William H Velander, PhD, MChE

Professor

  • 1668 Citations
  • 24 h-Index
1987 …2019
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Research Output 1987 2019

1987
4 Citations (Scopus)

Induced Convective Effects on Intrawafer Uniformity in LPCVD

Velander, W. & White, D., Apr 1987, In : Journal of the Electrochemical Society. 134, 4, p. 951-956 6 p.

Research output: Contribution to journalArticle

wafers
Gases
Solid state devices
Deposition rates
Stoichiometry
1989
34 Citations (Scopus)

Conformational changes in an epitope localized to the NH2-terminal region of protein C. Evidence for interaction of protein C domains

Orthner, C. L., Madurawe, R. D., Velander, W. H., Drohan, W. N., Battey, F. D. & Strickland, D. K., Jan 1 1989, In : Journal of Biological Chemistry. 264, 31, p. 18781-18788 8 p.

Research output: Contribution to journalArticle

Protein Interaction Domains and Motifs
Protein C
Epitopes
Antibodies
Factor X
21 Citations (Scopus)

Process Implications for Metal‐Dependent Immunoaffinity Interactions

Velander, W. H., Orthner, C. L., Tharakan, J. P., Madurawe, R. D., Ralston, A. H., Strickland, D. K. & Drohan, W. N., Sep 1989, In : Biotechnology Progress. 5, 3, p. 119-125 7 p.

Research output: Contribution to journalArticle

Immunosorbents
Factor IX
Protein C
Edetic Acid
Blood Proteins
1990
25 Citations (Scopus)

Increased oxygen transfer in a yeast fermentation using a microbubble dispersion

Kaster, J. A., Michelsen, D. L. & Velander, W. H., Mar 1 1990, In : Applied Biochemistry and Biotechnology. 24-25, 1, p. 469-484 16 p.

Research output: Contribution to journalArticle

Microbubbles
Yeast
Fermentation
Yeasts
Oxygen
1991
9 Citations (Scopus)

An o-toluidine method for detection of carbohydrates in protein hydrolysates

Morcol, T. & Velander, W. H., May 15 1991, In : Analytical Biochemistry. 195, 1, p. 153-159 7 p.

Research output: Contribution to journalArticle

2-toluidine
Protein Hydrolysates
Thin Layer Chromatography
Sugars
Thin layer chromatography
22 Citations (Scopus)

Comparison of the performance of immunosorbents prepared by site-directed or random coupling of monoclonal antibodies

Orthner, C. L., Highsmith, F. A., Tharakan, J., Madurawe, R. D., Morcol, T. & Velander, W. H., Sep 27 1991, In : Journal of Chromatography A. 558, 1, p. 55-70 16 p.

Research output: Contribution to journalArticle

Immunosorbents
Monoclonal Antibodies
Cyanogen Bromide
Carbohydrates
Antibodies
2 Citations (Scopus)

Oxygen mass transfer to flowing ground water using oxygen microbubbles

Michelsen, D. L., Lotfi, M., Velander, W. H., Mann, J. W. & Khalichi, P., Jan 1 1991, Air-Water Mass Transfer. Publ by ASCE, p. 765-777 13 p. (Air-Water Mass Transfer).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Groundwater
Mass transfer
Oxygen
Dissolved oxygen
Biodegradation
1992
7 Citations (Scopus)

Evaluation of systems for collection of porcine zygotes for DNA microinjection and transfer

Williams, B. L., Sparks, A. E. T., Canseco, R. S., Knight, J. W., Johnson, J. L., Velander, W. H., Page, R. L., Drohan, W. N., Kornegay, E. T., Pearson, R. E., Wilkins, T. D. & Gwazdauskas, F. C., Sep 1992, In : Theriogenology. 38, 3, p. 501-511 11 p.

Research output: Contribution to journalArticle

Superovulation
superovulation
Zygote
Microinjections
zygote
137 Citations (Scopus)

High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C

Velander, W. H., Johnson, J. L., Page, R. L., Russell, C. G., Subramanian, A., Wilkins, T. D., Gwazdauskas, F. C., Pittius, C. & Drohan, W. N., Dec 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 24, p. 12003-12007 5 p.

Research output: Contribution to journalArticle

Open Access
Milk Proteins
Protein C
Swine
Complementary DNA
Human Mammary Glands
17 Citations (Scopus)

In vitro development of zygotes from prepubertal gilts after microinjection of DNA.

Williams, B. L., Sparks, A. E., Canseco, R. S., Knight, J. W., Johnson, J. L., Velander, W. H., Page, R. L., Drohan, W. N., Young, J. M. & Pearson, R. E., Jul 1992, In : Journal of animal science. 70, 7, p. 2207-2211 5 p.

