Peter F Kador, PhD

Tenure Professor

  • 6231 Citations
  • 41 h-Index
1975 …2019
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Research Output 1975 2019

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Article
2019
1 Citation (Scopus)

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Daszynski, D. M., Santhoshkumar, P., Phadte, A. S., Sharma, K. K., Zhong, H. A., Lou, M. F. & Kador, P. F., Dec 1 2019, In : Scientific reports. 9, 1, 8459.

Research output: Contribution to journalArticle

Open Access
Lanosterol
Crystallins
Cataract
Lenses
Adenosine Triphosphate
2015
5 Citations (Scopus)

Effects of multifunctional antioxidants on mitochondrial dysfunction and amyloid-β metal dyshomeostasis

Kawada, H., Blessing, K., Kiyota, T., Woolman, T., Winchester, L. & Kador, P. F., Jan 1 2015, In : Journal of Alzheimer's Disease. 44, 1, p. 297-307 11 p.

Research output: Contribution to journalArticle

Amyloid
Antioxidants
Metals
Zinc
Aptitude
8 Citations (Scopus)
Chelating Agents
Neurodegenerative Diseases
Antioxidants
Metals
Clioquinol
2014
7 Citations (Scopus)

Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus

Guo, C., Zhang, Z., Zhang, P., Makita, J., Kawada, H., Blessing, K. & Kador, P. F., Feb 1 2014, In : Experimental Eye Research. 119, p. 77-87 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Diabetic Retinopathy
Transgenic Mice
Diabetes Mellitus
Green Fluorescent Proteins
5 Citations (Scopus)

Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells

Zhang, P., Zhang, Z. & Kador, P. F., Feb 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 1, p. 4-11 8 p.

Research output: Contribution to journalArticle

Pericytes
Aldehyde Reductase
Intercellular Signaling Peptides and Proteins
Galactitol
Fibroblast Growth Factor 1
7 Citations (Scopus)

Topical nutraceutical optixcare eh ameliorates experimental ocular oxidative stress in rats

Kador, P. F., Guo, C., Kawada, H., Randazzo, J. & Blessing, K., Sep 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 7, p. 593-602 10 p.

Research output: Contribution to journalArticle

Dietary Supplements
Oxidative Stress
Health
Scopolamine Hydrobromide
Tears
2012
9 Citations (Scopus)

Novel Diabetic Mouse Models as Tools for Investigating Diabetic Retinopathy

Kador, P. F., Zhang, P., Makita, J., Zhang, Z., Guo, C., Randazzo, J., Kawada, H., Haider, N. & Blessing, K., Dec 12 2012, In : PloS one. 7, 12, e49422.

Research output: Contribution to journalArticle

aldehyde reductase
diabetic retinopathy
Aldehyde Reductase
Diabetic Retinopathy
Green Fluorescent Proteins
28 Citations (Scopus)

Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation

Zhang, P., Xing, K., Randazzo, J., Blessing, K., Lou, M. F. & Kador, P. F., Aug 1 2012, In : Experimental Eye Research. 101, p. 36-43 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Osmotic Pressure
Cataract
Lenses
Intercellular Signaling Peptides and Proteins
2011
59 Citations (Scopus)

Aldose reductase/polyol inhibitors for diabetic retinopathy

Obrosova, I. G. & Kador, P. F., Feb 10 2011, In : Current Pharmaceutical Biotechnology. 12, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Diabetic Retinopathy
Diabetes Complications
Blood-Retinal Barrier
Advanced Glycosylation End Products
20 Citations (Scopus)

Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats

Kador, P. F., O'Meara, J. D., Blessing, K., Marx, D. B. & Reinhardt, R. A., Jun 1 2011, In : Journal of periodontology. 82, 6, p. 926-933 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Periodontitis
Alveolar Bone Loss
Lipopolysaccharides
Injections
12 Citations (Scopus)

Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage

Randazzo, J., Zhang, Z., Hoff, M., Kawada, H., Sachs, A., Yuan, Y., Haider, N. & Kador, P. F., Jul 19 2011, In : PloS one. 6, 7, e21926.

Research output: Contribution to journalArticle

diketopiperazines
Rats
Oxidative stress
sulfonamides
Antioxidants
24 Citations (Scopus)

Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats

Randazzo, J., Zhang, P., Makita, J., Blessing, K. & Kador, P. F., May 9 2011, In : PloS one. 6, 4, e18980.

