Natalia A Osna, MD, PhD

Associate Professor

  • 1305 Citations
  • 22 h-Index
1984 …2019
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Research Output 1984 2019

  • 1305 Citations
  • 22 h-Index
  • 62 Article
  • 15 Review article
  • 6 Editorial
2019
2 Citations (Scopus)

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

Acetaldehyde
Major Histocompatibility Complex
Hepatitis B virus
Hepatocytes
Cytotoxic T-Lymphocytes
1 Citation (Scopus)
Comorbidity
HIV
Viruses
Liver
Hepatitis B virus

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

Poloxamer
Proteasome Inhibitors
Multiple Myeloma
Ubiquitinated Proteins
Paraproteins
2018
7 Citations (Scopus)

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. Y., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

Hepacivirus
Interferons
Ethanol
Methylation
Acetaldehyde
1 Citation (Scopus)
Hepatic Stellate Cells
Macrophages
Viruses
Hepacivirus
Liver Cirrhosis
5 Citations (Scopus)

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Dagur, R. S., Wang, W., Cheng, Y., Makarov, E., Ganesan, M., Suemizu, H., Gebhart, C. L., Gorantla, S., Osna, N. A. & Poluektova, L. Y., Jan 1 2018, In : Biology Open. 7, 2, bio029785.

Research output: Contribution to journalArticle

Virus Diseases
Human immunodeficiency virus 1
Viruses
hepatocytes
HIV-1
4 Citations (Scopus)

Liver as a target of human immunodeficiency virus infection

Ganesan, M., Poluektova, L. Y., Kharbanda, K. & Osna, N. A., Nov 14 2018, In : World Journal of Gastroenterology. 24, 42, p. 4728-4737 10 p.

Research output: Contribution to journalReview article

Virus Diseases
HIV
Liver
Alcohols
Wounds and Injuries
3 Citations (Scopus)
Stiffness matrix
Cell death
Liver Cirrhosis
Liver
Hepatocytes
2 Citations (Scopus)

The loss of α-and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing

Labisso, W. L., Raulin, A. C., Nwidu, L. L., Kocon, A., Wayne, D., Erdozain, A. M., Morentin, B., Schwendener, D., Allen, G., Enticott, J., Gerdes, H. K., Johnson, L., Grzeskowiak, J., Drizou, F., Tarbox, R., Osna, N. A., Kharbanda, K., Callado, L. F. & Carter, W. G., Sep 11 2018, In : Brain Sciences. 8, 9, 175.

Research output: Contribution to journalArticle

Tubulin
Alcohol Drinking
Brain
Proteins
Alcoholics
2017
5 Citations (Scopus)

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. & Kharbanda, K., Jan 1 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Fibrosis
Drinking
Liver
Alcohol Drinking
26 Citations (Scopus)

Alcoholic Liver Disease: Pathogenesis and Current Management

Osna, N. A., Donohue, T. & Kharbanda, K., Jan 1 2017, In : Alcohol research : current reviews. 38, 2, p. 147-161 15 p.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Fibrosis
Drinking
Liver
Alcohol Drinking
6 Citations (Scopus)

Bifunctional enzyme JMJD6 contributes to multiple disease pathogenesis: New twist on the old story

Vangimalla, S. S., Ganesan, M., Kharbanda, K. & Osna, N. A., Jun 2017, In : Biomolecules. 7, 2, 41.

