Pankaj Singh, PhD

Associate Professor

  • 2374 Citations
  • 25 h-Index
20062020

Research output per year

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Research Output

2020

Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia

Shukla, S. K., Markov, S. D., Attri, K. S., Vernucci, E., King, R. J., Dasgupta, A., Grandgenett, P. M., Hollingsworth, M. A., Singh, P. K., Yu, F. & Mehla, K., Aug 1 2020, In : Cancer Letters. 484, p. 29-39 11 p.

Research output: Contribution to journalArticle

Metabolic alterations in pancreatic cancer progression

Vernucci, E., Abrego, J., Gunda, V., Shukla, S. K., Dasgupta, A., Rai, V., Chaika, N., Buettner, K., Illies, A., Yu, F., Lazenby, A. J., Swanson, B. J. & Singh, P. K., Jan 2020, In : Cancers. 12, 1, 2.

Research output: Contribution to journalArticle

Open Access

Metabolic subtyping for novel personalized therapies against pancreatic cancer

Mehla, K. & Singh, P. K., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism

Olou, A. A., King, R. J., Yu, F. & Singh, P. K., Apr 16 2020, In : Oncogene. 39, 16, p. 3381-3395 15 p.

Research output: Contribution to journalArticle

2019

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Erratum: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 (Immunity (2019) 50(3) (576–590.e6), (S1074761319300305), (10.1016/j.immuni.2019.01.007))

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Apr 16 2019, In : Immunity. 50, 4, 1 p.

Research output: Contribution to journalComment/debate

Evaluating the metabolic alterations in pancreatic cancer

Dasgupta, A., Shukla, S. K., Gunda, V., King, R. J. & Singh, P. K., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 221-228 8 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Metabolic Regulation of Macrophage Polarization in Cancer

Mehla, K. & Singh, P. K., Dec 2019, In : Trends in Cancer. 5, 12, p. 822-834 13 p.

Research output: Contribution to journalReview article

1 Scopus citations

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes

Moshfegh, C. M., Collins, C. W., Gunda, V., Vasanthakumar, A., Cao, J. Z., Singh, P. K., Godley, L. A. & Case, A. J., Oct 2019, In : Redox Biology. 27, 101141.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular and physiological evaluation of pancreatic cancer-induced cachexia

Shukla, S. K., Dasgupta, A., Mulder, S. E. & Singh, P. K., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 321-333 13 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

10 Scopus citations

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Hsieh, M. H., Choe, J. H., Gadhvi, J., Kim, Y. J., Arguez, M. A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J. K., Cha, M., Goodwin, J., Kang, M. K., Jeong, J. Y., Lee, S. Y., Faubert, B., Xuan, Z., Abel, E. D., Scafoglio, C. & 11 others, Shackelford, D. B., Minna, J. D., Singh, P. K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R. J., Kim, T. H. & Kim, J. W., Aug 13 2019, In : Cell Reports. 28, 7, p. 1860-1878.e9

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

RNA-binding protein hur regulates both mutant and wild-type IDH1 in IDH1-mutated cancer

Zarei, M., Lal, S., Vaziri-Gohar, A., O'Hayer, K., Gunda, V., Singh, P. K., Brody, J. R. & Winter, J. M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access
2018

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors

Mehla, K., Tremayne, J., Grunkemeyer, J. A., O’Connell, K. A., Steele, M. M., Caffrey, T. C., Zhu, X., Yu, F., Singh, P. K., Schultes, B. C., Madiyalakan, R., Nicodemus, C. F. & Hollingsworth, M. A., Mar 1 2018, In : Cancer Immunology, Immunotherapy. 67, 3, p. 445-457 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Evaluating the metabolic impact of hypoxia on pancreatic cancer cells

Murthy, D., Vernucci, E., Goode, G., Abrego, J. & Singh, P. K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 81-93 13 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

Evaluation of macrophage polarization in pancreatic cancer microenvironment under hypoxia

Attri, K. S., Mehla, K. & Singh, P. K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 265-276 12 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Hypoxia-induced metabolomic alterations in pancreatic cancer cells

Gunda, V., Kumar, S., Dasgupta, A. & Singh, P. K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 95-105 11 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Hypoxia-mediated in vivo tumor glucose uptake measurement and analysis

Shukla, S. K., Mulder, S. E. & Singh, P. K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 107-113 7 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

Insights into gemcitabine resistance and the potential for therapeutic monitoring

Gebregiworgis, T., Bhinderwala, F., Purohit, V., Chaika, N. V., Singh, P. K. & Powers, R., Dec 1 2018, In : Metabolomics. 14, 12, 156.

