Natalia A Osna, MD, PhD

Associate Professor

  • 1305 Citations
  • 22 h-Index
1984 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1984 2019

  • 1305 Citations
  • 22 h-Index
  • 62 Article
  • 15 Review article
  • 6 Editorial
Filter
Article
2019
2 Citations (Scopus)

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

Acetaldehyde
Major Histocompatibility Complex
Hepatitis B virus
Hepatocytes
Cytotoxic T-Lymphocytes
1 Citation (Scopus)
Comorbidity
HIV
Viruses
Liver
Hepatitis B virus

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

Poloxamer
Proteasome Inhibitors
Multiple Myeloma
Ubiquitinated Proteins
Paraproteins
2018
7 Citations (Scopus)

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. Y., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

Hepacivirus
Interferons
Ethanol
Methylation
Acetaldehyde
1 Citation (Scopus)
Hepatic Stellate Cells
Macrophages
Viruses
Hepacivirus
Liver Cirrhosis
5 Citations (Scopus)

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Dagur, R. S., Wang, W., Cheng, Y., Makarov, E., Ganesan, M., Suemizu, H., Gebhart, C. L., Gorantla, S., Osna, N. A. & Poluektova, L. Y., Jan 1 2018, In : Biology Open. 7, 2, bio029785.

Research output: Contribution to journalArticle

Virus Diseases
Human immunodeficiency virus 1
Viruses
hepatocytes
HIV-1
3 Citations (Scopus)
Stiffness matrix
Cell death
Liver Cirrhosis
Liver
Hepatocytes
2 Citations (Scopus)

The loss of α-and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing

Labisso, W. L., Raulin, A. C., Nwidu, L. L., Kocon, A., Wayne, D., Erdozain, A. M., Morentin, B., Schwendener, D., Allen, G., Enticott, J., Gerdes, H. K., Johnson, L., Grzeskowiak, J., Drizou, F., Tarbox, R., Osna, N. A., Kharbanda, K., Callado, L. F. & Carter, W. G., Sep 11 2018, In : Brain Sciences. 8, 9, 175.

Research output: Contribution to journalArticle

Tubulin
Alcohol Drinking
Brain
Proteins
Alcoholics
2017
5 Citations (Scopus)

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. & Kharbanda, K., Jan 1 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Fibrosis
Drinking
Liver
Alcohol Drinking
2016
10 Citations (Scopus)

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, N. A., Carter, W. G., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L. & Kharbanda, K., Jul 21 2016, In : World Journal of Gastroenterology. 22, 27, p. 6192-6200 9 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Alcohols
Physiological Phenomena
Liver
Wounds and Injuries
12 Citations (Scopus)
Acetaldehyde
Viruses
Interferon-alpha
Hepacivirus
Liver
4 Citations (Scopus)

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

Ganesan, M., Feng, D., Barton, R. W., Thomes, P. G., McVicker, B. L., Tuma, D. J., Osna, N. A. & Kharbanda, K., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2312-2319 8 p.

Research output: Contribution to journalArticle

Creatine
S-Adenosylmethionine
S-Adenosylhomocysteine
Nutrition
Liver
3 Citations (Scopus)

Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury

Osna, N. A., Feng, D., Ganesan, M., Maillacheruvu, P. F., Orlicky, D. J., French, S. W., Tuma, D. J. & Kharbanda, K., Oct 14 2016, In : World Journal of Gastroenterology. 22, 38, p. 8497-8508 12 p.

Research output: Contribution to journalArticle

Ethanol
Liver
Wounds and Injuries
Methylation
Creatine
11 Citations (Scopus)
Acetaldehyde
Hepacivirus
Hepatocytes
Apoptosis
Alcohols
2015
20 Citations (Scopus)
Acetaldehyde
Innate Immunity
Hepacivirus
Methylation
Liver
4 Citations (Scopus)

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Proteins
Oxidative stress
Hepatocytes
10 Citations (Scopus)

Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury

Carter, W. G., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., Brewer, C., Raut, N., Gerdes, H. K., Erdozain, A. M., Tooth, D., Bolt, E. L., Osna, N. A., Tuma, D. J. & Kharbanda, K., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 626-631 6 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase III
Isoaspartic Acid
Carbamyl Phosphate
Biomarkers
Liver
10 Citations (Scopus)

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics

Zhang, J., Garrison, J. C., Poluektova, L. Y., Bronich, T. K. & Osna, N. A., Nov 1 2015, In : Biomaterials. 70, p. 37-47 11 p., 17009.

