Samuel Sathyanesan, PhD

Associate Professor

  • 3271 Citations
  • 30 h-Index
20022020
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Research Output 2002 2020

  • 3271 Citations
  • 30 h-Index
  • 42 Article
  • 8 Review article
  • 3 Comment/debate
  • 2 Chapter
2020

Carbamoylated erythropoietin produces antidepressant-like effects in male and female mice

Sampath, D., McWhirt, J., Sathyanesan, M. & Newton, S. S., Jan 10 2020, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 96, 109754.

Research output: Contribution to journalArticle

Open Access
Erythropoietin
Antidepressive Agents
Hindlimb Suspension
Cyclic AMP Response Element-Binding Protein
Aptitude
2019
1 Citation (Scopus)

Carbamoylated erythropoietin induces a neurotrophic gene profile in neuronal cells

Tiwari, N. K., Sathyanesan, M., Schweinle, W. & Newton, S. S., Jan 10 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 88, p. 132-141 10 p.

Research output: Contribution to journalArticle

Erythropoietin
Genes
Erythropoiesis
Long-Term Potentiation
Gene Expression

Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice

McWhirt, J., Sathyanesan, M., Sampath, D. & Newton, S. S., Feb 2019, In : Neurobiology of Stress. 10, 100169.

Research output: Contribution to journalArticle

Open Access
Glutamate Receptors
Genes
Inflammation
Inbred C57BL Mouse
Gene expression
2018
3 Citations (Scopus)

Carbamoylated erythropoietin modulates cognitive outcomes of social defeat and differentially regulates gene expression in the dorsal and ventral hippocampus

Sathyanesan, M., Watt, M. J., Haiar, J. M., Scholl, J. L., Davies, S. R., Paulsen, R. T., Wiederin, J., Ciborowski, P. S. & Sathyanesan, S., Dec 1 2018, In : Translational Psychiatry. 8, 1, 113.

Research output: Contribution to journalArticle

Erythropoietin
Hippocampus
Cognition
Gene Expression
Fear
1 Citation (Scopus)
Open Access
Erythropoietin
Catalytic Domain
Cell proliferation
Computational methods
Mutation
5 Citations (Scopus)

Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression

Staton, C. D., Yaeger, J. D. W., Khalid, D., Haroun, F., Fernandez, B. S., Fernandez, J. S., Summers, B. K., Summers, T. R., Sathyanesan, M., Newton, S. S. & Summers, C. H., Dec 2018, In : Neuropharmacology. 143, p. 79-94 16 p.

Research output: Contribution to journalArticle

Orexin Receptors
Anxiety
Depression
Anti-Anxiety Agents
Interpersonal Relations
2017
20 Citations (Scopus)

Cognitive dysfunction in major depression and Alzheimer’s disease is associated with hippocampal–prefrontal cortex dysconnectivity

Sampath, D., Sathyanesan, M. & Newton, S. S., Jun 12 2017, In : Neuropsychiatric Disease and Treatment. 13, p. 1509-1519 11 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Depression
Connectome
Optogenetics
Affective Symptoms
11 Citations (Scopus)

Restraint stress differentially regulates inflammation and glutamate receptor gene expression in the hippocampus of C57BL/6 and BALB/c mice

Sathyanesan, M., Haiar, J. M., Watt, M. J. & Newton, S. S., Jan 1 2017, In : Stress. 20, 2, p. 197-204 8 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Hippocampus
Inflammation
Gene Expression
Genes
2016
6 Citations (Scopus)

Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy

Sane, S., Abdullah, A., Nelson, M. E., Wang, H., Chauhan, S. C., Newton, S. S. & Rezvani, K., Mar 1 2016, In : Cell Stress and Chaperones. 21, 2, p. 313-326 14 p.

Research output: Contribution to journalArticle

Chemotherapy
Drug Therapy
Cells
Fluorouracil
Proteins
2015
4 Citations (Scopus)

Indomethacin induced gene regulation in the rat hippocampus

Sathyanesan, M., Girgenti, M. J., Warner-Schmidt, J. & Newton, S. S., Oct 6 2015, In : Molecular Brain. 8, 1, 59.

