Oksana Lockridge, PhD

Professor

  • 11617 Citations
  • 59 h-Index
1971 …2019
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Research Output 1971 2019

  • 11617 Citations
  • 59 h-Index
  • 242 Article
  • 11 Review article
  • 6 Chapter
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Article
2019

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Organophosphates
Enzymes
Electrophoresis
Cell culture

Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution

Lockridge, O., Verdier, L. & Schopfer, L. M., Sep 25 2019, In : Chemico-Biological Interactions. 311, 108788.

Research output: Contribution to journalArticle

Open Access
Half-Life
Esters
Crosslinking
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate
Artifacts
2 Citations (Scopus)
Lysine
Mass spectrometry
Mass Spectrometry
Tubulin
Proteins
4 Citations (Scopus)
Butyrylcholinesterase
Affinity chromatography
cholinesterase
Ion Exchange
ion exchange
2018
2 Citations (Scopus)

Characterization of butyrylcholinesterase from porcine milk

Saxena, A., Belinskaya, T., Schopfer, L. M. & Lockridge, O., Aug 15 2018, In : Archives of Biochemistry and Biophysics. 652, p. 38-49 12 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Milk
Swine
Butyrylthiocholine
Acetylthiocholine
2 Citations (Scopus)
Tubulin
Agglomeration
Lysine
Molecular Weight
Molecular weight
3 Citations (Scopus)

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

Leung, M. R., van Bezouwen, L. S., Schopfer, L. M., Sussman, J. L., Silman, I., Lockridge, O. & Zeev-Ben-Mordehai, T., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13270-13275 6 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Cryoelectron Microscopy
Cholinesterases
Proline
Catalytic Domain

Delipidation of plasma has minimal effects on human butyrylcholinesterase

Onder, S., Tacal, O. & Lockridge, O., Feb 15 2018, In : Frontiers in Pharmacology. 9, FEB, 117.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Dextran Sulfate
Fats
Electrophoresis
Gels
1 Citation (Scopus)
Butyrylcholinesterase
Aryldialkylphosphatase
carboxylesterase
Carboxylesterase
cholinesterase
4 Citations (Scopus)

Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment

Onder, S., Schopfer, L. M., Tacal, O., Blake, T. A., Johnson, R. C. & Lockridge, O., Jun 18 2018, In : Chemical Research in Toxicology. 31, 6, p. 520-530 11 p.

Research output: Contribution to journalArticle

HEK293 Cells
Tyrosine
Monoclonal Antibodies
Peptides
Proteins
7 Citations (Scopus)

Optimization of cholinesterase-based catalytic bioscavengers against organophosphorus agents

Lushchekina, S. V., Schopfer, L. M., Grigorenko, B. L., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 211.

Research output: Contribution to journalArticle

Cholinesterases
Water
Enzymes
Hydrolases
Mutation
1 Citation (Scopus)

Purification of recombinant human butyrylcholinesterase on Hupresin®

Lockridge, O., David, E., Schopfer, L. M., Masson, P., Brazzolotto, X. & Nachon, F., Dec 1 2018, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1102-1103, p. 109-115 7 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Purification
Procainamide
Acetylcholinesterase
Sepharose
cholinesterase
Sus scrofa
mass spectrometry
peptides
milk
2 Citations (Scopus)

Use of Hupresin to Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure

Onder, S., Schopfer, L. M., Cashman, J. R., Tacal, O., Johnson, R. C., Blake, T. A. & Lockridge, O., Jan 2 2018, In : Analytical chemistry. 90, 1, p. 974-979 6 p.

