Raul G Barletta, PhD

Professor

  • 4447 Citations
  • 29 h-Index
1981 …2019

Research output per year

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Research Output

  • 4447 Citations
  • 29 h-Index
  • 61 Article
  • 8 Review article
  • 5 Chapter
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Article
2019

Novel amphiphilic cyclobutene and cyclobutane cis-C18 fatty acid derivatives inhibit Mycobacterium avium subsp. paratuberculosis growth

Zinniel, D. K., Sittiwong, W., Marshall, D. D., Rathnaiah, G., Sakallioglu, I. T., Powers, R., Dussault, P. H. & Barletta, R. G., Jun 1 2019, In : Veterinary Sciences. 6, 2, 46.

Research output: Contribution to journalArticle

Open Access
2017

Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d -Alanine Biosynthesis

Marshall, D. D., Halouska, S., Zinniel, D. K., Fenton, R. J., Kenealy, K., Chahal, H. K., Rathnaiah, G., Barletta, R. G. & Powers, R., Mar 3 2017, In : Journal of proteome research. 16, 3, p. 1270-1279 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Analysis of mycobacterium avium subsp. Paratuberculosis mutant libraries reveals loci-dependent transposition biases and strategies for novel mutant discovery

Rathnaiah, G., Bannantine, J. P., Bayles, D. O., Zinniel, D. K., Stabel, J. R., Gröhn, Y. T. & Barletta, R. G., Apr 2016, In : Microbiology (United Kingdom). 162, 4, p. 633-641 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Whole genomic sequence analysis of Bacillus infantis: Defining the genetic blueprint of strain NRRL B-14911, an emerging cardiopathogenic microbe

Massilamany, C., Mohammed, A., Loy, J. D., Purvis, T., Krishnan, B., Basavalingappa, R. H., Kelley, C. M., Guda, C., Barletta, R. G., Moriyama, E. N., Smith, T. P. L. & Reddy, J., Aug 22 2016, In : BMC genomics. 17, 511.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against mycobacterium tuberculosis

Sittiwong, W., Zinniel, D. K., Fenton, R. J., Marshall, D. D., Story, C. B., Kim, B., Lee, J. Y., Powers, R., Barletta, R. G. & Dussault, P. H., Aug 2014, In : ChemMedChem. 9, 8, p. 1838-1849 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evaluation of eight live attenuated vaccine candidates for protection against challenge with virulent Mycobacterium avium subspecies paratuberculosis in mice

Bannantine, J. P., Everman, J. L., Rose, S. J., Babrak, L., Katani, R., Barletta, R. G., Talaat, A. M., Gröhn, Y. T., Chang, Y. F., Kapur, V. & Bermudez, L. E., Jan 1 2014, In : Frontiers in Cellular and Infection Microbiology. 4, JUL, 88.

Research output: Contribution to journalArticle

17 Scopus citations

Evaluation of novel oral vaccine candidates and validation of a caprine model of Johne's disease

Hines, M. E., Turnquist, S. E., Ilha, M. R. S., Rajeev, S., Jones, A. L., Whittington, L., Bannantine, J. P., Barletta, R. G., Gröhn, Y. T., Katani, R., Talaat, A. M., Li, L. & Kapur, V., Jan 1 2014, In : Frontiers in Cellular and Infection Microbiology. 5, MAR, Article 26.

Research output: Contribution to journalArticle

30 Scopus citations

Generation and screening of a comprehensive Mycobacterium avium subsp. paratuberculosis transposon mutant bank

Rathnaiah, G., Lamont, E. A., Harris, N. B., Fenton, R. J., Zinniel, D. K., Liu, X., Sotos, J., Feng, Z., Livneh-Kol, A., Shpigel, N. Y., Czuprynski, C. J., Sreevatsan, S. & Barletta, R. G., Apr 2014, In : Frontiers in Cellular and Infection Microbiology. 4, 144.

