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Thomas L McDonald, PhD, DVM

Professor

  • 2036 Citations
  • 23 h-Index
1970 …2018
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Research Output 1970 2018

  • 2036 Citations
  • 23 h-Index
  • 74 Article
  • 1 Chapter
2018

Creatinine downregulates TNF-α in macrophage and T cell lines

Riesberg, L. A., McDonald, T. L., Wang, Y., Chen, X. M., Holzmer, S. W., Tracy, S. M. & Drescher, K. M., Oct 2018, In : Cytokine. 110, p. 29-38 10 p.

Research output: Contribution to journal › Article

T-cells
Macrophages
Creatinine
Down-Regulation
Tumor Necrosis Factor-alpha
2 Citations (Scopus)

Serum amyloid A1 (SAA1) protein in human colostrum

Sack, G. H., Zachara, N., Rosenblum, N., Talbot, C. C., Kreimer, S., Cole, R. & McDonald, T. L., Mar 2018, In : FEBS Open Bio. 8, 3, p. 435-441 7 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Colostrum
Amyloid
Mass spectrometry
Serum
2016
10 Citations (Scopus)

Beyond muscles: The untapped potential of creatine

Riesberg, L. A., Weed, S. A., McDonald, T. L., Eckerson, J. M. & Drescher, K. M., Aug 1 2016, In : International Immunopharmacology. 37, p. 31-42 12 p.

Research output: Contribution to journal › Article

Creatine
Muscles
Immune System
Sarcopenia
Wasting Syndrome
2014
3 Citations (Scopus)

A novel, broadly applicable approach to isolation of fungi in diverse growth media

Smithee, S., Tracy, S., Drescher, K. M., Pitz, L. A. & McDonald, T., Oct 2014, In : Journal of Microbiological Methods. 105, p. 155-161 7 p.

Research output: Contribution to journal › Article

Creatinine
Fungi
Growth
Agar
Waste Products
2012
4 Citations (Scopus)

Creatinine inhibits bacterial replication

McDonald, T., Drescher, K. M., Weber, A. & Tracy, S., Mar 1 2012, In : Journal of Antibiotics. 65, 3, p. 153-156 4 p.

Research output: Contribution to journal › Article

Creatinine
Anti-Bacterial Agents
Bacteria
2011
10 Citations (Scopus)

Effect of creatine, creatinine, and creatine ethyl ester on TLR expression in macrophages

Leland, K. M., McDonald, T. L. & Drescher, K. M., Sep 1 2011, In : International Immunopharmacology. 11, 9, p. 1341-1347 7 p.

Research output: Contribution to journal › Article

Creatine
Creatinine
Macrophages
Toll-Like Receptor 2
Waste Products
2009
13 Citations (Scopus)

Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: In vitro and in murine models of intestinal disease

Gardiner, G. E., O'Flaherty, S., Casey, P. G., Weber, A., McDonald, T. L., Cronin, M., Hill, C., Ross, R. P., Gahan, C. G. M. & Shanahan, F., Apr 1 2009, In : FEMS Immunology and Medical Microbiology. 55, 3, p. 404-413 10 p.

Research output: Contribution to journal › Article

Amyloidogenic Proteins
Intestinal Diseases
Colostrum
Blood Proteins
Breast
2007
114 Citations (Scopus)

Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast

Manuell, A. L., Beligni, M. V., Elder, J. H., Siefker, D. T., Tran, M., Weber, A., McDonald, T. L. & Mayfield, S. P., May 1 2007, In : Plant Biotechnology Journal. 5, 3, p. 402-412 11 p.

Research output: Contribution to journal › Article

Chlamydomonas
Chloroplasts
amyloid
Amyloid
breasts
2006
10 Citations (Scopus)

Bovine serum amyloid A3 gene structure and promoter analysis: Induced transcriptional expression by bacterial components and the hormone prolactin

Larson, M. A., Weber, A. & McDonald, T. L., Oct 1 2006, In : Gene. 380, 2, p. 104-110 7 p.

