Tammy L Kielian, PhD

Professor

  • 5414 Citations
  • 45 h-Index
19942019

Research output per year

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Research Output

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Article
2019
4 Scopus citations

Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities

Bosch, M. E. & Kielian, T., Mar 2019, In : Journal of Neurochemistry. 148, 5, p. 612-624 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis

Burkovetskaya, M., Bosch, M. E., Karpuk, N., Fallet, R. & Kielian, T., Mar 2019, In : Journal of Neurochemistry. 148, 5, p. 652-668 17 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
2 Scopus citations

Protease-mediated growth of staphylococcus aureus on host proteins is opp3 dependent

Lehman, M. K., Nuxoll, A. S., Yamada, K. J., Kielian, T., Carson, S. D. & Feya, P. D., Mar 1 2019, In : mBio. 10, 2, e02553-18.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection

Zhou, C., Bhinderwala, F., Lehman, M. K., Thomas, V. C., Chaudhari, S. S., Yamada, K. J., Foster, K. W., Powers, R., Kielian, T. & Fey, P. D., Jan 1 2019, In : PLoS pathogens. 15, 1, e1007538.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Arginase-1 expression in myeloid cells regulates Staphylococcus aureus planktonic but not biofilm infection

Yamada, K. J., Heim, C. E., Aldrich, A. L., Gries, C. M., Staudacher, A. G. & Kielian, T., Jul 1 2018, In : Infection and immunity. 86, 7, e00206-18.

Research output: Contribution to journalArticle

11 Scopus citations

Heterogeneity of Ly6G+ Ly6C+ myeloid-derived suppressor cell infiltrates during Staphylococcus aureus biofilm infection

Heim, C. E., West, S. C., Ali, H. & Kielian, T., Dec 1 2018, In : Infection and immunity. 86, 12, e00684.

Research output: Contribution to journalArticle

7 Scopus citations

Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): Implications for infection persistence

Heim, C. E., Vidlak, D., Odvody, J., Hartman, C. W., Garvin, K. L. & Kielian, T., Jun 2018, In : Journal of Orthopaedic Research. 36, 6, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Searching for novel biomarkers using a mouse model of CLN3-Batten disease

Timm, D., Cain, J. T., Geraets, R. D., White, K. A., Koh, S. Y., Kielian, T., Pearce, D. A., Hastings, M. L. & Weimer, J. M., Aug 2018, In : PloS one. 13, 8, e0201470.

Research output: Contribution to journalArticle

4 Scopus citations
2017
6 Scopus citations

SaeRS is responsive to cellular respiratory status and regulates fermentative biofilm formation in Staphylococcus aureus

Mashruwala, A. A., Gries, C. M., Scherr, T. D., Kielian, T. & Boyd, J. M., Aug 1 2017, In : Infection and immunity. 85, 8, e00157-17.

Research output: Contribution to journalArticle

14 Scopus citations

Staphylococcal biofilms and immune polarization during prosthetic joint infection

Gries, C. M. & Kielian, T., Jan 1 2017, In : Journal of the American Academy of Orthopaedic Surgeons. 25, p. S20-S24

Research output: Contribution to journalArticle

22 Scopus citations
2016

Cyclic di-AMP released from Staphylococcus aureus biofilm induces a macrophage type I interferon response

Gries, C. M., Bruger, E. L., Moormeier, D. E., Scherr, T. D., Waters, C. M. & Kielian, T., Jan 1 2016, In : Infection and immunity. 84, 12, p. 3564-3574 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3)

Aldrich, A., Bosch, M. E., Fallet, R., Odvody, J., Burkovetskaya, M., Rama Rao, K. V., Cooper, J. D., Drack, A. V. & Kielian, T., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 909-923 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Infectious dose dictates the host response during Staphylococcus aureus orthopedic-implant biofilm infection

Vidlak, D. & Kielian, T., Jan 1 2016, In : Infection and immunity. 84, 7, p. 1957-1965 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia

Sun, K., Yajjala, V. K., Bauer, C., Talmon, G. A., Fischer, K. J., Kielian, T. & Metzger, D. W., Jan 1 2016, In : Journal of Experimental Medicine. 213, 9, p. 1851-1864 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Resistance to acute macrophage killing promotes airway fitness of prevalent community-acquired staphylococcus aureus strains

