Vinai Thomas, PhD

Assistant Professor

  • 955 Citations
  • 16 h-Index
20072019
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Research Output 2007 2019

  • 955 Citations
  • 16 h-Index
  • 26 Article
  • 1 Chapter
  • 1 Review article
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Article
2019

CidR and CcpA synergistically regulate staphylococcus aureus cidABC expression

Sadykov, M. R., Windham, I. H., Widhelm, T. J., Yajjala, V. K., Watson, S. M., Endres, J. L., Bavari, A. I., Thomas, V. C., Bose, J. L. & Bayles, K. W., Dec 1 2019, In : Journal of bacteriology. 201, 23, e00371-19.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Operon
Staphylococcus aureus
Biofilms
Carbon

Dual gene expression analysis identifies factors associated with Staphylococcus aureus virulence in diabetic mice

Jacquet, R., LaBauve, A. E., Akoolo, L., Patel, S., Alqarzaee, A. A., Fok Lung, T. W., Poorey, K., Stinear, T. P., Thomas, V. C., Meagher, R. J. & Parker, D., May 1 2019, In : Infection and immunity. 87, 5, e00163-19.

Research output: Contribution to journalArticle

Endopeptidase Clp
Statistical Factor Analysis
Virulence
Staphylococcus aureus
Gene Expression
5 Citations (Scopus)

Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection

Zhou, C., Bhinderwala, F., Lehman, M. K., Thomas, V. C., Chaudhari, S. S., Yamada, K. J., Foster, K. W., Powers, R., Kielian, T. & Fey, P. D., Jan 1 2019, In : PLoS pathogens. 15, 1, e1007538.

Research output: Contribution to journalArticle

Urease
Staphylococcus aureus
Kidney
Acids
Infection
2017
7 Citations (Scopus)

Nitrite derived from endogenous bacterial nitric oxide synthase activity promotes aerobic respiration

Chaudhari, S. S., Kim, M., Lei, S., Razvi, F., Alqarzaee, A. A., Hutfless, E. H., Powers, R., Zimmerman, M. C., Fey, P. D. & Chittezham Thomas, V., Jul 1 2017, In : mBio. 8, 4, e00887-17.

Research output: Contribution to journalArticle

Nitrites
Nitric Oxide Synthase
Respiration
Nitric Oxide
Growth
1 Citation (Scopus)

Take my breath away?

Chittezham Thomas, V. & Fey, P. D., Apr 4 2017, In : eLife. 6, e23845.

Research output: Contribution to journalArticle

Open Access
Biofilms
Cell Wall
Cells
Oxygen
9 Citations (Scopus)

The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus

Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, D., Dec 1 2017, In : Scientific reports. 7, 1, 11739.

Research output: Contribution to journalArticle

Protein Unfolding
Proteolysis
Staphylococcus aureus
Peptide Hydrolases
Operon
2016
5 Citations (Scopus)

Potassium uptake modulates Staphylococcus aureus metabolism

Gries, C. M., Sadykov, M. R., Bulock, L. L., Chaudhari, S. S., Chittezham Thomas, V., Bose, J. L. & Bayles, K. W., May 1 2016, In : mSphere. 1, 3, e00125-16.

Research output: Contribution to journalArticle

Staphylococcus aureus
Potassium
Homeostasis
Carbon Cycle
Proton-Motive Force
7 Citations (Scopus)

Redox Imbalance Underlies the Fitness Defect Associated with Inactivation of the Pta-AckA Pathway in Staphylococcus aureus

Marshall, D. D., Sadykov, M. R., Chittezham Thomas, V., Bayles, K. W. & Powers, R., Apr 1 2016, In : Journal of proteome research. 15, 4, p. 1205-1212 8 p.