Research output: Contribution to journalArticle

Indomethacin
Hippocampus
Cyclooxygenase Inhibitors
Genes
Prostaglandin-Endoperoxide Synthases
34 Citations (Scopus)

Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder

Rajkowska, G., Mahajan, G., Maciag, D., Sathyanesan, M., Iyo, A. H., Moulana, M., Kyle, P. B., Woolverton, W. L., Miguel-Hidalgo, J. J., Stockmeier, C. A. & Newton, S. S., Jun 1 2015, In : Journal of Psychiatric Research. 65, p. 53-62 10 p.

Research output: Contribution to journalArticle

Oligodendroglia
Major Depressive Disorder
2',3'-Cyclic-Nucleotide Phosphodiesterases
Myelin Sheath
Messenger RNA
2013
105 Citations (Scopus)

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L. & Duman, R. S., Feb 1 2013, In : International Journal of Neuropsychopharmacology. 16, 1, p. 69-82 14 p.

Research output: Contribution to journalArticle

Synapses
Major Depressive Disorder
Glutamic Acid
Hippocampus
Genes
4 Citations (Scopus)

Evaluating effects of EPO in rodent behavioral assays related to depression

Duman, C. H. & Newton, S. S., 2013, Tissue-Protective Cytokines: Methods and Protocols. Humana Press Inc., p. 127-140 14 p. (Methods in Molecular Biology; vol. 982).

Research output: Chapter in Book/Report/Conference proceedingChapter

Erythropoietin
Rodentia
Depression
Antidepressive Agents
Depressive Disorder
27 Citations (Scopus)

Vascular growth factors in neuropsychiatry

Newton, S. S., Fournier, N. M. & Duman, R. S., Mar 11 2013, In : Cellular and Molecular Life Sciences. 70, 10, p. 1739-1752 14 p.

Research output: Contribution to journalReview article

Neuropsychiatry
Intercellular Signaling Peptides and Proteins
Neurons
Aptitude
Causality
2012
30 Citations (Scopus)

A molecular characterization of the choroid plexus and stress-induced gene regulation

Sathyanesan, M., Girgenti, M. J., Banasr, M., Stone, K., Bruce, C., Guilchicek, E., Wilczak-Havill, K., Nairn, A., Williams, K., Sass, S., Duman, J. G. & Newton, S. S., Jul 17 2012, In : Translational Psychiatry. 2, p. e139

Research output: Contribution to journalArticle

Choroid Plexus
Genes
Gene Expression
Brain
Proteins
17 Citations (Scopus)

Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression

Voleti, B., Tanis, K. Q., Newton, S. S. & Duman, R. S., Jan 1 2012, In : Biological Psychiatry. 71, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

Electroconvulsive Therapy
Seizures
Depression
Genes
Hippocampus
17 Citations (Scopus)

Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression

Ordway, G. A., Szebeni, A., Chandley, M. J., Stockmeier, C. A., Xiang, L., Newton, S. S., Turecki, G., Duffourc, M. M., Zhu, M. Y., Zhu, H. & Szebeni, K., Aug 1 2012, In : International Journal of Neuropsychopharmacology. 15, 7, p. 855-868 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 7
Locus Coeruleus
Major Depressive Disorder
Astrocytes
Brain Stem
2011
10 Citations (Scopus)

Characterization of electroconvulsive seizure-induced TIMP-1 and MMP-9 in hippocampal vasculature

Girgenti, M. J., Collier, E., Sathyanesan, M., Su, X. W. & Newton, S. S., May 1 2011, In : International Journal of Neuropsychopharmacology. 14, 4, p. 535-544 10 p.

Research output: Contribution to journalArticle

Metalloproteases
Seizures
Blood Vessels
Basement Membrane
Microdissection
2010
224 Citations (Scopus)

A negative regulator of MAP kinase causes depressive behavior

Duric, V., Banasr, M., Licznerski, P., Schmidt, H. D., Stockmeier, C. A., Simen, A. A., Newton, S. S. & Duman, R. S., Nov 1 2010, In : Nature Medicine. 16, 11, p. 1328-1332 5 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 1
Major Depressive Disorder
Phosphotransferases
Mitogen-Activated Protein Kinase Phosphatases
Gene transfer
21 Citations (Scopus)

Antipsychotic-induced gene regulation in multiple brain regions

Girgenti, M. J., Nisenbaum, L. K., Bymaster, F., Terwilliger, R., Duman, R. S. & Newton, S. S., Apr 1 2010, In : Journal of Neurochemistry. 113, 1, p. 175-187 13 p.

