William H Velander, PhD, MChE

Professor

  • 1668 Citations
  • 24 h-Index
1987 …2019
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Research Output 1987 2019

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9 Citations (Scopus)

Activation of recombinant human protein C

Lee, T. K., Bangalore, N., Velander, W., Drohan, W. N. & Lubon, H., May 1 1996, In : Thrombosis Research. 82, 3, p. 225-234 10 p.

Research output: Contribution to journalArticle

Protein C
Recombinant Proteins
Thrombin
Thrombomodulin
Enzyme Precursors
20 Citations (Scopus)

Affinity Purification of Biologically Active and Inactive Forms of Recombinant Human Protein C Produced in Porcine Mammary Gland

Van Cott, K. E., Williams, B., Velander, W. H., Gwazdauskas, F., Lee, T., Lubon, H. & Drohan, W. N., Jan 1 1996, In : Journal of Molecular Recognition. 9, 5-6, p. 407-414 8 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Protein C
Recombinant Proteins
Purification
Swine
26 Citations (Scopus)

Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milk

Gil, G. C., Velander, W. H. & Van Cott, K. E., Jul 1 2008, In : Glycobiology. 18, 7, p. 526-539 14 p.

Research output: Contribution to journalArticle

Factor IX
Human engineering
Polysaccharides
Milk
Swine
9 Citations (Scopus)

An o-toluidine method for detection of carbohydrates in protein hydrolysates

Morcol, T. & Velander, W. H., May 15 1991, In : Analytical Biochemistry. 195, 1, p. 153-159 7 p.

Research output: Contribution to journalArticle

2-toluidine
Protein Hydrolysates
Thin Layer Chromatography
Sugars
Thin layer chromatography
1 Citation (Scopus)

A totally recombinant fibrin matrix for mesenchymal stem cell culture and delivery

Wang, O., Ismail, A., Fabian, F. M., Lin, H., Li, Q., Elowsky, C., Carlson, M. A., Burgess, W., Velander, W. H., Kidambi, S. S. & Lei, Y., Dec 2018, In : Journal of Biomedical Materials Research - Part A. 106, 12, p. 3135-3142 8 p.

Research output: Contribution to journalArticle

Stem cells
Fibrin
Cell culture
Fibrinogen
Clinical laboratories
15 Citations (Scopus)

A totally recombinant human fibrin sealant

Carlson, M. A., Calcaterra, J., Johanning, J. M., Pipinos, I. I., Cordes, C. M. & Velander, W. H., Mar 1 2014, In : Journal of Surgical Research. 187, 1, p. 334-342 9 p.

Research output: Contribution to journalArticle

Fibrin Tissue Adhesive
Thrombelastography
Hemostatics
Fibrinogen
Swine
22 Citations (Scopus)

Bovine Follicular Dynamics, Oocyte Recovery, and Development of Oocytes Microinjected with a Green Fluorescent Protein Construct

Chauhan, M. S., Nadir, S., Bailey, T. L., Pryor, A. W., Butler, S. P., Notter, D. R., Velander, W. H. & Gwazdauskas, F. C., May 1999, In : Journal of Dairy Science. 82, 5, p. 918-926 9 p.

Research output: Contribution to journalArticle

Open Access
pronucleus
Green Fluorescent Proteins
green fluorescent protein
Oocytes
oocytes

Co-expressing Turnip Crinkle Virus-coat protein with the serine protease α-thrombin precursor (pFIIa) in Nicotiana benthamiana Domin

Laguia-Becher, M., Zaldúa, Z., Xu, W., Marconi, P. L., Velander, W. & Alvarez, M. A., Feb 15 2019, In : In Vitro Cellular and Developmental Biology - Plant. 55, 1, p. 88-98 11 p.

Research output: Contribution to journalArticle

Carmovirus
Turnip crinkle virus
thrombin
Nicotiana benthamiana
Capsid Proteins
22 Citations (Scopus)

Comparison of the performance of immunosorbents prepared by site-directed or random coupling of monoclonal antibodies

Orthner, C. L., Highsmith, F. A., Tharakan, J., Madurawe, R. D., Morcol, T. & Velander, W. H., Sep 27 1991, In : Journal of Chromatography A. 558, 1, p. 55-70 16 p.

Research output: Contribution to journalArticle

Immunosorbents
Monoclonal Antibodies
Cyanogen Bromide
Carbohydrates
Antibodies
34 Citations (Scopus)

Conformational changes in an epitope localized to the NH2-terminal region of protein C. Evidence for interaction of protein C domains

Orthner, C. L., Madurawe, R. D., Velander, W. H., Drohan, W. N., Battey, F. D. & Strickland, D. K., Jan 1 1989, In : Journal of Biological Chemistry. 264, 31, p. 18781-18788 8 p.

