Satyanarayana Rachagani, PhD

Assistant Professor

  • 2373 Citations
  • 25 h-Index
20062019
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Research Output 2006 2019

  • 2373 Citations
  • 25 h-Index
  • 61 Article
  • 10 Review article
  • 2 Comment/debate
  • 1 Short survey
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Article
2006
32 Citations (Scopus)

Genotyping of β-Lactoglobulin gene by PCR-RFLP in Sahiwal and Tharparkar cattle breeds

Rachagani, S., Gupta, I. D., Gupta, N. & Gupta, S. C., Dec 1 2006, In : BMC Genetics. 7, 31.

Research output: Contribution to journalArticle

Lactoglobulins
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction
Genes
Genotype
14 Citations (Scopus)

Single strand confirmation polymorphism (SSCP) detection in exon I of the α-lactalbumin gene of Indian Jamunapari milk goats (Capra hircus)

Kumar, D., Gupta, N., Ahlawat, S. P. S., Satyanarayana, R., Sunder, S. & Gupta, S. C., Jul 4 2006, In : Genetics and Molecular Biology. 29, 2, p. 287-289 3 p.

Research output: Contribution to journalArticle

Lactalbumin
Goats
Exons
Milk
Genes
2008
23 Citations (Scopus)

Bovine kappa-casein gene polymorphism and its association with milk production traits

Rachagani, S. & Gupta, I. D., Jan 1 2008, In : Genetics and Molecular Biology. 31, 4, p. 893-897 5 p.

Research output: Contribution to journalArticle

Open Access
Caseins
Milk
Gene Frequency
Genes
Polymerase Chain Reaction
2009
34 Citations (Scopus)

RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells

Palanimuthu Ponnusamy, M., Deb, S., Dey, P., Chakraborty, S., Rachagani, S., Senapati, S. & Batra, S. K., Dec 1 2009, In : STEM CELLS. 27, 12, p. 3001-3011 11 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Embryonic Stem Cells
Cell Cycle
Proteins
Maintenance
739 Citations (Scopus)

The genome sequence of taurine cattle: A window to ruminant biology and evolution

