 10, p. 998-1005 8 p.

Research output: Contribution to journalArticle

Crystallins
Desmin
Proteins
Heart Failure
Small Heat-Shock Proteins
2004
57 Citations (Scopus)

Genetic modification of the heart: Chaperones and the cytoskeleton

Kumarapeli, A. R. K. & Wang, X., Dec 2004, In : Journal of Molecular and Cellular Cardiology. 37, 6, p. 1097-1109 13 p.

Research output: Contribution to journalReview article

Desmin
Cytoskeleton
Up-Regulation
Small Heat-Shock Proteins
Crystallins
49 Citations (Scopus)

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes

Dong, X., Liu, J., Zheng, H., Glasford, J. W., Huang, W., Chen, Q. H., Harden, N. R., Li, F., Gerdes, A. M. & Wang, X., Sep 1 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 3 56-3, p. H1417-H1425

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Cardiac Myocytes
Green Fluorescent Proteins
Proteins
12 Citations (Scopus)

Structural basis of ventricular remodeling: role of the myocyte.

Li, F., Wang, X., Yi, X. P. & Gerdes, A. M., Jan 1 2004, In : Current heart failure reports. 1, 1, p. 5-8 4 p.

Research output: Contribution to journalReview article

Ventricular Remodeling
Muscle Cells
Heart Failure
Heart Diseases
Extracellular Matrix
2005
90 Citations (Scopus)

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

Kumarapeli, A. R. K., Horak, K. M., Glasford, J. W., Li, J., Chen, Q., Liu, J., Zheng, H. & Wang, X., Dec 1 2005, In : FASEB Journal. 19, 14, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

Antineoplastic Antibiotics
Echocardiography
Biological Models
Deregulation
Fluorescence microscopy
120 Citations (Scopus)

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

Chen, Q., Liu, J. B., Horak, K. M., Zheng, H., Kumarapeli, A. R. K., Li, J., Li, F., Gerdes, A. M., Wawrousek, E. F. & Wang, X., Nov 1 2005, In : Circulation Research. 97, 10, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

Amyloidosis
Proteasome Endopeptidase Complex
Cardiac Myocytes
Ubiquitin
Proteins
110 Citations (Scopus)

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

Tang, Y. D., Kuzman, J. A., Said, S., Anderson, B. E., Wang, X. & Gerdes, A. M., Nov 1 2005, In : Circulation. 112, 20, p. 3122-3130 9 p.

Research output: Contribution to journalArticle

Propylthiouracil
Arterioles
Atrophy
Dilatation
Thyroid Gland
23 Citations (Scopus)

Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure

Xian, P. Y., Zhou, J., Baker, J., Wang, X., Gerdes, A. M. & Li, F., Jan 1 2005, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 282, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
heart failure
hypertrophy
Hypertrophy
phosphotransferases (kinases)
40 Citations (Scopus)

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy

Gard, J. J., Yamada, K., Green, K. G., Eloff, B. C., Rosenbaum, D. S., Wang, X., Robbins, J., Schuessler, R. B., Yamada, K. A. & Saffitz, J. E., Aug 15 2005, In : Cardiovascular research. 67, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

Desmin
Gap Junctions
Cardiomyopathies
Connexin 43
Proteins
2006
74 Citations (Scopus)
Desmin
Proteasome Endopeptidase Complex
Ubiquitin
Cardiac Myocytes
Proteins
142 Citations (Scopus)

Heart failure and protein quality control

Wang, X. & Robbins, J., Dec 1 2006, In : Circulation Research. 99, 12, p. 1315-1328 14 p.

Research output: Contribution to journalReview article

Cardiac Myocytes
Quality Control
Heart Failure
Protein Unfolding
Peptides
120 Citations (Scopus)

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts

Liu, J., Chen, Q., Huang, W., Horak, K. M., Zheng, H., Mestril, R. & Wang, X., Feb 1 2006, In : FASEB Journal. 20, 2, p. 362-364 3 p.

Research output: Contribution to journalArticle

Protein folding
Desmin
Protein Folding
Muscular Diseases
Proteasome Endopeptidase Complex
20 Citations (Scopus)

Nuclear compartmentalization of FAK and FRNK in cardiac myocytes

Xian, P. Y., Zhou, J., Huber, L., Qu, J., Wang, X., Gerdes, A. M. & Li, F., Jun 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 6, p. H2509-H2515

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Cardiac Myocytes
Serine
Phosphorylation
Protein Kinase C

Response from the Authors [2]

Kumarapeli, A. R. K., Horak, K. M., Zheng, H. & Wang, X., May 1 2006, In : FASEB Journal. 20, 7, p. 1827-1828 2 p.

Research output: Contribution to journalLetter

2007
47 Citations (Scopus)

Cardiac-specific haploinsufficiency of β-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction

Qu, J., Zhou, J., Ping Yi, X., Dong, B., Zheng, H., Miller, L. M., Wang, X., Schneider, M. D. & Li, F., Sep 1 2007, In : Journal of Molecular and Cellular Cardiology. 43, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Catenins
Cardiomegaly
Constriction
Gene Expression
41 Citations (Scopus)

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury

Kobayashi, S., Mao, K., Zheng, H., Wang, X., Patterson, C., O'Connell, T. D. & Liang, Q., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 21945-21952 8 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hyperglycemia
Wounds and Injuries
Proteins
Mannitol
56 Citations (Scopus)

Upregulation of γ-catenin compensates for the loss of β-catenin in adult cardiomyocytes