Research output: Contribution to journalArticle

Protein Interaction Domains and Motifs
Protein C
Epitopes
Antibodies
Factor X
22 Citations (Scopus)

Construction and characterization of a thrombin-resistant designer FGF-based collagen binding domain angiogen

Brewster, L. P., Washington, C., Brey, E. M., Gassman, A., Subramanian, A., Calceterra, J., Wolf, W., Hall, C. L., Velander, W. H., Burgess, W. H. & Greisler, H. P., Jan 1 2008, In : Biomaterials. 29, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 1
Fibroblast Growth Factors
Fibroblasts
Collagen
Thrombin
20 Citations (Scopus)

Current progress in the production of recombinant human fibrinogen in the milk of transgenic animals

Butler, S. P., Van Cott, K., Subrumanian, A., Gwazduaskas, F. C. & Velander, W. H., Jul 1 1997, In : Thrombosis and Haemostasis. 78, 1, p. 537-542 6 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Fibrinogen
Milk
Human Mammary Glands
Breast
2 Citations (Scopus)
Liver
hemorrhage
Swine
Hemorrhage
liver
2 Citations (Scopus)

Development of bovine morulae after bisection and biopsy and assessment of DNA amplification by the polymerase chain reaction

Sparks, A. E. T., Canseco, R. S., Russell, C. G., Johnson, J. L., Page, J. L., Velander, W. H., McGilliard, M. L. & Gwazdauskas, F. C., Mar 1994, In : Animal Reproduction Science. 35, 1-2, p. 1-7 7 p.

Research output: Contribution to journalArticle

Morula
morula
DNA-Directed DNA Polymerase
biopsy
embryo (animal)

Development of murine embryos following electroporation

Schmotzer, C. A., Dunlap-Brown, M. E., Butler, S. P., Velander, W. H. & Gwazdauskas, F. C., Apr 1 2003, In : Journal of Assisted Reproduction and Genetics. 20, 4, p. 148-152 5 p.

Research output: Contribution to journalArticle

Electroporation
Zygote
Embryonic Development
Embryonic Structures
Electric Stimulation
29 Citations (Scopus)

Dot-blot analysis of the degree of covalent modification of proteins and antibodies at amino groups

Morçöl, T., Subramanian, A. & Velander, W. H., Apr 11 1997, In : Journal of Immunological Methods. 203, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Trinitrobenzenesulfonic Acid
Antibodies
Proteins
Membranes
Sample Size
23 Citations (Scopus)

Effect of Antibody Orientation on Immunosorbent Performance

Subramanian, A. & Velander, W. H., Jan 1 1996, In : Journal of Molecular Recognition. 9, 5-6, p. 528-535 8 p.

Research output: Contribution to journalArticle

Immunosorbents
Monoclonal antibodies
Antibodies
Monoclonal Antibodies
Immobilization
16 Citations (Scopus)

Effect of culture conditions, donor age, and injection site on in vitro development of DNA microinjected porcine zygotes.

Hajdu, M. A., Knight, J. W., Canseco, R. S., Krisher, R. L., Velander, W. H., Pearson, R. E. & Gwazdauskas, F. C., May 1994, In : Journal of animal science. 72, 5, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

Zygote
injection site
zygote
Swine
Injections
4 Citations (Scopus)

Effects of Time of Deoxyribonucleic Acid Microinjection on Gene Detection and In Vitro Development of Bovine Embryos

Sparks, A. E. T., Canseco, R. S., Russell, C. G., Johnson, J. L., Moll, H. D., Velander, W. H. & Gwazdauskas, F. C., Jan 1 1994, In : Journal of Dairy Science. 77, 3, p. 718-724 7 p.

Research output: Contribution to journalArticle

Open Access
Microinjections
Embryonic Development
embryo (animal)
Embryonic Structures
cattle
6 Citations (Scopus)

Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk

Zhao, J., Xu, W., Ross, J. W., Walters, E. M., Butler, S. P., Whyte, J. J., Kelso, L., Fatemi, M., Vanderslice, N. C., Giroux, K., Spate, L. D., Samuel, M. S., Murphy, C. N., Wells, K. D., Masiello, N. C., Prather, R. S. & Velander, W. H., Sep 21 2015, In : Scientific reports. 5, 14176.