Elsik, C. G., Tellam, R. L., Worley, K. C., Gibbs, R. A., Muzny, D. M., Weinstock, G. M., Adelson, D. L., Eichler, E. E., Elnitski, L., Guigó, R., Hamernik, D. L., Kappes, S. M., Lewin, H. A., Lynn, D. J., Nicholas, F. W., Reymond, A., Rijnkels, M., Skow, L. C., Zdobnov, E. M., Schook, L. & 288 others, Womack, J., Alioto, T., Antonarakis, S. E., Astashyn, A., Chappie, C. E., Chen, H. C., Chrast, J., Câmara, F., Ermolaeva, O., Henrichsen, C. N., Hlavina, W., Kapustin, Y., Kiryutin, B., Kitts, P., Kokocinski, F., Landrum, M., Maglott, D., Pruitt, K., Sapojnikov, V., Searle, S. M., Solovyev, V., Souvorov, A., Ucla, C., Wyss, C., Anzola, J. M., Gerlach, D., Elhaik, E., Graur, D., Reese, J. T., Edgar, R. C., McEwan, J. C., Payne, G. M., Raison, J. M., Junier, T., Kriventseva, E. V., Eyras, E., Plass, M., Donthu, R., Larkin, D. M., Reecy, J., Yang, M. Q., Chen, L., Cheng, Z., Chitko-McKown, C. G., Liu, G. E., Matukumalli, L. K., Song, J., Zhu, B., Bradley, D. G., Brinkman, F. S. L., Lau, L. P. L., Whiteside, M. D., Walker, A., Wheeler, T. T., Casey, T., German, J. B., Lemay, D. G., Maqbool, N. J., Molenaar, A. J., Seo, S., Stothard, P., Baldwin, C. L., Baxter, R., Brinkmeyer-Larigford, C. L., Brown, W. C., Childers, C. P., Connelley, T., Ellis, S. A., Fritz, K., Glass, E. J., Herzig, C. T. A., Livanainen, A., Lahmers, K. K., Bennett, A. K., Dickens, C. M., Gilbert, J. G. R., Hagen, D. E., Salih, H., Aerts, J., Caetano, A. R., Dalrymple, B., Garcia, J. F., Gill, C. A., Hiendleder, S. G., Memili, E., Spurlock, D., Williams, J. L., Alexander, L., Brownstein, M. J., Guan, L., Holt, R. A., Jones, S. J. M., Marra, M. A., Moore, R., Moore, S. S., Roberts, A., Taniguchi, M., Waterman, R. C., Chacko, J., Chandrabose, M. M., Cree, A., Dao, M. D., Dinh, H. H., Gabisi, R. A., Hines, S., Hume, J., Jhangiani, S. N., Joshi, V., Kovar, C. L., Lewis, L. R., Liu, Y. S., Lopez, J., Morgan, M. B., Nguyen, N. B., Okwuonu, G. O., Ruiz, S. J., Santibanez, J., Wright, R. A., Buhay, C., Ding, Y., Dugan-Rocha, S., Herdandez, J., Holder, M., Sabo, A., Egan, A., Goodell, J., Wilczek-Boney, K., Fowler, G. R., Hitchens, M. E., Lozado, R. J., Moen, C., Steffen, D., Warren, J. T., Zhang, J., Chiu, R., Schein, J. E., Durbin, K. J., Havlak, P., Jiang, H., Liu, Y., Qin, X., Ren, Y., Shen, Y., Song, H., Bell, S. N., Davis, C., Johnson, A. J., Lee, S., Nazareth, L. V., Patel, B. M., Pu, L. L., Vattathil, S., Williams, R. L., Curry, S., Hamilton, C., Sodergren, E., Wheeler, D. A., Barris, W., Bennett, G. L., Eggen, A., Green, R. D., Harhay, G. P., Hobbs, M., Jann, O., Keele, J. W., Kent, M. P., Lien, S., McKay, S. D., McWilliam, S., Ratnakumar, A., Schnabel, R. D., Smith, T., Snelling, W. M., Sonstegard, T. S., Stone, R. T., Sugimoto, Y., Takasuga, A., Taylor, J. F., Van Tassell, C. P., MacNeil, M. D., Abatepaulo, A. R. R., Abbey, C. A., Ahola, V., Almeida, L. G., Amadio, A. F., Anatriello, E., Bahadue, S. M., Biase, F. H., Boldt, C. R., Carroll, J. A., Carvalho, W. A., Cervelatti, E. P., Chacko, E., Chapin, J. E., Cheng, Y., Choi, J., Colley, A. J., DeCampos, T. A., De Donato, M., De Miranda Santos, I. K. F., De Oliveira, C. J. F., Deobald, H., Devinoy, E., Donohue, K. E., Dove, P., Eberlein, A., Fitzsimmons, C. J., Franzin, A. M., Garcia, G. R., Genini, S., Gladney, C. J., Grant, J. R., Greaser, M. L., Green, J. A., Hadsell, D. L., Hakimov, H. A., Halgren, R., Harrow, J. L., Hart, E. A., Hastings, N., Hernandez, M., Hu, Z. L., Iivanainen, A., Ingham, A., Iso-Touru, T., Jamis, C., Jensen, K., Kapetis, D., Kerr, T., Khalil, S. S., Khatib, H., Kolbehdari, D., Kumar, C. G., Kumar, D., Leach, R., Lee, J. C. M., Li, C., Logan, K. M., Malinverni, R., Marques, E., Martin, W. F., Martins, N. F., Maruyama, S. R., Mazza, R., McLean, K. L., Medrano, J. F., Moreno, B. T., More, D. D., Muntean, C. T., Nandakumar, H. P., Nogueira, M. F. G., Olsaker, I., Pant, S. D., Panzitta, F., Pastor, R. C. P., Poli, M. A., Poslusny, N., Rachagani, S., Ranganathan, S., Razpet, A., Riggs, P. K., Rincón, G., Rodriguez-Osorio, N., Rodriguez-Zas, S. L., Romero, N. E., Rosenwald, A., Sando, L., Schmutz, S. M., Shen, L., Sherman, L., Southey, B. R., Lutzow, Y. S., Sweedler, J. V., Tammen, I., Telugu, B. P. V. L., Urbanski, J. M., Utsunomiya, Y. T., Verschoor, C. P., Waardenberg, A. J., Wang, Z., Ward, R., WeiKard, R., Welsh, T. H., White, S. N., Wilming, L. G., Wunderlich, K. R., Yang, J. & Zhao, F. Q., Apr 24 2009, In : Science. 324, 5926, p. 522-528 7 p.

Research output: Contribution to journalArticle

Taurine
Ruminants
Genome
Genes
Genomic Segmental Duplications
2010
26 Citations (Scopus)

Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis

Luu, Y., Junker, W., Rachagani, S., Das, S., Batra, S. K., Heinrikson, R. L., Shekels, L. L. & Ho, S. B., Jun 1 2010, In : International Journal of Biochemistry and Cell Biology. 42, 6, p. 996-1006 11 p.