Research output: Contribution to journalArticle

Liver
Peptides
Antiviral Agents
Therapeutics
Cytotoxicity
10 Citations (Scopus)
Betaine
Methylation
Liver
Tubercidin
Ethanol
2014
11 Citations (Scopus)

Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity

Kharbanda, K., Todero, S. L., Moats, J. C., Harris, R. M., Osna, N. A., Thomes, P. G. & Tuma, D. J., Mar 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 641-648 8 p.

Research output: Contribution to journalArticle

Guanidinoacetate N-Methyltransferase
Creatine
Biosynthesis
Alcohol Drinking
Rats
7 Citations (Scopus)

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K., Sun, Y., Simpson, R. L., Poluektova, L. Y., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

Hepatitis C
Ethanol
Viral RNA
Liver
Oxidative stress
39 Citations (Scopus)

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice

Gutti, T. L., Knibbe, J. S., Makarov, E., Zhang, J., Yannam, G. R., Gorantla, S., Sun, Y., Mercer, D. F., Suemizu, H., Wisecarver, J. L., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

treosulfan
Hepatocytes
Transplantation
Urokinase-Type Plasminogen Activator
Severe Combined Immunodeficiency
10 Citations (Scopus)

Increased methylation demand exacerbates ethanol-induced liver injury

Kharbanda, K., Todero, S. L., Thomes, P. G., Orlicky, D. J., Osna, N. A., French, S. W. & Tuma, D. J., Aug 2014, In : Experimental and Molecular Pathology. 97, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Methylation
Liver
Ethanol
Wounds and Injuries
Nutrition
2013
18 Citations (Scopus)

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

Zhang, J., Mulvenon, A., Makarov, E., Wagoner, J., Knibbe, J., Kim, J. O., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., May 1 2013, In : Biomaterials. 34, 15, p. 3846-3857 12 p.

Research output: Contribution to journalArticle

Virus Diseases
Coinfection
Viruses
Hepacivirus
Peptides
16 Citations (Scopus)
Early Growth Response Protein 1
Hep G2 Cells
Ethanol
Growth
Triglycerides
11 Citations (Scopus)
Cytochrome P-450 CYP2E1
Autophagy
Antigen Presentation
Oxidants
Metabolism
7 Citations (Scopus)
Asialoglycoprotein Receptor
T-Lymphocytes
Liver
Wounds and Injuries
Liver Diseases
2012
22 Citations (Scopus)

Early Growth Response-1 Contributes to Steatosis Development After Acute Ethanol Administration

Donohue, T., Osna, N. A., Trambly, C. S., Whitaker, N. P., Thomes, P. G., Todero, S. L. & Davis, J. S., May 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Fatty Liver
Growth
Endotoxins
8 Citations (Scopus)

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. & Kharbanda, K., Dec 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Viruses
Hepacivirus
Hepatocytes
Ethanol
2010
19 Citations (Scopus)

Chronic Ethanol Consumption Results in Atypical Liver Injury in Copper/Zinc Superoxide Dismutase Deficient Mice

Curry-Mccoy, T. V., Osna, N. A., Nanji, A. A. & Donohue, T., Feb 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

Liver
Superoxide Dismutase
Zinc
Copper
Ethanol
19 Citations (Scopus)

Impaired methylation as a novel mechanism for proteasome suppression in liver cells

Osna, N. A., White, R. L., Donohue, T., Beard, M. R., Tuma, D. J. & Kharbanda, K., Jan 8 2010, In : Biochemical and Biophysical Research Communications. 391, 2, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

Methylation
Proteasome Endopeptidase Complex
Liver
S-Adenosylmethionine
Ethanol
2009
18 Citations (Scopus)

Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells

Osna, N. A., White, R. L., Thiele, G. M. & Donohue, T., Jun 24 2009, In : Hepatology. 49, 4, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Antigen Presentation
Major Histocompatibility Complex
Proteasome Endopeptidase Complex
Ethanol
16 Citations (Scopus)

Modulation of lysozyme function and degradation after nitration with peroxynitrite

Curry-McCoy, T. V., Osna, N. A. & Donohue, T., Aug 1 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 8, p. 778-786 9 p.