Yajjala, V. K., Thomas, V. C., Bauer, C., Scherr, T. D., Fischer, K. J., Fey, P. D., Bayles, K. W., Kielian, T. & Sun, K., May 15 2016, In : Journal of Immunology. 196, 10, p. 4196-4203 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Self-complementary AAV9 gene delivery partially corrects pathology associated with juvenile neuronal ceroid lipofuscinosis (CLN3)

Bosch, M. E., Aldrich, A., Fallet, R., Odvody, J., Burkovetskaya, M., Schuberth, K., Fitzgerald, J. A., Foust, K. D. & Kielian, T., Sep 14 2016, In : Journal of Neuroscience. 36, 37, p. 9669-9682 14 p.

Research output: Contribution to journalArticle

29 Scopus citations
2015

IL-12 promotes myeloid-derived suppressor cell recruitment and bacterial persistence during Staphylococcus aureus orthopedic implant infection

Heim, C. E., Vidlak, D., Scherr, T. D., Hartman, C. W., Garvin, K. L. & Kielian, T., Apr 15 2015, In : Journal of Immunology. 194, 8, p. 3861-3872 12 p.

Research output: Contribution to journalArticle

55 Scopus citations
42 Scopus citations
11 Scopus citations

Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation

Rama Rao, K. V. & Kielian, T., Aug 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 3, p. 245-263 19 p.

Research output: Contribution to journalArticle

28 Scopus citations

Rot is a key regulator of Staphylococcus aureus biofilm formation

Mootz, J. M., Benson, M. A., Heim, C. E., Crosby, H. A., Kavanaugh, J. S., Dunman, P. M., Kielian, T., Torres, V. J. & Horswill, A. R., Apr 1 2015, In : Molecular Microbiology. 96, 2, p. 388-404 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Staphylococcus aureus biofilms induce macrophage dysfunction through leukocidin AB and alpha-toxin

Scherr, T. D., Hanke, M. L., Huang, O., James, D. B. A., Horswill, A. R., Bayles, K. W., Fey, P. D., Torres, V. J. & Kielian, T., Aug 25 2015, In : mBio. 6, 4, e01021-15.

Research output: Contribution to journalArticle

57 Scopus citations
2014

Critical role for the AIM2 inflammasome during acute CNS bacterial infection

Hanamsagar, R., Aldrich, A. & Kielian, T., May 2014, In : Journal of Neurochemistry. 129, 4, p. 704-711 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Evidence for aberrant astrocyte hemichannel activity in juvenile neuronal ceroid lipofuscinosis (JNCL)

Burkovetskaya, M., Karpuk, N., Xiong, J., Bosch, M., Boska, M. D., Takeuchi, H., Suzumura, A. & Kielian, T., Apr 15 2014, In : PloS one. 9, 4, e95023.

Research output: Contribution to journalArticle

33 Scopus citations

Hemichannels in neurodegenerative diseases: Is there a link to pathology?

Bosch, M. & Kielian, T., Aug 20 2014, In : Frontiers in Cellular Neuroscience. 8, AUG, 242.

Research output: Contribution to journalArticle

24 Scopus citations

Hiding in plain sight: Interplay between staphylococcal biofilms and host immunity

Scherr, T. D., Heim, C. E., Morrison, J. M. & Kielian, T., Jan 1 2014, In : Frontiers in immunology. 5, FEB, Article 37.

Research output: Contribution to journalArticle

60 Scopus citations

Myeloid-derived suppressor cells contribute to staphylococcus aureus orthopedic biofilm infection

Heim, C. E., Vidlak, D., Scherr, T. D., Kozel, J. A., Holzapfel, M., Muirhead, D. E. & Kielian, T., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3778-3792 15 p.

