Steven Claude Sansom, PhD

Professor

  • 2661 Citations
  • 34 h-Index
1976 …2019
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Research Output 1976 2019

2019
1 Citation (Scopus)

Furosemide reduces BK-αβ4-mediated K+ secretion in mice on an alkaline high-K+ diet

Wang, B., Wang-France, J., Li, H. & Sansom, S. C., Feb 1 2019, In : American journal of physiology. Renal physiology. 316, 2, p. F341-F350

Research output: Contribution to journalArticle

Furosemide
Diet
Urine
Vacuolar Proton-Translocating ATPases
Acetazolamide

Potassium-sparing effects of furosemide in mice on high-potassium diets

Wang, B. & Sansom, S. C., May 2019, In : American Journal of Physiology - Renal Physiology. 316, 5, p. F970-F973

Research output: Contribution to journalReview article

Furosemide
Potassium
Diet
Nephrons
Aldosterone
2017
5 Citations (Scopus)

Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet

Wang, B., Wen, D., Li, H., Wang-France, J. & Sansom, S. C., Oct 2017, In : Kidney International. 92, 4, p. 864-875 12 p.

Research output: Contribution to journalArticle

Extremities
Diet
Furosemide
Diuretics
Kidney
2016
4 Citations (Scopus)

Maintaining K+ balance on the low-Na+, high-K+ diet

Cornelius, R. J., Wang, B., Wang-France, J. & Sansom, S. C., Apr 1 2016, In : American Journal of Physiology - Renal Physiology. 310, 7, p. F581-F595

Research output: Contribution to journalReview article

Diet
Aldosterone
Alkalosis
Nephrons
Kidney
2015
5 Citations (Scopus)

Deficient acid handling with distal RTA in the NBCe2 knockout mouse

Wen, D., Yuan, Y., Cornelius, R. J., Li, H., Warner, P. C., Wang, B., Wang-France, J., Boettger, T. & Sansom, S. C., Sep 15 2015, In : American Journal of Physiology - Renal Physiology. 309, 6, p. F523-F530

Research output: Contribution to journalArticle

Renal Tubular Acidosis
Knockout Mice
Acids
Proton-Translocating ATPases
Cell Membrane
14 Citations (Scopus)

Increased epithelial sodium channel activity contributes to hypertension caused by Na+-HCO3- cotransporter electrogenic 2 deficiency

Wen, D., Yuan, Y., Warner, P. C., Wang, B., Cornelius, R. J., Wang-France, J., Li, H., Boettger, T. & Sansom, S. C., Jul 4 2015, In : Hypertension. 66, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Amiloride
Hypertension
Member 3 Solute Carrier Family 12
Arterial Pressure
16 Citations (Scopus)

Low Na, high K diet and the role of aldosterone in BK-mediated K excretion

Cornelius, R. J., Wen, D., Li, H., Yuan, Y., Wang-France, J., Warner, P. C. & Sansom, S. C., Jan 21 2015, In : PloS one. 10, 1, e0115515.

Research output: Contribution to journalArticle

aldosterone
Nutrition
Aldosterone
excretion
Diet
3 Citations (Scopus)

Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron

Wen, D. & Sansom, S. C., Sep 15 2015, In : American Journal of Physiology - Renal Physiology. 309, 6, p. F489-F491

Research output: Contribution to journalReview article

Nephrons
Electrolytes
Blood Pressure
Kidney
Acids
2014
13 Citations (Scopus)

Interacting influence of diuretics and diet on BK channel-regulated K homeostasis

Wen, D., Cornelius, R. J. & Sansom, S. C., Apr 1 2014, In : Current Opinion in Pharmacology. 15, 1, p. 28-32 5 p.

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Diuretics
Nephrons
Homeostasis
Diet
14 Citations (Scopus)

Relation between BK-α/β4-mediated potassium secretion and ENaC-mediated sodium reabsorption

Wen, D., Cornelius, R. J., Rivero-Hernandez, D., Yuan, Y., Li, H., Weinstein, A. M. & Sansom, S. C., Jul 2014, In : Kidney International. 86, 1, p. 139-145 7 p.