Research output: Contribution to journalArticle

Zygote
Microinjections
zygote
Oviducts
gilts
29 Citations (Scopus)

Isolation of recombinant proteins from milk

Wilkins, T. D. & Velander, W., Aug 1992, In : Journal of Cellular Biochemistry. 49, 4, p. 333-338 6 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Micelles
Milk
Caseins
Fats
43 Citations (Scopus)

Polyoxazoline‐Peptide adducts that retain antibody avidity

Velander, W. H., Madurawe, R. D., Subramanian, A., Kumar, G., Sinai‐Zingde, G., Riffle, J. S. & Orthner, C. L., Apr 25 1992, In : Biotechnology and Bioengineering. 39, 10, p. 1024-1030 7 p.

Research output: Contribution to journalArticle

Antibody Affinity
Antibodies
Polymers
Hydrophilicity
Hydrophobic and Hydrophilic Interactions
44 Citations (Scopus)

Production of Biologically Active Human Protein C in the Milk of Transgenic Mice

VELANDER, WILLIAM. H., PAGE, RAYMOND. L., MORCÖL, TÜLIN., RUSSELL, CHRISTOPHER. G., CANSECO, RODOLFO., YOUNG, JANET. M., DROHAN, WILLIAM. N., GWAZDAUSKAS, FRANCIS. C., WILKINS, TRACY. D. & JOHNSON, JOHN. L., Oct 1992, In : Annals of the New York Academy of Sciences. 665, 1, p. 391-403 13 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Genetic Techniques
Restriction Mapping
Inbred Strains Mice
Partial Thromboplastin Time
14 Citations (Scopus)

The use of Fab‐masking antigens to enhance the activity of immobilized antibodies

Velander, W. H., Subramanian, A., Madurawe, R. D. & Orthner, C. L., Apr 25 1992, In : Biotechnology and Bioengineering. 39, 10, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

Immobilized Antibodies
Monoclonal antibodies
Antigens
Antibodies
Monoclonal Antibodies
1993
18 Citations (Scopus)

Optimization of pressure-flow limits, strength, intraparticle transport and dynamic capacity by hydrogel solids content and bead size in cellulose immunosorbents

Kaster, J. A., de Oliveira, W., Glasser, W. G. & Velander, W. H., Oct 1 1993, In : Journal of Chromatography A. 648, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

Immunosorbents
Hydrogel
Cellulose
Pressure
Thyroglobulin
1994
2 Citations (Scopus)

Development of bovine morulae after bisection and biopsy and assessment of DNA amplification by the polymerase chain reaction

Sparks, A. E. T., Canseco, R. S., Russell, C. G., Johnson, J. L., Page, J. L., Velander, W. H., McGilliard, M. L. & Gwazdauskas, F. C., Mar 1994, In : Animal Reproduction Science. 35, 1-2, p. 1-7 7 p.

Research output: Contribution to journalArticle

Morula
morula
DNA-Directed DNA Polymerase
biopsy
embryo (animal)
16 Citations (Scopus)

Effect of culture conditions, donor age, and injection site on in vitro development of DNA microinjected porcine zygotes.

Hajdu, M. A., Knight, J. W., Canseco, R. S., Krisher, R. L., Velander, W. H., Pearson, R. E. & Gwazdauskas, F. C., May 1994, In : Journal of animal science. 72, 5, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

Zygote
injection site
zygote
Swine
Injections
4 Citations (Scopus)

Effects of Time of Deoxyribonucleic Acid Microinjection on Gene Detection and In Vitro Development of Bovine Embryos

Sparks, A. E. T., Canseco, R. S., Russell, C. G., Johnson, J. L., Moll, H. D., Velander, W. H. & Gwazdauskas, F. C., Jan 1 1994, In : Journal of Dairy Science. 77, 3, p. 718-724 7 p.

Research output: Contribution to journalArticle

Open Access
Microinjections
Embryonic Development
embryo (animal)
Embryonic Structures
cattle
287 Citations (Scopus)

Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection

Fodor, W. L., Williams, B. L., Matis, L. A., Madri, J. A., Rollins, S. A., Knight, J. W., Velander, W. & Squnito, S. P., Nov 8 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 23, p. 11153-11157 5 p.