Research output: Contribution to journalArticle

Phosphate Acetyltransferase
Acetate Kinase
Oxidation-Reduction
Staphylococcus aureus
Metabolism
6 Citations (Scopus)

Resistance to acute macrophage killing promotes airway fitness of prevalent community-acquired staphylococcus aureus strains

Yajjala, V. K., Chittezham Thomas, V., Bauer, C., Scherr, T. D., Fischer, K. J., Fey, P. D., Bayles, K. W., Kielian, T. L. & Sun, K., May 15 2016, In : Journal of Immunology. 196, 10, p. 4196-4203 8 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Macrophages
Infection
Staphylococcal Pneumonia
10 Citations (Scopus)

SrrAB modulates Staphylococcus aureus cell death through regulation of cidABC transcription

Windham, I. H., Chaudhari, S. S., Bose, J. L., Chittezham Thomas, V. & Bayles, K. W., Jan 1 2016, In : Journal of bacteriology. 198, 7, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Cell Death
Operon
Biofilms
Reactive Oxygen Species
9 Citations (Scopus)

The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus

Chaudhari, S. S., Chittezham Thomas, V., Sadykov, M. R., Bose, J. L., Ahn, D. J., Zimmerman, M. C. & Bayles, K. W., Sep 1 2016, In : Molecular Microbiology. 101, 6, p. 942-953 12 p.

Research output: Contribution to journalArticle

Regulon
Operon
Staphylococcus aureus
Acetates
Cell Death
2014
39 Citations (Scopus)

A Central Role for Carbon-Overflow Pathways in the Modulation of Bacterial Cell Death

Chittezham Thomas, V., Sadykov, M. R., Chaudhari, S. S., Jones, J., Endres, J. L., Widhelm, T. J., Ahn, J. S., Jawa, R. S., Zimmerman, M. C. & Bayles, K. W., Jun 2014, In : PLoS pathogens. 10, 6, e1004205.

Research output: Contribution to journalArticle

Cell Death
Carbon
Biofilms
acetolactate decarboxylase
Acetolactate Synthase
35 Citations (Scopus)

Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis

Lindgren, J. K., Chittezham Thomas, V., Olson, M. E., Chaudhari, S. S., Nuxoll, A. S., Schaeffer, C. R., Lindgren, K. E., Jones, J., Zimmerman, M. C., Dunman, P. M., Bayles, K. W. & Fey, P. D., 2014, In : Journal of bacteriology. 196, 12, p. 2277-2289 13 p.

Research output: Contribution to journalArticle

Staphylococcus epidermidis
Biofilms
Homeostasis
Acids
Ammonia
42 Citations (Scopus)

Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds

Wang, G., Hanke, M. L., Mishra, B., Lushnikova, T., Heim, C. E., Chittezham Thomas, V., Bayles, K. W. & Kielian, T. L., Sep 19 2014, In : ACS Chemical Biology. 9, 9, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

Peptides
Pathogens
Screening
Peptide Library
Enterococcus faecium
2013
26 Citations (Scopus)

A dysfunctional tricarboxylic acid cycle enhances fitness of Staphylococcus epidermidis during β-lactam stress

Chittezham Thomas, V., Kinkead, L. C., Janssen, A., Schaeffer, C. R., Woods, K. M., Lindgren, J. K., Peaster, J. M., Chaudhari, S. S., Sadykov, M., Jones, J., Mohamadi AbdelGhani, S. M., Zimmerman, M. C., Bayles, K. W., Somerville, G. A. & Fey, P. D., Aug 20 2013, In : mBio. 4, 4

Research output: Contribution to journalArticle

Lactams
Citric Acid Cycle
Staphylococcus epidermidis
Anti-Bacterial Agents
Reactive Oxygen Species
34 Citations (Scopus)

Inactivation of the Pta-AckA pathway causes cell death in staphylococcus aureus

Sadykov, M. R., Chittezham Thomas, V., Marshall, D. D., Wenstrom, C. J., Moormeier, D. E., Widhelm, T. J., Nuxoll, A. S., Powers, R. & Bayles, K. W., Jul 16 2013, In : Journal of bacteriology. 195, 13, p. 3035-3044 10 p.

Research output: Contribution to journalArticle

Phosphate Acetyltransferase
Acetate Kinase
Staphylococcus aureus
Cause of Death
Pyruvic Acid
2012
51 Citations (Scopus)

Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37

Wang, G., Epand, R. F., Mishra, B., Lushnikova, T., Chittezham Thomas, V., Bayles, K. W. & Epand, R. M., Feb 1 2012, In : Antimicrobial Agents and Chemotherapy. 56, 2, p. 845-856 12 p.