Research output: Contribution to journalArticle

Hemophilia B
Protein Engineering
Factor IX
Human Mammary Glands
Milk
7 Citations (Scopus)

Evaluation of systems for collection of porcine zygotes for DNA microinjection and transfer

Williams, B. L., Sparks, A. E. T., Canseco, R. S., Knight, J. W., Johnson, J. L., Velander, W. H., Page, R. L., Drohan, W. N., Kornegay, E. T., Pearson, R. E., Wilkins, T. D. & Gwazdauskas, F. C., Sep 1992, In : Theriogenology. 38, 3, p. 501-511 11 p.

Research output: Contribution to journalArticle

Superovulation
superovulation
Zygote
Microinjections
zygote
287 Citations (Scopus)

Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection

Fodor, W. L., Williams, B. L., Matis, L. A., Madri, J. A., Rollins, S. A., Knight, J. W., Velander, W. & Squnito, S. P., Nov 8 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 23, p. 11153-11157 5 p.

Research output: Contribution to journalArticle

Complement Inactivating Agents
Swine
Organ Transplantation
Heterologous Transplantation
Vascular Endothelium

Fluid administration rate for uncontrolled intraabdominal hemorrhage in swine

Yanala, U. R., Johanning, J. M., Pipinos, I. I., High, R. R., Larsen, G., Velander, W. H. & Carlson, M. A., Nov 2018, In : PloS one. 13, 11, e0207708.

Research output: Contribution to journalArticle

hemorrhage
Resuscitation
hemoglobin
Hemoglobins
Blood
8 Citations (Scopus)

Functional factor VIII made with von Willebrand factor at high levels in transgenic milk

Pipe, S. W., Miao, H., Butler, S. P., Calcaterra, J. & Velander, W. H., Nov 1 2011, In : Journal of Thrombosis and Haemostasis. 9, 11, p. 2235-2242 8 p.

Research output: Contribution to journalArticle

Factor VIII
von Willebrand Factor
Milk
Hemophilia A
Furin
31 Citations (Scopus)

Gene transfer efficiency during gestation and the influence of co-transfer of non-manipulated embryos on production of transgenic mice

Canseco, R. S., Sparks, A. E. T., Page, R. L., Russell, C. G., Johnson, J. L., Velander, W. H., Pearson, R. E., Drohan, W. N. & Gwazdauskas, F. C., Jan 1 1994, In : Transgenic Research. 3, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

gene transfer
Transgenic Mice
embryo (animal)
Embryonic Structures
pregnancy
25 Citations (Scopus)

Haemophilic factors produced by transgenic livestock: Abundance that can enable alternative therapies worldwide

Van Cott, K. E., Monahan, P. E., Nichols, T. C. & Velander, W. H., Oct 1 2004, In : Haemophilia, Supplement. 10, 4, p. 70-76 7 p.

Research output: Contribution to journalArticle

Livestock
Complementary Therapies
Hemophilia A
Milk
Swine
137 Citations (Scopus)

High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C

Velander, W. H., Johnson, J. L., Page, R. L., Russell, C. G., Subramanian, A., Wilkins, T. D., Gwazdauskas, F. C., Pittius, C. & Drohan, W. N., Dec 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 24, p. 12003-12007 5 p.

Research output: Contribution to journalArticle

Open Access
Milk Proteins
Protein C
Swine
Complementary DNA
Human Mammary Glands
40 Citations (Scopus)
N-Acetylneuraminic Acid
Ionization
Mass spectrometry
Polysaccharides
Desorption
1 Citation (Scopus)

Human Plasma Proteins from Transgenic Animal Bioreactors

Paleyanda, R. K., Velander, W. H., Lee, T. K., Drews, R., Gwazdauskas, F. C., Knight, J. W., Drohan, W. N. & Lubon, H., Dec 1 1996, In : ACS Symposium Series. 647, p. 205-217 13 p.

Research output: Contribution to journalArticle

Plasma (human)
Bioreactors
Blood Proteins
Animals
Protein C
25 Citations (Scopus)

Increased oxygen transfer in a yeast fermentation using a microbubble dispersion

Kaster, J. A., Michelsen, D. L. & Velander, W. H., Mar 1 1990, In : Applied Biochemistry and Biotechnology. 24-25, 1, p. 469-484 16 p.

Research output: Contribution to journalArticle

Microbubbles
Yeast
Fermentation
Yeasts
Oxygen
4 Citations (Scopus)

Induced Convective Effects on Intrawafer Uniformity in LPCVD

Velander, W. & White, D., Apr 1987, In : Journal of the Electrochemical Society. 134, 4, p. 951-956 6 p.