Research output: Contribution to journalArticle

cataract
streptozotocin
Streptozocin
Cataract
Rats
12 Citations (Scopus)

Response of rat retinal capillary pericytes and endothelial cells to glucose

Makita, J., Hosoya, K. I., Zhang, P. & Kador, P. F., Feb 1 2011, In : Journal of Ocular Pharmacology and Therapeutics. 27, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Pericytes
Protein Binding
Immunoglobulins
Carrier Proteins
Endothelial Cells
15 Citations (Scopus)

Up-regulation of NDRG2 in senescent lens epithelial cells contributes to age-related cataract in human

Zhang, Z. F., Zhang, J., Hui, Y. N., Zheng, M. H., Liu, X. P., Kador, P. F., Wang, Y. S., Yao, L. B. & Zhou, J., Oct 17 2011, In : PloS one. 6, 10, e26102.

Research output: Contribution to journalArticle

cataract
Lens
Cataract
Lenses
epithelial cells
2010
149 Citations (Scopus)

Autoimmunity in membranous nephropathy targets aldose reductase and SOD2

Prunotto, M., Carnevali, M. L., Candiano, G., Murtas, C., Bruschi, M., Corradini, E., Trivelli, A., Magnasco, A., Petretto, A., Santucci, L., Mattei, S., Gatti, R., Scolari, F., Kador, P. F., Allegri, L. & Ghiggeri, G. M., Mar 1 2010, In : Journal of the American Society of Nephrology. 21, 3, p. 507-519 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Membranous Glomerulonephritis
Autoimmunity
Podocytes
Immunoglobulin G
5 Citations (Scopus)

Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats

Kador, P. F., Hamada, T., Reinhardt, R. A. & Blessing, K., May 1 2010, In : Postgraduate Medicine. 122, 3, p. 138-144 7 p.

Research output: Contribution to journalArticle

Alveolar Bone Loss
Aldehyde Reductase
Periodontitis
Dental Enamel
Injections
25 Citations (Scopus)

Multifunctional antioxidants for the treatment of age-related diseases

Jin, H., Randazzo, J., Zhang, P. & Kador, P. F., Mar 1 2010, In : Journal of Medicinal Chemistry. 53, 3, p. 1117-1127 11 p.

Research output: Contribution to journalArticle

Free Radical Scavengers
Antioxidants
Electrospray Ionization Mass Spectrometry
Sulfonamides
Macular Degeneration
21 Citations (Scopus)

Topical KINOSTAT ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus

Kador, P. F., Webb, T. R., Bras, D., Ketring, K. & Wyman, M., Nov 1 2010, In : Veterinary Ophthalmology. 13, 6, p. 363-368 6 p.

Research output: Contribution to journalArticle

cataract
diabetes mellitus
Cataract
Diabetes Mellitus
Dogs
2009
52 Citations (Scopus)

Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats

Drel, V. R., Xu, W., Zhang, J., Kador, P. F., Ali, T. K., Shin, J., Julius, U., Slusher, B., El-Remessy, A. B. & Obrosova, I. G., Apr 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 4, p. 1778-1790 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Streptozocin
Cataract
Lenses
Pericytes
17 Citations (Scopus)

Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)

Kador, P. F., Randazzo, J., Blessing, K., Makita, J., Zhang, P., Yu, K., Hosoya, K. I. & Terasaki, T., Aug 1 2009, In : Journal of Ocular Pharmacology and Therapeutics. 25, 4, p. 299-307 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Pericytes
Endothelial Cells
Cell Line
Sorbitol
2008
14 Citations (Scopus)

Asteroid hyalosis: Pathogenesis and prospects for prevention

Kador, P. F. & Wyman, M., Jan 1 2008, In : Eye. 22, 10, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

Minor Planets
Galactose
Calcium
Vitreous Body
Dogs
2007
13 Citations (Scopus)

Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs

Kador, P. F., Takahashi, Y., Akagi, Y., Blessing, K., Randazzo, J. & Wyman, M., Feb 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Pericytes
Galactose
Dogs
Diabetic Retinopathy
Cataract
41 Citations (Scopus)

Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats

Mulhern, M. L., Madson, C. J., Kador, P. F., Randazzo, J. & Shinohara, T., Aug 10 2007, In : Molecular Vision. 13, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

Cataract
Lenses
Cell Death
Epithelial Cells
Selenious Acid
18 Citations (Scopus)

Evaluation of the vascular targeting agent combretastatin A-4 prodrug on retinal neovascularization in the galactose-fed dog

Kador, P. F., Blessing, K., Randazzo, J., Makita, J. & Wyman, M., Apr 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 2, p. 132-142 11 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Prodrugs
Galactose
Blood Vessels
Dogs
15 Citations (Scopus)

Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts

Kador, P. F., Randazzo, J., Babb, T., Koushik, K., Takamura, Y., Zhu, W., Blessing, K. & Kompella, U. B., Apr 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cataract
Lenses
Suspensions
Pharmaceutical Preparations
2006
6 Citations (Scopus)

Aqueous flow in galactose-fed dogs

Toris, C. B., Lane, J. T., Akagi, Y., Blessing, K. A. & Kador, P. F., Oct 1 2006, In : Experimental Eye Research. 83, 4, p. 865-870 6 p.