Research output: Contribution to journal › Article

Amyloid
Prolactin
Lipopolysaccharides
Hormones
Serum
32 Citations (Scopus)

Staphylococcus aureus lipotechoic acid induces differential expression of bovine serum amyloid A3 (SAA3) by mammary epithelial cells: Implications for early diagnosis of mastitis

Weber, A., Weber, A. T., McDonald, T. L. & Larson, M. A., Jan 15 2006, In : Veterinary Immunology and Immunopathology. 109, 1-2, p. 79-83 5 p.

Research output: Contribution to journal › Article

Mastitis
early diagnosis
amyloid
Amyloid
mastitis
2005
42 Citations (Scopus)

Differential expression and secretion of bovine serum amyloid A3 (SAA3) by mammary epithelial cells stimulated with prolactin or lipopolysaccharide

Larson, M. A., Weber, A., Weber, A. T. & McDonald, T. L., Sep 15 2005, In : Veterinary Immunology and Immunopathology. 107, 3-4, p. 255-264 10 p.

Research output: Contribution to journal › Article

amyloid
prolactin
Amyloid
Prolactin
lipopolysaccharides
2003
53 Citations (Scopus)

Human serum amyloid A3 peptide enhances intestinal MUC3 expression and inhibits EPEC adherence

Larson, M. A., Wei, S. H., Weber, A., Mack, D. R. & McDonald, T. L., Jan 10 2003, In : Biochemical and Biophysical Research Communications. 300, 2, p. 531-540 10 p.

Research output: Contribution to journal › Article

Enteropathogenic Escherichia coli
Amyloid
Escherichia coli
Peptides
Mucins
53 Citations (Scopus)

Induction of human mammary-associated serum amyloid A3 expression by prolactin or lipopolysaccharide

Larson, M. A., Wei, S. H., Weber, A., Weber, A. T. & McDonald, T. L., Feb 21 2003, In : Biochemical and Biophysical Research Communications. 301, 4, p. 1030-1037 8 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Amyloid
Prolactin
Lipopolysaccharides
Protein Isoforms
35 Citations (Scopus)

The conserved TFLK motif of mammary-associated serum amyloid A3 is responsible for up-regulation of intestinal MUC3 mucin expression in vitro

Mack, D. R., McDonald, T. L., Larson, M. A., Wei, S. & Weber, A., Jan 1 2003, In : Pediatric Research. 53, 1, p. 137-142 6 p.

Research output: Contribution to journal › Article

Open Access
Mucins
Amyloid
Serum Amyloid A Protein
Breast
Up-Regulation
2001
230 Citations (Scopus)

Acute phase proteins in serum and milk from dairy cows with clinical mastitis

Eckersall, P. D., Young, F. J., McComb, C., Hogarth, C. J., Safi, S., Weber, A., McDonald, T., Nolan, A. M. & Fitzpatrick, J. L., Jan 13 2001, In : Veterinary Record. 148, 2, p. 35-41 7 p.

Research output: Contribution to journal › Article

acute phase proteins
Acute-Phase Proteins
Mastitis
haptoglobins
mastitis
158 Citations (Scopus)

Elevated extrahepatic expression and secretion of mammary-associated serum amyloid A 3 (M-SAA3) into colostrum

McDonald, T. L., Larson, M. A., Mack, D. R. & Weber, A., Dec 15 2001, In : Veterinary Immunology and Immunopathology. 83, 3-4, p. 203-211 9 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Colostrum
amyloid
colostrum
breasts
1998
9 Citations (Scopus)

Monoclonal and polyclonal antibodies recognizing acetaldehyde-protein adducts

Thiele, G. M., Tuma, D. J., Miller, J. A., Wegter, K. M., McDonald, T. L. & Klassen, L. W., Dec 1 1998, In : Biochemical Pharmacology. 56, 11, p. 1515-1523 9 p.

