• 1815 Citations
  • 24 h-Index
19982020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

CAR T-Cell Therapy in Hematologic Malignancies: A Voyage in Progress

Holstein, S. A. & Lunning, M. A., Jan 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 1, p. 112-122 11 p.

Research output: Contribution to journalReview article

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma

Dimopoulos, M. A., Jakubowiak, A. J., McCarthy, P. L., Orlowski, R. Z., Attal, M., Bladé, J., Goldschmidt, H., Weisel, K. C., Ramasamy, K., Zweegman, S., Spencer, A., Huang, J. S. Y., Lu, J., Sunami, K., Iida, S., Chng, W. J., Holstein, S. A., Rocci, A., Skacel, T., Labotka, R. & 2 others, Palumbo, A. & Anderson, K. C., Feb 1 2020, In : Blood Cancer Journal. 10, 2, 17.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Summary of the Third Annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Al-Kadhimi, Z., Costa, L. J., Hahn, T., Hari, P., Hillengass, J., Jacob, A., Munshi, N. C., Oliva, S., Pasquini, M. C., Shi, Q., Stadtmauer, E. A., Waldvogel, S. L. & McCarthy, P. L., Jan 2020, In : Biology of Blood and Marrow Transplantation. 26, 1, p. e7-e15

Research output: Contribution to journalReview article

Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

Anderson, D. E., Holstein, S. A. & Kedar, S., May 3 2020, In : Neuro-Ophthalmology. 44, 3, p. 139-147 9 p.

Research output: Contribution to journalReview article

2019

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Commentary on “Is posttransplant lenalidomide the standard-of-care after an autotransplant for plasma cell myeloma” by Giovanni Barosi and Robert Peter Gale

Holstein, S. A., Suman, V. J. & McCarthy, P. L., Feb 1 2019, In : Leukemia. 33, 2, p. 565-566 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Determination of Minimal Residual Disease in Multiple Myeloma: Does It Matter?

Kothari, S., Hillengass, J., McCarthy, P. L. & Holstein, S. A., Feb 15 2019, In : Current Hematologic Malignancy Reports. 14, 1, p. 39-46 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2 Scopus citations

Methods to prevent and treat relapse after hematopoietic stem cell transplantation with tyrosine kinase inhibitors, immunomodulating drugs, deacetylase inhibitors, and hypomethylating agents

Chen, Y. B., McCarthy, P. L., Hahn, T., Holstein, S. A., Ueda, M., Kröger, N., Bishop, M. & de Lima, M., Apr 1 2019, In : Bone marrow transplantation. 54, 4, p. 497-507 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

Modeling the Effects of Multiple Myeloma on Kidney Function

Walk, J. C., Ayati, B. P. & Holstein, S. A., Dec 1 2019, In : Scientific reports. 9, 1, 1726.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation

Bhuiyan, N. H., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Dec 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 24, 126757.

Research output: Contribution to journalArticle

Should Overall Survival Remain an Endpoint for Multiple Myeloma Trials?

Holstein, S. A., Suman, V. J. & McCarthy, P. L., Feb 15 2019, In : Current Hematologic Malignancy Reports. 14, 1, p. 31-38 8 p.

Research output: Contribution to journalReview article

2 Scopus citations

Summary of the Second Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Ye, J. C., Howard, A., Bhutani, M., Gormley, N., Hahn, T., Hillengass, J., Krishnan, A., Landgren, C. O., Munshi, N. C., Oliva, S., Owen, R. G., Pasquini, M. C., Puig, N., Weinhold, N., Weisel, K. & McCarthy, P. L., Mar 2019, In : Biology of Blood and Marrow Transplantation. 25, 3, p. e89-e97

Research output: Contribution to journalArticle

3 Scopus citations

The evolving role of maintenance therapy following autologous stem cell transplantation in multiple myeloma

Merz, A. M. A., Merz, M., Hillengass, J., Holstein, S. A. & McCarthy, P., Oct 3 2019, In : Expert review of anticancer therapy. 19, 10, p. 889-898 10 p.

Research output: Contribution to journalReview article

Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron

Haney, S. L., Varney, M. L., Safranek, H. R., Chhonker, Y. S., G-Dayanandan, N., Talmon, G., Murry, D. J., Wiemer, A. J., Wright, D. L. & Holstein, S. A., Feb 2019, In : Leukemia Research. 77, p. 17-27 11 p.

