Paras Kumar Mishra, PhD

Associate Professor

  • 1243 Citations
  • 21 h-Index
20052019
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Research Output 2005 2019

2019

Guidelines for evaluating myocardial cell death

Mishra, P. K., Adameova, A., Hill, J. A., Baines, C. P., Kang, P. M., Downey, J. M., Narula, J., Takahashi, M., Abbate, A., Piristine, H. C., Kar, S., Su, S., Higa, J. K., Kawasaki, N. K. & Matsui, T., Nov 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 5, p. H891-H922

Research output: Contribution to journalArticle

Cell Death
Guidelines
Heart Failure
Pathology
Autophagy

Hydrogen sulfide ameliorates homocysteine-induced cardiac remodeling and dysfunction

Kar, S., Shahshahan, H. R., Kambis, T. N., Yadav, S. K., Li, Z., Lefer, D. J. & Mishra, P. K., Jan 1 2019, In : Frontiers in Physiology. 10, MAY, 598.

Research output: Contribution to journalArticle

Open Access
Cystathionine beta-Synthase
Hydrogen Sulfide
Homocysteine
Hyperhomocysteinemia
Hypertrophy
1 Citation (Scopus)
Diabetic Cardiomyopathies
Hydrogen Sulfide
Cell Death
Cardiomyopathies
Diabetes Mellitus

Isolation, characterization, and differentiation of cardiac stem cells from the adult mouse heart

Yadav, S. K. & Mishra, P. K., Jan 2019, In : Journal of Visualized Experiments. 2019, 143, e58448.

Research output: Contribution to journalArticle

Adult Stem Cells
Stem cells
Stem Cells
Cardiac Myocytes
Myocardium

MTOR signaling in cardiometabolic disease, cancer, and aging 2018

Das, A., Reis, F. & Mishra, P. K., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 9692528.

Research output: Contribution to journalEditorial

Open Access
Aging of materials
Neoplasms
2018

Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice

Krishnan, B., Massilamany, C., Basavalingappa, R. H., Gangaplara, A., Rajasekaran, R. A., Afzal, M. Z., Khalilzad-Sharghi, V., Zhou, Y., Riethoven, J-J. M., Nandi, S. S., Mishra, P. K., Sobel, R. A., Strande, J. L., Steffen, D. J. & Reddy, N. R. J., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 523-537 15 p.

Research output: Contribution to journalArticle

Epitope Mapping
T-Lymphocyte Epitopes
Myocarditis
Epitopes
T-Lymphocytes

Isolation, characterization and differentiation of mouse cardiac progenitor cells

Yadav, S. K. & Mishra, P. K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 183-191 9 p. (Methods in Molecular Biology; vol. 1842).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiac Myocytes
Stem Cells
Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Regeneration

MiR-133a mimic alleviates T1DM-induced systolic dysfunction in akita: An MRI-based study

Nandi, S. S., Shahshahan, H. R., Shang, Q., Kutty, S., Boska, M. & Mishra, P. K., Oct 10 2018, In : Frontiers in Physiology. 9, OCT, 1275.

Research output: Contribution to journalArticle

Fibrosis
Magnetic Resonance Imaging
Cardiomegaly
Diabetic Cardiomyopathies
Hypertrophy
2 Citations (Scopus)

Targeting miRNA for therapy of juvenile and adult diabetic cardiomyopathy

Nandi, S. S. & Mishra, P. K., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 47-59 13 p. (Advances in Experimental Medicine and Biology; vol. 1056).

Research output: Chapter in Book/Report/Conference proceedingChapter

Diabetic Cardiomyopathies
Medical problems
MicroRNAs
Diabetes Mellitus
Blood Glucose
2017
6 Citations (Scopus)
Angiotensinogen
Renin-Angiotensin System
Paraventricular Hypothalamic Nucleus
MicroRNAs
Heart Failure
8 Citations (Scopus)

Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing

Kesherwani, V., Shahshahan, H. R. & Mishra, P. K., Aug 2017, In : PloS one. 12, 8, e0182828.