Research output: Contribution to journal › Article

Acetaldehyde
Monoclonal Antibodies
Antibodies
Liver
Proteins
80 Citations (Scopus)

Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant

Thiele, G. M., Tuma, D. J., Willis, M. S., Miller, J. A., McDonald, T. L., Sorrell, M. F. & Klassen, L. W., Nov 1998, In : Alcoholism: Clinical and Experimental Research. 22, 8, p. 1731-1739 9 p.

Research output: Contribution to journal › Article

Acetaldehyde
Malondialdehyde
Epitopes
Antibodies
Antibody Formation
1996
1 Citation (Scopus)

Assessment of the role of the immunoglobulin isotypes in the development of diabetic nephropathy in untreated streptozotocin-induced diabetic rats

Thiele, G. M. & McDonald, T. L., Dec 1 1996, In : Diatom Research. 12, 1, p. 15-24 10 p.

Research output: Contribution to journal › Article

diabetic nephropathy
Immunoglobulin Isotypes
streptozotocin
Diabetic Nephropathies
Streptozocin
83 Citations (Scopus)

Immunologic attributes of cytokine mobilized peripheral blood stem cells and recovery following transplantation

Talmadge, J. E., Reed, E. C., Kessinger, A., Kuszynski, C. A., Perry, G. A., Gordy, C. L., Mills, K. C., Thomas, M. L., Pirruccello, S. J., Letheby, B. A., Arneson, M. A. & Jackson, J. D., Jan 1 1996, In : Bone marrow transplantation. 17, 1, p. 101-109 9 p.

Research output: Contribution to journal › Article

Transplantation
Cytokines
Monocytes
Peripheral Blood Stem Cells
Hematopoietic System
16 Citations (Scopus)

Regulation and characterization of the interferon-α present in patients with advanced human immunodeficiency virus type 1 disease

Swindells, S., Baldwin, T., Kelly, C., Baca-Regen, L., Loomis, L., Post, D., Brichacek, B., Stevenson, M., Dominguez, E. A., Reddy, R., Klein, R., Liao, M. J., Testa, D., McDonald, T. L., Bellanti, J., Skurkovich, S. & Gendelman, H. E., Feb 1996, In : Journal of Interferon and Cytokine Research. 16, 2, p. 127-137 11 p.

Research output: Contribution to journal › Article

Virus Diseases
Interferons
HIV-1
Blood Component Removal
Acquired Immunodeficiency Syndrome
1994
23 Citations (Scopus)

Detection of Reduced Acetaldehyde Protein Adducts Using a Unique Monoclonal Antibody

Klassen, L. W., Tuma, D. J., Sorrell, M. F., McDonald, T. L., DeVasure, J. M. & Thiele, G. M., Feb 1994, In : Alcoholism: Clinical and Experimental Research. 18, 1, p. 164-171 8 p.

Research output: Contribution to journal › Article

Acetaldehyde
Monoclonal Antibodies
Antibodies
Proteins
Hybridomas
14 Citations (Scopus)

Specificity to N-ethyl lysine of a monoclonal antibody to acetaldehyde-modified proteins prepared under reducing conditions

Thiele, G. M., Wegter, K. M., Sorrell, M. F., Tuma, D. J., McDonald, T. L. & Klassen, L. W., Jul 5 1994, In : Biochemical Pharmacology. 48, 1, p. 183-189 7 p.

Research output: Contribution to journal › Article

Acetaldehyde
Monoclonal Antibodies
Epidermal Growth Factor
Proteins
Lysine
1993
363 Citations (Scopus)

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection

Bukrinsky, M. I., Sharova, N., Mcdonald, T. L., Pushkarskaya, T., Tarpley, W. G. & Stevenson, M., Jul 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 13, p. 6125-6129 5 p.

Research output: Contribution to journal › Article

Open Access
Integrases
Nucleoproteins
Viral DNA
Nucleic Acids
HIV-1
27 Citations (Scopus)

Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin

Braddock, S. W., Kay, H. D., Maennle, D., McDonald, T. L., Pirruccello, S. J., Masih, A., Klassen, L. W. & Sawka, A. R., Jan 1 1993, In : Journal of the American Academy of Dermatology. 28, 5, p. 691-695 5 p.