Research output: Contribution to journalArticle

Nitration
Peroxynitrous Acid
Muramidase
Proteasome Endopeptidase Complex
Modulation
2008
38 Citations (Scopus)

Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress

Osna, N. A., White, R. L., Krutik, V. M., Wang, T., Weinman, S. A. & Donohue, T., Jun 2008, In : Gastroenterology. 134, 7, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Hepatitis C
Oxidative Stress
Ethanol
Oxidants
2007
38 Citations (Scopus)

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., McVicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T., Jan 1 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Hepatocellular Carcinoma
Oxidative Stress
Ethanol
Peptides
26 Citations (Scopus)

Implication of altered proteasome function in alcoholic liver injury

Osna, N. A. & Donohue, T., Oct 7 2007, In : World Journal of Gastroenterology. 13, 37, p. 4931-4937 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Liver
Wounds and Injuries
Ethanol
Oxidative Stress
22 Citations (Scopus)

L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury

Donohue, T., Curry-McCoy, T. V., Todero, S. L., White, R. L., Kharbanda, K., Nanji, A. A. & Osna, N. A., Jun 2007, In : Alcoholism: Clinical and Experimental Research. 31, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

Liver
Glutathione
Ethanol
Wounds and Injuries
Nutrition
23 Citations (Scopus)
Liver
Rats
Ethanol
Wounds and Injuries
Enzymes
2006
88 Citations (Scopus)
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Hep G2 Cells
Cytotoxicity
Ethanol
2005
44 Citations (Scopus)

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

Osna, N. A., Clemens, D. L. & Donohue, T., Nov 1 2005, In : Hepatology. 42, 5, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Interferon-gamma
Ethanol
Phosphorylation
Cytochrome P-450 CYP2E1
2004
45 Citations (Scopus)

Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: Implications for impaired immune function during disease

Haorah, J., Heilman, D., Diekmann, C., Osna, N., Donohue, T. M., Ghorpade, A. & Persidsky, Y., Jun 1 2004, In : Cellular Immunology. 229, 2, p. 139-148 10 p.

Research output: Contribution to journalArticle

HIV Protease
HIV-1
Macrophages
Alcohols
HIV Infections
45 Citations (Scopus)

Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo

Osna, N. A., Haorah, J., Krutik, V. M. & Donohue, T., Sep 1 2004, In : Hepatology. 40, 3, p. 574-582 9 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Proteasome Endopeptidase Complex
Rodentia
Liver
S-Nitroso-N-Acetylpenicillamine
2003
48 Citations (Scopus)
Hep G2 Cells
Proteasome Endopeptidase Complex
Cytochromes
Interferon-gamma
Ethanol
2001
25 Citations (Scopus)

Alcohol consumption is associated with alterations in macrophage responses to interferon-γ and infection by Salmonella typhimurium

Sibley, D. A., Osna, N. A., Kusynski, C., Wilkie, L. & Jerrells, T. R., Dec 1 2001, In : FEMS Immunology and Medical Microbiology. 32, 1, p. 73-83 11 p.

Research output: Contribution to journalArticle

Salmonella typhimurium
Alcohol Drinking
Interferons
Macrophages
Infection
18 Citations (Scopus)

Histamine utilizes JAK-STAT pathway in regulating cytokine production

Osna, N., Elliott, K., Chaika, O., Patterson, E., Lewis, R. E. & Khan, M. M., Mar 22 2001, In : International Immunopharmacology. 1, 4, p. 759-762 4 p.

Research output: Contribution to journalArticle

Janus Kinases
Transducers
Histamine
Tyrphostins
Cytokines
38 Citations (Scopus)

Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells

Elliott, K. A., Osna, N. A., Scofield, M. A. & Khan, M. M., Sep 22 2001, In : International Immunopharmacology. 1, 11, p. 1923-1937 15 p.

Research output: Contribution to journalArticle

Th2 Cells
Interleukin-13
Histamine
Tyrphostins
Cyclic AMP-Dependent Protein Kinases
85 Citations (Scopus)

Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes

Osna, N., Elliott, K. & Khan, M. M., Mar 15 2001, In : International Immunopharmacology. 1, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

Interleukin-10
Histamine
Tyrphostins
Cytokines
Histamine H1 Receptors
37 Citations (Scopus)

The effects of histamine on interferon gamma production are dependent on the stimulatory signals

Osna, N., Elliott, K. & Khan, M. M., Mar 15 2001, In : International Immunopharmacology. 1, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

Histamine
Interferon-gamma
Ionomycin
Cyclic AMP-Dependent Protein Kinases
Protein Kinase Inhibitors
2000

Clinical and immunological study of diphtheritic polyneuropathy

Logina, I. A., Osna, N. A., Kravale, I. A., Vilgert, N. E., Sochnev, A. M. & Berzinsh, Y. E., Dec 1 2000, In : Zhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova. 100, 9, p. 58-60 3 p.

Research output: Contribution to journalArticle

Latvia
Diphtheria
Polyneuropathies
Acute Disease
Cellular Immunity
2 Citations (Scopus)
Lymphocytes
Flow cytometry
Flow Cytometry
Membrane Potentials
Depolarization