Simon Sherman, PhD

Professor

  • 2961 Citations
  • 27 h-Index
1984 …2021
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Research Output 1985 2019

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Article
2019

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers

Downs, B., Sherman, S., Cui, J., Kim, Y. C., Snyder, C., Christensen, M., Luo, J., Lynch, H. & Wang, S. M., Jan 2019, In : European Journal of Cancer. 107, p. 68-78 11 p.

Research output: Contribution to journalArticle

Penetrance
Mutation
Neoplasms
Breast
Breast Neoplasms
2016
2 Citations (Scopus)

Thyroid cancer and tumor collaborative registry (TCCR)

Shats, O., Goldner, W. S., Feng, J., Sherman, A., Smith, R. B. & Sherman, S., Jan 1 2016, In : Cancer Informatics. 15, p. 73-79 7 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Registries
Neoplasms
Thyroid Nodule
Medical History Taking
2015

Invariant characteristics of carcinogenesis

Sherman, S., Rathnayake, N. & Mdzinarishvili, T., Oct 14 2015, In : PloS one. 10, 10, e0140405.

Research output: Contribution to journalArticle

carcinogenesis
Carcinogenesis
neoplasms
Hazards
Neoplasms
2 Citations (Scopus)

Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer

Downs, B., Kim, Y. C., Xiao, F., Snyder, C., Chen, P., Fleissner, E. A., Becirovic, D., Wen, H., Sherman, S., Cowan, K. H., Lynch, H. T. & Wang, S. M., May 1 2015, In : Breast Cancer Research and Treatment. 151, 1, p. 219-224 6 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Mutation
Exome
Familial Breast Cancer
DNA Repair
2014
43 Citations (Scopus)

Effects of notch signaling on regulation of myeloid cell differentiation in cancer

Cheng, P., Kumar, V., Liu, H., Youn, J. I., Fishman, M., Sherman, S. & Gabrilovich, D., Jan 1 2014, In : Cancer Research. 74, 1, p. 141-152 12 p.

Research output: Contribution to journalArticle

Myeloid Cells
Cell Differentiation
Casein Kinase II
Neoplasms
Hematopoietic Stem Cells
11 Citations (Scopus)

Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

Wen, H., Kim, Y. C., Snyder, C., Xiao, F., Fleissner, E. A., Becirovic, D., Luo, J., Downs, B., Sherman, S., Cowan, K. H., Lynch, H. T. & Wang, S. M., Jun 26 2014, In : BMC cancer. 14, 1, 470.

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Familial Breast Cancer
Exome
Genetic Structures
Population Genetics
3 Citations (Scopus)

Heuristic modeling of carcinogenesis for the population with dichotomous susceptibility to cancer: A pancreatic cancer example

Mdzinarishvili, T. & Sherman, S., Jun 16 2014, In : PloS one. 9, 6, e100087.

Research output: Contribution to journalArticle

pancreatic neoplasms
Pancreatic Neoplasms
carcinogenesis
Hazards
Carcinogenesis
1 Citation (Scopus)

Web tool for estimating the cancer hazard rates in aging

Mdzinarishvili, T., Sherman, A., Shats, O. & Sherman, S., Dec 17 2014, In : Cancer Informatics. 13, p. 197-205 9 p.

Research output: Contribution to journalArticle

Neoplasms
Cohort Effect
Population
Lung Neoplasms
Age Groups
2013
4 Citations (Scopus)

Basic equations and computing procedures for frailty modeling of carcinogenesis: Application to pancreatic cancer data

Mdzinarishvili, T. & Sherman, S., Feb 27 2013, In : Cancer Informatics. 12, p. 67-81 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Carcinogenesis
Binomial Distribution
Population
Registries
9 Citations (Scopus)

Prognostic estimator of survival for patients with localized and extended pancreatic ductal adenocarcinoma

Gleason, M. X., Mdzinarishvili, T., Are, C., Sasson, A., Sherman, A., Shats, O. & Sherman, S., Mar 28 2013, In : Cancer Informatics. 12, p. 103-114 12 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Survival
Neoplasms
Marital Status
Proportional Hazards Models

Prognostic Estimator of Survival for Patients with Localized and Extended Pancreatic Ductal Adenocarcinoma

Gleason, M. X., Mdzinarishvili, T., Are, C., Sasson, A., Sherman, A., Shats, O. & Sherman, S., Jan 1 2013, In : Cancer Informatics. 12

Research output: Contribution to journalArticle

Open Access
Adenocarcinoma
Survival
Neoplasms
Marital Status
Proportional Hazards Models
2012
5 Citations (Scopus)

A heuristic solution of the identifiability problem of the age-period-cohort analysis of cancer occurrence: Lung cancer example

Mdzinarishvili, T. & Sherman, S., Apr 4 2012, In : PloS one. 7, 4, e34362.