Research output: Contribution to journalArticle

Potassium
Sodium
Diet
Amiloride
Knockout Mice
2013
25 Citations (Scopus)

Regulation of BK-α expression in the distal nephron by aldosterone and urine pH

Wen, D., Cornelius, R. J., Yuan, Y. & Sansom, S. C., May 8 2013, In : American Journal of Physiology - Renal Physiology. 305, 4, p. F463-F476

Research output: Contribution to journalArticle

Nephrons
Aldosterone
Urine
Diet
Knockout Mice
2012
16 Citations (Scopus)

Bicarbonate promotes BK-α/β4-mediated K excretion in the renal distal nephron

Cornelius, R. J., Wen, D., Hatcher, L. I. & Sansom, S. C., Dec 1 2012, In : American Journal of Physiology - Renal Physiology. 303, 11, p. F1563-F1571

Research output: Contribution to journalArticle

Nephrons
Bicarbonates
Knockout Mice
Diet
Chlorides
8 Citations (Scopus)

Flow-sensitive K+-coupled ATP secretion modulates activity of the epithelial Na+ channel in the distal nephron

Bugaj, V., Sansom, S. C., Wen, D., Hatcher, L. I., Stockand, J. D. & Mironova, E., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 38552-38558 7 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephrons
Adenosine Triphosphate
Sodium
Aldosterone
2011
32 Citations (Scopus)

Coupled ATP and potassium efflux from intercalated cells

David Holtzclaw, J., Cornelius, R. J., Hatcher, L. I. & Sansom, S. C., Jun 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 6, p. F1319-F1326

Research output: Contribution to journalArticle

Potassium
Adenosine Triphosphate
Suramin
Small Interfering RNA
Carbenoxolone
42 Citations (Scopus)

Role of BK channels in hypertension and potassium secretion

Holtzclaw, J. D., Grimm, P. R. & Sansom, S. C., Sep 1 2011, In : Current Opinion in Nephrology and Hypertension. 20, 5, p. 512-517 6 p.

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Potassium
Hypertension
Hyperaldosteronism
Kidney
2010
31 Citations (Scopus)

BK channels and a new form of hypertension

Grimm, P. R. & Sansom, S. C., Nov 1 2010, In : Kidney International. 78, 10, p. 956-962 7 p.

Research output: Contribution to journalShort survey

Large-Conductance Calcium-Activated Potassium Channels
Hypertension
Blood Vessels
Diet
Mineralocorticoid Receptors
41 Citations (Scopus)

Intercalated cell BK-α/β4 channels modulate sodium and potassium handling during potassium adaptation

Holtzclaw, J. D., Grimm, P. R. & Sansom, S. C., Apr 1 2010, In : Journal of the American Society of Nephrology. 21, 4, p. 634-645 12 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Potassium
Sodium
Diet
Cell Size
18 Citations (Scopus)

Shear stress-induced volume decrease in C11-MDCK cells by BK-α/β4

Holtzclaw, J. D., Liu, L., Grimm, P. R. & Sansom, S. C., Sep 1 2010, In : American Journal of Physiology - Renal Physiology. 299, 3, p. F507-F516

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Cell Size
Small Interfering RNA
Large-Conductance Calcium-Activated Potassium Channels
Photometry
2009
36 Citations (Scopus)

Biomechanical strain causes maladaptive gene regulation, contributing to alport glomerular disease

Meehan, D. T., Delimont, D., Cheung, L., Zallocchi, M. L., Sansom, S. C., Holzclaw, J. D., Rao, V. & Cosgrove, D. E., Nov 1 2009, In : Kidney International. 76, 9, p. 968-976 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Matrix Metalloproteinase 10
Interleukin-6
Podocytes
Glomerular Basement Membrane
74 Citations (Scopus)

Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism

Grimm, P. R., Irsik, D. L., Settles, D. C., Holtzclaw, J. D. & Sansom, S. C., Jul 14 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 28, p. 11800-11805 6 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Nephrons
Diet
Hypertension
Kidney
22 Citations (Scopus)

Role of BKβ1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice

Grimm, P. R., Irsik, D. L., Liu, L., Holtzclaw, J. D. & Sansom, S. C., Aug 1 2009, In : American Journal of Physiology - Renal Physiology. 297, 2, p. F420-F428

Research output: Contribution to journalArticle

Diet
Arterial Pressure
Cell Membrane
Large-Conductance Calcium-Activated Potassium Channels
Epithelial Sodium Channels
14 Citations (Scopus)

Simvastatin reverses podocyte injury but not mesangial expansion in early stage type 2 diabetes mellitus

Wei, P., Grimm, P. R., Settles, D. C., Balwanz, C. R., Padanilam, B. J. & Sansom, S. C., Dec 30 2009, In : Renal Failure. 31, 6, p. 503-513 11 p.

Research output: Contribution to journalArticle

Podocytes
Simvastatin
Type 2 Diabetes Mellitus
Wounds and Injuries
Hydroxymethylglutaryl-CoA Reductase Inhibitors
2008
12 Citations (Scopus)

Insulin increases the activity of mesangial BK channels through MAPK signaling

Foutz, R. M., Grimm, P. R. & Sansom, S. C., Jun 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 6, p. F1465-F1472

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Mitogen-Activated Protein Kinases
Mesangial Cells
Insulin
Cell Membrane
2007
26 Citations (Scopus)

Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells

Wang, X., Pluznick, J. L., Settles, D. C. & Sansom, S. C., Dec 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 6, p. F1768-F1776

Research output: Contribution to journalArticle

Mesangial Cells
Cations
Calcium
Serine
Western Blotting
29 Citations (Scopus)

BK channels in the kidney

Grimm, P. R. & Sansom, S. C., Sep 1 2007, In : Current Opinion in Nephrology and Hypertension. 16, 5, p. 430-436 7 p.

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Potassium
Kidney
Nephrons
Potassium Compounds
51 Citations (Scopus)

Identification and localization of BK-β subunits in the distal nephron of the mouse kidney

Grimm, P. R., Foutz, R. M., Brenner, R. & Sansom, S. C., Jul 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 1, p. F350-F359

Research output: Contribution to journalArticle

Nephrons
Kidney
Extremities
Western Blotting
Staining and Labeling
3 Citations (Scopus)

Reemergence of the maxi K+ as a K+ secretory channel [1]

Sansom, S. C., Jun 1 2007, In : Kidney International. 71, 12, p. 1322-1324 3 p.

Research output: Contribution to journalLetter

Inwardly Rectifying Potassium Channel
Calcium-Activated Potassium Channels
Nephrons
Ion Transport
Potassium
33 Citations (Scopus)

Two channels for one job

Sansom, S. C. & Welling, P. A., Sep 2007, In : Kidney International. 72, 5, p. 529-530 2 p.

Research output: Contribution to journalComment/debate

Potassium
Large-Conductance Calcium-Activated Potassium Channels
Potassium Channels
Nephrons
Research Personnel
2006
67 Citations (Scopus)

BK channels in the kidney: Role in K+ secretion and localization of molecular components

Pluznick, J. L. & Sansom, S. C., Sep 13 2006, In : American Journal of Physiology - Renal Physiology. 291, 3, p. F517-F529

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Kidney
Calcium-Activated Potassium Channels
Nephrons
Workload
2005
79 Citations (Scopus)

BK-β1 subunit: Immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion

Pluznick, J. L., Wei, P., Grimm, P. R. & Sansom, S. C., Apr 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 4 57-4, p. F846-F854

Research output: Contribution to journalArticle

Nephrons
Rabbits
Calcium-Activated Potassium Channels
Membranes
Knockout Mice
31 Citations (Scopus)

Ion channels in mesangial cells: Function, malfunction, or fiction

Ma, R., Pluznick, J. L. & Sansom, S. C., Apr 2005, In : Physiology. 20, 2, p. 102-111 10 p.