Research output: Contribution to journalArticle

9 Scopus citations

Metabolomics analysis identifies d-alanine-d-alanine ligase as the primary lethal target of d-cycloserine in mycobacteria

Halouska, S., Fenton, R. J., Zinniel, D. K., Marshall, D. D., Barletta, R. G. & Powers, R., Feb 7 2014, In : Journal of proteome research. 13, 2, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Molecular analysis of the Mycobacterium tuberculosis lux-like mel2 operon

Janagama, H. K., Tounkang, S., Cirillo, S. L. G., Zinniel, D. K., Barletta, R. G. & Cirillo, J. D., Dec 1 2013, In : Tuberculosis. 93, SUPPL., p. S83-S87

Research output: Contribution to journalArticle

5 Scopus citations

Revisiting protocols for the NMR analysis of bacterial metabolomes

Halouska, S., Zhang, B., Gaupp, R., Lei, S., Snell, E., Fenton, R. J., Barletta, R. G., Somerville, G. A. & Powers, R., Dec 2013, In : Journal of Integrated OMICS. 3, 2, p. 120-137 18 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Predicting the in vivo mechanism of action for drug leads using NMR metabolomics

Halouska, S., Fenton, R. J., Barletta, R. G. & Powers, R., Jan 20 2012, In : ACS chemical biology. 7, 1, p. 166-171 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Preparation of D-cycloserine and 13C-labeled D-cycloserine

Thacker, N. C., Molnár-Tóth, J., Miska, J. L., Barletta, R. G. & Takacs, J. M., Dec 1 2012, In : Heterocycles. 86, 2, p. 1575-1582 8 p.

Research output: Contribution to journalArticle

Sample preparation of mycobacterium tuberculosis extracts for nuclear magnetic resonance metabolomic studies

Zinniel, D. K., Fenton, R. J., Halouska, S., Powers, R. & Barletta, R. G., Sep 3 2012, In : Journal of Visualized Experiments. 67

Research output: Contribution to journalArticle

3 Scopus citations
2011

Characterization of the Mycobacterium avium subsp. paratuberculosis laminin-binding/histone-like protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease

Lefrançois, L. H., Pujol, C., Bodier, C. C., Teixeira-Gomez, A. P., Drobecq, H., Rosso, M. L., Raze, D., Dias, A. A., Hugot, J. P., Chacon, O., Barletta, R. G., Locht, C., Vidal Pessolani, M. C. & Biet, F., Jun 1 2011, In : Microbes and Infection. 13, 6, p. 585-594 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Immunogenicity and reactivity of novel Mycobacterium avium subsp. paratuberculosis PPE MAP1152 and conserved MAP1156 proteins with sera from experimentally and naturally infected animals

Bannantine, J. P., Paulson, A. L., Chacon, O., Fenton, R. J., Zinniel, D. K., McVey, D. S., Smith, D. R., Czuprynski, C. J. & Barletta, R. G., Jan 1 2011, In : Clinical and Vaccine Immunology. 18, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine

Bruning, J. B., Murillo, A. C., Chacon, O., Barletta, R. G. & Sacchettini, J. C., Jan 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 291-301 11 p.

Research output: Contribution to journalArticle

66 Scopus citations
2010
33 Scopus citations
2009

A kinetic study of in vitro lysis of mycobacterium smegmatis

Valente, W. J., Pienaar, E., Fast, A., Fluitt, A., Whitney, S. E., Fenton, R. J., Barletta, R. G., Chacon, O. & Viljoen, H. J., May 1 2009, In : Chemical Engineering Science. 64, 9, p. 1944-1952 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
5 Scopus citations

Impairment of D-Alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human macrophages

Chacon, O., Bermudez, L. E., Zinniel, D. K., Chahal, H. K., Fenton, R. J., Feng, Z., Hanford, K., Adams, L. G. & Barletta, R. G., Aug 10 2009, In : Microbiology. 155, 5, p. 1440-1450 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Demonstration of allelic exchange in the slow-growing bacterium Mycobacterium avium subsp. paratuberculosis, and generation of mutants with deletions at the pknG, relA, and lsr2 loci

Kun, T. P., Dahl, J. L., Bannantine, J. P., Barletta, R. G., Ahn, J., Allen, A. J., Hamilton, M. J. & Davis, W. C., Mar 1 2008, In : Applied and environmental microbiology. 74, 6, p. 1687-1695 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection

Roupie, V., Rosseels, V., Piersoel, V., Zinniel, D. K., Barletta, R. G. & Huygen, K., May 1 2008, In : Infection and immunity. 76, 5, p. 2099-2105 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Plasmid transformation and expression of the firefly luciferase in Microbacterium testaceum type and endophytic colonizing field strains

Zinniel, D. K., Feng, Z., Blum, P. H., Barletta, R. G. & Vidaver, A. K., Nov 1 2008, In : Canadian journal of microbiology. 54, 11, p. 964-970 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2007

Extracellular ATP is cytotoxic to mononuclear phagocytes but does not induce killing of intracellular Mycobacterium avium subsp. paratuberculosis

Woo, S. R., Barletta, R. G. & Czuprynski, C. J., Sep 1 2007, In : Clinical and Vaccine Immunology. 14, 9, p. 1078-1083 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Life and death in bovine monocytes: The fate of Mycobacterium avium subsp. paratuberculosis

Woo, S. R., Heintz, J. A., Albrecht, R., Barletta, R. G. & Czuprynski, C. J., Aug 1 2007, In : Microbial Pathogenesis. 43, 2, p. 106-113 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Use of NMR metabolomics to analyze the targets of D-cycloserine in mycobacteria: Role of D-alanine racemase

Halouska, S., Chacon, O., Fenton, R. J., Zinniel, D. K., Barletta, R. G. & Powers, R., Dec 1 2007, In : Journal of proteome research. 6, 12, p. 4608-4614 7 p.

Research output: Contribution to journalArticle

58 Scopus citations
2006

Bovine monocytes and a macrophage cell line differ in their ability to phagocytose and support the intracellular survival of Mycobacterium avium subsp. paratuberculosis

Woo, S. R., Sotos, J., Hart, A. P., Barletta, R. G. & Czuprynski, C. J., Mar 15 2006, In : Veterinary Immunology and Immunopathology. 110, 1-2, p. 109-120 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice

Rosseeis, V., Roupie, V., Zinniel, D., Barletta, R. G. & Huygen, K., Jun 1 2006, In : Infection and immunity. 74, 6, p. 3684-3686 3 p.

Research output: Contribution to journalArticle

21 Scopus citations
2004

Immune response of pigs inoculated with Mycobacterium bovis BCG expressing a truncated form of GP5 and M protein of porcine reproductive and respiratory syndrome virus

Bastos, R. G., Dellagostin, O. A., Barletta, R. G., Doster, A. R., Nelson, E., Zuckermann, F. & Osorio, F. A., Jan 2 2004, In : Vaccine. 22, 3-4, p. 467-474 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2003

B-Cell Epitopes in the Immunodominant p34 Antigen of Mycobacterium avium ssp. paratuberculosis Recognized by Antibodies from Infected Cattle

Ostrowski, M., Mundo, S. L., Harris, N. B., Barletta, R. G. & Lopez, O. J., Nov 1 2003, In : Scandinavian Journal of Immunology. 58, 5, p. 511-521 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
99 Scopus citations
2002

Antigenicity of Mycobacterium paratuberculosis superoxide dismutase in mice

Mullerad, J., Hovav, A. H., Fishman, Y., Barletta, R. G. & Bercovier, H., Sep 6 2002, In : FEMS Immunology and Medical Microbiology. 34, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cell sorting of formalin treated pathogenic Mycobacterium paratuberculosis expressing GFP

Harris, N. B., Zinniel, D. K., Hsieh, M. K., Cirillo, J. D. & Barletta, R. G., Mar 20 2002, In : BioTechniques. 32, 3, p. 522-527 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Construction and immunogenicity of recombinant Mycobacterium bovis BCG expressing GP5 and M protein of porcine reproductive respiratory syndrome virus

Bastos, R. G., Dellagostin, O. A., Barletta, R. G., Doster, A. R., Nelson, E. & Osorio, F. A., Nov 22 2002, In : Vaccine. 21, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Isolation and characterization of endophytic colonizing bacteria from agronomic crops and prairie plants

Zinniel, D. K., Lambrecht, P., Harris, N. B., Feng, Z., Kuczmarski, D., Higley, P., Ishimaru, C. A., Arunakumari, A., Barletta, R. G. & Vidaver, A. K., May 18 2002, In : Applied and environmental microbiology. 68, 5, p. 2198-2208 11 p.