Research output: Contribution to journalArticle

Soman
Acetylcholinesterase
Blood
Cells
Neurology
2017
4 Citations (Scopus)

Characterization of butyrylcholinesterase in bovine serum

Dafferner, A. J., Lushchekina, S., Masson, P., Xiao, G., Schopfer, L. M. & Lockridge, O., Mar 25 2017, In : Chemico-Biological Interactions. 266, p. 17-27 11 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Acetylcholinesterase
Serum
Peptides
Proteins
7 Citations (Scopus)

Hupresin retains binding capacity for butyrylcholinesterase and acetylcholinesterase after sanitation with sodium hydroxide

Onder, S., David, E., Tacal, O., Schopfer, L. M. & Lockridge, O., Oct 10 2017, In : Frontiers in Pharmacology. 8, OCT, 713.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Sodium Hydroxide
Sanitation
Acetylcholinesterase
Erythrocytes
4 Citations (Scopus)

Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure

Dafferner, A. J., Schopfer, L. M., Xiao, G., Cashman, J. R., Yerramalla, U., Johnson, R. C., Blake, T. A. & Lockridge, O., Oct 16 2017, In : Chemical Research in Toxicology. 30, 10, p. 1897-1910 14 p.

Research output: Contribution to journalArticle

Acetylcholinesterase
Blood
Erythrocytes
Cells
Soman
2 Citations (Scopus)

Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids

Onder, S., Dafferner, A. J., Schopfer, L. M., Xiao, G., Yerramalla, U., Tacal, O., Blake, T. A., Johnson, R. C. & Lockridge, O., Dec 18 2017, In : Chemical Research in Toxicology. 30, 12, p. 2218-2228 11 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
Tyrosine
Amino Acids
Peptides
Dichlorvos
8 Citations (Scopus)

The C5 variant of the butyrylcholinesterase tetramer includes a noncovalently bound 60 kDa lamellipodin fragment

Schopfer, L. M., Delacour, H., Masson, P., Leroy, J., Krejci, E. & Lockridge, O., Jul 2017, In : Molecules. 22, 7, 1083.

Research output: Contribution to journalArticle

Butyrylcholinesterase
genes
fragments
muscle relaxants
proteins
2016
1 Citation (Scopus)
Chromogenics
Butyrylcholinesterase
Endotoxins
Assays
Hot Temperature
3 Citations (Scopus)

Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins

Varfolomeev, S. D., Lushchekina, S. V., Nemukhin, A. V., Kulakova, A. M., Kots, E. D., Makhaeva, G. F., Delacour, H., Lockridge, O. & Masson, P., Jun 1 2016, In : Russian Chemical Bulletin. 65, 6, p. 1592-1607 16 p.

Research output: Contribution to journalArticle

Supercomputers
Polymorphism
Carboxylesterase
Cholinesterases
Esterases
6 Citations (Scopus)

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

Peng, H., Brimijoin, S., Hrabovska, A., Krejci, E., Blake, T. A., Johnson, R. C., Masson, P. & Lockridge, O., Jan 5 2016, In : Chemico-Biological Interactions. 243, p. 82-90 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Animals
Monoclonal Antibodies
Plasmas
Carboxylesterase
11 Citations (Scopus)

Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers

Peng, H., Schopfer, L. M. & Lockridge, O., Nov 25 2016, In : Chemico-Biological Interactions. 259, p. 63-69 7 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Peptides
Proteins
Plasma (human)
Plasmas
7 Citations (Scopus)
Butyrylcholinesterase
CHO Cells
Plasmas
Peptides
Genes
2015
20 Citations (Scopus)
Gulf War
Butyrylcholinesterase
Veterans
Case-Control Studies
Genotype
12 Citations (Scopus)

Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences

Peng, H., Brimijoin, S., Hrabovska, A., Targosova, K., Krejci, E., Blake, T. A., Johnson, R. C., Masson, P. & Lockridge, O., Oct 5 2015, In : Chemico-Biological Interactions. 240, p. 336-345 10 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Amino Acid Sequence
Monoclonal Antibodies
Amino Acids
Epitopes
26 Citations (Scopus)

Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin

Schopfer, L. M., Lockridge, O. & Brimijoin, S., Dec 1 2015, In : General and Comparative Endocrinology. 224, p. 61-68 8 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
ghrelin
Ghrelin
cholinesterase
Hydrolysis
2014
22 Citations (Scopus)

Characterization of a novel BCHE "silent" allele: Point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium

Delacour, H., Lushchekina, S., Mabboux, I., Bousquet, A., Ceppa, F., Schopfer, L. M., Lockridge, O. & Masson, P., Jul 23 2014, In : PloS one. 9, 7, e101552.