Research output: Contribution to journalArticle

Mucins
Colitis
Apoptosis
Phosphorylation
Proteins
22 Citations (Scopus)

Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle

Rachagani, S., Cheng, Y. & Reecy, J. M., Nov 15 2010, In : BMC Research Notes. 3, 297.

Research output: Contribution to journalArticle

Myostatin
Pectoralis Muscles
MicroRNAs
Muscle
Genotype
79 Citations (Scopus)

Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway

Senapati, S., Rachagani, S., Chaudhary, K., Johansson, S. L., Singh, R. K. & Batra, S. K., Mar 1 2010, In : Oncogene. 29, 9, p. 1293-1302 10 p.

Research output: Contribution to journalArticle

Growth Differentiation Factor 15
Focal Adhesion Protein-Tyrosine Kinases
Prostatic Neoplasms
Neoplasm Metastasis
Cell Movement
2011
52 Citations (Scopus)
Cadherins
Pancreatic Neoplasms
Alleles
Neoplasm Metastasis
Proto-Oncogenes
11 Citations (Scopus)

Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer

Baine, M. J., Menning, M., Smith, L. M., Mallya, K., Kaur, S., Rachagani, S., Chakraborty, S., Sasson, A. R., Brand, R. E. & Batra, S. K., Dec 1 2011, In : Cancer Biomarkers. 11, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Blood Cells
Gene Expression
Chronic Pancreatitis
5 Citations (Scopus)

Mapping genetic loci that interact with myostatin to affect growth traits

Cheng, Y., Rachagani, S., Dekkers, J. C. M., Mayes, M. S., Tait, R. & Reecy, J. M., Dec 1 2011, In : Heredity. 107, 6, p. 565-573 9 p.

Research output: Contribution to journalArticle

Myostatin
Genetic Loci
Quantitative Trait Loci
Growth
Genome
65 Citations (Scopus)

Pathobiological implications of MUC16 expression in pancreatic cancer

Haridas, D., Chakraborty, S., Palanimuthu Ponnusamy, M., Lakshmanan, I., Rachagani, S., Cruz, E., Kumar, S., Das, S., Lele, S. M., Anderson, J. M., Wittel, U. A., Hollingsworth, M. A. & Batra, S. K., Nov 4 2011, In : PloS one. 6, 10, e26839.

Research output: Contribution to journalArticle

pancreatic neoplasms
Pancreatic Neoplasms
Tissue
Tumors
Cells
2012
75 Citations (Scopus)

Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

Torres, M. P., Rachagani, S., Purohit, V., Pandey, P., Joshi, S., Moore, E. D., Johansson, S. L., Singh, P., Ganti, A. K. P. & Batra, S. K., Oct 1 2012, In : Cancer Letters. 323, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Pharmaceutical Preparations
Annona
Neoplasms
47 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Pancreatic Neoplasms
Cadherins
Down-Regulation
Neoplasm Metastasis
37 Citations (Scopus)

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: Potential implications for diagnosis and therapy

Rachagani, S., Torres, M. P., Kumar, S., Haridas, D., Baine, M., Macha, M. A., Kaur, S., Palanimuthu Ponnusamy, M., Dey, P., Seshacharyulu, P., Johansson, S. L., Jain, M., Wagner, K. U. & Batra, S. K., Oct 30 2012, In : Journal of Hematology and Oncology. 5, 68.

Research output: Contribution to journalArticle

Mucins
Pancreatic Neoplasms
Therapeutics
Pancreas
Neoplasms
16 Citations (Scopus)

Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis

Dey, P., Rachagani, S., Chakraborty, S., Singh, P., Zhao, X., Gurumurthy, C. B., Anderson, J. M., Lele, S. M., Hollingsworth, M. A., Band, V. & Batra, S. K., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6188-6198 11 p.