Research output: Contribution to journalArticle

Gene expression
Antipsychotic Agents
Brain
olanzapine
Genes
263 Citations (Scopus)

Glial pathology in an animal model of depression: Reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L. & Sanacora, G., May 1 2010, In : Molecular Psychiatry. 15, 5, p. 501-511 11 p.

Research output: Contribution to journalArticle

Riluzole
Neuroglia
Glutamic Acid
Animal Models
Depression
30 Citations (Scopus)

Increased peripheral blood expression of electron transport chain genes in bipolar depression

Beech, R. D., Lowthert, L., Leffert, J. J., Mason, P. N., Taylor, M. M., Umlauf, S., Lin, A., Lee, J. Y., Maloney, K., Muralidharan, A., Lorberg, B., Zhao, H., Newton, S. S., Mane, S., Epperson, C. N., Sinha, R., Blumberg, H. & Bhagwagar, Z., Dec 1 2010, In : Bipolar Disorders. 12, 8, p. 813-824 12 p.

Research output: Contribution to journalArticle

Electron Transport
Bipolar Disorder
Genes
Reverse Transcription
Up-Regulation
70 Citations (Scopus)

Wnt2 expression and signaling is increased by different classes of antidepressant treatments

Okamoto, H., Voleti, B., Banasr, M., Sarhan, M., Duric, V., Girgenti, M. J., Dileone, R. J., Newton, S. S. & Duman, R. S., Sep 15 2010, In : Biological Psychiatry. 68, 6, p. 521-527 7 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Antidepressive Agents
Mood Disorders
Hippocampus
Transcription Factors
2009
50 Citations (Scopus)

Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects

Girgenti, M. J., Hunsberger, J., Duman, C. H., Sathyanesan, M., Terwilliger, R. & Newton, S. S., Aug 1 2009, In : Biological Psychiatry. 66, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Erythropoietin
Antidepressive Agents
Seizures
Genes
Erythropoietin Receptors
91 Citations (Scopus)

Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise

Duman, C. H., Schlesinger, L., Terwilliger, R., Russell, D. S., Newton, S. S. & Duman, R. S., Mar 17 2009, In : Behavioural Brain Research. 198, 2, p. 366-371 6 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Antidepressive Agents
Depression
Aptitude
Nerve Growth Factors
169 Citations (Scopus)

Sweet taste signaling functions as a hypothalamic glucose sensor

Ren, X., Zhou, L., Terwilliger, R., Newton, S. S. & de Araujo, I. E., Jun 19 2009, In : Frontiers in Integrative Neuroscience. 3, JUN, 12.

Research output: Contribution to journalArticle

Glucose
trichlorosucrose
Genes
G-Protein-Coupled Receptors
GTP-Binding Proteins
2008

Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection (Pharmacological Reviews (2002) 60, (358-403))

Lieberman, J. A., Bymaster, F. P., Meltzer, H. Y., Deutch, A. Y., Duncan, G. E., Marx, C. E., Aprille, J. R., Dwyer, D. S., Li, X. M., Mahadik, S. P., Duman, R. S., Porter, J. H., Modica-Napolitano, J. S., Newton, S. S. & Csernansky, J. G., Dec 1 2008, In : Pharmacological Reviews. 60, 4, 1 p.

Research output: Contribution to journalComment/debate

Antipsychotic Agents
Neurotransmitter Agents
Animal Models
Pharmacology
Neuroprotection
164 Citations (Scopus)

Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection

Lieberman, J. A., Bymaster, F. P., Meltzer, H. Y., Deutch, A. Y., Duncan, G. E., Marx, C. E., Aprille, J. R., Dwyer, D. S., Li, X. M., Mahadik, S. P., Duman, R. S., Porter, J. H., Modica-Napolitano, J. S., Newton, S. S. & Csernansky, J. G., Sep 1 2008, In : Pharmacological Reviews. 60, 3, p. 358-403 46 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Neurotransmitter Agents
Animal Models
Schizophrenia
Aptitude
81 Citations (Scopus)

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Suda, S., Segi-Nishida, E., Newton, S. S. & Duman, R. S., Aug 15 2008, In : Biological Psychiatry. 64, 4, p. 311-319 9 p.