Research output: Contribution to journalArticle

Cohort Effect
lung neoplasms
Lung Neoplasms
Cohort Studies
Demography
35 Citations (Scopus)

Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: A multicenter study

Anderson, M. A., Zolotarevsky, E., Cooper, K. L., Sherman, S., Shats, O., Whitcomb, D. C., Lynch, H. T., Ghiorzo, P., Rubinstein, W. S., Vogel, K. J., Sasson, A. R., Grizzle, W. E., Ketcham, M. A., Lee, S. Y., Normolle, D., Plonka, C. M., Mertens, A. N., Tripon, R. C. & Brand, R. E., Nov 1 2012, In : American Journal of Gastroenterology. 107, 11, p. 1730-1739 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Multicenter Studies
Tobacco
Alcohols
Adenocarcinoma
6 Citations (Scopus)

Breast Cancer Incidence in Black and White Women Stratified by Estrogen and Progesterone Receptor Statuses

Gleason, M. X., Mdzinarishvili, T. & Sherman, S., Nov 14 2012, In : PloS one. 7, 11, e49359.

Research output: Contribution to journalArticle

Progesterone Receptors
Estrogen Receptors
breast neoplasms
estrogens
Progesterone
2011
1 Citation (Scopus)

Extension of Cox proportional hazard model for estimation of interrelated age-period-cohort effects on cancer survival

Mdzinarishvili, T., Gleason, M. X., Kinarsky, L. & Sherman, S., Mar 28 2011, In : Cancer Informatics. 10, p. 31-44 14 p.

Research output: Contribution to journalArticle

Cohort Effect
Proportional Hazards Models
Survival
Parturition
Neoplasms
10 Citations (Scopus)

Multicenter Breast Cancer Collaborative Registry

Sherman, S., Shats, O., Fleissner, E., Bascom, G., Yiee, K., Copur, M., Crow, K., Rooney, J., Mateen, Z., Ketcham, M. A., Feng, J., Sherman, A., Gleason, M., Kinarsky, L., Silva-Lopez, E., Edney, J., Reed, E., Berger, A. & Cowan, K., Oct 12 2011, In : Cancer Informatics. 10, p. 217-226 10 p.

Research output: Contribution to journalArticle

Registries
Breast Neoplasms
Controlled Vocabulary
Informatics
Survivors
6 Citations (Scopus)

PCCR: Pancreatic cancer collaborative registry

Sherman, S., Shats, O., Ketcham, M. A., Anderson, M. A., Whitcomb, D. C., Lynch, H. T., Ghiorzo, P., Rubinstein, W. S., Sasson, A. R., Grizzle, W. E., Haynatzki, G., Feng, J., Sherman, A., Kinarsky, L. & Brand, R. E., Jun 6 2011, In : Cancer Informatics. 10, p. 83-91 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Registries
Controlled Vocabulary
Informatics
Systematized Nomenclature of Medicine
184 Citations (Scopus)

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

Lu, T., Ramakrishnan, R., Altiok, S., Youn, J. I., Cheng, P., Celis, E., Pisarev, V., Sherman, S., Sporn, M. B. & Gabrilovich, D., Oct 3 2011, In : Journal of Clinical Investigation. 121, 10, p. 4015-4029 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
T-Lymphocytes
Peroxynitrous Acid
Neoplasms
Interleukin-1
2010
9 Citations (Scopus)

Estimation of hazard functions in the log-linear age-period-cohort model: Application to lung cancer risk associated with geographical area

Mdzinarishvili, T., Gleason, M. X. & Sherman, S., Jun 4 2010, In : Cancer Informatics. 9, p. 67-78 12 p.

Research output: Contribution to journalArticle

San Francisco
Lung Neoplasms
Population
Cohort Effect
Incidence
6 Citations (Scopus)

Weibull-like model of cancer development in aging

Mdzinarishvili, T. & Sherman, S., Oct 1 2010, In : Cancer Informatics. 9, p. 179-188 10 p.

Research output: Contribution to journalArticle

Carcinogenesis
Neoplasms
Lung Neoplasms
Clone Cells
Databases
2009
8 Citations (Scopus)

A generalized beta model for the age distribution of cancers: Application to pancreatic and kidney cancer

Mdzinarishvili, T., Gleason, M. X., Kinarsky, L. & Sherman, S., Dec 1 2009, In : Cancer Informatics. 7, p. 183-197 15 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Age Distribution
Pancreatic Neoplasms
Neoplasms
Incidence
8 Citations (Scopus)

A novel approach for analysis of the log-linear age-period-cohort model: Application to lung cancer incidence

Mdzinarishvili, T., Gleason, M. X. & Sherman, S., Dec 1 2009, In : Cancer Informatics. 7, p. 271-280 10 p.