Zhou, J., Qu, J., Xian, P. Y., Graber, K., Huber, L., Wang, X., Gerdes, A. M. & Li, F., Jan 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 1, p. H270-H276

Research output: Contribution to journalArticle

Catenins
Cardiac Myocytes
Up-Regulation
Tamoxifen
Knockout Mice
2008
56 Citations (Scopus)
Ubiquitination
Proteasome Endopeptidase Complex
Ubiquitin
Doxorubicin
Proteolysis
108 Citations (Scopus)

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

Tydlacka, S., Wang, C. E., Wang, X., Li, S. & Li, X. J., Dec 3 2008, In : Journal of Neuroscience. 28, 49, p. 13285-13295 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Neuroglia
Neurons
Proteins
70 Citations (Scopus)

Protein quality control and degradation in cardiomyocytes

Wang, X., Su, H. & Ranek, M. J., Jul 1 2008, In : Journal of Molecular and Cellular Cardiology. 45, 1, p. 11-27 17 p.

Research output: Contribution to journalReview article

Cardiac Myocytes
Quality Control
Proteins
Autophagy
Proteasome Endopeptidase Complex
36 Citations (Scopus)

Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia

Powell, S. R., Samuel, S. M., Wang, P., Divald, A., Thirunavukkarasu, M., Koneru, S., Wang, X. & Maulik, N., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 618-621 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Hyperglycemia
Up-Regulation
Ubiquitin
Proteins
53 Citations (Scopus)

αb-crystallin suppresses pressure overload cardiac hypertrophy

Kumarapeli, A. R. K., Su, H., Huang, W., Tang, M., Zheng, H., Horak, K. M., Li, M. & Wang, X., Dec 5 2008, In : Circulation Research. 103, 12, p. 1473-1482 10 p.

Research output: Contribution to journalArticle

Crystallins
Cardiomegaly
Cardiac Myocytes
Constriction
Transcriptional Activation
2009
39 Citations (Scopus)

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy

Wang, X. & Ranek, M. J., Dec 1 2009, In : Current Hypertension Reports. 11, 6, p. 389-395 7 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Cardiomyopathies
Doxorubicin
Cardiac Myocytes
38 Citations (Scopus)

Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies

Zheng, Q., Li, J. & Wang, X., Dec 1 2009, In : International Journal of Physiology, Pathophysiology and Pharmacology. 1, 2, p. 127-142 16 p.

Research output: Contribution to journalReview article

Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Proteins
Pharmacology
126 Citations (Scopus)

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo

Yang, H., Zhou, P., Huang, H., Chen, D., Ma, N., Cui, Q. C., Shen, S., Dong, W., Zhang, X., Lian, W., Wang, X., Dou, Q. P. & Liu, J., May 15 2009, In : International Journal of Cancer. 124, 10, p. 2450-2459 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cell Death
Leukemia P388
Neoplasms
Lithospermum
25 Citations (Scopus)

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription

Su, H., Huang, W. & Wang, X., Mar 1 2009, In : International Journal of Biochemistry and Cell Biology. 41, 3, p. 615-624 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Transcription
Cullin Proteins
Cyclins
Phosphotransferases
2010
31 Citations (Scopus)

Autophagy and the ubiquitin-proteasome system in cardiac dysfunction

Zheng, Q. & Wang, X., Mar 1 2010, In : Panminerva Medica. 52, 1, p. 9-25 17 p.

Research output: Contribution to journalReview article

Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Proteins
19 Citations (Scopus)

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Zheng, H., Tang, M., Zheng, Q., Kumarapeli, A. R. K., Horak, K. M., Tian, Z. & Wang, X., Oct 19 2010, In : Journal of the American College of Cardiology. 56, 17, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

Doxycycline
Cardiac Myocytes
Desmin
Cardiomyopathies
Proteins
79 Citations (Scopus)

Physiological levels of ATP negatively regulate proteasome function

Huang, H., Zhang, X., Li, S., Liu, N., Lian, W., McDowell, E., Zhou, P., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Dong, X., Lu, L., Ma, N., Dong, W., Dou, Q. P., Wang, X. & Liu, J., Dec 1 2010, In : Cell Research. 20, 12, p. 1372-1385 14 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Adenosine Triphosphate
Chymotrypsin
Ubiquitin
Proteolysis
71 Citations (Scopus)

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

Tang, M., Li, J., Huang, W., Su, H., Liang, Q., Tian, Z., Horak, K. M., Molkentin, J. D. & Wang, X., Dec 1 2010, In : Cardiovascular research. 88, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Calcineurin
Proteasome Endopeptidase Complex
Cardiac Myocytes
Desmin
10 Citations (Scopus)

Protein quality control in protection against systolic overload cardiomyopathy: The long term role of small heat shock proteins

Kumarapeli, A. R. K., Horak, K. & Wang, X., Oct 8 2010, In : American Journal of Translational Research. 2, 4, p. 390-401 12 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Cardiomyopathies
Quality Control
Quality control
Pressure
20 Citations (Scopus)

The role of the ubiquitin-proteasome pathway in cardiovascular disease

Depre, C., Powell, S. R. & Wang, X., Jan 1 2010, In : Cardiovascular research. 85, 2, p. 251-252 2 p.

Research output: Contribution to journalEditorial

Proteasome Endopeptidase Complex
Ubiquitin
Signal Transduction
Cardiovascular Diseases
78 Citations (Scopus)

The ubiquitin-proteasome system in cardiac proteinopathy: A quality control perspective

Su, H. & Wang, X., Jan 1 2010, In : Cardiovascular research. 85, 2, p. 253-262 10 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Quality Control
Proteins
Cardiomyopathies