Tammy L Kielian, PhD

Professor

  • 5205 Citations
  • 44 h-Index
19942019
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Research Output 1994 2019

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Article
2019
2 Citations (Scopus)
Macrophages
Biofilms
Antibiotics
Scaffolds (biology)
Anti-Bacterial Agents
4 Citations (Scopus)

Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities

Bosch, M. E. & Kielian, T. L., Mar 2019, In : Journal of Neurochemistry. 148, 5, p. 612-624 13 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Calcium Signaling
Astrocytes
Calcium
1 Citation (Scopus)

Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis

Burkovetskaya, M., Bosch, M. E., Karpuk, N., Fallet, R. & Kielian, T. L., Mar 2019, In : Journal of Neurochemistry. 148, 5, p. 652-668 17 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Caspase 1
Ceroid
Chemical activation
Inflammasomes
Open Access
Staphylococcus epidermidis
Cerebrospinal Fluid
Catheters
Biomarkers
Inflammation
Electrospinning
Multilayers
Fabrication
Curcumin
Lactic acid

Protease-mediated growth of staphylococcus aureus on host proteins is opp3 dependent

Lehman, M. K., Nuxoll, A. S., Yamada, K. J., Kielian, T., Carson, S. D. & Feya, P. D., Mar 1 2019, In : mBio. 10, 2, e02553-18.

Research output: Contribution to journalArticle

Open Access
Staphylococcus aureus
Peptide Hydrolases
Peptides
Abscess
Growth
6 Citations (Scopus)

Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection

Zhou, C., Bhinderwala, F., Lehman, M. K., Thomas, V. C., Chaudhari, S. S., Yamada, K. J., Foster, K. W., Powers, R., Kielian, T. & Fey, P. D., Jan 1 2019, In : PLoS pathogens. 15, 1, e1007538.

Research output: Contribution to journalArticle

Urease
Staphylococcus aureus
Kidney
Acids
Infection
2018
8 Citations (Scopus)

Arginase-1 expression in myeloid cells regulates Staphylococcus aureus planktonic but not biofilm infection

Yamada, K. J., Heim, C. E., Aldrich, A. L., Gries, C. M., Staudacher, A. G. & Kielian, T. L., Jul 1 2018, In : Infection and immunity. 86, 7, e00206-18.

Research output: Contribution to journalArticle

Arginase
Myeloid Cells
Biofilms
Staphylococcus aureus
Infection
5 Citations (Scopus)

Heterogeneity of Ly6G+ Ly6C+ myeloid-derived suppressor cell infiltrates during Staphylococcus aureus biofilm infection

Heim, C. E., West, S. C., Ali, H. H. & Kielian, T. L., Dec 1 2018, In : Infection and immunity. 86, 12, e00684.

Research output: Contribution to journalArticle

Biofilms
Staphylococcus aureus
Infection
Monocytes
Neutrophils
6 Citations (Scopus)
Joints
Infection
Biofilms
Interleukin-10
Leukocytes
3 Citations (Scopus)

Searching for novel biomarkers using a mouse model of CLN3-Batten disease

Timm, D., Cain, J. T., Geraets, R. D., White, K. A., Koh, S. Y., Kielian, T. L., Pearce, D. A., Hastings, M. L. & Weimer, J. M., Aug 2018, In : PloS one. 13, 8, e0201470.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Biomarkers
biomarkers
animal models
mice
2017
6 Citations (Scopus)
Neuronal Ceroid-Lipofuscinoses
Visual Cortex
Hippocampus
Neurons
Lysosomal Storage Diseases
10 Citations (Scopus)

SaeRS is responsive to cellular respiratory status and regulates fermentative biofilm formation in Staphylococcus aureus

Mashruwala, A. A., Gries, C. M., Scherr, T. D., Kielian, T. L. & Boyd, J. M., Aug 1 2017, In : Infection and immunity. 85, 8, e00157-17.

Research output: Contribution to journalArticle

Biofilms
Staphylococcus aureus
Respiration
N-Acetylmuramoyl-L-alanine Amidase
Cell Respiration
16 Citations (Scopus)

Staphylococcal biofilms and immune polarization during prosthetic joint infection

Gries, C. M. & Kielian, T. L., Jan 1 2017, In : Journal of the American Academy of Orthopaedic Surgeons. 25, p. S20-S24

Research output: Contribution to journalArticle

Biofilms
Joints
Infection
Community-Acquired Infections
Knee Replacement Arthroplasties
2016
16 Citations (Scopus)

Cyclic di-AMP released from Staphylococcus aureus biofilm induces a macrophage type I interferon response

Gries, C. M., Bruger, E. L., Moormeier, D. E., Scherr, T. D., Waters, C. M. & Kielian, T. L., Jan 1 2016, In : Infection and immunity. 84, 12, p. 3564-3574 11 p.