Research output: Contribution to journalArticle

wafers
Gases
Solid state devices
Deposition rates
Stoichiometry
38 Citations (Scopus)

Inefficient processing of human protein C in the mouse mammary gland

Drohan, W. N., Zhang, D. W., Paleyanda, R., Chang, R., Wroble, M., Velander, W. & Lubon, H., Nov 1 1994, In : Transgenic Research. 3, 6, p. 355-364 10 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Protein C
mammary glands
Recombinant Proteins
mice
18 Citations (Scopus)

Influence of time of gene microinjection on development and DNA detection frequency in bovine embryos

Krisher, R. L., Gibbons, J. R., Canseco, R. S., Johnson, J. L., Russell, C. G., Notter, D. R., Velander, W. H. & Gwazdauskas, F. C., Jul 1 1994, In : Transgenic Research. 3, 4, p. 226-231 6 p.

Research output: Contribution to journalArticle

Microinjections
Insemination
embryo (animal)
Embryonic Structures
insemination
11 Citations (Scopus)

Interferometric optical fiber microcantilever beam biosensor

Wavering, T., Meller, S., Evans, M., Pennington, C., Jones, M., Van Tassell, R., Murphy, K., Velander, W. & Valdes, E., Jan 1 2000, In : Proceedings of SPIE - The International Society for Optical Engineering. 4200, p. 10-16 7 p.

Research output: Contribution to journalArticle

Biosensor
bioinstrumentation
Biosensors
Optical Fiber
Optical fibers
17 Citations (Scopus)

In vitro development of zygotes from prepubertal gilts after microinjection of DNA.

Williams, B. L., Sparks, A. E., Canseco, R. S., Knight, J. W., Johnson, J. L., Velander, W. H., Page, R. L., Drohan, W. N., Young, J. M. & Pearson, R. E., Jul 1992, In : Journal of animal science. 70, 7, p. 2207-2211 5 p.

Research output: Contribution to journalArticle

Zygote
Microinjections
zygote
Oviducts
gilts
2 Citations (Scopus)

In vitro embryo development of good and poor quality bovine oocytes following microinjection of DNA

Garst, A. S., Carlin, S. K., Glbbons, J. R., Kendrick, K. W., Pearson, R. E., Akers, R. M., Bailey, T. L., Velander, W. H., Lubon, H. K. & Gwazdauskas, F. C., Jan 1 1999, In : Transgenics. 2, 4, p. 371-382 12 p.

Research output: Contribution to journalArticle

Microinjections
Oocytes
Embryonic Development
Abattoirs
DNA
29 Citations (Scopus)

Isolation of recombinant proteins from milk

Wilkins, T. D. & Velander, W., Aug 1992, In : Journal of Cellular Biochemistry. 49, 4, p. 333-338 6 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Micelles
Milk
Caseins
Fats
26 Citations (Scopus)

N-glycosylation microheterogeneity and site occupancy of an Asn-X-Cys sequon in plasma-derived and recombinant protein C

Gil, G. C., Velander, W. H. & Van Cott, K. E., May 1 2009, In : Proteomics. 9, 9, p. 2555-2567 13 p.

Research output: Contribution to journalArticle

Glycosylation
Protein C
Recombinant Proteins
Polysaccharides
Blood Proteins
18 Citations (Scopus)

Optimization of pressure-flow limits, strength, intraparticle transport and dynamic capacity by hydrogel solids content and bead size in cellulose immunosorbents

Kaster, J. A., de Oliveira, W., Glasser, W. G. & Velander, W. H., Oct 1 1993, In : Journal of Chromatography A. 648, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

Immunosorbents
Hydrogel
Cellulose
Pressure
Thyroglobulin
18 Citations (Scopus)

Ovulation rate, zygote recovery and follicular populations in FSH-superovulated goats treated with PGF and/or GnRH

Krisher, R. L., Gwazdauskas, F. C., Page, R. L., Russell, C. G., Canseco, R. S., Sparks, A. E. T., Velander, W. H., Johnson, J. L. & Pearson, R. E., Feb 1994, In : Theriogenology. 41, 2, p. 491-498 8 p.

Research output: Contribution to journalArticle

Dinoprost
Zygote
follicle-stimulating hormone
Follicle Stimulating Hormone
zygote
24 Citations (Scopus)

Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C

Van Cott, K. E., Lubon, H., Russell, C. G., Butler, S. P., Gwazdauskas, F. C., Knight, J., Drohan, W. N. & Velander, W. H., Jan 1 1997, In : Transgenic Research. 6, 3, p. 203-212 10 p.