Research output: Contribution to journalArticle

5 Scopus citations

Microscale Gene Expression Analysis of Tumor-Associated Macrophages

Attri, K. S., Mehla, K., Shukla, S. K. & Singh, P. K., Dec 1 2018, In : Scientific reports. 8, 1, 2408.

Research output: Contribution to journalArticle

3 Scopus citations

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

Li, T., Li, X., Attri, K. S., Liu, C., Li, L., Herring, L. E., Asara, J. M., Lei, Y. L., Singh, P. K., Gao, C. & Wen, H., Dec 12 2018, In : Cell Host and Microbe. 24, 6, p. 791-803.e6

Research output: Contribution to journalArticle

11 Scopus citations

Phosphoinositide 3-kinase signaling pathway in pancreatic ductal adenocarcinoma progression, pathogenesis, and therapeutics

Murthy, D., Attri, K. S. & Singh, P. K., Apr 4 2018, In : Frontiers in Physiology. 9, APR, 335.

Research output: Contribution to journalReview article

13 Scopus citations

Targeting hypoxia-inducible factor-1a/pyruvate dehydrogenase kinase 1 axis by dichloroacetate suppresses bleomycin-induced pulmonary fibrosis

Goodwin, J., Choi, H., Hsieh, M. H., Neugent, M. L., Ahn, J. M., Hayenga, H. N., Singh, P. K., Shackelford, D. B., Lee, I. K., Shulaev, V., Dhar, S., Takeda, N. & Kim, J. W., Feb 2018, In : American journal of respiratory cell and molecular biology. 58, 2, p. 216-231 16 p.

Research output: Contribution to journalEditorial

19 Scopus citations

Transcriptional profiling using RNA-seq to study hypoxia-mediated gene regulation

Shukla, S. K., King, R. J. & Singh, P. K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 55-66 12 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2017

Combination treatment with orlistat-containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells

Souchek, J. J., Davis, A. L., Hill, T. K., Holmes, M. B., Qi, B., Singh, P. K., Kridel, S. J. & Mohs, A. M., Sep 2017, In : Molecular cancer therapeutics. 16, 9, p. 1819-1830 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

De Novo lipid synthesis facilitates gemcitabine resistance through endoplasmic reticulum stress in pancreatic cancer

Tadros, S., Shukla, S. K., King, R. J., Gunda, V., Vernucci, E., Abrego, J., Chaika, N. V., Yu, F., Lazenby, A. J., Berim, L., Grem, J., Sasson, A. R. & Singh, P. K., Oct 15 2017, In : Cancer Research. 77, 20, p. 5503-5517 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Erratum: MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer (Cancer Cell (2017) 32(1) (71–87.e7) (S1535610817302544) (10.1016/j.ccell.2017.06.004))

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P., Sep 11 2017, In : Cancer Cell. 32, 3, 1 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

Glucose limitation alters glutamine metabolism in MUC1- overexpressing pancreatic cancer cells

Gebregiworgis, T., Purohit, V., Shukla, S. K., Tadros, S., Chaika, N. V., Abrego, J., Mulder, S. E., Gunda, V., Singh, P. K. & Powers, R., Oct 6 2017, In : Journal of proteome research. 16, 10, p. 3536-3546 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells

Abrego, J., Gunda, V., Vernucci, E., Shukla, S. K., King, R. J., Dasgupta, A., Goode, G., Murthy, D., Yu, F. & Singh, P. K., Aug 1 2017, In : Cancer Letters. 400, p. 37-46 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P. K., Jul 10 2017, In : Cancer Cell. 32, 1, p. 71-87.e7

Research output: Contribution to journalArticle

103 Scopus citations

MUC1 facilitates metabolomic reprogramming in triple-negative breast cancer

Goode, G., Gunda, V., Chaika, N. V., Purohit, V., Yu, F. & Singh, P. K., May 2017, In : PloS one. 12, 5, e0176820.