Research output: Contribution to journal › Article

Mucinoses
Antigen-Antibody Complex
Skin
Hydroxychloroquine
Natural Killer Cells
15 Citations (Scopus)

Glomerular injury in end-stage liver disease - role of circulating IgG and IgM immune complexes

Milner, L. S., Houser, M. T., Kolbeck, P. C., Antonson, D. L., McDonald, T. L., Markin, R. S. & Shaw, B. W., Feb 1 1993, In : Pediatric Nephrology. 7, 1, p. 6-10 5 p.

Research output: Contribution to journal › Article

End Stage Liver Disease
Antigen-Antibody Complex
Immunoglobulin M
Immunoglobulin G
Wounds and Injuries
1992
27 Citations (Scopus)

Comparison of serum amyloid A and C‐reactive protein as indicators of lung inflammation in corticosteroid treated and non‐corticosteroid treated cystic fibrosis patients

Smith, J. W., Colombo, J. L. & McDonald, T. L., 1992, In : Journal of Clinical Laboratory Analysis. 6, 4, p. 219-224 6 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Cystic Fibrosis
Pneumonia
Adrenal Cortex Hormones
Proteins
2 Citations (Scopus)

Comparison of the use of bulk to micro culture of cell preparations for lymphokine‐activated cytotoxicity assays

Anderson, L. H., McDonald, T. L., Thiele, G. M. & Klassen, L. W., 1992, In : Journal of Clinical Laboratory Analysis. 6, 3, p. 113-118 6 p.

Research output: Contribution to journal › Article

Cytotoxicity
Cell culture
Assays
Cell Culture Techniques
Centrifugation
49 Citations (Scopus)

Production of serum amyloid A and C-reactive protein by HepG2 cells: Stimulated with combinations of cytokines or monocyte conditioned media: The effects of prednisolone

Smith, J. W. & McDonald, T. L., Jan 1 1992, In : Clinical and Experimental Immunology. 90, 2, p. 293-299 7 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Hep G2 Cells
Conditioned Culture Medium
Prednisolone
Interleukin-1
1991
68 Citations (Scopus)

A monoclonal antibody sandwich immunoassay for serum amyloid A (SAA) protein

McDonald, T. L., Weber, A. & Smith, J. W., Nov 22 1991, In : Journal of Immunological Methods. 144, 2, p. 149-155 7 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Immunoassay
Monoclonal Antibodies
Serum
Hydrophobic and Hydrophilic Interactions
8 Citations (Scopus)

Use of ethanol-eluted hydrophobic interaction chromatography in the purification of serum amyloid A

Smith, J. W. & McDonald, T. L., Jan 1 1991, In : Protein Expression and Purification. 2, 2-3, p. 158-161 4 p.

Research output: Contribution to journal › Article

Serum Amyloid A Protein
Chromatography
Hydrophobic and Hydrophilic Interactions
Purification
Ethanol
1990
4 Citations (Scopus)

An enzyme‐linked immunosorbent assay for the detection of antitetanus toxoid antibody using aluminum‐absorbed coating antigen

Thiele, G. M., Rogers, J., Collins, M., Yasuda, N., McDonald, T. L. & McDonald, T. L., 1990, In : Journal of Clinical Laboratory Analysis. 4, 2, p. 126-129 4 p.

Research output: Contribution to journal › Article

Toxoids
Immunosorbents
Tetanus
Assays
Antigens
5 Citations (Scopus)

Autonomous growth of lymphoid cells following IL-2 expression from retrovirus vectors containing HIV-1 trans-acting elements

Shapiro, I. M., Meier, C., Vlach, V., McDonald, T. L., Wigzell, H. & Stevenson, M., Jan 1 1990, In : Somatic Cell and Molecular Genetics. 16, 1, p. 1-14 14 p.