Research output: Contribution to journalArticle

Glycolysis
Pancreatic Neoplasms
Carcinogenesis
Neoplasms
Glucose
2013
5 Citations (Scopus)

Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects

Cheng, Y., Rachagani, S., Cánovas, A., Mayes, M. S., Tait, R. G., Dekkers, J. C. M. & Reecy, J. M., Oct 29 2013, In : BMC Genetics. 14, 103.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Body Composition
Gene Expression
Myostatin
Chromosomes, Human, Pair 9
40 Citations (Scopus)
Pancreatic Neoplasms
Apoptosis
pregna-4,17-diene-3,16-dione
Neoplasms
Annexin A5
24 Citations (Scopus)

Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: Potential role in therapy

Shimizu, T., Torres, M. P., Chakraborty, S., Souchek, J. J., Rachagani, S., Kaur, S., Macha, M. A., Ganti, A. K. P., Hauke, R. J. & Batra, S. K., Aug 19 2013, In : Cancer Letters. 336, 2, p. 270-280 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Therapeutics
Down-Regulation
Aurora Kinase A
24 Citations (Scopus)

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

Pandey, P., Seshacharyulu, P., Das, S., Rachagani, S., Palanimuthu Ponnusamy, M., Yan, Y., Johansson, S. L., Datta, K., Lin, M-F. & Batra, S. K., Jun 25 2013, In : British journal of cancer. 108, 12, p. 2590-2600 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Prostatic Neoplasms
Androgens
Prostate
Catalytic Domain
66 Citations (Scopus)

Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation

Momi, N., Palanimuthu Ponnusamy, M., Kaur, S., Rachagani, S., Kunigal, S. S., Chellappan, S., Ouellette, M. M. & Batra, S. K., Mar 14 2013, In : Oncogene. 32, 11, p. 1384-1395 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Nicotine
Smoke
Tobacco Products
Up-Regulation
44 Citations (Scopus)

Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: Applications in diagnosis and therapy

Torres, M. P., Rachagani, S., Souchek, J. J., Mallya, K., Johansson, S. L. & Batra, S. K., Nov 20 2013, In : PloS one. 8, 11, e80580.

Research output: Contribution to journalArticle

pancreatic neoplasms
adenocarcinoma
Pancreatic Neoplasms
Adenocarcinoma
animal models
2014
36 Citations (Scopus)

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers

Macha, M. A., Seshacharyulu, P., Krishn, S. R., Pai, P., Rachagani, S., Jain, M. & Batra, S. K., Jan 1 2014, In : Current Pharmaceutical Design. 20, 33, p. 5287-5297 11 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
MicroRNAs
Biomarkers
Neoplasms
Biological Phenomena
18 Citations (Scopus)

MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer

Kaur, S., Sharma, N., Krishn, S. R., Lakshmanan, I., Rachagani, S., Baine, M. J., Smith, L. M., Lele, S. M., Sasson, A. R., Guha, S., Mallya, K., Anderson, J. M., Hollingsworth, M. A. & Batra, S. K., Feb 11 2014, In : Clinical Cancer Research. 20, 3, p. 688-700 13 p.

Research output: Contribution to journalArticle

Acute-Phase Proteins
Pancreatic Neoplasms
Confidence Intervals
Lipocalin-2
Luciferases
19 Citations (Scopus)
Neoplastic Stem Cells
Pancreatic Neoplasms
Drug Resistance
gemcitabine
Maintenance
12 Citations (Scopus)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinarto-ductal metaplasia

Dey, P., Rachagani, S., Vaz, A. P., Palanimuthu Ponnusamy, M. & Batra, S. K., 2014, In : Oncotarget. 5, 12, p. 4480-4491 12 p.

Research output: Contribution to journalArticle

Open Access
Acinar Cells
Metaplasia
Pancreatic Neoplasms
Ceruletide
Amylases
22 Citations (Scopus)

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages

Kumar, S., Torres, M. P., Kaur, S., Rachagani, S., Joshi, S., Johansson, S. L., Momi, N., Baine, M. J., Cutucache, C. E., Smith, L. M., Wyatt, T. A., Jain, M., Joshi, S. S. & Batra, S. K., Jun 9 2014, In : Oncogene. 34, 16, p. 2052-2060 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Smoke
Smoking
Macrophages
Metaplasia
28 Citations (Scopus)

Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation.

Souchek, J. J., Baine, M. J., Lin, C., Rachagani, S., Gupta, S., Kaur, S., Lester, K., Zheng, D., Chen, S., Smith, L. M., Lazenby, A. J., Johansson, S. L., Jain, M. & Batra, S. K., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Cholesterol
Radiation
Geranyltranstransferase
zoledronic acid
2015
10 Citations (Scopus)