Research output: Contribution to journalArticle

304 Scopus citations

Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent Mycobacterium: A model for phage therapy of intracellular bacterial pathogens

Broxmeyer, L., Sosnowska, D., Miltner, E., Chacoón, O., Wagner, D., Mc Garvey, J., Barletta, R. G. & Bermudez, L. E., Oct 15 2002, In : Journal of Infectious Diseases. 186, 8, p. 1155-1160 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Molecular cloning, sequencing, and characterization of bovine transporter associated with antigen processing 2 (BoTAP2)

Ambagala, A. P. N., Feng, Z., Barletta, R. G. & Srikumaran, S., May 20 2002, In : Immunogenetics. 54, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mycobacterium smegmatis D-alanine racemase mutants are not dependent on D-alanine for growth

Chacon, O., Feng, Z., Harris, N. B., Cáceres, N. E., Adams, L. G. & Barletta, R. G., Jan 15 2002, In : Antimicrobial Agents and Chemotherapy. 46, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Mycobacterium smegmatis L-alanine dehydrogenase (Ald) is required for proficient utilization of alanine as a sole nitrogen source and sustained anaerobic growth

Feng, Z., Cáceres, N. E., Sarath, G. & Barletta, R. G., Sep 1 2002, In : Journal of bacteriology. 184, 18, p. 5001-5010 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

The immunogenicity of Mycobacterium paratuberculosis 85B antigen

Mullerad, J., Michal, I., Fishman, Y., Hovav, A. H., Barletta, R. G. & Bercovier, H., Mar 26 2002, In : Medical Microbiology and Immunology. 190, 4, p. 179-187 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

Identification of a secreted superoxide dismutase in Mycobacterium avium ssp. paratuberculosis

Liu, X., Feng, Z., Harris, N. B., Cirillo, J. D., Bercovier, H. & Barletta, R. G., Aug 21 2001, In : FEMS Microbiology Letters. 202, 2, p. 233-238 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
1999

Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis

Williams, S. L., Harris, N. B. & Barletta, R. G., Jan 1 1999, In : Journal of clinical microbiology. 37, 2, p. 304-309 6 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Development of a transposon mutagenesis system for Mycobacterium avium subsp. paratuberculosis

Harris, N. B., Feng, Z., Liu, X., Cirillo, S. L. G., Cirillo, J. D. & Barletta, R. G., Jun 1 1999, In : FEMS Microbiology Letters. 175, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
1998

Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets

Moxley, R. A., Berberov, E. M., Francis, D. H., Xing, J., Moayeri, M., Welch, R. A., Baker, D. R. & Barletta, R. G., Oct 14 1998, In : Infection and immunity. 66, 10, p. 5031-5035 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Regulation of the Escherichia coli sheA gene and characterization of its encoded hemolytic activity

Fernández, S. V., Xing, J., Kapur, V., Libby, S. J., Barletta, R. G. & Moxley, R. A., Nov 1 1998, In : FEMS Microbiology Letters. 168, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
1997

Identification of Mycobacterium paratuberculosis gene expression signals

Bannantine, J. P., Barletta, R. G., Thoen, C. O. & Andrews, R. E., Mar 1997, In : Microbiology. 143, 3, p. 921-928 8 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Overexpression of the D-alanine racemase gene confers resistance to D- cycloserine in Mycobacterium smegmatis

Cáceres, N. E., Harris, N. B., Wellehan, J. F., Feng, Z., Kapur, V. & Barletta, R. G., Aug 1997, In : Journal of bacteriology. 179, 16, p. 5046-5055 10 p.

Research output: Contribution to journalArticle

123 Scopus citations
1995

Bacterial vaccine vectors and bacillus calmette-guérin

Cirillo, J. D., Stover, C. K., Bloom, B. R., Jacobs, W. R. & Barletta, R. G., Apr 1995, In : Clinical Infectious Diseases. 20, 4, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Phage infection, transfection and transformation of Mycobacterium avium complex and Mycobacterium paratuberculosis

Foley-Thomas, E. M., Whipple, D. L., Bermudez, L. E. & Barletta, R. G., Jan 1 1995, In : Microbiology. 141, 5, p. 1173-1181 9 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations