Tadayoshi Bessho, PhD

Associate Professor

  • 1986 Citations
  • 19 h-Index
1986 …2019
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Research Output 1986 2019

  • 1986 Citations
  • 19 h-Index
  • 40 Article
  • 2 Comment/debate
  • 2 Review article
2019
4 Citations (Scopus)

Aberrations in DNA repair pathways in cancer and therapeutic significances

Motegi, A., Masutani, M., Yoshioka, K. I. & Bessho, T., Oct 2019, In : Seminars in Cancer Biology. 58, p. 29-46 18 p.

Research output: Contribution to journalReview article

DNA Repair
Genomic Instability
Neoplasms
Physiological Phenomena
Therapeutics
1 Citation (Scopus)

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
Phosphoric Monoester Hydrolases
DNA Repair
Breast Neoplasms
Survival
DNA Damage

Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

George, J. W., Bessho, M. & Bessho, T., Jan 1 2019, In : Journal of Nucleic Acids. 2019, 6357609.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Cells
Repair
Neoplasms
DNA
2018

Correction: KSR1 is required for cell cycle reinitiation following DNA damage.(Journal of Biological Chemistry (2018)284 (6705– 6715))

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Jan 1 2018, In : Journal of Biological Chemistry. 293, 49, 1 p.

Research output: Contribution to journalComment/debate

DNA Damage
Cell Cycle
Cells
DNA
2017
9 Citations (Scopus)

MUC1-mediated metabolic alterations regulate response to radiotherapy in pancreatic cancer

Gunda, V., Souchek, J., Abrego, J., Shukla, S. K., Goode, G. D., Vernucci, E., Dasgupta, A., Chaika, N. V., King, R. J., Li, S., Wang, S., Yu, F., Bessho, T., Lin, C. & Singh, P., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5881-5891 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Radiotherapy
Radiation
Glycolysis
Nucleotides
5 Citations (Scopus)

Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining

Zhu, S., Fisher, L. A., Bessho, T. & Peng, A., Oct 1 2017, In : Nucleic acids research. 45, 18, p. 10583-10594 12 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Protein Phosphatase 1
Phosphoric Monoester Hydrolases
Catalytic Domain
Phosphorylation
2014
7 Citations (Scopus)

Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines

Okamoto, S., Narita, T., Sasanuma, H., Takeda, S., Masunaga, S. I., Bessho, T. & Tano, K., Jan 1 2014, In : Genes and Cancer. 5, 7-8, p. 285-292 8 p.

Research output: Contribution to journalArticle

DNA Repair
Chickens
Cell Line
Homologous Recombination
Reactive Oxygen Species
2012
15 Citations (Scopus)

Bypass of a psoralen DNA interstrand cross-link by DNA polymerases β, l, and κ in Vitro

Smith, L. A., Makarova, A. V., Samson, L., Thiesen, K. E., Dhar, A. & Bessho, T., Nov 6 2012, In : Biochemistry. 51, 44, p. 8931-8938 8 p.

Research output: Contribution to journalArticle

Ficusin
DNA-Directed DNA Polymerase
DNA
Repair
DNA Repair
21 Citations (Scopus)
Phosphoproteins
Breast Neoplasms
Mutation
Poly Adenosine Diphosphate Ribose
Therapeutics
2011
17 Citations (Scopus)

Inaccurate DNA synthesis in cell extracts of yeast producing active human DNA Polymerase iota

Makarova, A. V., Grabow, C., Gening, L. V., Tarantul, V. Z., Tahirov, T. H., Bessho, T. & Pavlov, Y. I., Feb 9 2011, In : PloS one. 6, 1, e16612.

Research output: Contribution to journalArticle

DNA-directed DNA polymerase
yeast extract
Cell Extracts
Yeast
Yeasts
17 Citations (Scopus)

Removal of reactive oxygen species-induced 3′-blocked ends by XPF-ERCC1

Fisher, L. A., Samson, L. & Bessho, T., Nov 21 2011, In : Chemical Research in Toxicology. 24, 11, p. 1876-1881 6 p.

Research output: Contribution to journalArticle

DNA Damage
Reactive Oxygen Species
Repair
DNA Repair
DNA
13 Citations (Scopus)

Role of interaction of XPF with RPA in nucleotide excision repair

Fisher, L. A., Bessho, M., Wakasugi, M., Matsunaga, T. & Bessho, T., Oct 21 2011, In : Journal of Molecular Biology. 413, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

DNA Repair
Two-Hybrid System Techniques
Genomic Instability
Endonucleases
DNA-Binding Proteins
2009
35 Citations (Scopus)

Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links

Zietlow, L., Smith, L. A., Bessho, M. & Bessho, T., Dec 15 2009, In : Biochemistry. 48, 49, p. 11817-11824 8 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
DNA-Directed DNA Polymerase
DNA
Mitomycin
11 Citations (Scopus)

KSR1 is required for cell cycle reinitiation following DNA Damage

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Mar 13 2009, In : Journal of Biological Chemistry. 284, 11, p. 6705-6715 11 p.