Research output: Contribution to journalArticle

Postpartum Depression
Postpartum Period
Steroids
Gene Expression
Hormones
51 Citations (Scopus)

CREB Binding and Activity in Brain: Regional Specificity and Induction by Electroconvulsive Seizure

Tanis, K. Q., Duman, R. S. & Newton, S. S., Apr 1 2008, In : Biological Psychiatry. 63, 7, p. 710-720 11 p.

Research output: Contribution to journalArticle

Seizures
Brain
Frontal Lobe
Hippocampus
Binding Sites
57 Citations (Scopus)

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

Lynch, W. J., Girgenti, M. J., Breslin, F. J., Newton, S. S. & Taylor, J. R., Jun 5 2008, In : Brain Research. 1213, p. 166-177 12 p.

Research output: Contribution to journalArticle

Self Administration
Cocaine
Gene Expression
Genes
Addictive Behavior
2007
184 Citations (Scopus)

Antidepressant actions of the exercise-regulated gene VGF

Hunsberger, J. G., Newton, S. S., Bennett, A. H., Duman, C. H., Russell, D. S., Salton, S. R. & Duman, R. S., Dec 1 2007, In : Nature Medicine. 13, 12, p. 1476-1482 7 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Genes
Peptides
Neuronal Plasticity
Gene encoding

Customizing microarrays for neuroscience drug discovery

Girgenti, M. J. & Newton, S. S., Aug 1 2007, In : Expert Opinion on Drug Discovery. 2, 8, p. 1139-1149 11 p.

Research output: Contribution to journalReview article

Drug Discovery
Neurosciences
Technology
RNA Transport
Microdissection
30 Citations (Scopus)

Epigenetic Marking and Neuronal Plasticity

Duman, R. S. & Newton, S. S., Jul 1 2007, In : Biological Psychiatry. 62, 1, p. 1-3 3 p.

Research output: Contribution to journalComment/debate

Genetic Epigenesis
Neuronal Plasticity
Chromatin Assembly and Disassembly
Central Nervous System Diseases
Psychotropic Drugs
Neurochemistry
Dentate Gyrus
Transcriptome
Hippocampus
Seizures
76 Citations (Scopus)

Gene expression profiling in postmortem prefrontal cortex of major depressive disorder

Hyo, J. K., Adams, D. H., Simen, A., Simen, B. B., Rajkowska, G., Stockmeier, C. A., Overholser, J. C., Meltzer, H. Y., Jurjus, G. J., Konick, L. C., Newton, S. S. & Duman, R. S., Nov 28 2007, In : Journal of Neuroscience. 27, 48, p. 13329-13340 12 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Gene Expression Profiling
Prefrontal Cortex
Microdissection
Oligonucleotide Array Sequence Analysis
70 Citations (Scopus)

Neurogenic actions of atypical antipsychotic drugs and therapeutic implications

Newton, S. S. & Duman, R. S., Aug 27 2007, In : CNS Drugs. 21, 9, p. 715-725 11 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Neurogenesis
Lateral Ventricles
Antidepressive Agents
Hippocampus
4 Citations (Scopus)

Regulation of gene transcription in the central nervous system by norepinephrine

Duman, R. S. & Newton, S. S., Jan 1 2007, Brain Norepinephrine: Neurobiology and Therapeutics. Cambridge University Press, p. 95-118 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Norepinephrine
Central Nervous System
Brain
Genes
Transcription Factors
51 Citations (Scopus)

Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development

Tanis, K. Q., Newton, S. S. & Duman, R. S., Apr 1 2007, In : CNS and Neurological Disorders - Drug Targets. 6, 2, p. 151-160 10 p.

Research output: Contribution to journalReview article

Nerve Growth Factors
Antidepressive Agents
Intercellular Signaling Peptides and Proteins
Gene Expression
Atrophy
2006
22 Citations (Scopus)

Chromatin remodeling: A novel mechanism of psychotropic drug action

Newton, S. S. & Duman, R. S., Jul 26 2006, In : Molecular pharmacology. 70, 2, p. 440-443 4 p.