Research output: Contribution to journalArticle

14 Scopus citations

MUC1-mediated metabolic alterations regulate response to radiotherapy in pancreatic cancer

Gunda, V., Souchek, J., Abrego, J., Shukla, S. K., Goode, G. D., Vernucci, E., Dasgupta, A., Chaika, N. V., King, R. J., Li, S., Wang, S., Yu, F., Bessho, T., Lin, C. & Singh, P. K., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5881-5891 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Racial disparity in metabolic regulation of cancer

Attri, K. S., Murthy, D. & Singh, P. K., Mar 1 2017, In : Frontiers in Bioscience - Landmark. 22, 8, p. 1221-1246 26 p.

Research output: Contribution to journalReview article

2 Scopus citations

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Enkins, D. M. R. J., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J. M., Minna, J. D., Helke, K. L. & 3 others, Singh, P. K., Shackelford, D. B. & Kim, J. W., May 26 2017, In : Nature communications. 8, 15503.

Research output: Contribution to journalArticle

48 Scopus citations
2016

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., Jan 1 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer

Mondal, G., Kumar, V., Shukla, S. K., Singh, P. K. & Mahato, R. I., Jan 11 2016, In : Biomacromolecules. 17, 1, p. 301-313 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
15 Scopus citations
2015

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

Yang, S., Zhang, L., Purohit, V., Shukla, S. K., Chen, X., Yu, F., Fu, K., Chen, Y., Solheim, J., Singh, P. K., Song, W. & Dong, J., Jan 1 2015, In : Oncotarget. 6, 34, p. 36019-36031 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

Shukla, S. K., Gunda, V., Abrego, J., Haridas, D., Mishra, A., Souchek, J., Chaika, N. V., Yu, F., Sasson, A. R., Lazenby, A. J., Batra, S. K. & Singh, P. K., Jan 1 2015, In : Oncotarget. 6, 22, p. 19118-19131 14 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

Shukla, S. K., Dasgupta, A., Mehla, K., Gunda, V., Vernucci, E., Souchek, J., Goode, G., King, R., Mishra, A., Rai, I., Nagarajan, S., Chaika, N. V., Yu, F. & Singh, P. K., Jan 1 2015, In : Oncotarget. 6, 38, p. 41146-41161 16 p.

Research output: Contribution to journalArticle

27 Scopus citations

Targeted therapy for glioblastoma: Lessons learned and future directions

Shonka, N. A., Gupta, S. & Singh, P. K., Jul 1 2015, In : Current Cancer Therapy Reviews. 11, 1, p. 44-58 15 p.

Research output: Contribution to journalArticle

2014

MUC1: A novel metabolic master regulator

Mehla, K. & Singh, P. K., Apr 1 2014, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1845, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin

Liu, X., Caffrey, T. C., Steele, M. M., Mohr, A., Singh, P., Radhakrishnan, P., Kelly, D. L., Wen, Y. & Hollingsworth, M. A., Jun 30 2014, In : Oncogenesis. 3, e107.

Research output: Contribution to journalArticle

19 Scopus citations

Structure and function of human DnaJ homologue subfamily A member 1 (DNAJA1) and its relationship to pancreatic cancer

Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., Montelione, G. T. & Powers, R., Mar 4 2014, In : Biochemistry. 53, 8, p. 1360-1372 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma

Chaika, N. V., Yu, F., Purohit, V., Mehla, K., Lazenby, A. J., DiMaio, D., Anderson, J. M., Yeh, J. J., Johnson, K. R., Hollingsworth, M. A. & Singh, P. K., Mar 7 2012, In : PloS one. 7, 3, e32996.

Research output: Contribution to journalArticle

49 Scopus citations

Exome sequencing and advances in crop improvement

Singh, D., Singh, P. K., Chaudhary, S., Mehla, K. & Kumar, S., 2012, In : Advances in Genetics. 79, p. 87-121 35 p.

Research output: Contribution to journalArticle

6 Scopus citations