Research output: Contribution to journalArticle

Escherichia coli
Staphylococcus aureus
Membranes
Antimicrobial Cationic Peptides
Peptides
41 Citations (Scopus)

The NsrR regulon in nitrosative stress resistance of Salmonella enterica serovar Typhimurium

Karlinsey, J. E., Bang, I. S., Becker, L. A., Frawley, E. R., Porwollik, S., Robbins, H. F., Thomas, V. C., Urbano, R., Mcclelland, M. & Fang, F. C., Sep 1 2012, In : Molecular Microbiology. 85, 6, p. 1179-1193 15 p.

Research output: Contribution to journalArticle

Regulon
Salmonella enterica
Nitric Oxide
Salmonella
Virulence
2011
70 Citations (Scopus)

Multiple targets of nitric oxide in the tricarboxylic acid cycle of salmonella enterica serovar typhimurium

Richardson, A. R., Payne, E. C., Younger, N., Karlinsey, J. E., Thomas, V. C., Becker, L. A., Navarre, W. W., Castor, M. E., Libby, S. J. & Fang, F. C., Jul 21 2011, In : Cell Host and Microbe. 10, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

Salmonella enterica
Citric Acid Cycle
Nitric Oxide
Dihydrolipoamide Dehydrogenase
Methionine
2010
75 Citations (Scopus)

Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis

Thurlow, L. R., Thomas, V. C., Narayanan, S., Olson, S., Fleming, S. D. & Hancock, L. E., Nov 1 2010, In : Infection and immunity. 78, 11, p. 4936-4943 8 p.

Research output: Contribution to journalArticle

Gelatinases
Enterococcus faecalis
Endocarditis
Aortic Valve
Neutrophils
2009
115 Citations (Scopus)

A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis

Thomas, V. C., Hiromasa, Y., Harms, N., Thurlow, L., Tomich, J. & Hancock, L. E., May 1 2009, In : Molecular Microbiology. 72, 4, p. 1022-1036 15 p.

Research output: Contribution to journalArticle

Gelatinases
Enterococcus faecalis
Biofilms
DNA
N-Acetylmuramoyl-L-alanine Amidase
67 Citations (Scopus)

Capsular polysaccharide production in Enterococcus faecalis and contribution of CpsF to capsule serospecificity

Thurlow, L. R., Thomas, V. C. & Hancock, L. E., Oct 1 2009, In : Journal of bacteriology. 191, 20, p. 6203-6210 8 p.

Research output: Contribution to journalArticle

Enterococcus faecalis
Capsules
Polysaccharides
Serogroup
Operon
46 Citations (Scopus)

Enterococcus faecalis capsular polysaccharide serotypes C and D and their contributions to host innate immune evasion

Thurlow, L. R., Thomas, V. C., Fleming, S. D. & Hancock, L. E., Dec 1 2009, In : Infection and immunity. 77, 12, p. 5551-5557 7 p.

Research output: Contribution to journalArticle

Immune Evasion
Enterococcus faecalis
Polysaccharides
Capsules
Virulence Factors
24 Citations (Scopus)

Enterococcus faecalis with the gelatinase phenotype regulated by the fsr operon and with biofilm-forming capacity are common in the agricultural environment

MacOvei, L., Ghosh, A., Thomas, V. C., Hancock, L. E., Mahmood, S. & Zurek, L., Jun 1 2009, In : Environmental microbiology. 11, 6, p. 1540-1547 8 p.

Research output: Contribution to journalArticle

Gelatinases
Enterococcus faecalis
operon
Operon
Biofilms
2008
172 Citations (Scopus)

Regulation of autolysis-dependent extracellular DNA release by Enterococcus faecalis extracellular proteases influences biofilm development

Thomas, V. C., Thurlow, L. R., Boyle, D. & Hancock, L. E., Aug 1 2008, In : Journal of bacteriology. 190, 16, p. 5690-5698 9 p.

Research output: Contribution to journalArticle

Autolysis
Enterococcus faecalis
Biofilms
Peptide Hydrolases
DNA
2007
29 Citations (Scopus)

Full activation of Enterococcus faecalis gelatinase by a C-terminal proteolytic cleavage

Del Papa, M. F., Hancock, L. E., Thomas, V. C. & Perego, M., Dec 1 2007, In : Journal of bacteriology. 189, 24, p. 8835-8843 9 p.

Research output: Contribution to journalArticle

Gelatinases
Enterococcus faecalis
His-His-His-His-His-His
Peptide Hydrolases
Metalloendopeptidases