Tony Hollingsworth, PhD

Professor

  • 16059 Citations
  • 66 h-Index
1981 …2021
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  • 34 Similar Profiles
Pancreatic Neoplasms Medicine & Life Sciences
Mucins Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences
Glycosylation Chemical Compounds
Tandem Repeat Sequences Medicine & Life Sciences
Pancreas Medicine & Life Sciences
Cell Line Medicine & Life Sciences

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Projects 1984 2021

LABORATORY CANCER RESEARCH CENTER

Cerny, R., Issenberg, P., Bresnick, E., Kuszynski, C. A., Christman, J., Lynch, J. C., Tempero, M., Nagel, D., Smith, D. L., Kuszynski, C. A., Pour, P., Vose, J. M., Hollingsworth, T., Rogan, E. G., Bridge, J. A., Sherman, S., Lawson, T. A., Johnson, D. R., Kessinger, M. A., Cowan, K. H., Hollingsworth, T., Rogan, E. G., Bridge, J. A., Volsky, D., Conrad, R., Nagel, D., Rhode, S., Ruddon, R., Ramspott, E., Pour, P., Gmeiner, W., Lewis, R. E., Borgstahl, G. E., Caplan, S. H., Band, H., Ganti, A. K. P., Meza, J. L., Black, J. D., Guda, B., Wang, J., Semerad, C. L. & Wang, G.

National Institutes of Health

7/1/847/31/21

Project: Research project

Neoplasms
Research
Tissue and Organ Procurement
Molecular Biology
Research Personnel
Pancreatic Neoplasms
Tumor Microenvironment
Neoplasm Metastasis
Neoplasms
Cadherins
gemcitabine
rosiglitazone
Adenocarcinoma
Neoplasms
Pancreatic Neoplasms
Alternative Splicing
Pancreatic Neoplasms
Protein Isoforms
Phosphorylation
Adenocarcinoma

Research Output 1981 2019

A polymeric nanogel-based treatment regimen for enhanced efficacy and sequential administration of synergistic drug combination in pancreatic cancer

Soni, K. S., Thomas, D., Caffrey, T., Mehla, K., Lei, F., O'Connell, K. A., Sagar, S., Lele, S. M., Hollingsworth, M. A., Radhakrishnan, P. & Bronich, T. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 894-901 8 p.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Drug Combinations
Pancreatic Neoplasms
Adenocarcinoma
Nanomedicine

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 1 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Down-Regulation
Cell Line
Apoptosis
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Adenocarcinoma
Mucins
Unfolded Protein Response
Terpenes
5 Citations (Scopus)

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

Connor, A. A., Denroche, R. E., Jang, G. H., Lemire, M., Zhang, A., Chan-Seng-Yue, M., Wilson, G., Grant, R. C., Merico, D., Lungu, I., Bartlett, J. M. S., Chadwick, D., Liang, S. B., Eagles, J., Mbabaali, F., Miller, J. K., Krzyzanowski, P., Armstrong, H., Luo, X., Jorgensen, L. G. T. & 25 others, Romero, J. M., Bavi, P., Fischer, S. E., Serra, S., Hafezi-Bakhtiari, S., Caglar, D., Roehrl, M. H. A., Cleary, S., Hollingsworth, M. A., Petersen, G. M., Thayer, S., Law, C. H. L., Nanji, S., Golan, T., Smith, A. L., Borgida, A., Dodd, A., Hedley, D., Wouters, B. G., O'Kane, G. M., Wilson, J. M., Zogopoulos, G., Notta, F., Knox, J. J. & Gallinger, S., Feb 11 2019, In : Cancer Cell. 35, 2, p. 267-282.e7

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Cell Cycle
Neoplasm Metastasis
Neoplasms
Cell Hypoxia

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
Mucin-1
Enterovirus
Pancreatitis
Macrophages
Inflammation