Research output: Contribution to journalArticle

87 Scopus citations

Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds

Wang, G., Hanke, M. L., Mishra, B., Lushnikova, T., Heim, C. E., Thomas, V. C., Bayles, K. W. & Kielian, T., Sep 19 2014, In : ACS chemical biology. 9, 9, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

Blue light eliminates community-acquired methicillin-resistant Staphylococcus aureus in infected mouse skin abrasions

Dai, T., Gupta, A., Huang, Y. Y., Sherwood, M. E., Murray, C. K., Vrahas, M. S., Kielian, T. & Hamblin, M. R., Nov 1 2013, In : Photomedicine and Laser Surgery. 31, 11, p. 531-538 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Compartmentalization of immune responses during staphylococcus aureus cranial bone flap infection

Cheatle, J., Aldrich, A., Thorell, W. E., Boska, M. D. & Kielian, T., Aug 1 2013, In : American Journal of Pathology. 183, 2, p. 450-458 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Global transcriptome analysis of staphylococcus aureus biofilms in response to innate immune cells

Scherr, T. D., Roux, C. M., Hanke, M. L., Angle, A., Dunman, P. M. & Kielian, T., Dec 1 2013, In : Infection and immunity. 81, 12, p. 4363-4376 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype

Xiong, J. & Kielian, T., Oct 1 2013, In : Journal of Neurochemistry. 127, 2, p. 245-258 14 p.

Research output: Contribution to journalArticle

31 Scopus citations
27 Scopus citations

Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation

Snowden, J. N., Beaver, M., Beenken, K., Smeltzer, M., Horswill, A. R. & Kielian, T., Dec 30 2013, In : PloS one. 8, 12, e84089.

Research output: Contribution to journalArticle

17 Scopus citations

Targeting macrophage activation for the prevention and treatment of staphylococcus aureus biofilm infections

Hanke, M. L., Heim, C. E., Angle, A., Sanderson, S. D. & Kielian, T., Mar 1 2013, In : Journal of Immunology. 190, 5, p. 2159-2168 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2012

Biofilm-infected intracerebroventricular shunts elicit inflammation within the central nervous system

Snowden, J. N., Beaver, M., Smeltzer, M. S. & Kielian, T., Sep 1 2012, In : Infection and immunity. 80, 9, p. 3206-3214 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

CcpA Regulates Arginine Biosynthesis in Staphylococcus aureus through Repression of Proline Catabolism

Nuxoll, A. S., Halouska, S. M., Sadykov, M. R., Hanke, M. L., Bayles, K. W., Kielian, T., Powers, R. & Fey, P. D., Nov 1 2012, In : PLoS pathogens. 8, 11, e1003033.

Research output: Contribution to journalArticle

38 Scopus citations

CD11c+/CD11b+ cells are critical for organic dust-elicited murine lung inflammation

Poole, J. A., Gleason, A. M., Bauer, C., West, W. W., Alexis, N., Van Rooijen, N., Reynolds, S. J., Romberger, D. J. & Kielian, T. L., Nov 1 2012, In : American journal of respiratory cell and molecular biology. 47, 5, p. 652-659 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300

Menousek, J., Mishra, B., Hanke, M. L., Heim, C. E., Kielian, T. & Wang, G., May 1 2012, In : International Journal of Antimicrobial Agents. 39, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

49 Scopus citations
9 Scopus citations

IL-1RI (interleukin-1 receptor type I) signalling is essential for host defence and hemichannel activity during acute central nervous system bacterial infection

Xiong, J., Burkovetskaya, M., Karpuk, N. & Kielian, T., May 9 2012, In : ASN Neuro. 4, 3, p. 175-185 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
8 Scopus citations

MyD88-dependent signaling influences fibrosis and alternative macrophage activation during staphylococcus aureus biofilm infection

Hanke, M. L., Angle, A. & Kielian, T., Aug 3 2012, In : PloS one. 7, 8, e42476.

Research output: Contribution to journalArticle

39 Scopus citations

Neuroinflammation alters voltage-dependent conductance in striatal astrocytes

Karpuk, N., Burkovetskaya, M. & Kielian, T., Jul 1 2012, In : Journal of Neurophysiology. 108, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Th1 and Th17 cells regulate innate immune responses and bacterial clearance during central nervous system infection

Holley, M. M. & Kielian, T., Feb 1 2012, In : Journal of Immunology. 188, 3, p. 1360-1370 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia

Holley, M. M., Zhang, Y., Lehrmann, E., Wood, W. H., Becker, K. G. & Kielian, T., Jan 1 2012, In : Glia. 60, 1, p. 29-42 14 p.

Research output: Contribution to journalArticle

14 Scopus citations