Research output: Contribution to journalArticle

Gene Expression Profiling
Microarrays
transcriptomics
cardiomyopathy
heart
21 Citations (Scopus)

Diabetic cardiomyopathy: An immunometabolic perspective

Mishra, P. K., Ying, W., Nandi, S. S., Bandyopadhyay, G. K., Patel, K. P. & Mahata, S. K., Apr 7 2017, In : Frontiers in Endocrinology. 8, APR, 72.

Research output: Contribution to journalShort survey

Diabetic Cardiomyopathies
Sarcoplasmic Reticulum
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Cardiac Myocytes
MicroRNAs
12 Citations (Scopus)
Cystathionine gamma-Lyase
Cystathionine beta-Synthase
Homocysteine
Cardiac Myocytes
Up-Regulation
26 Citations (Scopus)

Stem Cell-Derived Exosomes, Autophagy, Extracellular Matrix Turnover, and miRNAs in Cardiac Regeneration during Stem Cell Therapy

Prathipati, P., Nandi, S. S. & Mishra, P. K., Feb 1 2017, In : Stem Cell Reviews and Reports. 13, 1, p. 79-91 13 p.

Research output: Contribution to journalReview article

Exosomes
Autophagy
Cell- and Tissue-Based Therapy
MicroRNAs
Extracellular Matrix
2016
9 Citations (Scopus)

Ablation of matrix metalloproteinase-9 prevents cardiomyocytes contractile dysfunction in diabetics

Prathipati, P., Metreveli, N., Nandi, S. S., Tyagi, S. C. & Mishra, P. K., Mar 15 2016, In : Frontiers in Physiology. 7, MAR, 93.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Cardiac Myocytes
Calcium-Transporting ATPases
Calcium
Endoplasmic Reticulum
19 Citations (Scopus)

Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases

Hackfort, B. T. & Mishra, P. K., Apr 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 7, p. H802-H812

Research output: Contribution to journalReview article

MicroRNAs
Hydrogen
Cardiovascular Diseases
Gasotransmitters
Heart Failure
12 Citations (Scopus)

Lack of MIR-133a decreases contractility of diabetic hearts: A role for novel cross talk between tyrosine aminotransferase and tyrosine hydroxylase

Nandi, S. S., Zheng, H., Sharma, N. M., Shahshahan, H. R., Patel, K. P. & Mishra, P. K., Oct 1 2016, In : Diabetes. 65, 10, p. 3075-3090 16 p.

Research output: Contribution to journalArticle

Tyrosine Transaminase
Myocardial Contraction
Tyrosine 3-Monooxygenase
MicroRNAs
Norepinephrine
2015
21 Citations (Scopus)

Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10

Kesherwani, V., Chavali, V., Hackfort, B. T., Tyagi, S. C. & Mishra, P. K., Jan 1 2015, In : Frontiers in Physiology. 6, APR, 124.

Research output: Contribution to journalArticle

High Fat Diet
Interleukin-10
Tumor Necrosis Factor-alpha
Diet
Cardiomyopathies
17 Citations (Scopus)

Hydrogen sulfide mitigates homocysteine-mediated pathological remodeling by inducing miR-133a in cardiomyocytes

Kesherwani, V., Nandi, S. S., Sharawat, S. K., Shahshahan, H. R. & Mishra, P. K., Jun 18 2015, In : Molecular and cellular biochemistry. 404, 1-2, p. 241-250 10 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Homocysteine
Myosins
Cardiac Myocytes
Hyperhomocysteinemia
22 Citations (Scopus)
Autophagy
Unloading
Heart Failure
Heart-Assist Devices
Left ventricular assist devices
2014
12 Citations (Scopus)
Paraventricular Hypothalamic Nucleus
Type 2 Diabetes Mellitus
Dopamine
Dopamine D1 Receptors
Arterial Pressure
48 Citations (Scopus)

Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/- Akita Hearts

Chavali, V., Tyagi, S. C. & Mishra, P. K., Jan 1 2014, In : Cell Biochemistry and Biophysics. 68, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Tumor Necrosis Factor-alpha
Diabetic Cardiomyopathies
Interleukin-10
Down-Regulation
4 Citations (Scopus)

Generating double knockout mice to model genetic intervention for diabetic cardiomyopathy in humans

Chavali, V., Nandi, S. S. U., Singh, S. R. A. & Mishra, P. K., 2014, In : Methods in molecular biology (Clifton, N.J.). 1194, p. 385-400 16 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Genetic Engineering
Matrix Metalloproteinase 9
Knockout Mice
Genes
2 Citations (Scopus)

MicroRNomics of diabetic cardiomyopathy

Mishra, P. K. & Tyagi, S. C., Jan 1 2014, Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms. Springer New York, p. 179-187 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diabetic Cardiomyopathies
MicroRNAs
Medical problems
RNA
Heart Failure
2013
38 Citations (Scopus)

Cardiac matrix: A clue for future therapy

Mishra, P. K., Givvimani, S., Chavali, V. & Tyagi, S. C., Dec 1 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 12, p. 2271-2276 6 p.

Research output: Contribution to journalReview article

MicroRNAs
Cardiac Myocytes
Muscle Cells
Fibrosis
Matrix Metalloproteinase 9
5 Citations (Scopus)

Cardiac stem cell niche, mmp9, and culture and differentiation of embryonic stem cells

Mishra, P. K., Kuypers, N. J., Singh, S. R., Leiberh, N. D., Chavali, V. & Tyagi, S. C., 2013, Stem Cell Niche: Methods and Protocols. Humana Press Inc., p. 153-163 11 p. (Methods in Molecular Biology; vol. 1035).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem Cell Niche
Embryonic Stem Cells
Cell Differentiation
Matrix Metalloproteinase 9
Extracellular Matrix
74 Citations (Scopus)

Predictors and prevention of diabetic cardiomyopathy

Chavali, V., Tyagi, S. C. & Mishra, P. K., Apr 10 2013, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 6, p. 151-160 10 p.

Research output: Contribution to journalReview article

Diabetic Cardiomyopathies
Type 2 Diabetes Mellitus
Heart Failure
Sedentary Lifestyle
High Fat Diet
2012
31 Citations (Scopus)
Matrix Metalloproteinase 9
Cardiac Myocytes
Extracellular Matrix
Stem Cells
Cell Survival
61 Citations (Scopus)

Hydrogen sulfide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis

Qipshidze, N., Metreveli, N., Mishra, P. K., Lominadze, D. & Tyagi, S. C., Feb 28 2012, In : International Journal of Biological Sciences. 8, 4, p. 430-441 12 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
hydrogen sulfide
myocardial infarction
angiogenesis
Myocardial Infarction
64 Citations (Scopus)

Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia

Sen, U., Sathnur, P. B., Kundu, S., Givvimani, S., Coley, D. M., Mishra, P. K., Qipshidze, N., Tyagi, N., Metreveli, N. & Tyagi, S. C., Jul 1 2012, In : American Journal of Physiology - Cell Physiology. 303, 1, p. C41-C51

Research output: Contribution to journalArticle

Cystathionine
Hyperhomocysteinemia
Lyases
Homocysteine
Genetic Therapy
34 Citations (Scopus)

MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes

Chavali, V., Tyagi, S. C. & Mishra, P. K., Aug 31 2012, In : Biochemical and Biophysical Research Communications. 425, 3, p. 668-672 5 p.

Research output: Contribution to journalArticle

DNA Methylation
MicroRNAs
Cardiac Myocytes
Medical problems
Methylation
2011
5 Citations (Scopus)

Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery

Basu, P., Qipshidze, N., Sen, U., Givvimani, S., Munjal, C., Mishra, P. K. & Tyagi, S. C., Dec 1 2011, In : Archives of Physiology and Biochemistry. 117, 5, p. 270-282 13 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Aorta
Veins
Arteries
Phenotype
15 Citations (Scopus)

Exercise mitigates homocysteine - β2-adrenergic receptor interactions to ameliorate contractile dysfunction in diabetes

Mishra, P. K., Awe, O., Metreveli, N., Qipshidze, N., Joshua, I. G. & Tyagi, S. C., Jul 14 2011, In : International Journal of Physiology, Pathophysiology and Pharmacology. 3, 2, p. 97-106 10 p.