Research output: Contribution to journalArticle

Cohort Effect
Lung Neoplasms
Age Distribution
Parturition
Incidence
11 Citations (Scopus)

Dynamic properties of pH-dependent structural organization of the amyloidogenic β-protein (1-40)

Rubinstein, A., Lyubchenko, Y. L. & Sherman, S., Jan 1 2009, In : Prion. 3, 1, p. 31-43 13 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Oligomerization
Coulomb interactions
Molecular dynamics
Hydrogen bonds
2008
194 Citations (Scopus)

Nitrated α-synuclein immunity accelerates degeneration of nigral dopaminergic neurons

Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P. S., Przedborski, S., Mosley, R. L. & Gendelman, H. E., Jan 2 2008, In : PloS one. 3, 1, e1376.

Research output: Contribution to journalArticle

Synucleins
Dopaminergic Neurons
Substantia Nigra
Parkinson disease
Neurons
2007
606 Citations (Scopus)

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

Nagaraj, S., Gupta, K., Pisarev, V., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. & Gabrilovich, D. I., Jul 1 2007, In : Nature Medicine. 13, 7, p. 828-835 8 p.

Research output: Contribution to journalArticle

T-cells
Nitration
T-Cell Antigen Receptor
Major Histocompatibility Complex
T-Lymphocytes
7 Citations (Scopus)

A protein encoded by the bovine herpesvirus 1 open reading frame E gene induces neurite-like morphological changes in mouse neorublastoma cells and is expressed in trigeminal ganglionic neurons

Perez, S., Meyer, F., Henderson, G., Jiang, Y., Sherman, S., Doster, A. R., Inman, M. & Jones, C., Mar 1 2007, In : Journal of neurovirology. 13, 2, p. 139-149 11 p.

Research output: Contribution to journalArticle

Bovine Herpesvirus 1
Neurites
Open Reading Frames
Neurons
Genes
42 Citations (Scopus)

Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors

Nagaraj, S., Pisarev, V., Kinarsky, L., Sherman, S., Muro-Cacho, C., Altieri, D. C. & Gabrilovich, D. I., Feb 1 2007, In : Journal of Immunotherapy. 30, 2, p. 169-179 11 p.

Research output: Contribution to journalArticle

Dendritic Cells
Vaccines
Neoplasms
Therapeutics
Hematopoietic Stem Cells
15 Citations (Scopus)
Coulomb interactions
Static Electricity
Electrostatics
Proteins
Water
192 Citations (Scopus)

Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells

Nefedova, Y., Fishman, M., Sherman, S., Wang, X., Beg, A. A. & Gabrilovich, D. I., Nov 15 2007, In : Cancer Research. 67, 22, p. 11021-11028 8 p.

Research output: Contribution to journalArticle

Tretinoin
Glutathione Synthase
Neoplasms
Reactive Oxygen Species
Tumor Escape
12 Citations (Scopus)

New computational models for electrostatics of macromolecules in solvents

Dai, J., Tsukerman, I., Rubinstein, A. & Sherman, S., Apr 1 2007, In : IEEE Transactions on Magnetics. 43, 4, p. 1217-1220 4 p.

Research output: Contribution to journalArticle

Macromolecules
macromolecules
Electrostatics
electrostatics
Boltzmann equation
2006
64 Citations (Scopus)

Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: Pluronic P85

Batrakova, E. V., Kelly, D. L., Li, S., Li, Y., Yang, Z., Xiao, L., Alakhova, D. Y., Sherman, S., Alakhov, V. Y. & Kabanov, A. V., Mar 1 2006, In : Molecular Pharmaceutics. 3, 2, p. 113-123 11 p.

Research output: Contribution to journalArticle

Poloxamer
Excipients
Doxorubicin
Polymers
Breast Neoplasms
2005
34 Citations (Scopus)

Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket

Kinarsky, L., Feng, B., Skifter, D. A., Morley, R. M., Sherman, S., Jane, D. E. & Monaghan, D. T., Jun 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 3, p. 1066-1074 9 p.