Research output: Contribution to journalArticle

Complement Inactivating Agents
Swine
Organ Transplantation
Heterologous Transplantation
Vascular Endothelium
31 Citations (Scopus)

Gene transfer efficiency during gestation and the influence of co-transfer of non-manipulated embryos on production of transgenic mice

Canseco, R. S., Sparks, A. E. T., Page, R. L., Russell, C. G., Johnson, J. L., Velander, W. H., Pearson, R. E., Drohan, W. N. & Gwazdauskas, F. C., Jan 1 1994, In : Transgenic Research. 3, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

gene transfer
Transgenic Mice
embryo (animal)
Embryonic Structures
pregnancy
38 Citations (Scopus)

Inefficient processing of human protein C in the mouse mammary gland

Drohan, W. N., Zhang, D. W., Paleyanda, R., Chang, R., Wroble, M., Velander, W. & Lubon, H., Nov 1 1994, In : Transgenic Research. 3, 6, p. 355-364 10 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Protein C
mammary glands
Recombinant Proteins
mice
18 Citations (Scopus)

Influence of time of gene microinjection on development and DNA detection frequency in bovine embryos

Krisher, R. L., Gibbons, J. R., Canseco, R. S., Johnson, J. L., Russell, C. G., Notter, D. R., Velander, W. H. & Gwazdauskas, F. C., Jul 1 1994, In : Transgenic Research. 3, 4, p. 226-231 6 p.

Research output: Contribution to journalArticle

Microinjections
Insemination
embryo (animal)
Embryonic Structures
insemination
18 Citations (Scopus)

Ovulation rate, zygote recovery and follicular populations in FSH-superovulated goats treated with PGF and/or GnRH

Krisher, R. L., Gwazdauskas, F. C., Page, R. L., Russell, C. G., Canseco, R. S., Sparks, A. E. T., Velander, W. H., Johnson, J. L. & Pearson, R. E., Feb 1994, In : Theriogenology. 41, 2, p. 491-498 8 p.

Research output: Contribution to journalArticle

Dinoprost
Zygote
follicle-stimulating hormone
Follicle Stimulating Hormone
zygote
26 Citations (Scopus)

Role of local antibody density effects on immunosorbent efficiency

Subramanian, A., Van Cott, K. E., Milbrath, D. S. & Velander, W. H., Jun 24 1994, In : Journal of Chromatography A. 672, 1-2, p. 11-24 14 p.

Research output: Contribution to journalArticle

Immunosorbents
Antibodies
Immobilized Antibodies
Permeation
Antigens
26 Citations (Scopus)

The Porcine Mammary Gland as a Bioreactor for Complex Proteinsa

MORCÖL, TÜLIN., AKERS, ROBERT. M., JOHNSON, JOHN. L., WILLIAMS, BARRY. L., GWAZDAUSKAS, FRANCIS. C., KNIGHT, JAMES. W., LUBON, HENRYK., PALEYANDA, REKHA. K., DROHAN, WILLIAM. N. & VELANDER, WILLIAM. H., Jun 1994, In : Annals of the New York Academy of Sciences. 721, 1, p. 218-233 16 p.

Research output: Contribution to journalArticle

Bioreactors
Human Mammary Glands
Swine
Bioactivity
Cell culture
1995
15 Citations (Scopus)

Transgene detection during early murine embryonic development after pronuclear microinjection

Page, R. L., Canseco, R. S., Russell, C. G., Johnson, J. L., Velander, W. H. & Gwazdauskas, F. C., Jan 1 1995, In : Transgenic Research. 4, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

Microinjections
Transgenes
transgenes
Embryonic Development
embryogenesis
34 Citations (Scopus)

Transgenesis in mice by cytoplasmic injection of polylysine/DNA mixtures

Page, R. L., Butler, S. P., Subramanian, A., Gwazdauskas, F. C., Johnson, J. L. & Velander, W. H., Nov 1 1995, In : Transgenic Research. 4, 6, p. 353-360 8 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Polylysine
injection
Injections
DNA
1996
9 Citations (Scopus)

Activation of recombinant human protein C

Lee, T. K., Bangalore, N., Velander, W., Drohan, W. N. & Lubon, H., May 1 1996, In : Thrombosis Research. 82, 3, p. 225-234 10 p.

Research output: Contribution to journalArticle

Protein C
Recombinant Proteins
Thrombin
Thrombomodulin
Enzyme Precursors
20 Citations (Scopus)

Affinity Purification of Biologically Active and Inactive Forms of Recombinant Human Protein C Produced in Porcine Mammary Gland

Van Cott, K. E., Williams, B., Velander, W. H., Gwazdauskas, F., Lee, T., Lubon, H. & Drohan, W. N., Jan 1 1996, In : Journal of Molecular Recognition. 9, 5-6, p. 407-414 8 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Protein C
Recombinant Proteins
Purification
Swine
23 Citations (Scopus)

Effect of Antibody Orientation on Immunosorbent Performance

Subramanian, A. & Velander, W. H., Jan 1 1996, In : Journal of Molecular Recognition. 9, 5-6, p. 528-535 8 p.