Research output: Contribution to journalArticle

Galactose
Dogs
Diet
Anterior Chamber
Intraocular Pressure
20 Citations (Scopus)

Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose

Kador, P. F., Betts, D., Wyman, M., Blessing, K. & Randazzo, J., Oct 26 2006, In : American journal of veterinary research. 67, 10, p. 1783-1787 5 p.

Research output: Contribution to journalArticle

aldehyde reductase
Topical Administration
Aldehyde Reductase
cataract
Galactose
49 Citations (Scopus)

Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation

Ikesugi, K., Mulhern, M. L., Madson, C. J., Hosoya, K. I., Terasaki, T., Kador, P. F. & Shinohara, T., Nov 1 2006, In : Current Eye Research. 31, 11, p. 947-953 7 p.

Research output: Contribution to journalArticle

Pericytes
Endoplasmic Reticulum Stress
Unfolded Protein Response
Glucose
Retinal Degeneration
5 Citations (Scopus)

Structure of asteroid bodies in the vitreous of galactose-fed dogs

Wang, M., Kador, P. F. & Wyman, M., Apr 4 2006, In : Molecular Vision. 12, p. 283-289 7 p.

Research output: Contribution to journalArticle

Minor Planets
Vitreous Body
Galactose
Dogs
Calcium
90 Citations (Scopus)

The unfolded protein response in lens epithelial cells from galactosemic rat lenses

Mulhern, M. L., Madson, C. J., Danford, A., Ikesugi, K., Kador, P. F. & Shinohara, T., Sep 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 9, p. 3951-3959 9 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Lenses
Epithelial Cells
Cataract
Galactose
2005
2 Citations (Scopus)
Chromans
Aldehyde Reductase
Dione
inhibitors
Nuclear magnetic resonance
2004
6 Citations (Scopus)

Anticataract activity of analogs of a sorbitol dehydrogenase inhibitor

Kador, P. F., Inoue, J. & Blessing, K., Aug 1 2004, In : Journal of Ocular Pharmacology and Therapeutics. 20, 4, p. 333-344 12 p.

Research output: Contribution to journalArticle

L-Iditol 2-Dehydrogenase
Aldehyde Reductase
Cataract
Sorbitol
Streptozocin

Dr Abraham Spector International Symposium

Kador, P. F. & Reddy, V., Dec 1 2004, In : Experimental Eye Research. 79, 6, p. 737-739 3 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney

Lim, S. W., Li, C., Sun, B. K., Han, K. H., Kim, W. Y., Oh, Y. W., Lee, J. U., Kador, P. F., Knepper, M. A., Sands, J. M., Kim, J. & Yang, C. W., Jul 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 1 56-1, p. F139-F151

Research output: Contribution to journalArticle

Aquaporins
Cyclosporine
Vasopressins
Urine
Kidney
3 Citations (Scopus)

Method for isolating tight-binding inhibitors of rat lens aldose reductase

Sun, G., Ma, Y., Gao, X., König, S., Fales, H. M. & Kador, P. F., Dec 1 2004, In : Experimental Eye Research. 79, 6, p. 919-926 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
NADP
Electrospray Ionization Mass Spectrometry
Methanol
2003
29 Citations (Scopus)

Diabetes can alter the signal transduction pathways in the lens of rats

Zatechka, D. S., Kador, P. F., Garcia-Castiñeiras, S. & Lou, M. F., Apr 1 2003, In : Diabetes. 52, 4, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

Lenses
Signal Transduction
Cataract
Aldehyde Reductase
Osmotic Pressure
27 Citations (Scopus)

Effects of Aldose Reductase Inhibitors and Galactose Withdrawal on Fluorescein Angiographic Lesions in Galactose-Fed Dogs

Cusick, M., Chew, E. Y., Ferris, F., Cox, T. A., Chan, C. C. & Kador, P. F., Dec 1 2003, In : Archives of Ophthalmology. 121, 12, p. 1745-1751 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Fluorescein
Galactose
Dogs
Diet
8 Citations (Scopus)

Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay

Lee, Y. S., Hodoscek, M., Kador, P. F. & Sugiyama, K., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 307-316 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Molecular Dynamics Simulation
Hydrogen Bonding
NADP
Molecular dynamics
2002
15 Citations (Scopus)