Research output: Contribution to journalArticle

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

2018

BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling: Summary and Recommendations from the Organizing Committee

Holstein, S. A., Avet-Loiseau, H., Hahn, T., Ho, C. M., Lohr, J. G., Munshi, N. C., Paiva, B., Pasquini, M. C., Tario, J. D., Usmani, S. Z., Wallace, P. K., Weisel, K. & McCarthy, P. L., Apr 2018, In : Biology of Blood and Marrow Transplantation. 24, 4, p. 641-648 8 p.

Research output: Contribution to journalReview article

7 Scopus citations
1 Scopus citations

Maintenance Treatment and Survival in Patients with Myeloma: A Systematic Review and Network Meta-analysis

Gay, F., Jackson, G., Rosiñol, L., Holstein, S. A., Moreau, P., Spada, S., Davies, F., Lahuerta, J. J., Leleu, X., Bringhen, S., Evangelista, A., Hulin, C., Panzani, U., Cairns, D. A., Di Raimondo, F., Macro, M., Liberati, A. M., Pawlyn, C., Offidani, M., Spencer, A. & 11 others, Hájek, R., Terpos, E., Morgan, G. J., Bladé, J., Sonneveld, P., San-Miguel, J., McCarthy, P. L., Ludwig, H., Boccadoro, M., Mateos, M. V. & Attal, M., Oct 2018, In : JAMA Oncology. 4, 10, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Multiple Myeloma, version 3.2018: Featured updates to the NCCN guidelines

Kumar, S. K., Callander, N. S., Alsina, M., Atanackovic, D., Biermann, J. S., Castillo, J., Chandler, J. C., Costello, C., Faiman, M., Fung, H. C., Godby, K., Hofmeister, C., Holmberg, L., Holstein, S., Huff, C. A., Kang, Y., Kassim, A., Liedtke, M., Malek, E., Martin, T. & 10 others, Neppalli, V. T., Omel, J., Raje, N., Singhal, S., Somlo, G., Stockerl-Goldstein, K., Weber, D., Yahalom, J., Kumar, R. & Shead, D. A., Jan 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 1, p. 11-20 10 p.

Research output: Contribution to journalReview article

52 Scopus citations

Next-generation drugs targeting the cereblon ubiquitin ligase

Holstein, S. A., Hillengass, J. & McCarthy, P. L., Jul 10 2018, In : Journal of Clinical Oncology. 36, 20, p. 2101-2104 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor

Haney, S. L., Chhonker, Y. S., Varney, M. L., Talmon, G., Murry, D. J. & Holstein, S. A., Oct 1 2018, In : Investigational New Drugs. 36, 5, p. 810-818 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Present and future of immunotherapy in the management of multiple myeloma

Baljevic, M. & Holstein, S. A., Jul 1 2018, In : Journal of oncology practice. 14, 7, p. 403-410 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Quantitative determination of a potent geranylgeranyl diphosphate synthase inhibitor using LC–MS/MS: Derivatization and application

Chhonker, Y. S., Haney, S. L., Matthiesen, R. A., Wiemer, D. F., Holstein, S. A. & Murry, D. J., May 10 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 153, p. 22-28 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Simultaneous quantitation of isoprenoid pyrophosphates in plasma and cancer cells using LC-MS/MS

Chhonker, Y. S., Haney, S. L., Bala, V., Holstein, S. A. & Murry, D. J., Dec 11 2018, In : Molecules. 23, 12, 3275.

Research output: Contribution to journalArticle

3 Scopus citations

α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

Matthiesen, R. A., Varney, M. L., Xu, P. C., Rier, A. S., Wiemer, D. F. & Holstein, S. A., Jan 15 2018, In : Bioorganic and Medicinal Chemistry. 26, 2, p. 376-385 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase

Wills, V. S., Metzger, J. I., Allen, C., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 8, p. 2437-2444 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Clinical practice guidelines in oncology

Kumar, S. K., Callander, N. S., Alsina, M., Atanackovic, D., Biermann, J. S., Chandler, J. C., Costello, C., Faiman, M., Fung, H. C., Gasparetto, C., Godby, K., Hofmeister, C., Holmberg, L., Holstein, S., Huff, C. A., Kassim, A., Liedtke, M., Martin, T., Omel, J., Raje, N. & 9 others, Reu, F. J., Singhal, S., Somlo, G., Stockerl-Goldstein, K., Treon, S. P., Weber, D., Yahalom, J., Shead, D. A. & Kumar, R., Feb 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 2, p. 230-269 40 p.