Research output: Contribution to journal › Article

Retroviridae
Interleukin-2
HIV-1
Lymphocytes
Growth
1 Citation (Scopus)

Construction and use of a template block for radial immunodiffusion

McDonald, T. L., Weber, A. & Thiele, G., Apr 1990, In : Analytical Biochemistry. 186, 1, p. 165-168 4 p.

Research output: Contribution to journal › Article

Immunodiffusion
Sepharose
Albumins
Assays
Immunoglobulin G
1 Citation (Scopus)

Immunoglobulin subclasses in the urine of control and streptozotocin-induced diabetic rats and their role in the development of diabetic nephropathy.

McDonald, T. L. & Thiele, G. M., Apr 1990, In : Diabetes research (Edinburgh, Lothian). 13, 4, p. 169-176 8 p.

Research output: Contribution to journal › Article

Diabetic Nephropathies
Streptozocin
Immunoglobulins
Urine
Immunoglobulin G
1989
58 Citations (Scopus)

IgG subclasses in gingival crevicular fluid from active versus stable periodontal sites.

Reinhardt, R. A., McDonald, T. L., Bolton, R. W., DuBois, L. M. & Kaldahl, W. B., Jan 1989, In : Journal of periodontology. 60, 1, p. 44-50 7 p.

Research output: Contribution to journal › Article

Gingival Crevicular Fluid
Immunoglobulin G
Periodontitis
Albumins
Catalytic Domain
58 Citations (Scopus)

Injury induces increase of von Willebrand factor in rat endothelial cells

Reidy, M. A., Chopek, M., Chao, S., McDonald, T. & Schwartz, S. M., Jan 1 1989, In : American Journal of Pathology. 134, 4, p. 857-864 8 p.

Research output: Contribution to journal › Article

von Willebrand Factor
Endothelial Cells
Wounds and Injuries
Antibodies
Endotoxins
1988
26 Citations (Scopus)

In situ activated T lymphocytes in active versus stable periodontal lesions

Reinhardt, R. A., McDonald, T. L., Bolton, R. W., DuBois, L. M., Feely, D. E. & Kaldahl, W. B., Sep 1988, In : Journal of Periodontal Research. 23, 5, p. 295-302 8 p.

Research output: Contribution to journal › Article

T-Lymphocytes
Biopsy
Helper-Inducer T-Lymphocytes
T-Lymphocyte Subsets
Alkaline Phosphatase
67 Citations (Scopus)

In situ lymphocyte subpopulations from active versus stable periodontal sites.

Reinhardt, R. A., Bolton, R. W., McDonald, T. L., DuBois, L. M. & Kaldahl, W. B., Oct 1988, In : Journal of periodontology. 59, 10, p. 656-670 15 p.

Research output: Contribution to journal › Article

Lymphocyte Subsets
Catalytic Domain
Biopsy
B-Lymphocytes
Helper-Inducer T-Lymphocytes
14 Citations (Scopus)

Protection of mice against the lethal effect of an intraperitoneal infection with Haemophilus (Actinobacillus) pleuropneumoniae after vaccination with capsular proteins

Lenser, D. K., McDonald, T. L. & Miller, N. G., Dec 1988, In : Veterinary Microbiology. 18, 3-4, p. 335-348 14 p.

Research output: Contribution to journal › Article

Actinobacillus pleuropneumoniae
Haemophilus
serotypes
Vaccination
vaccination
1987
2 Citations (Scopus)

Immunoglobulin isotypes in the circulating immune complexes of diabetic rats with and without proteinuria: A chronological study

Thiele, G. M. & McDonald, T. L., Jan 1 1987, In : Journal of Clinical and Laboratory Immunology. 22, 1, p. 19-28 10 p.

Research output: Contribution to journal › Article

Immunoglobulin Isotypes
Antigen-Antibody Complex
Proteinuria
Albuminuria
Diabetic Nephropathies
15 Citations (Scopus)

Isolation and characterization of circulating immune complexes from patients with pneumococcal pneumonia.

Mellencamp, M. A., Preheim, L. C. & McDonald, T. L., Aug 1 1987, In : Infection and immunity. 55, 8, p. 1737-1742 6 p.