Research output: Contribution to journalArticle

DNA Damage
Cell Cycle
Cells
Mitomycin
DNA
2008
6 Citations (Scopus)

DNA polymerase I-mediated translesion synthesis in RecA-independent DNA interstrand cross-link Repair in E. coli

Zietlow, L. & Bessho, T., May 13 2008, In : Biochemistry. 47, 19, p. 5460-5464 5 p.

Research output: Contribution to journalArticle

DNA Polymerase I
DNA Repair
Escherichia coli
Repair
Homologous Recombination
51 Citations (Scopus)

Processing of a psoralen DNA interstrand cross-link by XPF-ERCC1 complex in vitro

Fisher, L. A., Bessho, M. & Bessho, T., Jan 18 2008, In : Journal of Biological Chemistry. 283, 3, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

Ficusin
DNA
Processing
Repair
In Vitro Techniques
2006
36 Citations (Scopus)

The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro

Cipak, L., Watanabe, N. & Bessho, T., Aug 1 2006, In : Nature Structural and Molecular Biology. 13, 8, p. 729-733 5 p.

Research output: Contribution to journalArticle

DNA Replication
Ficusin
DNA Repair
Cell Line
In Vitro Techniques
2004
50 Citations (Scopus)

Physical and Functional Interaction between the XPF/ERCC1 Endonuclease and hRad52

Motycka, T. A., Bessho, T., Post, S. M., Sung, P. & Tomkinson, A. E., Apr 2 2004, In : Journal of Biological Chemistry. 279, 14, p. 13634-13639 6 p.

Research output: Contribution to journalArticle

Endonucleases
DNA
Gene Targeting
Repair
Genetic Recombination
2003
69 Citations (Scopus)

Induction of DNA replication-mediated double strand breaks by psoralen DNA interstrand cross-links

Bessho, T., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 5250-5254 5 p.

Research output: Contribution to journalArticle

Ficusin
Double-Stranded DNA Breaks
DNA Replication
DNA
Polyomavirus Transforming Antigens
2000
112 Citations (Scopus)

DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts

Mu, D., Bessho, T., Nechev, L. V., Chen, D. J., Harris, T. M., Hearst, J. E. & Sancar, A., Apr 1 2000, In : Molecular and cellular biology. 20, 7, p. 2446-2454 9 p.

Research output: Contribution to journalArticle

Cell Extracts
DNA
DNA Repair
Ficusin
Exonucleases
65 Citations (Scopus)

Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease

Bessho, T. & Sancar, A., Mar 17 2000, In : Journal of Biological Chemistry. 275, 11, p. 7451-7454 4 p.

Research output: Contribution to journalArticle

Phosphodiesterase I
Exonucleases
DNA Damage
DNA
Proteins
1999
86 Citations (Scopus)
Thymine DNA Glycosylase
Endonucleases
DNA Repair
Enzymes
Proteins
1998
26 Citations (Scopus)

Nucleotide excision repair of melphalan monoadducts

Grant, D. F., Bessho, T. & Reardon, J. T., Nov 15 1998, In : Cancer Research. 58, 22, p. 5196-5200 5 p.

Research output: Contribution to journalArticle

Melphalan
Cell Extracts
DNA Repair
Xeroderma Pigmentosum
DNA Adducts
1997

Characterization of the XPF endonuclease complex

McCutchen-Maloney, S. L., Hwang, M., Bessho, T., Sancar, A. & Thelen, M. P., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1371

Research output: Contribution to journalArticle

Endonucleases
Repair
DNA Repair
Genetic Recombination
Antibodies
108 Citations (Scopus)
Open Access
DNA Repair
Nucleotides
DNA
Cell Extracts
Rodentia
298 Citations (Scopus)
Xeroderma Pigmentosum
DNA Repair
DNA Damage
Pyrimidine Dimers
Sunlight
153 Citations (Scopus)

Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex

Bessho, T., Sancar, A., Thompson, L. H. & Thelen, M. P., Feb 20 1997, In : Journal of Biological Chemistry. 272, 6, p. 3833-3837 5 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA Repair
Repair
Sf9 Cells
Proteins
1996
151 Citations (Scopus)

Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease

Matsunaga, T., Park, C. H., Bessho, T., Mu, D. & Sancar, A., Jun 4 1996, In : Journal of Biological Chemistry. 271, 19, p. 11047-11050 4 p.

Research output: Contribution to journalArticle

Replication Protein A
Endonucleases
DNA Repair
Repair
DNA
1995
105 Citations (Scopus)

Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

Park, C. H., Bessho, T., Matsunaga, T. & Sancar, A., Jan 1 1995, In : Journal of Biological Chemistry. 270, 39, p. 22657-22660 4 p.

Research output: Contribution to journalArticle

DNA Repair
Purification
Repair
Superhelical DNA
Endonucleases
1994
17 Citations (Scopus)

Nucleoside and nucleobase analog mutagens

Negishi, K., Bessho, T. & Hayatsu, H., Dec 1994, In : Mutation Research/Reviews in Genetic Toxicology. 318, 3, p. 227-238 12 p.