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

Pandey, P., Rachagani, S., Das, S., Seshacharyulu, P., Sheinin, Y., Naslavsky, N., Pan, Z., Smith, B. L., Peters, H. L., Radhakrishnan, P., McKenna, N. R., Panapakkam Giridharan, S. S., Haridas, D., Kaur, S., Hollingsworth, M. A., MacDonald, R. G., Meza, J. L., Caplan, S. H., Batra, S. K. & Solheim, J. C., Jan 1 2015, In : Oncotarget. 6, 4, p. 2064-2075 12 p.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
Actin Cytoskeleton
Pancreatic Neoplasms
Neoplasm Metastasis
Growth
29 Citations (Scopus)

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

Das, S., Rachagani, S., Torres-Gonzalez, M. P., Lakshmanan, I., Majhi, P. D., Smith, L. M., Wagner, K. U. & Batra, S. K., Jan 1 2015, In : Oncotarget. 6, 8, p. 5772-5787 16 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Neoplastic Stem Cells
Epitopes
G2 Phase
Luciferases
27 Citations (Scopus)

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model

Rachagani, S., Macha, M. A., Menning, M. S., Dey, P., Pai, P., Smith, L. M., Mo, Y. Y. & Batra, S. K., Jan 1 2015, In : Oncotarget. 6, 37, p. 40295-40309 15 p.

Research output: Contribution to journalArticle

MicroRNAs
Pancreatic Neoplasms
Down-Regulation
Up-Regulation
Karyopherins
46 Citations (Scopus)

Codelivery of small molecule hedgehog inhibitor and miRNA for treating pancreatic cancer

Kumar, V., Mondal, G., Slavik, P., Rachagani, S., Batra, S. K. & Mahato, R. I., Apr 6 2015, In : Molecular Pharmaceutics. 12, 4, p. 1289-1298 10 p.

Research output: Contribution to journalArticle

HhAntag691
MicroRNAs
Pancreatic Neoplasms
Hedgehogs
Micelles
15 Citations (Scopus)

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Mimeault, M., Rachagani, S., Muniyan, S., Seshacharyulu, P., Johansson, S. L., Datta, K., Lin, M-F. & Batra, S. K., Jan 1 2015, In : Oncotarget. 6, 6, p. 3887-3903 17 p.

Research output: Contribution to journalArticle

Open Access
docetaxel
HhAntag691
Anticarcinogenic Agents
Prostatic Neoplasms
Side-Population Cells
19 Citations (Scopus)

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments

Das, S., Majhi, P. D., Al-Mugotir, M. H., Rachagani, S., Sorgen, P. L. & Batra, S. K., Jun 5 2015, In : Scientific reports. 5, 9759.

Research output: Contribution to journalArticle

Membranes
Secretory Pathway
Gene Expression Regulation
Tumor Biomarkers
Ovarian Neoplasms
11 Citations (Scopus)

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Lee, J. H., Meza, J. L., Ganti, A. K. P., Jain, M. & Batra, S. K., Mar 26 2015, In : Oncogene. 34, 13, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

Cell Aging
Cyclin E
Histone Deacetylase 2
Up-Regulation
Down-Regulation
13 Citations (Scopus)
Mucins
Pancreatic Neoplasms
Up-Regulation
Chromatin
Ubiquitin C
17 Citations (Scopus)

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K. P., Palanimuthu Ponnusamy, M. & Batra, S. K., Jan 1 2015, In : Oncotarget. 6, 25, p. 21085-21099 15 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Phenotype
Computational Biology
Phosphatidylinositol 3-Kinases
Immunoprecipitation
27 Citations (Scopus)

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Seshacharyulu, P., Palanimuthu Ponnusamy, M., Rachagani, S., Lakshmanan, I., Haridas, D., Yan, Y., Ganti, A. K. P. & Batra, S. K., Jan 1 2015, In : Oncotarget. 6, 7, p. 5164-5181 18 p.

Research output: Contribution to journalArticle

Open Access
Mucins
Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Down-Regulation
Neoplasm Metastasis
2016
4 Citations (Scopus)

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

Joshi, S., Cruz, E., Rachagani, S., Guha, S., Brand, R. E., Palanimuthu Ponnusamy, M., Kumar, S. & Batra, S. K., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1063-1077 15 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Pancreatic Neoplasms
Up-Regulation
Pancreatic Juice
Neoplasms
15 Citations (Scopus)

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Purohit, A., Varney, M., Rachagani, S., Ouellette, M. M., Batra, S. K. & Singh, R. K., Jan 1 2016, In : Oncotarget. 7, 6, p. 7280-7296 17 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Growth
Adenocarcinoma
Pharmacology
CXC Chemokines
17 Citations (Scopus)

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

Das, S., Rachagani, S., Sheinin, Y., Smith, L. M., Gurumurthy, C. B., Roy, H. K. & Batra, S. K., May 19 2016, In : Oncogene. 35, 20, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

Colitis
Colorectal Neoplasms
Dextran Sulfate
Azoxymethane
Colon
18 Citations (Scopus)

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism

Muniyan, S., Haridas, D., Chugh, S., Rachagani, S., Lakshmanan, I., Gupta, S., Seshacharyulu, P., Smith, L. M., Palanimuthu Ponnusamy, M. & Batra, S. K., Mar 2016, In : Genes and Cancer. 7, 3-4, p. 110-124 15 p.

Research output: Contribution to journalArticle

Focal Adhesions
Adenocarcinoma
Neoplasm Metastasis
Galectin 3
Immunoprecipitation
8 Citations (Scopus)

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the notch effector hath1 in colorectal cancer

Pai, P., Rachagani, S., Dhawan, P., Sheinin, Y. M., Macha, M. A., Qazi, A. K., Chugh, S., Palanimuthu Ponnusamy, M., Mallya, K., Pothuraju, R. & Batra, S. K., May 2016, In : Genes and Cancer. 7, 5-6, p. 154-168 15 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Colorectal Neoplasms
Luciferases
Cell Line
23 Citations (Scopus)

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

Lakshmanan, I., Rachagani, S., Hauke, R., Krishn, S. R., Paknikar, S., Seshacharyulu, P., Karmakar, S., Nimmakayala, R. K., Kaushik, G., Johansson, S. L., Carey, G. B., Palanimuthu Ponnusamy, M., Kaur, S., Batra, S. K. & Ganti, A. K. P., Aug 4 2016, In : Oncogene. 35, 31, p. 4112-4121 10 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Integrins
Lung Neoplasms
Phosphorylation
Cell Movement
11 Citations (Scopus)

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Vaz, A. P., Deb, S., Rachagani, S., Dey, P., Muniyan, S., Lakshmanan, I., Karmakar, S., Smith, L. M., Johansson, S., Lele, S. M., Ouellette, M. M., Palanimuthu Ponnusamy, M. & Batra, S. K., Jan 1 2016, In : Oncotarget. 7, 3, p. 3317-3331 15 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
Carcinogenesis
Up-Regulation
Cyclin D1
8 Citations (Scopus)

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Wang, Y., Kumar, S., Rachagani, S., Sajja, B. R., Xie, Y., Hang, Y., Jain, M., Li, J., Boska, M. D., Batra, S. K. & Oupicky, D., Sep 1 2016, In : Biomaterials. 101, p. 108-120 13 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Chromatin Assembly and Disassembly
Chemokine Receptors
Cytoplasmic and Nuclear Receptors
Pancreatic Neoplasms
20 Citations (Scopus)

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Palanimuthu Ponnusamy, M., Mumby, M. C., Batra, S. K. & Yan, Y., Apr 15 2016, In : Cancer Research. 76, 8, p. 2243-2253 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Pancreatic Neoplasms
Catenins
Holoenzymes
Viral Tumor Antigens
13 Citations (Scopus)

The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma

Pai, P., Rachagani, S., Lakshmanan, I., Macha, M. A., Sheinin, Y., Smith, L. M., Palanimuthu Ponnusamy, M. & Batra, S. K., Feb 1 2016, In : Molecular Oncology. 10, 2, p. 224-239 16 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Mucins
Adenocarcinoma
Neoplasm Metastasis
2017
13 Citations (Scopus)

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Macha, M. A., Rachagani, S., Qazi, A. K., Jahan, R., Gupta, S., Patel, A. A., Seshacharyulu, P., Lin, C., Li, S., Wang, S., Verma, V., Kishida, S., Kishida, M., Nakamura, N., Kibe, T., Lydiatt, W. M., Smith, R. B., Ganti, A. K. P., Jones, D. T., Batra, S. K. & 1 others, Jain, M., Jan 1 2017, In : Oncotarget. 8, 13, p. 20961-20973 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Ionizing Radiation
Epidermal Growth Factor Receptor
Heterografts
Radiation-Induced Neoplasms
13 Citations (Scopus)

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Lakshmanan, I., Salfity, S., Seshacharyulu, P., Rachagani, S., Thomas, A., Das, S., Majhi, P. D., Nimmakayala, R. K., Vengoji, R., Lele, S. M., Palanimuthu Ponnusamy, M., Batra, S. K. & Ganti, A. K. P., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Glucocorticoid Receptors
Growth
gemcitabine
Down-Regulation