Terrence Donohue, PhD

Professor

  • 5027 Citations
  • 33 h-Index
1979 …2019
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Research Output 1979 2019

  • 5027 Citations
  • 33 h-Index
  • 78 Article
  • 16 Review article
  • 3 Comment/debate
  • 1 Chapter
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Article
2019

Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue

Natarajan, G., Perriotte-Olson, C., Casey, C. A., Donohue, T. M., Talmon, G. A., Harris, E. N., Kabanov, A. V. & Saraswathi, V., Sep 2019, In : Alcohol. 79, p. 71-79 9 p.

Research output: Contribution to journalArticle

Liver
Superoxide Dismutase
Adipose Tissue
Zinc
Copper
1 Citation (Scopus)

Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism

Thomes, P. G., Rasineni, K., Yang, L., Donohue, T. M., Kubik, J. L., McNiven, M. A. & Casey, C. A., Apr 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 4, p. G509-G518

Research output: Contribution to journalArticle

Fatty Liver
Autophagy
Ethanol
Lipids
Liver
1 Citation (Scopus)

Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis

Fonseca, T. L., Fernandes, G. W., Bocco, B. M. L. C., Keshavarzian, A., Jakate, S., Donohue, T. M., Gereben, B. & Bianco, A. C., Jul 2019, In : Alcoholism: Clinical and Experimental Research. 43, 7, p. 1376-1383 8 p.

Research output: Contribution to journalArticle

Iodide Peroxidase
Fatty Liver
Liver
Animals
Genes
2018
3 Citations (Scopus)

Diurnal variations in intestinal barrier integrity and liver pathology in mice: Implications for alcohol binge

Voigt, R. M., Forsyth, C. B., Shaikh, M., Zhang, L., Raeisi, S., Aloman, C., Preite, N. Z., Donohue, T., Fogg, L. & Keshavarzian, A., Jan 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 1, p. G131-G141

Research output: Contribution to journalArticle

Alcohols
Pathology
Liver
Permeability
Diet
2017
4 Citations (Scopus)

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. & Kharbanda, K., Jan 1 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Fibrosis
Drinking
Liver
Alcohol Drinking
2 Citations (Scopus)

Data on the effect of pro-fibrotic cytokine TGF-β on hepatic stellate cell autophagy

Thomes, P. G., Brandon-Warner, E., Li, T., Donohue, T. & Schrum, L. W., Feb 1 2017, In : Data in Brief. 10, p. 312-314 3 p.

Research output: Contribution to journalArticle

experiment
2 Citations (Scopus)

Dietary fructose augments ethanol-induced liver pathology

Thomes, P. G., Benbow, J. H., Brandon-Warner, E., Thompson, K. J., Jacobs, C., Donohue, T. & Schrum, L. W., May 1 2017, In : Journal of Nutritional Biochemistry. 43, p. 141-150 10 p.

Research output: Contribution to journalArticle

Pathology
Fructose
Liver
Ethanol
Nutrition
2016
21 Citations (Scopus)

Neuropilin-2 regulates endosome maturation and EGFR trafficking to support cancer cell pathobiology

Dutta, S., Roy, S., Polavaram, N. S., Stanton, M. J., Zhang, H., Bhola, T., Hönscheid, P., Donohue, T., Band, H., Batra, S. K., Muders, M. H. & Datta, K., Jan 15 2016, In : Cancer Research. 76, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

Neuropilin-2
Endosomes
Neoplasms
Endocytosis
Drug Resistance
6 Citations (Scopus)

Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype

Thomes, P. G., Brandon-Warner, E., Li, T., Donohue, T. & Schrum, L. W., Dec 1 2016, In : International Journal of Biochemistry and Cell Biology. 81, p. 137-147 11 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Autophagy
70-kDa Ribosomal Protein S6 Kinases
Phosphorylation
Phenotype
2015
19 Citations (Scopus)
Acetaldehyde
Innate Immunity
Hepacivirus
Methylation
Liver
32 Citations (Scopus)

Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB

Thomes, P. G., Trambly, C. S., Fox, H. S., Tuma, D. J. & Donohue, T., Dec 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 12, p. 2354-2363 10 p.