Research output: Contribution to journalReview article

Mesangial Cells
Ion Channels
Calcium-Activated Potassium Channels
Gene Knockout Techniques
Molecular Structure
2004
29 Citations (Scopus)
Inositol 1,4,5-Trisphosphate
Mesangial Cells
Epidermal Growth Factor
Type C Phospholipases
Thapsigargin
58 Citations (Scopus)

Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes

Wei, P., Lane, P. H., Lane, J. T., Padanilam, B. J. & Sansom, S. C., Sep 1 2004, In : Diabetologia. 47, 9, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

High Fat Diet
Type 2 Diabetes Mellitus
Diabetic Nephropathies
Mesangial Cells
Cell Dedifferentiation
70 Citations (Scopus)

TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells

Wang, X., Pluznick, J. L., Wei, P., Padanilam, B. J. & Sansom, S. C., Aug 1 2004, In : American Journal of Physiology - Cell Physiology. 287, 2 56-2, p. C357-C364

Research output: Contribution to journalArticle

Mesangial Cells
Fura-2
Staining and Labeling
Polymerase Chain Reaction
Thapsigargin
2003
63 Citations (Scopus)

Renal fluid and electrolyte handling in BKCa-β1-/- mice

Pluznick, J. L., Wei, P., Carmines, P. K. & Sansom, S. C., Jun 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 6 53-6, p. F1274-F1279

Research output: Contribution to journalArticle

Electrolytes
Salts
Glomerular Filtration Rate
Kidney
Diet
28 Citations (Scopus)

Role of hβ 1 in activation of human mesangial BK channels by cGMP kinase

Kudlacek, P. E., Pluznick, J. L., Ma, R., Padanilam, B. & Sansom, S. C., Aug 1 2003, In : American Journal of Physiology - Renal Physiology. 285, 2 54-2, p. F289-F294

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Mesangial Cells
Phosphotransferases
HEK293 Cells
Antisense Oligonucleotides
2002
39 Citations (Scopus)

Protein kinase Cα participates in activation of store-operated Ca2+ channels in human glomerular mesangial cells

Ma, R., Kudlacek, P. E. & Sansom, S. C., Nov 1 2002, In : American Journal of Physiology - Cell Physiology. 283, 5 52-5, p. C1390-C1398

Research output: Contribution to journalArticle

Mesangial Cells
Protein Kinase C
Chemical activation
Thapsigargin
5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate
2001
36 Citations (Scopus)
Mesangial Cells
Calcium Channels
Epidermal Growth Factor
Protein Kinase C
Acetates
43 Citations (Scopus)

Influence of Ca2+-activated K+ channels on rat renal arteriolar responses to depolarizing agonists

Fallet, R. W., Bast, J. P., Fujiwara, K., Ishii, N., Sansom, S. C. & Carmines, P. K., Apr 1 2001, In : American Journal of Physiology - Renal Physiology. 280, 4 49-4, p. F583-F591

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Constriction
Kidney
Dilatation
Tetraethylammonium
47 Citations (Scopus)

Protein Kinase C Activates Store-operated Ca2+ Channels in Human Glomerular Mesangial Cells

Ma, R., Pluznick, J., Kudlacek, P. & Sansom, S. C., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25759-25765 7 p.

