Wallace B Thoreson, PhD

Professor

  • 4011 Citations
  • 37 h-Index
1986 …2019
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Research Output 1988 2019

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Article
2019

Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors

Grassmeyer, J. J., Cahill, A. L., Hays, C. L., Barta, C., Quadros, R. M., Gurumurthy, C. B. & Thoreson, W. B., Jun 2019, In : eLife. 8, e45946.

Research output: Contribution to journalArticle

Open Access
Synaptotagmin I
Exocytosis
Sensors
Vertebrate Photoreceptor Cells
Cones
Retinal Cone Photoreceptor Cells
Amino Acid Transport System X-AG
Egtazic Acid
Retina
Urodela

Simultaneous Release of Multiple Vesicles from Rods Involves Synaptic Ribbons and Syntaxin 3B

Hays, C. L., Grassmeyer, J. J., Wen, X., Janz, R., Heidelberger, R. & Thoreson, W. B., Jan 1 2019, (Accepted/In press) In : Biophysical journal.

Research output: Contribution to journalArticle

Qa-SNARE Proteins
Excitatory Postsynaptic Potentials
Synapses
Retinal Rod Photoreceptor Cells
Amino Acid Transport System X-AG
2018

Elevated pressure increases Ca2+ influx through AMPA receptors in select populations of retinal ganglion cells

Wen, X., Cahill, A. L., Barta, C., Thoreson, W. B. & Nawy, S. A., Jun 13 2018, In : Frontiers in Cellular Neuroscience. 12, 162.

Research output: Contribution to journalArticle

AMPA Receptors
Retinal Ganglion Cells
Ganglia
Retina
Pressure
1 Citation (Scopus)

Endocytosis sustains release at photoreceptor ribbon synapses by restoring fusion competence

Wen, X., Van Hook, M., Grassmeyer, J. J., Wiesman, A. I., Rich, G. M., Cork, K. M. & Thoreson, W. B., Apr 1 2018, In : Journal of General Physiology. 150, 4, p. 591-611 21 p.

Research output: Contribution to journalArticle

Endocytosis
Synapses
Mental Competency
Membranes
Synaptic Vesicles
2017
7 Citations (Scopus)

A presynaptic group III mGluR recruits Gβγ/SNARE interactions to inhibit synaptic transmission by cone photoreceptors in the vertebrate retina

Van Hook, M., Babai, N., Zurawski, Z., Yim, Y. Y., Hamm, H. E. & Thoreson, W. B., Apr 26 2017, In : Journal of Neuroscience. 37, 17, p. 4618-4634 17 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
SNARE Proteins
Metabotropic Glutamate Receptors
Synaptic Transmission
Vertebrates
76 Citations (Scopus)

Easi-CRISPR: A robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Quadros, R. M., Miura, H., Harms, D. W., Akatsuka, H., Sato, T., Aida, T., Redder, R., Richardson, G. P., Inagaki, Y., Sakai, D., Buckley-McKeown, S. M., Seshacharyulu, P., Batra, S. K., Behlke, M. A., Zeiner, S. A., Jacobi, A. M., Izu, Y., Thoreson, W. B., Urness, L. D., Mansour, S. L. & 2 others, Ohtsuka, M. & Gurumurthy, C. B., May 17 2017, In : Genome biology. 18, 1, 92.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
ribonucleoproteins
single-stranded DNA
Ribonucleoproteins
allele
5 Citations (Scopus)

Kiss-and-run is a significant contributor to synaptic exocytosis and endocytosis in photoreceptors

Wen, X., Saltzgaber, G. W. & Thoreson, W. B., Sep 20 2017, In : Frontiers in Cellular Neuroscience. 11, 286.