Research output: Contribution to journalReview article

Mutagens
Nucleosides
Cell Proliferation
DNA
1993
181 Citations (Scopus)

Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8- oxoguanine) in human cells

Bessho, T., Tano, K., Kasai, H., Ohtsuka, E. & Nishimura, S., Jan 1 1993, In : Journal of Biological Chemistry. 268, 26, p. 19416-19421 6 p.

Research output: Contribution to journalArticle

DNA Repair Enzymes
Endonucleases
Cells
DNA
Substrates
19 Citations (Scopus)
Riboflavin
Light
Mutation
Ouabain
Mutation Rate
133 Citations (Scopus)

Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase

Bessho, T., Roy, R., Yamamoto, K., Kasai, H., Nishimura, S., Tano, K. & Mitra, S., Oct 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 8901-8904 4 p.

Research output: Contribution to journalArticle

Open Access
DNA
DNA Glycosylases
Escherichia coli
Bacterial DNA
Proteins
1992
1 Citation (Scopus)

Analysis of phage M13mp2 mutants produced from transfection of phage DNA having N4-aminocytosines at defined sequence positions

Matsumoto, K., Yashiki, T., Bessho, T., Negishi, K. & Hayatsu, H., Jul 1992, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 268, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

Bacteriophages
Transfection
DNA
Mutation
Cytidine
6 Citations (Scopus)

Blockage of polymerase-catalyzed DNA chain elongation by chemiscally modified cytosine residues in templates and the release of blockage for readthrough

Bessho, T., Nitta, N., Negishi, K. & Hayatsu, H., Aug 25 1992, In : Nucleic acids research. 20, 16, p. 4213-4220 8 p.

Research output: Contribution to journalArticle

Cytosine
DNA-Directed DNA Polymerase
Exonucleases
DNA Polymerase I
DNA
43 Citations (Scopus)
Endonucleases
Deoxyribonuclease I
Escherichia coli
DNA
Repair
19 Citations (Scopus)

Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

Kasai, H., Yamaizumi, Z., Yamamoto, F., Bessho, T., Nishimura, S., Berger, M. & Cadet, J., 1992, In : Nucleic acids symposium series. 27, p. 181-182 2 p.

Research output: Contribution to journalArticle

Riboflavin
Guanine
DNA
Cations
8-hydroxyguanine
85 Citations (Scopus)

Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8‐Hydroxyguanine‐containing DNA

Yamamoto, F., Kasai, H., Bessho, T., Chung, MH. H., Inoue, H., Ohtsuka, E., Hori, T. & Nishimura, S., Apr 1992, In : Japanese Journal of Cancer Research. 83, 4, p. 351-357 7 p.

Research output: Contribution to journalArticle

DNA
Polyacrylamide Gel Electrophoresis
Digestion
Liver
Brain
1990

Probing salt-induced and supercoiling-induced B-Z junctions in DNA by bisulfitemethoxyamine.

Negishi, K., Yamashita, T., Zacharias, W., Wells, R. D., Bessho, T. & Hayatsu, H., 1990, In : Nucleic acids symposium series. 22, p. 109-110 2 p.

Research output: Contribution to journalArticle

Cytosine
Salts
DNA
DNA-Directed DNA Polymerase
Nucleic Acids
1989

Modification of 5-methylcytosine in DNA and its relation to mutagenesis.

Negishi, K., Harada, Y., Atsumi, G., Bessho, T., Negishi, T. & Hayatsu, H., 1989, In : Nucleic acids symposium series. 21, p. 111-112 2 p.

Research output: Contribution to journalArticle

DNA-Cytosine Methylases
5-Methylcytosine
Cytosine
Mutagenesis
Methylation
8 Citations (Scopus)

Spectrum of N4-aminocytidine mutagenesis

Bessho, T., Matsumoto, K., Nomura, A., Hayatsu, H. & Negishi, K., Feb 20 1989, In : Journal of Molecular Biology. 205, 4, p. 659-664 6 p.

Research output: Contribution to journalArticle

Mutagenesis
Bacteriophages
Point Mutation
Coliphages
Cytosine
1988
3 Citations (Scopus)

In vitro mutagenesis by incorporation of N4-aminodeoxycytidine 5'-triphosphate.

Negishi, K., Matsumoto, K., Bessho, T., Tada, F. & Hayatsu, H., 1988, In : Nucleic acids symposium series. 19, p. 33-36 4 p.

Research output: Contribution to journalArticle

Mutagenesis
DNA Primers
DNA
Mutant Proteins
DNA Sequence Analysis
1986

Inhibition of DNA chain elongation by N4-aminocytosine-bisulfite adduct on template.

Negishi, K., Bessho, T., Nishizawa, M., Kawakami, M. & Hayatsu, H., Dec 1 1986, In : Nucleic acids symposium series. 17, p. 139-140 2 p.

Research output: Contribution to journalArticle

Genetic Templates
DNA Polymerase I
Cytosine
DNA Replication
Escherichia coli