Research output: Contribution to journalArticle

Dicarboxylic Acids
N-Methyl-D-Aspartate Receptors
Glutamic Acid
Amino Acids
selfotel
27 Citations (Scopus)

Sequence-variant repeats of MUC1 show higher conformational flexibility, are less densely O-glycosylated and induce differential B lymphocyte responses

von Mensdorff-Pouilly, S., Kinarsky, L., Engelmann, K., Baldus, S. E., Verheijen, R. H., Hollingsworth, M. A., Pisarev, V., Sherman, S. & Hanisch, F. G., Aug 1 2005, In : Glycobiology. 15, 8, p. 735-746 12 p.

Research output: Contribution to journalArticle

Glycosylation
Lymphocytes
B-Lymphocytes
Mucins
Immunoglobulin G
18 Citations (Scopus)

T cells recognize PD(N/T)R motif common in a variable number of tandem repeat and degenerate repeat sequences of MUC1

Pisarev, V. M., Kinarsky, L., Caffrey, T., Hanisch, F. G., Sanderson, S., Hollingsworth, M. A. & Sherman, S., Feb 1 2005, In : International Immunopharmacology. 5, 2, p. 315-330 16 p.

Research output: Contribution to journalArticle

Minisatellite Repeats
T-Lymphocytes
Peptides
T-Lymphocyte Epitopes
Epitopes
36 Citations (Scopus)

The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins

Palmai-Pallag, T., Khodabukus, N., Kinarsky, L., Leir, S. H., Sherman, S., Hollingsworth, M. A. & Harris, A., Jun 1 2005, In : FEBS Journal. 272, 11, p. 2901-2911 11 p.

Research output: Contribution to journalArticle

Agrin
Enteropeptidase
Sea Urchins
Mucins
Spermatozoa
2004
214 Citations (Scopus)

BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma

Iqbal, J., Sanger, W. G., Horsman, D. E., Rosenwald, A., Pickering, D. L., Dave, B. J., Dave, S., Xiao, L., Cao, K., Zhu, Q., Sherman, S., Hans, C. P., Weisenburger, D. D., Greiner, T. C., Gascoyne, R. D., Ott, G., Müller-Hermelink, H. K., Delabie, J., Braziel, R. M., Jaffe, E. S. & 8 others, Campo, E., Lynch, J. C., Connors, J. M., Vose, J. M., Armitage, J. O., Grogan, T. M., Staudt, L. M. & Chan, W. C., Jul 2004, In : American Journal of Pathology. 165, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Germinal Center
Lymphoma, Large B-Cell, Diffuse
B-Lymphocytes
Neoplasms
Fluorescence In Situ Hybridization
39 Citations (Scopus)

Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs

Shen, Y., Iqbal, J., Xiao, L., Lynch, R. C., Rosenwald, A., Staudt, L. M., Sherman, S., Dybkaer, K., Zhou, G., Eudy, J. D., Delabie, J., McKeithan, T. W. & Chan, W. C., Sep 15 2004, In : BMC Immunology. 5, 20.

Research output: Contribution to journalArticle

Transcriptome
B-Lymphocytes
Germinal Center
Genes
Chemokines
6 Citations (Scopus)

Identification of disulfide bonds among the nine core 2 N-acetylglucosaminyltransferase-M cysteines conserved in the mucin β6-N-acetylglucosaminyltransferase family

Singh, J., Khan, G. A., Kinarsky, L., Cheng, H., Wilken, J., Choi, K. H., Bedows, E., Sherman, S. & Cheng, P-W., Sep 10 2004, In : Journal of Biological Chemistry. 279, 37, p. 38969-38977 9 p.

Research output: Contribution to journalArticle

Mucin-6
Disulfides
Cysteine
Mucin-1
Mucins
39 Citations (Scopus)

Influence of the solvent structure on the interactions in proteins

Rubinstein, A. & Sherman, S., Sep 2004, In : Biophysical journal. 87, 3, p. 1544-1557 14 p.

Research output: Contribution to journalArticle

Static Electricity
Proteins
Hydrogen
6 Citations (Scopus)

Microarray analysis of differential gene expression in androgen independent prostate cancer using a metastatic human prostate cancer cell line model

Balaji, K. C., Rao, P. S., Smith, D. J., Louis, S., Smith, L. M., Sherman, S., Bacich, D. & O'Keefe, D., Jul 1 2004, In : Urologic Oncology: Seminars and Original Investigations. 22, 4, p. 313-320 8 p.

Research output: Contribution to journalArticle

Microarray Analysis
Androgens
Prostatic Neoplasms
Gene Expression
Cell Line
4 Citations (Scopus)

Molecular dynamics simulations of the O-glycosylated 21-residue MUC1 peptides

Rubinstein, A., Kinarsky, L. & Sherman, S., Mar 1 2004, In : International journal of molecular sciences. 5, 3, p. 119-128 10 p.