Research output: Contribution to journalReview article

Enzymes
Proteins
Carcinogenesis
2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
Oxygenases
1 Citation (Scopus)

Structure, function and metabolism of hepatic and adipose tissue lipid droplets: Implications in alcoholic liver disease

Natarajan, S. K., Rasineni, K., Ganesan, M., Feng, D., McVicker, B. L., McNiven, M. A., Osna, N. A., Mott, J. L., Casey, C. A. & Kharbanda, K., Aug 1 2017, In : Current Molecular Pharmacology. 10, 3, p. 237-248 12 p.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Adipose Tissue
Liver
Lipids
Virus Assembly
24 Citations (Scopus)

Treatment options for alcoholic and non-alcoholic fatty liver disease: A review

Singh, S., Osna, N. A. & Kharbanda, K., Sep 28 2017, In : World Journal of Gastroenterology. 23, 36, p. 6549-6570 22 p.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Therapeutics
Non-alcoholic Fatty Liver Disease
Pentoxifylline
Nutritional Support
2016
10 Citations (Scopus)

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, N. A., Carter, W. G., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L. & Kharbanda, K., Jul 21 2016, In : World Journal of Gastroenterology. 22, 27, p. 6192-6200 9 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Alcohols
Physiological Phenomena
Liver
Wounds and Injuries
12 Citations (Scopus)
Acetaldehyde
Viruses
Interferon-alpha
Hepacivirus
Liver
4 Citations (Scopus)

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

Ganesan, M., Feng, D., Barton, R. W., Thomes, P. G., McVicker, B. L., Tuma, D. J., Osna, N. A. & Kharbanda, K., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2312-2319 8 p.

Research output: Contribution to journalArticle

Creatine
S-Adenosylmethionine
S-Adenosylhomocysteine
Nutrition
Liver
6 Citations (Scopus)

Multi-organ alcohol-related damage: Mechanisms and treatment

Osna, N. A. & Kharbanda, K., Apr 15 2016, In : Biomolecules. 6, 2, 20.

Research output: Contribution to journalEditorial

Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Oxidative Stress
Ethanol
Alcohols
3 Citations (Scopus)

Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury

Osna, N. A., Feng, D., Ganesan, M., Maillacheruvu, P. F., Orlicky, D. J., French, S. W., Tuma, D. J. & Kharbanda, K., Oct 14 2016, In : World Journal of Gastroenterology. 22, 38, p. 8497-8508 12 p.

Research output: Contribution to journalArticle

Ethanol
Liver
Wounds and Injuries
Methylation
Creatine
11 Citations (Scopus)
Acetaldehyde
Hepacivirus
Hepatocytes
Apoptosis
Alcohols
2015
20 Citations (Scopus)
Acetaldehyde
Innate Immunity
Hepacivirus
Methylation
Liver
20 Citations (Scopus)

Alcoholic liver disease: Clinical and translational research

Neuman, M. G., Malnick, S., Maor, Y., Nanau, R. M., Melzer, E., Ferenci, P., Seitz, H. K., Mueller, S., Mell, H., Samuel, D., Cohen, L. B., Kharbanda, K., Osna, N. A., Ganesan, M., Thompson, K. J., McKillop, I. H., Bautista, A., Bataller, R. & French, S. W., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 596-610 15 p.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Translational Medical Research
Liver
Alcohols
Morbidity
4 Citations (Scopus)

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Proteins
Oxidative stress
Hepatocytes
15 Citations (Scopus)

Hepatitis C, innate immunity and alcohol: Friends or foes?

Osna, N. A., Ganesan, M. & Kharbanda, K., Jan 1 2015, In : Biomolecules. 5, 1, p. 76-94 19 p.

Research output: Contribution to journalReview article

Hepatitis C
Viruses
Innate Immunity
Hepacivirus
Alcohols
10 Citations (Scopus)

Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury

Carter, W. G., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., Brewer, C., Raut, N., Gerdes, H. K., Erdozain, A. M., Tooth, D., Bolt, E. L., Osna, N. A., Tuma, D. J. & Kharbanda, K., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 626-631 6 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase III
Isoaspartic Acid
Carbamyl Phosphate
Biomarkers
Liver
10 Citations (Scopus)

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics

Zhang, J., Garrison, J. C., Poluektova, L. Y., Bronich, T. K. & Osna, N. A., Nov 1 2015, In : Biomaterials. 70, p. 37-47 11 p., 17009.