Research output: Contribution to journalArticle

suxamethonium
apnea
Butyrylthiocholine
Succinylcholine
Apnea
14 Citations (Scopus)

Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium

Delacour, H., Lushchekina, S., Mabboux, I., Ceppa, F., Masson, P., Schopfer, L. M. & Lockridge, O., Dec 1 2014, In : Biochemical Pharmacology. 92, 3, p. 476-483 8 p.

Research output: Contribution to journalArticle

Butyrylthiocholine
Butyrylcholinesterase
Point Mutation
Substrates
Molecular Dynamics Simulation
15 Citations (Scopus)

Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome

Schopfer, L. M., Masson, P., Lamourette, P., Simon, S. & Lockridge, O., Sep 15 2014, In : Analytical Biochemistry. 461, p. 17-26 10 p.

Research output: Contribution to journalArticle

Plasma (human)
Butyrylcholinesterase
Phosphates
Plasmas
Mass spectrometry
19 Citations (Scopus)

Polyproline promotes tetramerization of recombinant human butyrylcholinesterase

Larson, M. A., Lockridge, O. & Hinrichs, S. H., Sep 1 2014, In : Biochemical Journal. 462, 2, p. 329-335 7 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Peptides
Proline
Plasma (human)
Affinity chromatography
2013
3 Citations (Scopus)

Application of chromosomal DNA and protein targeting for the identification of Yersinia pestis

Larson, M. A., Ding, S. J., Slater, S. R., Hanway, A., Bartling, A. M., Fey, P. D., Lockridge, O., Francesconi, S. C. & Hinrichs, S. H., Jun 1 2013, In : Proteomics - Clinical Applications. 7, 5-6, p. 416-423 8 p.

Research output: Contribution to journalArticle

Yersinia pestis
Protein Transport
Biomarkers
DNA
Pathogens
1 Citation (Scopus)
Butyrylcholinesterase
Histidine
Phosphates
Catalytic Domain
Tritolyl Phosphates
7 Citations (Scopus)
Butyrylcholinesterase
Pesticides
Mass spectrometry
Mass Spectrometry
Blood
26 Citations (Scopus)
Butyrylcholinesterase
Osmotic Pressure
Molecular Dynamics Simulation
Viscosity
Molecular dynamics
20 Citations (Scopus)

Human serum albumin-based design of a diflunisal prodrug

Yang, F., Ma, Z. Y., Zhang, Y., Li, G. Q., Li, M., Qin, J. K., Lockridge, O. & Liang, H., Aug 1 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 84, 3, p. 549-554 6 p.

Research output: Contribution to journalArticle

Diflunisal
Prodrugs
Serum Albumin
Albumins
Cyclooxygenase 2 Inhibitors
23 Citations (Scopus)

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

Carletti, E., Colletier, J. P., Schopfer, L. M., Santoni, G., Masson, P., Lockridge, O., Nachon, F. & Weik, M., Feb 18 2013, In : Chemical Research in Toxicology. 26, 2, p. 280-289 10 p.

Research output: Contribution to journalArticle

Organophosphates
Cholinesterases
Acetylcholinesterase
Mass spectrometry
Mass Spectrometry
12 Citations (Scopus)

Mass Spectrometry Method to Identify Aging Pathways of Sp- and Rp-Tabun Adducts on Human Butyrylcholinesterase Based on the Acid Labile P-N Bond

Jiang, W., Cashman, J. R., Nachon, F., Masson, P., Schopfer, L. M. & Lockridge, O., Apr 1 2013, In : Toxicological Sciences. 132, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Mass spectrometry
Dealkylation
Mass Spectrometry
Deamination
16 Citations (Scopus)