Research output: Contribution to journalReview article

Chromatin Assembly and Disassembly
Psychotropic Drugs
Gene Expression Regulation
Street Drugs
Acetylation
44 Citations (Scopus)

Electroconvulsive seizure increases adult hippocampal angiogenesis in rats

Newton, S. S., Girgenti, M. J., Collier, E. F. & Duman, R. S., Aug 1 2006, In : European Journal of Neuroscience. 24, 3, p. 819-828 10 p.

Research output: Contribution to journalArticle

Blood Vessels
Seizures
Dentate Gyrus
Cell Proliferation
Treatment-Resistant Depressive Disorder
62 Citations (Scopus)

Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer

Ploski, J. E., Newton, S. S. & Duman, R. S., Nov 1 2006, In : Journal of Neurochemistry. 99, 4, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Electroshock
Transcriptome
Gene expression
Hippocampus
2005
69 Citations (Scopus)

Blockade of melanocortin transmission inhibits cocaine reward

Hsu, R., Taylor, J. R., Newton, S. S., Alvaro, J. D., Haile, C., Han, G., Hruby, V. J., Nestler, E. J. & Duman, R. S., Apr 1 2005, In : European Journal of Neuroscience. 21, 8, p. 2233-2242 10 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 4
Melanocortins
Reward
Cocaine
Nucleus Accumbens
69 Citations (Scopus)

Gene profiling the response to kainic acid induced seizures

Hunsberger, J. G., Bennett, A. H., Selvanayagam, E., Duman, R. S. & Newton, S. S., Nov 18 2005, In : Molecular Brain Research. 141, 1, p. 95-112 18 p.

Research output: Contribution to journalArticle

Kainic Acid
Seizures
Genes
Neuronal Plasticity
Glutamate Receptors
11 Citations (Scopus)

Production of custom microarrays for neuroscience research

Newton, S. S., Bennett, A. & Duman, R. S., Nov 1 2005, In : Methods. 37, 3, p. 238-246 9 p.

Research output: Contribution to journalArticle

Microarrays
Neurosciences
Technology
Genes
Research
2004
14 Citations (Scopus)

Downregulation of the CCAAT-Enhancer Binding Protein β in ΔFosB Transgenic Mice and by Electroconvulsive Seizures

Chen, J., Newton, S. S., Zeng, L., Adams, D. H., Dow, A. L., Madsen, T. M., Nestler, E. J. & Duman, R. S., Jan 1 2004, In : Neuropsychopharmacology. 29, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Transgenic Mice
Carrier Proteins
Seizures
Down-Regulation
13 Citations (Scopus)

Regulation of growth factor receptor bound 2 by electroconvulsive seizure

Newton, S. S., Collier, E. F., Bennett, A. H., Russell, D. S. & Duman, R. S., Oct 22 2004, In : Molecular Brain Research. 129, 1-2, p. 185-188 4 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Seizures
Antidepressive Agents
Intercellular Signaling Peptides and Proteins
Parahippocampal Gyrus
61 Citations (Scopus)

Regulation of neurogenesis and angiogenesis in depression.

Newton, S. S. & Duman, R. S., Jul 2004, In : Current neurovascular research. 1, 3, p. 261-267 7 p.

Research output: Contribution to journalReview article

Neurogenesis
Antidepressive Agents
Research
Intercellular Signaling Peptides and Proteins
Parturition
2003
31 Citations (Scopus)

Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors

Wu, M., Newton, S. S., Atkins, J. B., Xu, C., Duman, R. S. & Alreja, M., Nov 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 2, p. 535-543 9 p.

Research output: Contribution to journalArticle

GABAergic Neurons
Cholinesterase Inhibitors
Nicotinic Receptors
Cholinergic Agents
Acetylcholine
99 Citations (Scopus)

Chronic electroconvulsive seizure up-regulates β-catenin expression in rat hippocampus: Role in adult neurogenesis

Madsen, T. M., Newton, S. S., Eaton, M. E., Russell, D. S. & Duman, R. S., Nov 15 2003, In : Biological Psychiatry. 54, 10, p. 1006-1014 9 p.

Research output: Contribution to journalArticle

Catenins
Neurogenesis
Hippocampus
Seizures
Up-Regulation