Research output: Contribution to journalArticle

Glycosylation
Molecular Dynamics Simulation
Peptides
peptides
Molecular dynamics

Molecular dynamics simulations of the O-glycosylated 21-residue MUC1 peptides

Rubinstein, A., Kinarsky, L. & Sherman, S., Mar 2004, In : International Journal of Molecular Sciences. 5, 3, p. 119-128 10 p.

Research output: Contribution to journalArticle

Glycosylation
Molecular Dynamics Simulation
Peptides
peptides
Molecular dynamics
2 Citations (Scopus)

NMR-based structural studies of the glycosylated MUC1 tandem repeat peptide

Suryanarayanan, G., Keifer, P. A., Wang, G., Kinarsky, L., Hollingsworth, M. A. & Sherman, S., Mar 2004, In : International journal of molecular sciences. 5, 3, p. 84-92 9 p.

Research output: Contribution to journalArticle

Open Access
Peptides
peptides
Nuclear magnetic resonance
nuclear magnetic resonance
Conformations
4 Citations (Scopus)

Suitability of Stratagene reference RNA for analysis of lymphoid tissues

Dybkær, K., Zhou, G., Iqbal, J., Kelly, D. L., Xiao, L., Sherman, S., D'Amore, F. & Chan, W. C., Sep 1 2004, In : BioTechniques. 37, 3, p. 470-474 5 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
RNA
Tissue
Cells
Genes
2003
44 Citations (Scopus)

Conformational studies on the MUC1 tandem repeat glycopeptides: Implication for the enzymatic O-glycosylation of the mucin protein core

Kinarsky, L., Suryanarayanan, G., Prakash, O., Paulsen, H., Clausen, H., Hanisch, F. G., Hollingsworth, M. A. & Sherman, S., Dec 1 2003, In : Glycobiology. 13, 12, p. 929-939 11 p.

Research output: Contribution to journalArticle

Glycosylation
Tandem Repeat Sequences
Glycopeptides
Mucins
Peptides
93 Citations (Scopus)

Full-Length Dominant-Negative Survivin for Cancer Immunotherapy

Pisarev, V., Yu, B., Salup, R., Sherman, S., Altieri, D. C. & Gabrilovich, D. I., Dec 15 2003, In : Clinical Cancer Research. 9, 17, p. 6523-6533 11 p.

Research output: Contribution to journalArticle

Immunotherapy
Hematopoietic Stem Cells
HLA-A2 Antigen
Dendritic Cells
Enzyme-Linked Immunospot Assay
2002
1 Citation (Scopus)

Role of disulphide bond formation in folding, secretion, and assembly of human chorionic gonadotropin subunits

Bedows, E., Darling, R. J., Wilken, J. A. & Sherman, S., Jan 1 2002, In : Indian journal of experimental biology. 40, 4, p. 467-476 10 p.

Research output: Contribution to journalArticle

Chorionic Gonadotropin
Disulfides
Cystines
Proteins
Glycoproteins
2001
31 Citations (Scopus)

Development of response-selective agonists of human C5a anaphylatoxin: Conformational, biological, and therapeutic considerations

Taylor, S. M., Sherman, S., Kirnarsky, L. & Sanderson, S. D., Jan 1 2001, In : Current medicinal chemistry. 8, 6, p. 675-684 10 p.

Research output: Contribution to journalArticle

Anaphylatoxins
Anaphylatoxin C5a Receptor
Peptidomimetics
Peptides
Humoral Immunity
27 Citations (Scopus)

Differential activities of decapeptide agonists of human C5a: The conformational effects of backbone N-methylation

Vogen, S. M., Paczkowski, N. J., Kirnarsky, L., Short, A., Whitmore, J. B., Sherman, S., Taylor, S. M. & Sanderson, S. D., Oct 27 2001, In : International Immunopharmacology. 1, 12, p. 2151-2162 12 p.

Research output: Contribution to journalArticle

Methylation
Peptides
Smooth Muscle
Muscle Contraction
Macrophages
9 Citations (Scopus)

Functional Contributions of Noncysteine Residues within the Cystine Knots of Human Chorionic Gonadotropin Subunits

Darling, R. J., Wilken, J. A., Miller-Lindholm, A. K., Urlacher, T. M., Ruddon, R. W., Sherman, S. & Bedows, E., Apr 6 2001, In : Journal of Biological Chemistry. 276, 14, p. 10692-10699 8 p.

Research output: Contribution to journalArticle

Cystine
Chorionic Gonadotropin
Cystine Knot Motifs
Substitution reactions
Consensus Sequence