Research output: Contribution to journalArticle

Homocysteine
Adrenergic Receptors
Cardiac Myocytes
Albuterol
Calcium
12 Citations (Scopus)

Synergism between arrhythmia and hyperhomocysteinemia in structural heart disease

Givvimani, S., Qipshidze, N., Tyagi, N., Mishra, P. K., Sen, U. & Tyagi, S. C., Jul 14 2011, In : International Journal of Physiology, Pathophysiology and Pharmacology. 3, 2, p. 107-119 13 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Cardiac Arrhythmias
Heart Diseases
Homocysteine
Connexin 43
22 Citations (Scopus)

Synergy of microRNA and stem cell: A novel therapeutic approach for diabetes mellitus and cardiovascular diseases

Tyagi, A. C., Sen, U. & Mishra, P. K., Nov 1 2011, In : Current Diabetes Reviews. 7, 6, p. 367-376 10 p.

Research output: Contribution to journalReview article

MicroRNAs
Diabetes Mellitus
Cardiovascular Diseases
Stem Cells
Therapeutics
2010
24 Citations (Scopus)

Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy

Mishra, P. K., Givvimani, S., Metreveli, N. & Tyagi, S. C., Oct 15 2010, In : Biochemical and Biophysical Research Communications. 401, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Homocysteine
Adrenergic Receptors
Cardiac Myocytes
Enzymes
59 Citations (Scopus)

H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure

Mishra, P. K., Tyagi, N., Sen, U., Givvimani, S. & Tyagi, S. C., Jan 29 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 2, p. H451-H456

Research output: Contribution to journalArticle

Arteriovenous Fistula
Matrix Metalloproteinases
Oxidative Stress
Heart Failure
Apoptosis
90 Citations (Scopus)

Homocysteine to hydrogen sulfide or hypertension

Sen, U., Mishra, P. K., Tyagi, N. & Tyagi, S. C., Apr 13 2010, In : Cell Biochemistry and Biophysics. 57, 2, p. 49-58 10 p.

Research output: Contribution to journalReview article

Hydrogen Sulfide
Hyperhomocysteinemia
Homocysteine
Blood Vessels
Hypertension
53 Citations (Scopus)

MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure

Givvimani, S., Tyagi, N., Sen, U., Mishra, P. K., Qipshidze, N., Munjal, C., Vacek, J. C., Abe, O. A. & Tyagi, S. C., May 1 2010, In : Archives of Physiology and Biochemistry. 116, 2, p. 63-72 10 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Tissue Inhibitor of Metalloproteinase-2
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Hypertrophy
30 Citations (Scopus)

MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: A plausible role of dicer and miRNA

Mishra, P. K., Metreveli, N. & Tyagi, S. C., Jul 5 2010, In : Cell Biochemistry and Biophysics. 57, 2, p. 67-76 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Ablation
MicroRNAs
Cardiac Myocytes
Genes
39 Citations (Scopus)

Stem cells as a therapeutic target for diabetes

Mishra, P. K., Singh, S. R., Joshua, I. G. & Tyagi, S. C., Jan 1 2010, In : Frontiers in Bioscience. 15, 2, p. 461-477 17 p.

Research output: Contribution to journalArticle

Medical problems
Stem cells
Stem Cells
Insulin
Islets of Langerhans
45 Citations (Scopus)

Synergism in hyperhomocysteinemia and diabetes: Role of PPAR gamma and tempol

Mishra, P. K., Tyagi, N., Sen, U., Joshua, I. G. & Tyagi, S. C., Sep 9 2010, In : Cardiovascular Diabetology. 9, 49.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
PPAR gamma
Matrix Metalloproteinase 9
Tissue Inhibitor of Metalloproteinase-3
Diabetic Cardiomyopathies
2009
11 Citations (Scopus)

Homocysteine, hydrogen sulfide (H2S) and NMDA-receptor in heart failure

Tyagi, N., Mishra, P. K. & Tyagi, S. C., Dec 1 2009, In : Indian journal of biochemistry & biophysics. 46, 6, p. 441-446 6 p.