Research output: Contribution to journalArticle

Liver
Peptides
Antiviral Agents
Therapeutics
Cytotoxicity
10 Citations (Scopus)
Betaine
Methylation
Liver
Tubercidin
Ethanol
2014
11 Citations (Scopus)

Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity

Kharbanda, K., Todero, S. L., Moats, J. C., Harris, R. M., Osna, N. A., Thomes, P. G. & Tuma, D. J., Mar 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 641-648 8 p.

Research output: Contribution to journalArticle

Guanidinoacetate N-Methyltransferase
Creatine
Biosynthesis
Alcohol Drinking
Rats
32 Citations (Scopus)

Alcoholic and non-alcoholic steatohepatitis

Neuman, M. G., French, S. W., French, B. A., Seitz, H. K., Cohen, L. B., Mueller, S., Osna, N. A., Kharbanda, K., Seth, D., Bautista, A., Thompson, K. J., McKillop, I. H., Kirpich, I. A., McClain, C. J., Bataller, R., Nanau, R. M., Voiculescu, M., Opris, M., Shen, H., Tillman, B. & 5 others, Li, J., Liu, H., Thomes, P. G., Ganesan, M. & Malnick, S., Dec 1 2014, In : Experimental and Molecular Pathology. 97, 3, p. 492-510 19 p.

Research output: Contribution to journalReview article

Alcoholic Fatty Liver
Fatty Liver
Liver
Alcohols
Alcoholic Liver Diseases
7 Citations (Scopus)

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K., Sun, Y., Simpson, R. L., Poluektova, L. Y., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

Hepatitis C
Ethanol
Viral RNA
Liver
Oxidative stress
39 Citations (Scopus)

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice

Gutti, T. L., Knibbe, J. S., Makarov, E., Zhang, J., Yannam, G. R., Gorantla, S., Sun, Y., Mercer, D. F., Suemizu, H., Wisecarver, J. L., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

treosulfan
Hepatocytes
Transplantation
Urokinase-Type Plasminogen Activator
Severe Combined Immunodeficiency
10 Citations (Scopus)

Increased methylation demand exacerbates ethanol-induced liver injury

Kharbanda, K., Todero, S. L., Thomes, P. G., Orlicky, D. J., Osna, N. A., French, S. W. & Tuma, D. J., Aug 2014, In : Experimental and Molecular Pathology. 97, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Methylation
Liver
Ethanol
Wounds and Injuries
Nutrition
5 Citations (Scopus)

Proteasome- and ethanol-dependent regulation of HCV-infection pathogenesis

Osna, N. A., Ganesan, M. & Donohue, T., Dec 1 2014, In : Biomolecules. 4, 4, p. 885-896 12 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ethanol
Infection
Hepatocytes
Oxidative stress
2013
18 Citations (Scopus)

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

Zhang, J., Mulvenon, A., Makarov, E., Wagoner, J., Knibbe, J., Kim, J. O., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., May 1 2013, In : Biomaterials. 34, 15, p. 3846-3857 12 p.

Research output: Contribution to journalArticle

Virus Diseases
Coinfection
Viruses
Hepacivirus
Peptides
16 Citations (Scopus)
Early Growth Response Protein 1
Hep G2 Cells
Ethanol
Growth
Triglycerides
11 Citations (Scopus)
Cytochrome P-450 CYP2E1
Autophagy
Antigen Presentation
Oxidants
Metabolism
6 Citations (Scopus)

Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases

Kharbanda, K., Bardag-Gorce, F., Barve, S., Molina, P. E. & Osna, N. A., Jan 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

Methylation
Virus Diseases
Proteasome Endopeptidase Complex
Liver
Alcohols
7 Citations (Scopus)
Asialoglycoprotein Receptor
T-Lymphocytes
Liver
Wounds and Injuries
Liver Diseases
2012
22 Citations (Scopus)