Research output: Contribution to journalArticle

Immunosorbents
Monoclonal antibodies
Antibodies
Monoclonal Antibodies
Immobilization
1 Citation (Scopus)

Human Plasma Proteins from Transgenic Animal Bioreactors

Paleyanda, R. K., Velander, W. H., Lee, T. K., Drews, R., Gwazdauskas, F. C., Knight, J. W., Drohan, W. N. & Lubon, H., Dec 1 1996, In : ACS Symposium Series. 647, p. 205-217 13 p.

Research output: Contribution to journalArticle

Plasma (human)
Bioreactors
Blood Proteins
Animals
Protein C
36 Citations (Scopus)

Proteins from transgenic animal bioreactors

Lubon, H., Paleyanda, R. K., Velander, W. H. & Drohan, W. N., Jan 1 1996, In : Transfusion Medicine Reviews. 10, 2, p. 131-143 13 p.

Research output: Contribution to journalArticle

Recombinant Fusion Proteins
Species Specificity
Animal Mammary Glands
Genetically Modified Animals
Protein Precursors
11 Citations (Scopus)

Rate limitations in posttranslational processing by the mammary gland of transgenic animals

Subramanian, A., Paleyanda, R. K., Lubon, H., Williams, B. L., Gwazdauskas, F. C., Knight, J. W., Drohan, W. N. & Velander, W. H., Jan 1 1996, In : Annals of the New York Academy of Sciences. 782, p. 87-96 10 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Human Mammary Glands
Protein C
Animals
Recombinant Proteins
1997
20 Citations (Scopus)

Current progress in the production of recombinant human fibrinogen in the milk of transgenic animals

Butler, S. P., Van Cott, K., Subrumanian, A., Gwazduaskas, F. C. & Velander, W. H., Jul 1 1997, In : Thrombosis and Haemostasis. 78, 1, p. 537-542 6 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Fibrinogen
Milk
Human Mammary Glands
Breast
29 Citations (Scopus)

Dot-blot analysis of the degree of covalent modification of proteins and antibodies at amino groups

Morçöl, T., Subramanian, A. & Velander, W. H., Apr 11 1997, In : Journal of Immunological Methods. 203, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Trinitrobenzenesulfonic Acid
Antibodies
Proteins
Membranes
Sample Size
1 Citation (Scopus)

Expression of human fibrinogen in transgenic mice

Subramanian, A., Butler, S. P., Gwazdauskas, F. C., Lubon, H. & Velander, W. H., Jan 1 1997, p. 57-60. 4 p.

Research output: Contribution to conferencePaper

Proteins
Polypeptides
Molecular weight
Plasmas
Substrates
24 Citations (Scopus)

Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C

Van Cott, K. E., Lubon, H., Russell, C. G., Butler, S. P., Gwazdauskas, F. C., Knight, J., Drohan, W. N. & Velander, W. H., Jan 1 1997, In : Transgenic Research. 6, 3, p. 203-212 10 p.

Research output: Contribution to journalArticle

genetic stability
Protein C
Recombinant Proteins
Swine
transgenes
28 Citations (Scopus)

Transgenic livestock as drug factories

Velander, W. H., Lubon, H. & Drohan, W. N., Jan 1 1997, In : Scientific American. 276, 1, p. [d]70-74

Research output: Contribution to journalArticle

Livestock
Genetic Engineering
Pharmaceutical Preparations
Sheep
Milk
101 Citations (Scopus)

Transgenic pigs produce functional human factor VIII in milk

Paleyanda, R. K., Velander, W. H., Lee, T. K., Scandella, D. H., Gwazdauskas, F. C., Knight, J. W., Hoyer, L. W., Drohan, W. N. & Lubon, H., Oct 1997, In : Nature Biotechnology. 15, 10, p. 971-975 5 p.

Research output: Contribution to journalArticle

Plasma (human)
Factor VIII
Human engineering
Assays
Milk
1998
8 Citations (Scopus)

Transgenic animals as drug factories: A new source of recombinant protein therapeutics

Van Cott, K. E. & Velander, W. H., Oct 14 1998, In : Expert Opinion on Investigational Drugs. 7, 10, p. 1683-1690 8 p.