Research output: Contribution to journalReview article

Hydrogen Sulfide
Cystathionine beta-Synthase
Homocysteine
N-Methyl-D-Aspartate Receptors
Cystathionine gamma-Lyase
2 Citations (Scopus)

Homocysteine, hydrogen sulfide (H2S) and NMDA-receptor in heart failure

Tyagi, N., Mishra, P. K. & Tyagi, S. C., Dec 1 2009, In : Indian Journal of Biochemistry and Biophysics. 46, 6, p. 441-446 6 p.

Research output: Contribution to journalReview article

Hydrogen Sulfide
Homocysteine
N-Methyl-D-Aspartate Receptors
Heart Failure
Cystathionine
4 Citations (Scopus)

Homocysteine effects classical pathway of GPCR down regulation: Gαq/11, Gα12/13, Gi/o

Vacek, T. P., Sen, U., Tyagi, N., Kumar, M., Moshal, K. S., Passmore, J. C. & Tyagi, S. C., Jan 1 2009, In : Molecular and cellular biochemistry. 321, 1-2, p. 1-8 8 p.

Research output: Contribution to journalArticle

Homocysteine
G-Protein-Coupled Receptors
Down-Regulation
Gq-G11 GTP-Binding Protein alpha Subunits
Signal transduction
58 Citations (Scopus)

MicroRNAs Are Involved in Homocysteine-Induced Cardiac Remodeling

Mishra, P. K., Tyagi, N., Kundu, S. & Tyagi, S. C., Aug 11 2009, In : Cell Biochemistry and Biophysics. 55, 3, p. 153-162 10 p.

Research output: Contribution to journalArticle

Homocysteine
MicroRNAs
Hyperhomocysteinemia
Cardiac Myocytes
Matrix Metalloproteinases
93 Citations (Scopus)

MicroRNAs as a therapeutic target for cardiovascular diseases

Mishra, P. K., Tyagi, N., Kumar, M. & Tyagi, S. C., Apr 1 2009, In : Journal of cellular and molecular medicine. 13, 4, p. 778-789 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Cardiovascular Diseases
Therapeutics
Cardiomyopathies
Cardiac Arrhythmias
20 Citations (Scopus)

Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice

Kundu, S., Kumar, M., Sen, U., Mishra, P. K., Tyagi, N., Metreveli, N., Lominadze, D., Rodriguez, W. & Tyagi, S. C., Jan 1 2009, In : Journal of Cellular Biochemistry. 106, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Nitric Oxide Synthase Type II
Knockout Mice
Muscle Cells
Homocysteine
25 Citations (Scopus)

Restoration of contractility in hyperhomocysteinemia by cardiac-specific deletion of NMDA-R1

Moshal, K. S., Kumar, M., Tyagi, N., Mishra, P. K., Metreveli, N., Rodriguez, W. E. & Tyagi, S. C., Mar 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 296, 3, p. H887-H892

Research output: Contribution to journalArticle

Hyperhomocysteinemia
N-Methyl-D-Aspartate Receptors
Muscle Cells
Permeability
Homocysteine
2008
31 Citations (Scopus)

Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery

Kumar, M., Tyagi, N., Moshal, K. S., Sen, U., Kundu, S., Mishra, P. K., Givvimani, S. & Tyagi, S. C., Dec 1 2008, In : Neurochemistry International. 53, 6-8, p. 214-219 6 p.

Research output: Contribution to journalArticle

Homocysteine
Matrix Metalloproteinases
Carotid Arteries
Tissue Inhibitor of Metalloproteinase-3
Vascular Resistance