Aldose reductase: An aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia

Kawamura, M., Eisenhofer, G., Kopin, I. J., Kador, P. F., Lee, Y. S., Fujisawa, S. & Sato, S., Mar 18 2002, In : Autonomic Neuroscience: Basic and Clinical. 96, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sympathetic Ganglia
Aldehydes
Norepinephrine
Enzymes
23 Citations (Scopus)

Effect of galactose diet removal on the progression of retinal vessel changes in galactose-fed dogs

Kador, P. F., Takahashi, Y., Akagi, Y., Neuenschwander, H., Greentree, W., Lackner, P., Blessing, K. & Wyman, M., Jun 13 2002, In : Investigative Ophthalmology and Visual Science. 43, 6, p. 1916-1921 6 p.

Research output: Contribution to journalArticle

Retinal Vessels
Galactose
Dogs
Diet
Pericytes
32 Citations (Scopus)

Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation

Murata, M., Ohta, N., Fujisawa, S., Tsai, J. Y., Sato, S., Akagi, Y., Takahashi, Y., Neuenschwander, H. & Kador, P. F., Jan 1 2002, In : Journal of Diabetes and Its Complications. 16, 5, p. 363-370 8 p.

Research output: Contribution to journalArticle

Galactitol
Aldehyde Reductase
Pericytes
Retinal Degeneration
Galactose
2001
3 Citations (Scopus)

Determination of aldose reductase activity in the eye by localized magnetic resonance spectroscopy

Lizak, M. J., Mori, K. & Kador, P. F., Jan 1 2001, In : Journal of Ocular Pharmacology and Therapeutics. 17, 5, p. 475-483 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Magnetic Resonance Spectroscopy
Lenses
Anterior Eye Segment
Intravitreal Injections

Effect of bovine small intestine thioredoxin on aldose reductase activity

Mizoguchi, T., Maeda, I., Yagi, K. & F. Kador, P., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 609-615 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Thioredoxins
Oxidative stress
Small Intestine
Chemical activation
1 Citation (Scopus)

Intrinsic inhibition of aldose reductase

Kador, P. F., Sun, G., Rait, V. K., Rodriguez, L., Ma, Y. & Sugiyama, K., Aug 1 2001, In : Journal of Ocular Pharmacology and Therapeutics. 17, 4, p. 373-381 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
Diabetes Complications
Sugar Alcohols
Kidney
8 Citations (Scopus)

Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements

Schlitzer, M., Rodriguez, L. & Kador, P. F., Jun 23 2001, In : Journal of Pharmacy and Pharmacology. 53, 6, p. 831-839 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Amides
Esters
Carbon
aniline
54 Citations (Scopus)

The role of aldose reductase in sugar cataract formation: Aldose reductase plays a key role in lens epithelial cell death (apoptosis)

Murata, M., Ohta, N., Sakurai, S., Alam, S., Tsai, J. Y., Kador, P. F. & Sato, S., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 617-625 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cell death
Galactose
Sugars
Cataract
2000
11 Citations (Scopus)

Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex

Sugiyama, K., Chen, Z., Lee, Y. S. & Kador, P. F., Feb 15 2000, In : Biochemical Pharmacology. 59, 4, p. 329-336 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
NADP
Nucleotides
Hydantoins
Molecular modeling
17 Citations (Scopus)

MRI of the human eye using magnetization transfer contrast enhancement

Lizak, M. J., Datiles, M. B., Aletras, A. H., Kador, P. F. & Balaban, R. S., Nov 16 2000, In : Investigative Ophthalmology and Visual Science. 41, 12, p. 3878-3881 4 p.

Research output: Contribution to journalArticle

Lenses
Magnetic Resonance Imaging
Volunteers
Artifacts
Cataract
33 Citations (Scopus)

Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats

Kador, P. F., Lee, J. W., Fujisawa, S., Blessing, K. & Lou, M. F., Apr 2000, In : Journal of Ocular Pharmacology and Therapeutics. 16, 2, p. 149-160 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Glycosylation
Cataract
Lenses
Crystallins
7 Citations (Scopus)

Synthesis and aldose reductase inhibitory activities of novel N-nitromethylsulfonanilide derivatives

Inoue, J., Cui, Y. S., Sakai, O., Nakamura, Y., Kogiso, H. & Kador, P. F., Aug 1 2000, In : Bioorganic and Medicinal Chemistry. 8, 8, p. 2167-2173 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Derivatives
Structure-Activity Relationship
Medical problems
Sugars