Research output: Contribution to journalArticle

92 Scopus citations

Immune signatures associated with improved progression-free and overall survival for myeloma patients treated with AHSCT

Ho, C. M., McCarthy, P. L., Wallace, P. K., Zhang, Y., Fora, A., Mellors, P., Tario, J. D., McCarthy, B. L. S., Chen, G. L., Holstein, S. A., Balderman, S. R., Cao, X., Paiva, B. & Hahn, T., Jun 27 2017, In : Blood Advances. 1, 15, p. 1056-1066 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Immunomodulatory Drugs in Multiple Myeloma: Mechanisms of Action and Clinical Experience

Holstein, S. A. & McCarthy, P. L., Apr 1 2017, In : Drugs. 77, 5, p. 505-520 16 p.

Research output: Contribution to journalReview article

29 Scopus citations

Lenalidomide in combination or alone as maintenance therapy following autologous stem cell transplant in patients with multiple myeloma: a review of options for and against

Richardson, P. G., Holstein, S. A., Schlossman, R. L., Anderson, K. C., Attal, M. & McCarthy, P. L., Dec 12 2017, In : Expert Opinion on Pharmacotherapy. 18, 18, p. 1975-1985 11 p.

Research output: Contribution to journalReview article

3 Scopus citations

Lenalidomide maintenance after autologous stem-cell transplantation in newly diagnosed multiple myeloma: A meta-analysis

McCarthy, P. L., Holstein, S. A., Petrucci, M. T., Richardson, P. G., Hulin, C., Tosi, P., Bringhen, S., Musto, P., Anderson, K. C., Caillot, D., Gay, F., Moreau, P., Marit, G., Jung, S. H., Yu, Z., Winograd, B., Knight, R. D., Palumbo, A. & Attal, M., Oct 10 2017, In : Journal of Clinical Oncology. 35, 29, p. 3279-3289 11 p.

Research output: Contribution to journalArticle

175 Scopus citations

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

Haney, S. L., Allen, C., Varney, M. L., Dykstra, K. M., Falcone, E. R., Colligan, S. H., Hu, Q., Aldridge, A. M., Wright, D. L., Wiemer, A. J. & Holstein, S. A., Jan 1 2017, In : Oncotarget. 8, 44, p. 76085-76098 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Olefin isomers of a triazole bisphosphonate synergistically inhibit geranylgeranyl diphosphate synthase

Allen, C., Kortagere, S., Tong, H., Matthiesen, R. A., Metzger, J. I., Wiemer, D. F. & Holstein, S. A., Mar 2017, In : Molecular pharmacology. 91, 3, p. 229-236 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma

Raje, N. S., Moreau, P., Terpos, E., Benboubker, L., Grząśko, N., Holstein, S. A., Oriol, A., Huang, S. Y., Beksac, M., Kuliczkowski, K., Tai, D. F., Wooldridge, J. E., Conti, I., Kaiser, C. J., Nguyen, T. S., Cronier, D. M. & Palumbo, A., Mar 1 2017, In : British Journal of Haematology. 176, 5, p. 783-795 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Recent advances in the development of mammalian geranylgeranyl diphosphate synthase inhibitors

Haney, S. L., Wills, V. S., Wiemer, D. F. & Holstein, S. A., Jun 2017, In : Molecules. 22, 6, 886.

Research output: Contribution to journalReview article

10 Scopus citations

Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial

Holstein, S. A., Jung, S. H., Richardson, P. G., Hofmeister, C. C., Hurd, D. D., Hassoun, H., Giralt, S., Stadtmauer, E. A., Weisdorf, D. J., Vij, R., Moreb, J. S., Callander, N. S., van Besien, K., Gentile, T. G., Isola, L., Maziarz, R. T., Bashey, A., Landau, H., Martin, T., Qazilbash, M. H. & 18 others, Rodriguez, C., McClune, B., Schlossman, R. L., Smith, S. E., Hars, V., Owzar, K., Jiang, C., Boyd, M., Schultz, C., Wilson, M., Hari, P., Pasquini, M. C., Horowitz, M. M., Shea, T. C., Devine, S. M., Linker, C., Anderson, K. C. & McCarthy, P. L., Sep 2017, In : The Lancet Haematology. 4, 9, p. e431-e442