Research output: Contribution to journalArticle

Exocytosis
Endocytosis
Coloring Agents
Vertebrate Photoreceptor Cells
Dextrans
5 Citations (Scopus)

Synaptic ribbon active zones in cone photoreceptors operate independently from one another

Grassmeyer, J. J. & Thoreson, W. B., Jul 11 2017, In : Frontiers in Cellular Neuroscience. 11, 198.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Darkness
Neurons
Urodela
Synaptic Vesicles
3 Citations (Scopus)

Two Pools of Vesicles Associated with Synaptic Ribbons Are Molecularly Prepared for Release

Datta, P., Gilliam, J., Thoreson, W. B., Janz, R. & Heidelberger, R., Nov 21 2017, In : Biophysical journal. 113, 10, p. 2281-2298 18 p.

Research output: Contribution to journalArticle

SNARE Proteins
Exocytosis
Synapses
Synaptic Vesicles
Peptides
2016
10 Citations (Scopus)

Kinetics of inhibitory feedback from horizontal cells to photoreceptors: Implications for an ephaptic mechanism

Warren, T. J., Van Hook, M., Tranchina, D. & Thoreson, W. B., Sep 28 2016, In : Journal of Neuroscience. 36, 39, p. 10075-10088 14 p.

Research output: Contribution to journalArticle

Photoreceptor Cells
Ambystoma
Vertebrate Photoreceptor Cells
Presynaptic Terminals
Synapses
9 Citations (Scopus)

Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors

Cork, K. M., Van Hook, M. & Thoreson, W. B., Aug 1 2016, In : European Journal of Neuroscience. 44, 3, p. 2015-2027 13 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Exocytosis
Synapses
7 Citations (Scopus)
Synapses
Ambystoma
Retinal Cone Photoreceptor Cells
Patch-Clamp Techniques
Exercise Test
6 Citations (Scopus)

Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV

Grishchuk, Y., Stember, K. G., Matsunaga, A., Olivares, A. M., Cruz, N. M., King, V. E., Humphrey, D. M., Wang, S. L., Muzikansky, A., Betensky, R. A., Thoreson, W. B., Haider, N. & Slaugenhaupt, S. A., Jan 1 2016, In : American Journal of Pathology. 186, 1, p. 199-209 11 p.

Research output: Contribution to journalArticle

Mucolipidoses
Retinal Dystrophies
Optic Nerve
Pathology
Transient Receptor Potential Channels
16 Citations (Scopus)

Sources of protons and a role for bicarbonate in inhibitory feedback from horizontal cells to cones in Ambystoma tigrinum retina

Warren, T. J., Van Hook, M., Supuran, C. T. & Thoreson, W. B., Nov 15 2016, In : Journal of Physiology. 594, 22, p. 6661-6677 17 p.

Research output: Contribution to journalArticle

Ambystoma
Bicarbonates
Retina
Protons
Sodium-Hydrogen Antiporter
2015
8 Citations (Scopus)
Darkness
Endoplasmic Reticulum
Carisoprodol
Coloring Agents
Cytoplasm
1 Citation (Scopus)

Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons

Ahmad, I., Zhao, X., Parameswaran, S., Destache, C. J., Rodriguez-Sierra, J., Thoreson, W. B., Ahmad, H., Sorrentino, J. & Balasubramanian, S., Jan 1 2015, In : International Journal of Stem Cells. 8, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dopaminergic Neurons
Parkinson Disease
Stem Cells
Transplantation
3 Citations (Scopus)

Naturally occurring deletion mutants of the Pig-Specific, Intestinal crypt epithelial cell protein CLCA4b without Apparent Phenotype

Plog, S., Klymiuk, N., Binder, S., Van Hook, M., Thoreson, W. B., Gruber, A. D. & Mundhenk, L., Oct 16 2015, In : PloS one. 10, 10, e0140050.

Research output: Contribution to journalArticle

intestinal crypts
cystic fibrosis
epithelial cells
Swine
Genes
10 Citations (Scopus)
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Urodela
Vertebrate Photoreceptor Cells
Synaptic Transmission
2014
12 Citations (Scopus)

Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors

Van Hook, M., Parmelee, C. M., Chen, M., Cork, K. M., Curto, C. & Thoreson, W. B., Jan 1 2014, In : Journal of General Physiology. 144, 5, p. 357-378 22 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Calmodulin
Synaptic Transmission
Synapses
Aptitude
10 Citations (Scopus)

Endogenous calcium buffering at photoreceptor synaptic terminals in salamander retina

Van Hook, M. & Thoreson, W. B., Nov 1 2014, In : Synapse. 68, 11, p. 518-528 11 p.