Research output: Contribution to journalArticle

Autophagy
Lysosomes
Ethanol
Transcription Factors
Liver
2013
15 Citations (Scopus)
Early Growth Response Protein 1
Hep G2 Cells
Ethanol
Growth
Triglycerides
9 Citations (Scopus)
Cytochrome P-450 CYP2E1
Autophagy
Antigen Presentation
Oxidants
Metabolism
27 Citations (Scopus)

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

Martin-Murphy, B. V., Kominsky, D. J., Orlicky, D. J., Donohue, T. & Ju, C., Apr 1 2013, In : Hepatology. 57, 4, p. 1575-1584 10 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Acetaminophen
Liver
Wounds and Injuries
Cytochrome P-450 CYP2E1
43 Citations (Scopus)

Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells

Thomes, P. G., Ehlers, R. A., Trambly, C. S., Clemens, D. L., Fox, H. S., Tuma, D. J. & Donohue, T., Jan 2013, In : Autophagy. 9, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Ethanol
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Acetaldehyde
2012
21 Citations (Scopus)

Early Growth Response-1 Contributes to Steatosis Development After Acute Ethanol Administration

Donohue, T., Osna, N. A., Trambly, C. S., Whitaker, N. P., Thomes, P. G., Todero, S. L. & Davis, J. S., May 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Fatty Liver
Growth
Endotoxins
7 Citations (Scopus)

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. & Kharbanda, K., Dec 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Viruses
Hepacivirus
Hepatocytes
Ethanol
42 Citations (Scopus)

Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment

Thomes, P. G., Trambly, C. S., Thiele, G. M., Duryee, M. J., Fox, H. S., Haorah, J. & Donohue, T., Jan 6 2012, In : Biochemical and Biophysical Research Communications. 417, 1, p. 262-267 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Liver
Ethanol
Therapeutics
Rats
2010
48 Citations (Scopus)

Acetyl-l-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain

Rump, T. J., Muneer, P. M. A., Szlachetka, A. M., Lamb, A., Haorei, C., Alikunju, S., Xiong, H., Keblesh, J., Liu, J., Zimmerman, M. C., Jones, J., Donohue, T., Persidsky, Y. & Haorah, J., Nov 30 2010, In : Free Radical Biology and Medicine. 49, 10, p. 1494-1504 11 p.

Research output: Contribution to journalArticle

Acetylcarnitine
Carnitine
Brain
Alcohols
Synaptic Transmission
19 Citations (Scopus)

Chronic Ethanol Consumption Results in Atypical Liver Injury in Copper/Zinc Superoxide Dismutase Deficient Mice

Curry-Mccoy, T. V., Osna, N. A., Nanji, A. A. & Donohue, T., Feb 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

Liver
Superoxide Dismutase
Zinc
Copper
Ethanol
18 Citations (Scopus)

Impaired methylation as a novel mechanism for proteasome suppression in liver cells

Osna, N. A., White, R. L., Donohue, T., Beard, M. R., Tuma, D. J. & Kharbanda, K., Jan 8 2010, In : Biochemical and Biophysical Research Communications. 391, 2, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

Methylation
Proteasome Endopeptidase Complex
Liver
S-Adenosylmethionine
Ethanol
2009
17 Citations (Scopus)

Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells

Osna, N. A., White, R. L., Thiele, G. M. & Donohue, T., Jun 24 2009, In : Hepatology. 49, 4, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Antigen Presentation
Major Histocompatibility Complex
Proteasome Endopeptidase Complex
Ethanol
15 Citations (Scopus)

Modulation of lysozyme function and degradation after nitration with peroxynitrite

Curry-McCoy, T. V., Osna, N. A. & Donohue, T., Aug 1 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 8, p. 778-786 9 p.

Research output: Contribution to journalArticle

Nitration
Peroxynitrous Acid
Muramidase
Proteasome Endopeptidase Complex
Modulation
2008
36 Citations (Scopus)

A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury

Tipoe, G. L., Liong, E. C., Casey, C. A., Donohue, T., Eagon, P. K., So, H., Leung, T. M., Fogt, F. & Nanji, A. A., Apr 1 2008, In : Alcoholism: Clinical and Experimental Research. 32, 4, p. 669-682 14 p.

