Sushil Kumar, PhD

Assistant Professor

  • 666 Citations
  • 14 h-Index
20082020
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Research Output 2008 2020

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Article
2019

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., Jan 1 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
Mucin-4
Polyanhydrides
Dendritic Cells
Nanoparticles
Pancreatic Neoplasms

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Acetamides
Inwardly Rectifying Potassium Channel
Potassium Channels
GTP-Binding Proteins
6 Citations (Scopus)

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition

Abdalla, M. Y., Ahmad, I. M., Rachagani, S., Banerjee, K., Thompson, C. M., Maurer, H. C., Olive, K. P., Bailey, K. L., Britigan, B. E. & Kumar, S., May 2019, In : Translational Research. 207, p. 56-69 14 p.

Research output: Contribution to journalArticle

gemcitabine
Heme Oxygenase-1
Pancreatic Neoplasms
Cells
Adenocarcinoma

Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane

Mokhtari, R. B., Baluch, N., Morgatskaya, E., Kumar, S., Sparaneo, A., Muscarella, L. A., Zhao, S., Cheng, H. L., Das, B. & Yeger, H., Aug 30 2019, In : BMC cancer. 19, 1, 864.

Research output: Contribution to journalArticle

Open Access
Acetazolamide
Neoplastic Stem Cells
Carcinoid Tumor
Cell Line
Neoplasms
2018
7 Citations (Scopus)

Advanced pancreatic cancer: A meta-analysis of clinical trials over thirty years

Hall, B. R., Cannon, A., Atri, P., Wichman, C. S., Smith, L. M., Ganti, A. K. P., Are, C., Sasson, A. R., Kumar, S. & Batra, S. K., Apr 10 2018, In : Oncotarget. 9, 27, p. 19396-19405 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Meta-Analysis
gemcitabine
Clinical Trials
Adenocarcinoma
6 Citations (Scopus)

Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Cannon, A., Thompson, C., Hall, B. R., Jain, M., Kumar, S. & Batra, S. K., Mar 2018, In : Genes and Cancer. 9, 3-4, p. 78-86 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Therapeutics
Research
3 Citations (Scopus)
bone morphogenetic proteins
Bone Morphogenetic Protein 2
amyloid
Mitogen-Activated Protein Kinases
mitogen-activated protein kinase
2016
4 Citations (Scopus)

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

Joshi, S., Cruz, E., Rachagani, S., Guha, S., Brand, R. E., Palanimuthu Ponnusamy, M., Kumar, S. & Batra, S. K., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1063-1077 15 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Pancreatic Neoplasms
Up-Regulation
Pancreatic Juice
Neoplasms
18 Citations (Scopus)

Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival

Joshi, S., Kumar, S., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 10 2016, In : Oncogene. 35, 45, p. 5882-5892 11 p.

Research output: Contribution to journalArticle

Autophagy
Pancreatic Neoplasms
Cell Survival
Oxidative Stress
Reactive Oxygen Species
9 Citations (Scopus)

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Wang, Y., Kumar, S., Rachagani, S., Sajja, B. R., Xie, Y., Hang, Y., Jain, M., Li, J., Boska, M. D., Batra, S. K. & Oupicky, D., Sep 1 2016, In : Biomaterials. 101, p. 108-120 13 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Chromatin Assembly and Disassembly
Chemokine Receptors
Cytoplasmic and Nuclear Receptors
Pancreatic Neoplasms
2015
13 Citations (Scopus)
Mucins
Pancreatic Neoplasms
Up-Regulation
Chromatin
Ubiquitin C
2014
22 Citations (Scopus)

Altered Mucins (MUC) trafficking in Benign and malignant conditions

Joshi, S., Kumar, S., Choudhury, A., Palanimuthu Ponnusamy, M. & Batra, S. K., Jan 1 2014, In : Oncotarget. 5, 17, p. 7272-7284 13 p.

Research output: Contribution to journalArticle

Open Access
Mucins
Receptor Protein-Tyrosine Kinases
Therapeutic Uses
Post Translational Protein Processing
Neoplasms
23 Citations (Scopus)

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages

Kumar, S., Torres, M. P., Kaur, S., Rachagani, S., Joshi, S., Johansson, S. L., Momi, N., Baine, M. J., Cutucache, C. E., Smith, L. M., Wyatt, T. A., Jain, M., Joshi, S. S. & Batra, S. K., Jun 9 2014, In : Oncogene. 34, 16, p. 2052-2060 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Smoke
Smoking
Macrophages
Metaplasia
2012
37 Citations (Scopus)

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: Potential implications for diagnosis and therapy

Rachagani, S., Torres, M. P., Kumar, S., Haridas, D., Baine, M., Macha, M. A., Kaur, S., Palanimuthu Ponnusamy, M., Dey, P., Seshacharyulu, P., Johansson, S. L., Jain, M., Wagner, K. U. & Batra, S. K., Oct 30 2012, In : Journal of Hematology and Oncology. 5, 68.

Research output: Contribution to journalArticle

Mucins
Pancreatic Neoplasms
Therapeutics
Pancreas
Neoplasms
21 Citations (Scopus)

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

Kassmeier, M. D., Mondal, K., Palmer, V. L., Raval, P., Kumar, S., Perry, G. A., Anderson, D. K., Ciborowski, P. S., Jackson, S., Xiong, Y. & Swanson, P. C., Feb 15 2012, In : EMBO Journal. 31, 4, p. 945-958 14 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Ubiquitin-Protein Ligases
B-Lymphocytes
Cullin Proteins
Cells
2011
52 Citations (Scopus)
Cadherins
Pancreatic Neoplasms
Alleles
Neoplasm Metastasis
Proto-Oncogenes
9 Citations (Scopus)

Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer

Jain, M., Venkatraman, G., Moniaux, N., Kaur, S., Kumar, S., Chakraborty, S., Varshney, G. C. & Batra, S. K., Aug 23 2011, In : PloS one. 6, 8, e23344.

Research output: Contribution to journalArticle

pancreatic neoplasms
mucins
Mucins
Pancreatic Neoplasms
monoclonal antibodies
66 Citations (Scopus)

Pathobiological implications of MUC16 expression in pancreatic cancer

Haridas, D., Chakraborty, S., Palanimuthu Ponnusamy, M., Lakshmanan, I., Rachagani, S., Cruz, E., Kumar, S., Das, S., Lele, S. M., Anderson, J. M., Wittel, U. A., Hollingsworth, M. A. & Batra, S. K., Nov 4 2011, In : PloS one. 6, 10, e26839.

Research output: Contribution to journalArticle

pancreatic neoplasms
Pancreatic Neoplasms
Tissue
Tumors
Cells
2009
7 Citations (Scopus)
Protein Sorting Signals
Genetic Recombination
V(D)J Recombination
Chromosome Pairing
Proteins
24 Citations (Scopus)

Molecular mechanism underlying RAG1/RAG2 synaptic complex formation

Shlyakhtenko, L. S., Gilmore, J., Kriatchko, A. N., Kumar, S., Swanson, P. C. & Lyubchenko, Y. L., Jul 31 2009, In : Journal of Biological Chemistry. 284, 31, p. 20956-20965 10 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Genetic Recombination
Proteins
Stoichiometry
Cations
2008
30 Citations (Scopus)

Evidence for Ku70/Ku80 association with full-length RAG1

Raval, P., Kriatchko, A. N., Kumar, S. & Swanson, P. C., Apr 1 2008, In : Nucleic acids research. 36, 6, p. 2060-2072 13 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Antigen Receptors
DNA Breaks
Proteins
Double-Stranded DNA Breaks