Research output: Contribution to journalArticle

Mesangial Cells
Thapsigargin
Protein Kinase C
Acetates
Adenosine Triphosphate
2000
30 Citations (Scopus)

Dihydropyridine-sensitive Ca2+ channels in human glomerular mesangial cells

Hall, D. A., Carmines, P. K. & Sansom, S. C., Jan 1 2000, In : American Journal of Physiology - Renal Physiology. 278, 1 47-1, p. F97-F103

Research output: Contribution to journalArticle

Mesangial Cells
Diltiazem
Membranes
Fura-2
Extracellular Fluid
23 Citations (Scopus)

Regulation of Ca2+-activated K+ channels by multifunctional Ca2+/calmodulin-dependent protein kinase

Sansom, S. C., Ma, R., Carmines, P. K. & Hall, D. A., Sep 18 2000, In : American Journal of Physiology - Renal Physiology. 279, 2 48-2, p. F283-F288

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Calcium-Calmodulin-Dependent Protein Kinases
Large-Conductance Calcium-Activated Potassium Channels
Mesangial Cells
Enzyme Activation
45 Citations (Scopus)

Store-operated Ca2+ channels in human glomerular mesangial cells

Ma, R., Smith, S., Child, A., Carmines, P. K. & Sansom, S. C., Jun 1 2000, In : American Journal of Physiology - Renal Physiology. 278, 6 47-6, p. F954-F961

Research output: Contribution to journalArticle

Mesangial Cells
Thapsigargin
Baths
Inhibitory Concentration 50
Calcium
1999
3 Citations (Scopus)
Mesangial Cells
Epidermal Growth Factor
Arachidonic Acid
Osmolar Concentration
Glucose
1998
16 Citations (Scopus)

Arachidonic acid potentiates the feedback response of mesangial BKCa channels to angiotensin II

Stockand, J. D., Silverman, M., Hall, D., Derr, T., Kubacak, B. & Sansom, S. C., Apr 1 1998, In : American Journal of Physiology - Renal Physiology. 274, 4 43-4, p. F658-F664

Research output: Contribution to journalArticle

Arachidonic Acid
Angiotensin II
Protein Phosphatase 2
Phosphorylation
Calcium-Activated Potassium Channels
159 Citations (Scopus)

Glomerular mesangial cells: Electrophysiology and regulation of contraction

Stockand, J. D. & Sansom, S. C., Jul 1998, In : Physiological Reviews. 78, 3, p. 723-744 22 p.

Research output: Contribution to journalReview article

Mesangial Cells
Electrophysiology
Membranes
Calcium-Activated Potassium Channels
Cyclic GMP-Dependent Protein Kinases
1997
49 Citations (Scopus)

Regulation of filtration rate by glomerular mesangial cells in health and diabetic renal disease

Stockand, J. D. & Sansom, S. C., Jun 1997, In : American Journal of Kidney Diseases. 29, 6, p. 971-981 11 p.

Research output: Contribution to journalArticle

Mesangial Cells
Kidney
Health
Large-Conductance Calcium-Activated Potassium Channels
Glomerular Filtration Rate
48 Citations (Scopus)

Regulation of large calcium-activated potassium channels by protein phosphatase 2A

Sansom, S. C., Stockand, J. D., Hall, D. & Williams, B., Apr 11 1997, In : Journal of Biological Chemistry. 272, 15, p. 9902-9906 5 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Protein Phosphatase 2
Mesangial Cells
Okadaic Acid
Chemical activation

Regulation of mesangial large Ca-activated K channels by protein phosphatase 2A

Sansom, S. C., Stockand, J. D., Hall, D. A. & Williams, B. R., Dec 1 1997, In : FASEB Journal. 11, 3, p. A87

Research output: Contribution to journalArticle

Protein Phosphatase 2
phosphoprotein phosphatase
Mesangial Cells
Chemical activation
Large-Conductance Calcium-Activated Potassium Channels
1996
2 Citations (Scopus)

Activation by high ambient glucose of large ca2+-activated k+ channels ibk(Ci) in human mesangial cells

Silverman, M., Stockand, J. D. & Sansom, S. C., Dec 1 1996, In : FASEB Journal. 10, 3, p. A545

Research output: Contribution to journalArticle

Charybdotoxin
Mesangial Cells
Chemical activation
calcium
Glucose