Research output: Contribution to journalArticle

Liver
Rats
Ethanol
Nitric Oxide Synthase Type II
Wounds and Injuries
37 Citations (Scopus)

Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress

Osna, N. A., White, R. L., Krutik, V. M., Wang, T., Weinman, S. A. & Donohue, T., Jun 2008, In : Gastroenterology. 134, 7, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Hepatitis C
Oxidative Stress
Ethanol
Oxidants
2007
38 Citations (Scopus)

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., McVicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T., Jan 1 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Hepatocellular Carcinoma
Oxidative Stress
Ethanol
Peptides
25 Citations (Scopus)

Implication of altered proteasome function in alcoholic liver injury

Osna, N. A. & Donohue, T., Oct 7 2007, In : World Journal of Gastroenterology. 13, 37, p. 4931-4937 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Liver
Wounds and Injuries
Ethanol
Oxidative Stress
22 Citations (Scopus)

L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury

Donohue, T., Curry-McCoy, T. V., Todero, S. L., White, R. L., Kharbanda, K., Nanji, A. A. & Osna, N. A., Jun 2007, In : Alcoholism: Clinical and Experimental Research. 31, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

Liver
Glutathione
Ethanol
Wounds and Injuries
Nutrition
23 Citations (Scopus)
Liver
Rats
Ethanol
Wounds and Injuries
Enzymes
2006
87 Citations (Scopus)
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Hep G2 Cells
Cytotoxicity
Ethanol
2005
43 Citations (Scopus)

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

Osna, N. A., Clemens, D. L. & Donohue, T., Nov 1 2005, In : Hepatology. 42, 5, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Interferon-gamma
Ethanol
Phosphorylation
Cytochrome P-450 CYP2E1
42 Citations (Scopus)

Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption

Chakkalakal, D. A., Novak, J. R., Fritz, E. D., Mollner, T. J., McVicker, D. L., Garvin, K. L., McGuire, M. H. & Donohue, T., Jul 1 2005, In : Alcohol. 36, 3, p. 201-214 14 p.

Research output: Contribution to journalArticle

alcohol consumption
Alcohol Drinking
Rats
Bone
Repair
8 Citations (Scopus)

Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol

Lakshman, R., Cederbaum, A. I., Hoek, J. B., Konishi, M., Koop, D. & Donohue, T., Sep 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1726-1734 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Liver
Hep G2 Cells
Ethanol
Cells
2004
44 Citations (Scopus)

Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: Implications for impaired immune function during disease

Haorah, J., Heilman, D., Diekmann, C., Osna, N., Donohue, T. M., Ghorpade, A. & Persidsky, Y., Jun 1 2004, In : Cellular Immunology. 229, 2, p. 139-148 10 p.

Research output: Contribution to journalArticle

HIV Protease
HIV-1
Macrophages
Alcohols
HIV Infections
31 Citations (Scopus)
Alcoholic Liver Diseases
Oxidative stress
Pathology
Proteasome Endopeptidase Complex
Liver
14 Citations (Scopus)

Effects of chronic alcohol consumption on dermal penetration of pesticides in rats

Brand, R. M., Charron, A. R., Dutton, L., Gavlik, T. L., Mueller, C., Hamel, F. G., Chakkalakal, D. & Donohue, T., Jan 2004, In : Journal of Toxicology and Environmental Health - Part A. 67, 2, p. 153-161 9 p.

Research output: Contribution to journalArticle

Pesticides
Alcohol Drinking
Rats
Ethanol
Alcohols
21 Citations (Scopus)

Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats

Casey, C. A., McVicker, B. L., Donohue, T., McFarland, M. A., Wiegert, R. L. & Nanji, A. A., Jan 1 2004, In : Journal of Applied Physiology. 96, 1, p. 76-80 5 p.