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase

Jiang, W., Murashko, E. A., Dubrovskii, Y. A., Podolskaya, E. P., Babakov, V. N., Mikler, J., Nachon, F., Masson, P., Schopfer, L. M. & Lockridge, O., Jan 1 2013, In : Analytical Biochemistry. 439, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ionization
Mass spectrometry
Desorption
Mass Spectrometry
5 Citations (Scopus)

Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor

Liyasova, M. S., Schopfer, L. M., Kodani, S., Lantz, S. R., Casida, J. E. & Lockridge, O., Mar 18 2013, In : Chemical Research in Toxicology. 26, 3, p. 422-431 10 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Chemical activation
Catalytic Domain
Serine
ethephon
1 Citation (Scopus)

Noncholinesterase Protein Targets of Organophosphorus Pesticides

Lockridge, O., 2013, In : Advances in Molecular Toxicology. 7, p. 179-205 27 p.

Research output: Contribution to journalArticle

Pesticides
Serine
Albumins
Chlorpyrifos
Hydrolases
10 Citations (Scopus)

PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin

Jiang, W., Dubrovskii, Y. A., Podolskaya, E. P., Murashko, E. A., Babakov, V., Nachon, F., Masson, P., Schopfer, L. M. & Lockridge, O., Dec 16 2013, In : Chemical Research in Toxicology. 26, 12, p. 1917-1925 9 p.

Research output: Contribution to journalArticle

Albumins
Iron
Peptides
Pepsin A
Plasma (human)
7 Citations (Scopus)

Polyclonal antibody to soman-tyrosine

Li, B., Duysen, E. G., Froment, M. T., Masson, P., Nachon, F., Jiang, W., Schopfer, L. M., Thiele, G. M., Klassen, L. W., Cashman, J., Williams, G. R. & Lockridge, O., Apr 15 2013, In : Chemical Research in Toxicology. 26, 4, p. 584-592 9 p.

Research output: Contribution to journalArticle

Soman
Tyrosine
Antibodies
Albumins
Transferrin
10 Citations (Scopus)

Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase

Biberoglu, K., Schopfer, L. M., Saxena, A., Tacal, O. & Lockridge, O., Apr 1 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 4, p. 745-753 9 p.

Research output: Contribution to journalArticle

Acetylcholinesterase
Peptides
Serum
Butyrylcholinesterase
Amino Acids
16 Citations (Scopus)

Protein tyrosine adduct in humans self-poisoned by chlorpyrifos

Li, B., Eyer, P., Eddleston, M., Jiang, W., Schopfer, L. M. & Lockridge, O., Jun 15 2013, In : Toxicology and Applied Pharmacology. 269, 3, p. 215-225 11 p.

Research output: Contribution to journalArticle

Chlorpyrifos
Tyrosine
Proteins
Plasmas
Butyrylcholinesterase
1 Citation (Scopus)
Butyrylcholinesterase
Methylene Blue
methylene blue
Mass spectrometry
Mass Spectrometry
2012
13 Citations (Scopus)
Histidine
Serum Albumin
Lysine
Tyrosine
Phosphates
18 Citations (Scopus)
Thiocholine
Carbofuran
Dichlorvos
Diazinon
Parathion
45 Citations (Scopus)

Human butyrylcholinesterase produced in insect cells: Huprine-based affinity purification and crystal structure

Brazzolotto, X., Wandhammer, M., Ronco, C., Trovaslet, M., Jean, L., Lockridge, O., Renard, P. Y. & Nachon, F., Aug 1 2012, In : FEBS Journal. 279, 16, p. 2905-2916 12 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Purification
Insects
Crystal structure
Cricetulus
5 Citations (Scopus)

Induction of plasma acetylcholinesterase activity and apoptosis in mice treated with the organophosphorus toxicant, tri-o-cresyl phosphate

Jiang, W., Duysen, E. G. & Lockridge, O., Jan 1 2012, In : Toxicology Research. 1, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Acetylcholinesterase
Apoptosis
Plasmas
Organophosphorus Compounds
tri-o-cresyl phosphate