Early Growth Response-1 Contributes to Steatosis Development After Acute Ethanol Administration

Donohue, T., Osna, N. A., Trambly, C. S., Whitaker, N. P., Thomes, P. G., Todero, S. L. & Davis, J. S., May 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Fatty Liver
Growth
Endotoxins
8 Citations (Scopus)

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. & Kharbanda, K., Dec 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Viruses
Hepacivirus
Hepatocytes
Ethanol
2011
2 Citations (Scopus)

An annual topic highlight: Alcohol and liver, 2011

Osna, N. A., May 28 2011, In : World Journal of Gastroenterology. 17, 20, 1 p.

Research output: Contribution to journalEditorial

Alcoholic Liver Diseases
Alcohols
Liver
Autophagy
Hepacivirus
32 Citations (Scopus)

Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis

Osna, N. A., Thomes, P. G. & Donohue, T., May 28 2011, In : World Journal of Gastroenterology. 17, 20, p. 2507-2514 8 p.

Research output: Contribution to journalReview article

Autophagy
Hepatitis C
Hepacivirus
Ethanol
Liver
2010
56 Citations (Scopus)

Alcohol and hepatitis C virus-interactions in immune dysfunctions and liver damage

Szabo, G., Wands, J. R., Eken, A., Osna, N. A., Weinman, S. A., MacHida, K. & Joe Wang, H., Oct 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 10, p. 1675-1686 12 p.

Research output: Contribution to journalReview article

Viruses
Hepacivirus
Liver
Liver Diseases
Alcohols
2 Citations (Scopus)

Alcohol and liver, 2010

Osna, N. A., Mar 21 2010, In : World Journal of Gastroenterology. 16, 11, 1 p.

Research output: Contribution to journalEditorial

Alcoholic Liver Diseases
Alcohols
Liver
Nutrigenomics
Liver Failure
19 Citations (Scopus)

Chronic Ethanol Consumption Results in Atypical Liver Injury in Copper/Zinc Superoxide Dismutase Deficient Mice

Curry-Mccoy, T. V., Osna, N. A., Nanji, A. A. & Donohue, T., Feb 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

Liver
Superoxide Dismutase
Zinc
Copper
Ethanol
19 Citations (Scopus)

Impaired methylation as a novel mechanism for proteasome suppression in liver cells

Osna, N. A., White, R. L., Donohue, T., Beard, M. R., Tuma, D. J. & Kharbanda, K., Jan 8 2010, In : Biochemical and Biophysical Research Communications. 391, 2, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

Methylation
Proteasome Endopeptidase Complex
Liver
S-Adenosylmethionine
Ethanol
2009

Alcohol and liver

Osna, N. A., Mar 14 2009, In : World Journal of Gastroenterology. 15, 10, 1 p.

Research output: Contribution to journalEditorial

Alcoholic Liver Diseases
Alcohol Drinking
Ethanol
Alcohols
Liver
3 Citations (Scopus)

Alcohol and liver disease

Osna, N. A., May 1 2009, In : Seminars in liver disease. 29, 2, 1 p.

Research output: Contribution to journalEditorial

Alcoholic Liver Diseases
Disease Progression
Liver Diseases
Alcohols
18 Citations (Scopus)

Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells

Osna, N. A., White, R. L., Thiele, G. M. & Donohue, T., Jun 24 2009, In : Hepatology. 49, 4, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Antigen Presentation
Major Histocompatibility Complex
Proteasome Endopeptidase Complex
Ethanol
16 Citations (Scopus)

Hepatitis C virus and ethanol alter antigen presentation in liver cells

Osna, N. A., Mar 14 2009, In : World Journal of Gastroenterology. 15, 10, p. 1201-1208 8 p.

Research output: Contribution to journalReview article

Antigen Presentation
Hepacivirus
Ethanol
Liver
Major Histocompatibility Complex