Research output: Contribution to journalArticle

Interferon Type I
Biofilms
Cyclic AMP
Staphylococcus aureus
Macrophages
18 Citations (Scopus)

Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3)

Aldrich, A., Bosch, M. E., Fallet, R., Odvody, J., Burkovetskaya, M., Rama Rao, K. V., Cooper, J. D., Drack, A. V. & Kielian, T. L., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 909-923 15 p.

Research output: Contribution to journalArticle

Phosphodiesterase 4 Inhibitors
Neuronal Ceroid-Lipofuscinoses
Amino Acid Transport System X-AG
Cyclic AMP
Pathology
13 Citations (Scopus)

Infectious dose dictates the host response during Staphylococcus aureus orthopedic-implant biofilm infection

Vidlak, D. & Kielian, T. L., Jan 1 2016, In : Infection and immunity. 84, 7, p. 1957-1965 9 p.

Research output: Contribution to journalArticle

Biofilms
Orthopedics
Staphylococcus aureus
Joints
Infection
13 Citations (Scopus)

Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia

Sun, K., Yajjala, V. K., Bauer, C., Talmon, G. A., Fischer, K. J., Kielian, T. L. & Metzger, D. W., Jan 1 2016, In : Journal of Experimental Medicine. 213, 9, p. 1851-1864 14 p.

Research output: Contribution to journalArticle

Coinfection
NAD
Human Influenza
Pneumonia
Oxidoreductases
6 Citations (Scopus)

Resistance to acute macrophage killing promotes airway fitness of prevalent community-acquired staphylococcus aureus strains

Yajjala, V. K., Chittezham Thomas, V., Bauer, C., Scherr, T. D., Fischer, K. J., Fey, P. D., Bayles, K. W., Kielian, T. L. & Sun, K., May 15 2016, In : Journal of Immunology. 196, 10, p. 4196-4203 8 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Macrophages
Infection
Staphylococcal Pneumonia
27 Citations (Scopus)

Self-complementary AAV9 gene delivery partially corrects pathology associated with juvenile neuronal ceroid lipofuscinosis (CLN3)

Bosch, M. E., Aldrich, A., Fallet, R., Odvody, J., Burkovetskaya, M., Schuberth, K., Fitzgerald, J. A., Foust, K. D. & Kielian, T. L., Sep 14 2016, In : Journal of Neuroscience. 36, 37, p. 9669-9682 14 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Dependovirus
Methyl-CpG-Binding Protein 2
Pathology
Genes
2015
48 Citations (Scopus)

IL-12 promotes myeloid-derived suppressor cell recruitment and bacterial persistence during Staphylococcus aureus orthopedic implant infection

Heim, C. E., Vidlak, D., Scherr, T. D., Hartman, C. W., Garvin, K. L. & Kielian, T. L., Apr 15 2015, In : Journal of Immunology. 194, 8, p. 3861-3872 12 p.

Research output: Contribution to journalArticle

Interleukin-12
Orthopedics
Staphylococcus aureus
Biofilms
Infection
36 Citations (Scopus)
Biofilms
Interleukin-10
Orthopedics
Staphylococcus aureus
Infection
9 Citations (Scopus)
Dust
Lung
Epithelial Cells
Cell Movement
Neutrophils
27 Citations (Scopus)

Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation

Rama Rao, K. V. & Kielian, T. L., Aug 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 3, p. 245-263 19 p.

Research output: Contribution to journalArticle

Astrocytes
Neurodegenerative Diseases
Neurons
Intrinsic Factor
Central Nervous System
29 Citations (Scopus)

Rot is a key regulator of Staphylococcus aureus biofilm formation

Mootz, J. M., Benson, M. A., Heim, C. E., Crosby, H. A., Kavanaugh, J. S., Dunman, P. M., Kielian, T. L., Torres, V. J. & Horswill, A. R., Apr 1 2015, In : Molecular Microbiology. 96, 2, p. 388-404 17 p.

Research output: Contribution to journalArticle

Biofilms
Staphylococcus aureus
Peptide Hydrolases
Phenotype
Methicillin Resistance
53 Citations (Scopus)

Staphylococcus aureus biofilms induce macrophage dysfunction through leukocidin AB and alpha-toxin

Scherr, T. D., Hanke, M. L., Huang, O., James, D. B. A., Horswill, A. R., Bayles, K. W., Fey, P. D., Torres, V. J. & Kielian, T. L., Aug 25 2015, In : mBio. 6, 4, e01021-15.