Research output: Contribution to journalArticle

Asialoglycoprotein Receptor
Ethanol
Fish Oils
Liver
Triglycerides
44 Citations (Scopus)

Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo

Osna, N. A., Haorah, J., Krutik, V. M. & Donohue, T., Sep 1 2004, In : Hepatology. 40, 3, p. 574-582 9 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Proteasome Endopeptidase Complex
Rodentia
Liver
S-Nitroso-N-Acetylpenicillamine
2003
9 Citations (Scopus)
IGF Type 2 Receptor
Ethanol
Messenger RNA
Rats
Hepatocytes
47 Citations (Scopus)
Hep G2 Cells
Proteasome Endopeptidase Complex
Cytochromes
Interferon-gamma
Ethanol
2002
9 Citations (Scopus)
IGF Type 2 Receptor
Rats
Hepatocytes
Ethanol
Ligands
40 Citations (Scopus)

Chronic ethanol consumption results in deficient bone repair in rats

Chakkalakal, D. A., Novak, J. R., Fritz, E. D., Mollner, T. J., McVicker, D. L., Lybarger, D. L., McGuire, M. H. & Donohue, T., Mar 7 2002, In : Alcohol and Alcoholism. 37, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

Rats
Bone
Repair
Ethanol
Nutrition
31 Citations (Scopus)

Effect of acute and chronic alcohol treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo

Koll, M., Ahmed, S., Mantle, D., Donohue, T. M., Palmer, T. N., Simanowski, U. A., Seitz, H. K., Peters, T. J. & Preedy, V. R., Jan 2002, In : Metabolism: Clinical and Experimental. 51, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Peptide Hydrolases
Alcohols
Acetaldehyde
dipeptidyl peptidase II
2001
15 Citations (Scopus)

Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism

Donohue, J., Clemens, D. L., Galli, A., Crabb, D., Nieto, N., Kato, J. & Barve, S. S., Jun 27 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 87S-93S

Research output: Contribution to journalArticle

Metabolism
Toxicity
Cultured Cells
Ethanol
Cells
2000
141 Citations (Scopus)

Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole (44545)

Gouillon, Z. Q., Lucas, D., Li, J., Hagbjork, A. L., French, B. A., Fu, P., Fang, C., Ingelman-Sundberg, M., Donohue, T. & French, S. W., Dec 1 2000, In : Experimental Biology and Medicine. 224, 4, p. 302-308 7 p.

Research output: Contribution to journalArticle

Chlormethiazole
Liver
Rats
Liver Diseases
Ethanol
1999
28 Citations (Scopus)

Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.

Gouillon, Z. Q., Miyamoto, K., Donohue, T. M., Wan, Y. J., French, B. A., Nagao, Y., Fu, P., Reitz, R. C., Hagbjork, A., Yap, C., Yuan, Q. X., Ingelman-Sundberg, M. & French, S. W., Sep 1 1999, In : Frontiers in bioscience : a journal and virtual library. 4, p. A16-25

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Alcoholic Liver Diseases
Proteasome Endopeptidase Complex
Ubiquitin
Liver
1998
4 Citations (Scopus)

Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferase

Donohue, T., Drey, M. L. & Zetterman, R. K., Feb 1 1998, In : Alcohol. 15, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

Tyrosine Transaminase
Liver
Rats
Ethanol
animal
58 Citations (Scopus)

Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration

Donohue, T., Zetterman, R. K., Zhang-Gouillon, Z. Q. & French, S. W., Aug 17 1998, In : Hepatology. 28, 2, p. 486-491 6 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Ethanol
Proteasome Endopeptidase Complex
Liver
Diet
1997
22 Citations (Scopus)

Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration

Kharbanda, K., McVicker, D. L., Zetterman, R. K., MacDonald, R. G. & Donohue, T., Oct 1997, In : Hepatology. 26, 4, p. 929-934 6 p.

Research output: Contribution to journalArticle

Hepatocytes
Ethanol
Lysosomes
Endosomes
Hydrolases
1996
21 Citations (Scopus)

Effects of ethanol administration on components of the ubiquitin proteolytic pathway in rat liver

Born, L. J., Kharbanda, K., McVicker, D. L., Zetterman, R. K. & Donohue, T., Jan 1 1996, In : Hepatology. 23, 6, p. 1556-1563 8 p.

Research output: Contribution to journalArticle

Ubiquitin
Ethanol
Liver
Cytosol
Hepatocytes