Research output: Contribution to journal › Article

Pneumococcal Pneumonia
Antigen-Antibody Complex
Immunoglobulin G
Serum
Counterimmunoelectrophoresis
1986
16 Citations (Scopus)

Circulating immune complexes in cystic fibrosis and their correlation to clinical parameters

Disis, M. L., McDonald, T. L., Colombo, J. L., Kobayashi, R. H., Angle, C. R. & Murray, S., May 1986, In : Pediatric Research. 20, 5, p. 385-390 6 p.

Research output: Contribution to journal › Article

Open Access
Antigen-Antibody Complex
Cystic Fibrosis
Immunoglobulin G
Peak Expiratory Flow Rate
Vital Signs
6 Citations (Scopus)

Interaction between canine platelets and adult heartworms: platelet recognition of heartworm surfaces.

Clemmons, R. M., Yamaguchi, R. A., Schaub, R. G., Fleming, J., Dorsey-Lee, M. R. & McDonald, T. L., Feb 1 1986, In : American journal of veterinary research. 47, 2, p. 322-325 4 p.

Research output: Contribution to journal › Article

heartworms
Dirofilariasis
Canidae
Blood Platelets
Platelet-Rich Plasma
36 Citations (Scopus)

Proliferation of human peripheral blood lymphocytes induced by recombinant human interleukin 2: Contribution of large granular lymphocytes and T lymphocytes

Talmadge, J. E., Wiltrout, R. H., Counts, D. F., Herberman, R. B., McDonald, T. & Ortaldo, J. R., Oct 15 1986, In : Cellular Immunology. 102, 2, p. 261-272 12 p.

Research output: Contribution to journal › Article

Interleukin-2
Lymphocytes
T-Lymphocytes
Antigens
Lymphocyte Subsets
24 Citations (Scopus)

Prospective study of familial canine dermatomyositis. Correlation of the severity of dermatomyositis and circulating immune complex levels

Hargis, A. M., Prieur, D. J., Haupt, K. H., McDonald, T. L. & Moore, M. P., Aug 27 1986, In : American Journal of Pathology. 123, 3, p. 465-479 15 p.

Research output: Contribution to journal › Article

Dermatomyositis
Antigen-Antibody Complex
Canidae
Prospective Studies
Dogs
1985
3 Citations (Scopus)

Accelerated onset of albuminuria in diabetic rats preimmunized with glucosylated rat serum albumin

Bassiouny, A. R., Rosenberg, H., Thiele, G. M. & McDonald, T. L., Dec 1 1985, In : Journal of Clinical and Laboratory Immunology. 18, 2, p. 69-73 5 p.

Research output: Contribution to journal › Article

Albuminuria
Serum Albumin
Antibody Formation
Albumins
Antibody Specificity

Animal model for the study of diabetic autoimmunity involving glucosylated proteins

Rosenberg, H., Bassiouny, A., Thiele, G. M. & McDonald, T. L., Jan 1 1985, In : Federation Proceedings. 44, 3, p. No. 1142

Research output: Contribution to journal › Article

Autoimmunity
Animal Models
Proteins

Correlation of circulating immune complexes with onset and severity of dermatomyositis in collies

Hargis, A. M., McDonald, T. L. & Prieur, D. J., Jan 1 1985, In : Federation Proceedings. 44, 3, p. No. 655

Research output: Contribution to journal › Article

Dermatomyositis
Antigen-Antibody Complex
28 Citations (Scopus)

Familial canine dermatomyositis: clinicopathologic, immunologic, and serologic studies.

Haupt, K. H., Prieur, D. J., Hargis, A. M., Cowell, R. L., McDonald, T. L., Werner, L. L. & Evermann, J. F., Sep 1 1985, In : American journal of veterinary research. 46, 9, p. 1870-1875 6 p.

Research output: Contribution to journal › Article

dermatomyositis
Dermatomyositis
serological surveys
Canidae
Dogs