Research output: Contribution to journalArticle

Urodela
Vertebrate Photoreceptor Cells
Presynaptic Terminals
Retina
Synapses
14 Citations (Scopus)

Examination of VLC-PUFA-deficient photoreceptor terminals

Bennett, L. D., Hopiavuori, B. R., Brush, R. S., Chan, M., Van Hook, M., Thoreson, W. B. & Anderson, R. E., Apr 24 2014, In : Investigative Ophthalmology and Visual Science. 55, 7, p. 4063-4072 10 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Retinal Rod Photoreceptor Cells
Retina
Ion Channels
Glutamic Acid
16 Citations (Scopus)

Intracellular calcium stores drive slow non-ribbon vesicle release from rod photoreceptors

Chen, M., Križaj, D. & Thoreson, W. B., Feb 3 2014, In : Frontiers in Cellular Neuroscience. 8, FEB, 20.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Endoplasmic Reticulum
Calcium
Ryanodine
Coloring Agents
4 Citations (Scopus)

Rapid kinetics of endocytosis at rod photoreceptor synapses depends upon endocytic load and calcium

Cork, K. M. & Thoreson, W. B., May 2014, In : Visual Neuroscience. 31, 3, p. 227-235 9 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Endocytosis
Synapses
Calcium
Dynamins
9 Citations (Scopus)

Simultaneous recording of mouse retinal ganglion cells during epiretinal or subretinal stimulation

Sim, S. L., Szalewski, R. J., Johnson, L. J., Akah, L. E., Shoemaker, L. E., Thoreson, W. B. & Margalit, E., Aug 2014, In : Vision research. 101, p. 41-50 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Retina
Electrodes
Electric Stimulation
Reaction Time
37 Citations (Scopus)

Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia

Ryskamp, D. A., Jo, A. O., Frye, A. M., Vazquez-Chona, F., MaCaulay, N., Thoreson, W. B. & Križaj, D., Nov 19 2014, In : Journal of Neuroscience. 34, 47, p. 15689-15700 12 p.

Research output: Contribution to journalArticle

Retinal Neurons
Eicosanoids
Neuroglia
Phospholipases A2
Gliosis
2013
10 Citations (Scopus)

Lateral mobility of L-type calcium channels in synaptic terminals of retinal bipolar cells

Thoreson, W. B., Mercer, A. J., Cork, K. M. & Szalewski, R. J., Jan 7 2013, In : Molecular Vision. 19, p. 16-24 9 p.

Research output: Contribution to journalArticle

Retinal Bipolar Cells
L-Type Calcium Channels
Presynaptic Terminals
Synapses
Actins
8 Citations (Scopus)
Proton Pump Inhibitors
Hallucinations
Macular Degeneration
Retinal Neurons
Amphibians
35 Citations (Scopus)

Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles

Chen, M., Van Hook, M., Zenisek, D. & Thoreson, W. B., Jan 30 2013, In : Journal of Neuroscience. 33, 5, p. 2071-2086 16 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Synaptic Vesicles
Darkness
Membranes
Lasers
25 Citations (Scopus)
Amphibians
Patch-Clamp Techniques
Neurons
Ambystoma
Retina
2 Citations (Scopus)
Quantum Dots
Vertebrate Photoreceptor Cells
Calcium Channels
Synapses
Spatial Behavior
2012
4 Citations (Scopus)

A comparison of optical and electrophysiological methods for recording retinal ganglion cells during electrical stimulation

Luo, J., Boosalis, B. J., Thoreson, W. B. & Margalit, E., Mar 1 2012, In : Current Eye Research. 37, 3, p. 218-227 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Electric Stimulation
Retina
Urodela
Evoked Potentials
53 Citations (Scopus)

CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway

Zhu, B., Xu, D., Deng, X., Chen, Q., Huang, Y., Peng, H., Li, Y., Jia, B., Thoreson, W. B., Ding, W., Ding, J., Zhao, L., Wang, Y., Wavrin, K. L., Duan, S. & Zheng, J. C., Nov 1 2012, In : STEM CELLS. 30, 11, p. 2571-2583 13 p.