Research output: Contribution to journalArticle

genetic stability
Protein C
Recombinant Proteins
Swine
transgenes
43 Citations (Scopus)

Polyoxazoline‐Peptide adducts that retain antibody avidity

Velander, W. H., Madurawe, R. D., Subramanian, A., Kumar, G., Sinai‐Zingde, G., Riffle, J. S. & Orthner, C. L., Apr 25 1992, In : Biotechnology and Bioengineering. 39, 10, p. 1024-1030 7 p.

Research output: Contribution to journalArticle

Antibody Affinity
Antibodies
Polymers
Hydrophilicity
Hydrophobic and Hydrophilic Interactions
21 Citations (Scopus)

Process Implications for Metal‐Dependent Immunoaffinity Interactions

Velander, W. H., Orthner, C. L., Tharakan, J. P., Madurawe, R. D., Ralston, A. H., Strickland, D. K. & Drohan, W. N., Sep 1989, In : Biotechnology Progress. 5, 3, p. 119-125 7 p.

Research output: Contribution to journalArticle

Immunosorbents
Factor IX
Protein C
Edetic Acid
Blood Proteins
44 Citations (Scopus)

Production of Biologically Active Human Protein C in the Milk of Transgenic Mice

VELANDER, WILLIAM. H., PAGE, RAYMOND. L., MORCÖL, TÜLIN., RUSSELL, CHRISTOPHER. G., CANSECO, RODOLFO., YOUNG, JANET. M., DROHAN, WILLIAM. N., GWAZDAUSKAS, FRANCIS. C., WILKINS, TRACY. D. & JOHNSON, JOHN. L., Oct 1992, In : Annals of the New York Academy of Sciences. 665, 1, p. 391-403 13 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Genetic Techniques
Restriction Mapping
Inbred Strains Mice
Partial Thromboplastin Time
36 Citations (Scopus)

Proteins from transgenic animal bioreactors

Lubon, H., Paleyanda, R. K., Velander, W. H. & Drohan, W. N., Jan 1 1996, In : Transfusion Medicine Reviews. 10, 2, p. 131-143 13 p.

Research output: Contribution to journalArticle

Recombinant Fusion Proteins
Species Specificity
Animal Mammary Glands
Genetically Modified Animals
Protein Precursors
1 Citation (Scopus)

Purificación del factor IX recombinante expresado en leche de cerdas transgénicas

Translated title of the contribution: Purification of recombinant factor IX expressed in milk of transgenic sowsLahens, A. C., Torres, A. M., Velander, W., Vidal, M. L., Sánchez, L. J., Rojas, A. R., Tito, L. S., Concepción, A. D., Almagro, P. C., González, D. C. & Vázquez, D. A., May 1 2006, In : Revista Cubana de Hematologia, Inmunologia y Hemoterapia. 22, 2

Research output: Contribution to journalArticle

Factor IX
Milk
Hemophilia B
Ion Exchange
Ultracentrifugation
34 Citations (Scopus)

Purification of recombinant DNA-derived factor IX produced in transgenic pig milk and fractionation of active and inactive subpopulations

Lindsay, M., Gil, G. C., Cadiz, A., Velander, W. H., Zhang, C. & Van Cott, K. E., Feb 13 2004, In : Journal of Chromatography A. 1026, 1-2, p. 149-157 9 p.

Research output: Contribution to journalArticle

Factor IX
Recombinant DNA
Fractionation
Purification
Milk
2 Citations (Scopus)

Quantifying vitamin K-dependent holoprotein compaction caused by differential γ-carboxylation using high-pressure size exclusion chromatography

Vanderslice, N. C., Messer, A. S., Vadivel, K., Bajaj, S. P., Phillips, M., Fatemi, M., Xu, W. & Velander, W. H., Jun 15 2015, In : Analytical Biochemistry. 479, p. 6-14 9 p.

Research output: Contribution to journalArticle

Carboxylation
Size exclusion chromatography
Vitamin K
Gel Chromatography
Compaction
3 Citations (Scopus)

Ranking the factors impacting immunosorbent performance

Subramanian, A. & Velander, W. H., Jan 1 2000, In : International Journal of Bio-Chromatography. 5, 1, p. 67-82 16 p.

Research output: Contribution to journalArticle

Immunosorbents
Immobilization
Immobilized Antibodies
Antigens
Antibodies
11 Citations (Scopus)

Rate limitations in posttranslational processing by the mammary gland of transgenic animals

Subramanian, A., Paleyanda, R. K., Lubon, H., Williams, B. L., Gwazdauskas, F. C., Knight, J. W., Drohan, W. N. & Velander, W. H., Jan 1 1996, In : Annals of the New York Academy of Sciences. 782, p. 87-96 10 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Human Mammary Glands
Protein C
Animals
Recombinant Proteins