Research output: Contribution to journalReview article

Genetically Modified Animals
Recombinant Proteins
Pharmaceutical Preparations
Therapeutics
Inborn Genetic Diseases
18 Citations (Scopus)

Zn2+-selective purification of recombinant proteins from the milk of transgenic animals

Degener, A., Belew, M. & Velander, W. H., Mar 13 1998, In : Journal of Chromatography A. 799, 1-2, p. 125-137 13 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Recombinant Proteins
Purification
Milk
Animals
1999
22 Citations (Scopus)

Bovine Follicular Dynamics, Oocyte Recovery, and Development of Oocytes Microinjected with a Green Fluorescent Protein Construct

Chauhan, M. S., Nadir, S., Bailey, T. L., Pryor, A. W., Butler, S. P., Notter, D. R., Velander, W. H. & Gwazdauskas, F. C., May 1999, In : Journal of Dairy Science. 82, 5, p. 918-926 9 p.

Research output: Contribution to journalArticle

Open Access
pronucleus
Green Fluorescent Proteins
green fluorescent protein
Oocytes
oocytes
2 Citations (Scopus)

In vitro embryo development of good and poor quality bovine oocytes following microinjection of DNA

Garst, A. S., Carlin, S. K., Glbbons, J. R., Kendrick, K. W., Pearson, R. E., Akers, R. M., Bailey, T. L., Velander, W. H., Lubon, H. K. & Gwazdauskas, F. C., Jan 1 1999, In : Transgenics. 2, 4, p. 371-382 12 p.

Research output: Contribution to journalArticle

Microinjections
Oocytes
Embryonic Development
Abattoirs
DNA
10 Citations (Scopus)

Optical fiber-based chemical sensors for detection of corrosion precursors and by-products

Elster, J., Greene, J., Jones, M., Bailey, T., Lenahan, S., Velander, W., VanTassell, R., Hodges, W. & Perez, I., Jan 1 1999, In : Proceedings of SPIE - The International Society for Optical Engineering. 3540, p. 251-257 7 p.

Research output: Contribution to journalConference article

Chemical Sensor
Corrosion
Chemical sensors
Precursor
Optical Fiber
36 Citations (Scopus)

Transgenic pigs as bioreactors: A comparison of gamma-carboxylation of glutamic acid in recombinant human protein C and factor IX by the mammary gland

Van Cott, K. E., Butler, S. P., Russell, C. G., Subramanian, A., Lubon, H., Gwazdauskas, F. C., Knight, J., Drohan, W. N. & Velander, W. H., Nov 1 1999, In : Genetic Analysis - Biomolecular Engineering. 15, 3-5, p. 155-160 6 p.

Research output: Contribution to journalArticle

Carboxylation
Coagulants
Factor IX
Bioreactors
Human Mammary Glands
2000
11 Citations (Scopus)

Interferometric optical fiber microcantilever beam biosensor

Wavering, T., Meller, S., Evans, M., Pennington, C., Jones, M., Van Tassell, R., Murphy, K., Velander, W. & Valdes, E., Jan 1 2000, In : Proceedings of SPIE - The International Society for Optical Engineering. 4200, p. 10-16 7 p.

Research output: Contribution to journalArticle

Biosensor
bioinstrumentation
Biosensors
Optical Fiber
Optical fibers
20 Citations (Scopus)

Optical fiber extrinsic Fabry-Perot interferometric (EFPI)-based biosensors

Elster, J. L., Jones, M. E., Evans, M. K., Lenahan, S. M., Boyce, C. A., Velander, W. & Van Tassell, R., Jan 1 2000, In : Proceedings of SPIE - The International Society for Optical Engineering. 3911, p. 105-112 8 p.

Research output: Contribution to journalConference article

Fabry-Perot
Biosensor
bioinstrumentation
Biosensors
Optical Fiber
3 Citations (Scopus)

Ranking the factors impacting immunosorbent performance

Subramanian, A. & Velander, W. H., Jan 1 2000, In : International Journal of Bio-Chromatography. 5, 1, p. 67-82 16 p.

Research output: Contribution to journalArticle

Immunosorbents
Immobilization
Immobilized Antibodies
Antigens
Antibodies
2001
30 Citations (Scopus)

Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels

Cott, K. E. V., Lubon, H., Gwazdauskas, F. C., Knight, J., Drohan, W. N. & Velander, W. H., Mar 12 2001, In : Transgenic Research. 10, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

transferrin
Transferrin
Protein C
Recombinant Proteins
immunoglobulins
2002
22 Citations (Scopus)

Scale-up of microbubble dispersion generator for aerobic fermentation

Hensirisak, P., Parasukulsatid, P., Agblevor, F. A., Cundiff, J. S. & Velander, W. H., Jul 2 2002, In : Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology. 101, 3, p. 211-227 17 p.

Research output: Contribution to journalArticle

Microbubbles
Fermentation
Air
Microorganisms
Yeast