Research output: Contribution to journalArticle

Cell Survival
Stem Cells
Endosomes
Endocytosis
CXCR4 Receptors
20 Citations (Scopus)

Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina

Van Hook, M. & Thoreson, W. B., Dec 12 2012, In : Journal of Neuroscience. 32, 50, p. 18112-18123 12 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Urodela
Synaptic Vesicles
Endocytosis
Retina
16 Citations (Scopus)

Regulation of presynaptic strength by controlling Ca 2+ channel mobility: Effects of cholesterol depletion on release at the cone ribbon synapse

Mercer, A. J., Szalewski, R. J., Jackman, S. L., Van Hook, M. & Thoreson, W. B., Jun 15 2012, In : Journal of Neurophysiology. 107, 12, p. 3468-3478 11 p.

Research output: Contribution to journalArticle

Synapses
Cholesterol
Cholesterol Oxidase
Synaptic Vesicles
Excitatory Postsynaptic Potentials
2011
83 Citations (Scopus)

Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming

Snellman, J., Mehta, B., Babai, N., Bartoletti, T. M., Akmentin, W., Francis, A., Matthews, G., Thoreson, W. B. & Zenisek, D., Sep 1 2011, In : Nature Neuroscience. 14, 9, p. 1135-1143 9 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Synapses
Urodela
Aptitude
Synaptic Vesicles
41 Citations (Scopus)

A positive feedback synapse from retinal horizontal cells to cone photoreceptors

Jackman, S. L., Babai, N., Chambers, J. J., Thoreson, W. B. & Kramer, R. H., May 1 2011, In : PLoS biology. 9, 5, e1001057.

Research output: Contribution to journalArticle

Retinal Horizontal Cells
Retinal Cone Photoreceptor Cells
cones (retina)
synapse
Synapses
1 Citation (Scopus)

Center/surround organization of retinal bipolar cells: High correlation of fundamental responses of center and surround to sinusoidal contrasts

Burkhardt, D. A., Bartoletti, T. M. & Thoreson, W. B., May 1 2011, In : Visual Neuroscience. 28, 3, p. 183-192 10 p.

Research output: Contribution to journalArticle

Retinal Bipolar Cells
Ambystoma
Synapses
Patch-Clamp Techniques
Fourier Analysis
26 Citations (Scopus)

Inner and outer retinal mechanisms engaged by epiretinal stimulation in normal and rd mice

Margalit, E., Babai, N., Luo, J. & Thoreson, W. B., Mar 1 2011, In : Visual Neuroscience. 28, 2, p. 145-154 10 p.

Research output: Contribution to journalArticle

Ganglia
Retina
Calcium
Aminobutyrates
Isoxazoles
10 Citations (Scopus)

Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors

Križaj, D., Mercer, A. J., Thoreson, W. B. & Barabas, P., Jan 1 2011, In : American Journal of Physiology - Cell Physiology. 300, 1, p. C187-C197

Research output: Contribution to journalArticle

Vertebrate Photoreceptor Cells
Homeostasis
Calcium
Retinal Photoreceptor Cell Inner Segment
Protons
49 Citations (Scopus)

Lateral mobility of presynaptic L-Type calcium channels at photoreceptor ribbon synapses

Mercer, A. J., Chen, M. & Thoreson, W. B., Mar 23 2011, In : Journal of Neuroscience. 31, 12, p. 4397-4406 10 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
Ambystoma
Synapses
Synaptic Vesicles
Antibodies
41 Citations (Scopus)

Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse

Mercer, A. J., Rabl, K., Riccardi, G. E., Brecha, N. C., Stella, S. L. & Thoreson, W. B., Jan 1 2011, In : Journal of Neurophysiology. 105, 1, p. 321-335 15 p.