Research output: Contribution to journalArticle

42 Scopus citations
2016

Anaplastic Multiple Myeloma: An Aggressive Variant With a Poor Response to Novel Therapies

Ammannagari, N., Celotto, K., Neppalli, V., Lee, K. & Holstein, S. A., Sep 1 2016, In : Clinical Lymphoma, Myeloma and Leukemia. 16, 9, p. e129-e131

Research output: Contribution to journalArticle

3 Scopus citations

A new motif for inhibitors of geranylgeranyl diphosphate synthase

Foust, B. J., Allen, C., Holstein, S. A. & Wiemer, D. F., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3734-3741 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Improved survival with salvage autologous stem-cell transplantation in myeloma

Holstein, S. A. & McCarthy, P. L., Jul 1 2016, In : The Lancet Haematology. 3, 7, p. e306-e307

Research output: Contribution to journalComment/debate

NCCN guidelines® insights multiple myeloma, version 3.2016 featured updates to the NCCN guidelines

Anderson, K. C., Alsina, M., Atanackovic, D., Biermann, J. S., Chandler, J. C., Costello, C., Djulbegovic, B., Fung, H. C., Gasparetto, C., Godby, K., Hofmeister, C., Holmberg, L., Holstein, S., Huff, C. A., Kassim, A., Krishnan, A. Y., Kumar, S. K., Liedtke, M., Lunning, M., Raje, N. & 9 others, Reu, F. J., Singhal, S., Somlo, G., Stockerl-Goldstein, K., Treon, S. P., Weber, D., Yahalom, J., Shead, D. A. & Kumar, R., Apr 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 4, p. 389-400 12 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis

Li, J., Falcone, E. R., Holstein, S. A., Anderson, A. C., Wright, D. L. & Wiemer, A. J., Nov 1 2016, In : Pharmacological Research. 113, p. 438-448 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of stem cell transplant and maintenance therapy in plasma cell disorders

McCarthy, P. L. & Holstein, S. A., Jan 1 2016, In : Hematology. 2016, 1, p. 504-511 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Stereocontrolled regeneration of olefins from epoxides

Wills, V. S., Zhou, X., Allen, C., Holstein, S. A. & Wiemer, D. F., Mar 23 2016, In : Tetrahedron Letters. 57, 12, p. 1335-1337 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates

Matthiesen, R. A., Wills, V. S., Metzger, J. I., Holstein, S. A. & Wiemer, D. F., Oct 7 2016, In : Journal of Organic Chemistry. 81, 19, p. 9438-9442 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma

Giralt, S., Garderet, L., Durie, B., Cook, G., Gahrton, G., Bruno, B., Hari, P., Lokhorst, H., McCarthy, P., Krishnan, A., Sonneveld, P., Goldschmidt, H., Jagannath, S., Barlogie, B., Mateos, M., Gimsing, P., Sezer, O., Mikhael, J., Lu, J., Dimopoulos, M. & 45 others, Mazumder, A., Palumbo, A., Abonour, R., Anderson, K., Attal, M., Blade, J., Bird, J., Cavo, M., Comenzo, R., de la Rubia, J., Einsele, H., Garcia-Sanz, R., Hillengass, J., Holstein, S., Johnsen, H. E., Joshua, D., Koehne, G., Kumar, S., Kyle, R., Leleu, X., Lonial, S., Ludwig, H., Nahi, H., Nooka, A., Orlowski, R., Rajkumar, V., Reiman, A., Richardson, P., Riva, E., San Miguel, J., Turreson, I., Usmani, S., Vesole, D., Bensinger, W., Qazilbash, M., Efebera, Y., Mohty, M., Gasparreto, C., Gajewski, J., LeMaistre, C. F., Bredeson, C., Moreau, P., Pasquini, M., Kroeger, N. & Stadtmauer, E., Dec 2015, In : Biology of Blood and Marrow Transplantation. 21, 12, p. 2039-2051 13 p.

Research output: Contribution to journalReview article

90 Scopus citations

Continued role for ASCT in multiple myeloma

McCarthy, P. L. & Holstein, S. A., Jan 1 2015, In : The Lancet Oncology. 16, 16, p. 1571-1573 3 p.

Research output: Contribution to journalComment/debate