Research output: Contribution to journalArticle

Leukocidins
Biofilms
Staphylococcus aureus
Macrophages
Phagocytosis
2014
46 Citations (Scopus)

Critical role for the AIM2 inflammasome during acute CNS bacterial infection

Hanamsagar, R., Aldrich, A. & Kielian, T. L., May 2014, In : Journal of Neurochemistry. 129, 4, p. 704-711 8 p.

Research output: Contribution to journalArticle

Central Nervous System Bacterial Infections
Inflammasomes
Neurology
Melanoma
Caspase 1
33 Citations (Scopus)

Evidence for aberrant astrocyte hemichannel activity in juvenile neuronal ceroid lipofuscinosis (JNCL)

Burkovetskaya, M., Karpuk, N., Xiong, J., Bosch, M., Boska, M. D., Takeuchi, H., Suzumura, A. & Kielian, T. L., Apr 15 2014, In : PloS one. 9, 4, e95023.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
astrocytes
Astrocytes
Wild Animals
23 Citations (Scopus)

Hemichannels in neurodegenerative diseases: Is there a link to pathology?

Bosch, M. & Kielian, T. L., Aug 20 2014, In : Frontiers in Cellular Neuroscience. 8, AUG, 242.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Connexins
Gap Junctions
Pathology
Neuroprotective Agents
56 Citations (Scopus)

Hiding in plain sight: Interplay between staphylococcal biofilms and host immunity

Scherr, T. D., Heim, C. E., Morrison, J. M. & Kielian, T. L., Jan 1 2014, In : Frontiers in immunology. 5, FEB, Article 37.

Research output: Contribution to journalArticle

Biofilms
Immunity
Staphylococcus epidermidis
Staphylococcal Vaccines
Staphylococcus aureus
80 Citations (Scopus)

Myeloid-derived suppressor cells contribute to staphylococcus aureus orthopedic biofilm infection

Heim, C. E., Vidlak, D., Scherr, T. D., Kozel, J. A., Holzapfel, M., Muirhead, D. E. & Kielian, T. L., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3778-3792 15 p.

Research output: Contribution to journalArticle

Biofilms
Orthopedics
Staphylococcus aureus
Infection
Monocytes
43 Citations (Scopus)

Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds

Wang, G., Hanke, M. L., Mishra, B., Lushnikova, T., Heim, C. E., Chittezham Thomas, V., Bayles, K. W. & Kielian, T. L., Sep 19 2014, In : ACS Chemical Biology. 9, 9, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

Peptides
Pathogens
Screening
Peptide Library
Enterococcus faecium
2013
51 Citations (Scopus)

Blue light eliminates community-acquired methicillin-resistant Staphylococcus aureus in infected mouse skin abrasions

Dai, T., Gupta, A., Huang, Y. Y., Sherwood, M. E., Murray, C. K., Vrahas, M. S., Kielian, T. L. & Hamblin, M. R., Nov 1 2013, In : Photomedicine and Laser Surgery. 31, 11, p. 531-538 8 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Abrasion
Skin
Light
Soft Tissue Infections
5 Citations (Scopus)

Compartmentalization of immune responses during staphylococcus aureus cranial bone flap infection

Cheatle, J., Aldrich, A., Thorell, W. E., Boska, M. D. & Kielian, T. L., Aug 1 2013, In : American Journal of Pathology. 183, 2, p. 450-458 9 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Bone and Bones
Infection
Electron Scanning Microscopy
Neutrophils
22 Citations (Scopus)

Global transcriptome analysis of staphylococcus aureus biofilms in response to innate immune cells

Scherr, T. D., Roux, C. M., Hanke, M. L., Angle, A., Dunman, P. M. & Kielian, T. L., Dec 1 2013, In : Infection and immunity. 81, 12, p. 4363-4376 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Biofilms
Innate Immunity
Staphylococcus aureus
Macrophages
31 Citations (Scopus)

Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype

Xiong, J. & Kielian, T. L., Oct 1 2013, In : Journal of Neurochemistry. 127, 2, p. 245-258 14 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Microglia
Phenotype
Chemical activation
26 Citations (Scopus)
Myeloid Differentiation Factor 88
Dust
Inflammation
Knockout Mice
Chemokines
17 Citations (Scopus)

Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation

Snowden, J., Beaver, M., Beenken, K., Smeltzer, M., Horswill, A. R. & Kielian, T. L., Dec 30 2013, In : PloS one. 8, 12, e84089.