Research output: Contribution to journalArticle

Chloride Channels
Calcium Channels
Synapses
Calcium Chloride
Presynaptic Terminals
12 Citations (Scopus)

Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate

Bartoletti, T. M. & Thoreson, W. B., May 9 2011, In : Molecular Vision. 17, p. 920-931 12 p.

Research output: Contribution to journalArticle

Synapses
Glutamic Acid
Excitatory Postsynaptic Potentials
Ambystoma
Social Adjustment
32 Citations (Scopus)

Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca 2+ channels

Bartoletti, T. M., Jackman, S. L., Babai, N., Mercer, A. J., Kramer, R. H. & Thoreson, W. B., Dec 1 2011, In : Journal of Neurophysiology. 106, 6, p. 2922-2935 14 p.

Research output: Contribution to journalArticle

Synapses
Excitatory Postsynaptic Potentials
Light
Retinal Cone Photoreceptor Cells
Urodela
2010
15 Citations (Scopus)

Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells

Babai, N., Kanevsky, N., Dascal, N., Rozanski, G. J., Singh, D. P., Fatma, N. & Thoreson, W. B., Jan 6 2010, In : PloS one. 5, 1, e8602.

Research output: Contribution to journalArticle

L-Type Calcium Channels
calcium channels
HEK293 Cells
anions
Anions
32 Citations (Scopus)

Calcium-induced calcium release contributes to synaptic release from mouse rod photoreceptors

Babai, N., Morgans, C. W. & Thoreson, W. B., Feb 17 2010, In : Neuroscience. 165, 4, p. 1447-1456 10 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Ryanodine
Calcium
Retina
Sarcoplasmic Reticulum Calcium-Transporting ATPases
35 Citations (Scopus)

Calcium regulates vesicle replenishment at the cone ribbon synapse

Babai, N., Bartoletti, T. M. & Thoreson, W. B., Nov 24 2010, In : Journal of Neuroscience. 30, 47, p. 15866-15877 12 p.

Research output: Contribution to journalArticle

Egtazic Acid
Darkness
Exercise Test
Membrane Potentials
Synapses
66 Citations (Scopus)

Flow of energy in the outer retina in darkness and in light

Linton, J. D., Holzhausen, L. C., Babai, N., Song, H., Miyagishima, K. J., Stearns, G. W., Lindsay, K., Wei, J., Chertov, A. O., Peters, T. A., Caffe, R., Pluk, H., Seeliger, M. W., Tanimoto, N., Fong, K., Bolton, L., Kuok, D. L. T., Sweet, I. R., Bartoletti, T. M., Radu, R. A. & 9 others, Travis, G. H., Zagotta, W. N., Townes-Anderson, E., Parker, E., Van Der Zee, C. E. E. M., Sampath, A. P., Sokolov, M., Thoreson, W. B. & Hurley, J. B., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8599-8604 6 p.

Research output: Contribution to journalArticle

Darkness
Retina
Mitochondria
Light
Presynaptic Terminals
87 Citations (Scopus)

Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: Therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration

Parameswaran, S., Balasubramanian, S., Babai, N., Qiu, F., Eudy, J. D., Thoreson, W. B. & Ahmad, I., Apr 1 2010, In : STEM CELLS. 28, 4, p. 695-703 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Retinal Ganglion Cells
Macular Degeneration
Glaucoma
Retinal Cone Photoreceptor Cells
27 Citations (Scopus)

Quantitative analysis of synaptic release at the photoreceptor synapse

Duncan, G., Rabl, K., Gemp, I., Heidelberger, R. & Thoreson, W. B., May 19 2010, In : Biophysical journal. 98, 10, p. 2102-2110 9 p.

Research output: Contribution to journalArticle

Exocytosis
Synapses
Retinal Rod Photoreceptor Cells
Neurons
Synaptic Potentials