Research output: Contribution to journalArticle

Biofilms
Neurology
biofilm
central nervous system
Staphylococcus aureus
59 Citations (Scopus)

Targeting macrophage activation for the prevention and treatment of staphylococcus aureus biofilm infections

Hanke, M. L., Heim, C. E., Angle, A., Sanderson, S. D. & Kielian, T. L., Mar 1 2013, In : Journal of Immunology. 190, 5, p. 2159-2168 10 p.

Research output: Contribution to journalArticle

Macrophage Activation
Biofilms
Staphylococcus aureus
Infection
Methicillin-Resistant Staphylococcus aureus
2012
21 Citations (Scopus)

Biofilm-infected intracerebroventricular shunts elicit inflammation within the central nervous system

Snowden, J., Beaver, M., Smeltzer, M. S. & Kielian, T. L., Sep 1 2012, In : Infection and immunity. 80, 9, p. 3206-3214 9 p.

Research output: Contribution to journalArticle

Biofilms
Catheters
Central Nervous System
Inflammation
Staphylococcus aureus
38 Citations (Scopus)

CcpA Regulates Arginine Biosynthesis in Staphylococcus aureus through Repression of Proline Catabolism

Nuxoll, A. S., Halouska, S. M., Sadykov, M. R., Hanke, M. L., Bayles, K. W., Kielian, T. L., Powers, R. & Fey, P. D., Nov 1 2012, In : PLoS pathogens. 8, 11, e1003033.

Research output: Contribution to journalArticle

Proline
Arginine
Staphylococcus aureus
arginine glutamate
Mutation
24 Citations (Scopus)

CD11c+/CD11b+ cells are critical for organic dust-elicited murine lung inflammation

Poole, J. A., Gleason, A. M., Bauer, C., West, W. W., Alexis, N., Van Rooijen, N., Reynolds, S. J., Romberger, D. & Kielian, T. L., Nov 1 2012, In : American journal of respiratory cell and molecular biology. 47, 5, p. 652-659 8 p.

Research output: Contribution to journalArticle

Dust
Pneumonia
Macrophages
Clodronic Acid
Liposomes
48 Citations (Scopus)

Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300

Menousek, J., Mishra, B., Hanke, M. L., Heim, C. E., Kielian, T. L. & Wang, G., May 1 2012, In : International Journal of Antimicrobial Agents. 39, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Databases
Peptides
Arachnida
Bacteria
9 Citations (Scopus)
Central Nervous System Bacterial Infections
Interleukin-17 Receptors
Adaptive Immunity
Innate Immunity
Interleukin-17
11 Citations (Scopus)

IL-1RI (interleukin-1 receptor type I) signalling is essential for host defence and hemichannel activity during acute central nervous system bacterial infection

Xiong, J., Burkovetskaya, M., Karpuk, N. & Kielian, T. L., May 9 2012, In : ASN Neuro. 4, 3, p. 175-185 11 p.

Research output: Contribution to journalArticle

Central Nervous System Bacterial Infections
Interleukin-1 Type I Receptors
Brain Abscess
Staphylococcus aureus
Interleukin-1
8 Citations (Scopus)
Rodentia
Brain
Datasets
36 Citations (Scopus)

MyD88-dependent signaling influences fibrosis and alternative macrophage activation during staphylococcus aureus biofilm infection

Hanke, M. L., Angle, A. & Kielian, T. L., Aug 3 2012, In : PloS one. 7, 8, e42476.

Research output: Contribution to journalArticle

macrophage activation
Macrophage Activation
Macrophages
Biofilms
fibrosis
8 Citations (Scopus)

Neuroinflammation alters voltage-dependent conductance in striatal astrocytes

Karpuk, N., Burkovetskaya, M. & Kielian, T. L., Jul 1 2012, In : Journal of Neurophysiology. 108, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

Corpus Striatum
Astrocytes
varespladib methyl
Membrane Potentials
Central Nervous System
29 Citations (Scopus)

Th1 and Th17 cells regulate innate immune responses and bacterial clearance during central nervous system infection

Holley, M. M. & Kielian, T. L., Feb 1 2012, In : Journal of Immunology. 188, 3, p. 1360-1370 11 p.

Research output: Contribution to journalArticle

Th17 Cells
Central Nervous System Infections
Th1 Cells
Brain Abscess
Innate Immunity
14 Citations (Scopus)

Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia

Holley, M. M., Zhang, Y., Lehrmann, E., Wood, W. H., Becker, K. G. & Kielian, T. L., Jan 1 2012, In : Glia. 60, 1, p. 29-42 14 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Microglia
Interleukin-12
Cytokines
Peptidoglycan