Lynette M Smith, PhD

Assistant Professor

  • 10730 Citations
  • 49 h-Index
20012020
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Research Output 2001 2020

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Article
2020

A comparative analysis of survival and funding discrepancies in cancers with high mortality

Hall, B. R., Cannon, A., Atri, P., Wichman, C. S., Smith, L. M., Kumar, S., Batra, S. K., Wang, H., Ganti, A. K., Sasson, A. R. & Are, C., Feb 1 2020, In : Annals of surgery. 271, 2, p. 296-302 7 p.

Research output: Contribution to journalArticle

Survival Analysis
Adenocarcinoma
Mortality
Research
Neoplasms

A phase I study of weekly doxorubicin and oral topotecan for patients with relapsed or refractory small cell lung cancer (SCLC): A Fred and Pamela Buffet Cancer Center Clinical Trials Network study

Ernani, V., Jahan, R., Smith, L. M., Marr, A. S., Kimbrough, S. E., Kos, M. E., Tijerina, J., Pivovar, S., Lakshmanan, I., Ketcham, M., Rauth, S., Mallya, K., Nasser, M. W., Jain, M., Kessinger, A., Batra, S. K. & Ganti, A. K., 2020, In : Cancer Treatment and Research Communications. 22, 100162.

Research output: Contribution to journalArticle

Open Access
Topotecan
Small Cell Lung Carcinoma
Doxorubicin
Clinical Trials
Neoplasms

Poisson cokriging as a generalized linear mixed model

Smith, L. M., Stroup, W. W. & Marx, D. B., Mar 2020, In : Spatial Statistics. 35, 100399.

Research output: Contribution to journalArticle

Open Access
Cokriging
Generalized Linear Mixed Model
Siméon Denis Poisson
Auxiliary Variables
Poisson distribution
2019
3 Citations (Scopus)
Radiotherapy
Survival
Adjuvant Chemotherapy
Confidence Intervals
Therapeutics
3 Citations (Scopus)

Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists

Bailey, K. L., Smith, L. M., Heires, A. J., Katafiasz, D. M., Romberger, D. & LeVan, T. D., Sep 1 2019, In : Aging Clinical and Experimental Research. 31, 9, p. 1185-1193 9 p.

Research output: Contribution to journalArticle

Innate Immunity
Toll-Like Receptors
Sepsis
Toll-Like Receptor 2
Toll-Like Receptor 4
1 Citation (Scopus)
Open Access
Non-Small Cell Lung Carcinoma
Survival
Therapeutics
Multivariate Analysis
Databases

Cash transfers and HIV/HSV-2 prevalence: A replication of a cluster randomized trial in Malawi

Smith, L. M., Hein, N. A. & Bagenda, D., Jan 2019, In : PloS one. 14, 1, e0210405.

Research output: Contribution to journalArticle

Human herpesvirus 2
Malawi
Human Herpesvirus 2
Viruses
HIV

Evaluating the decisions of glioma patients regarding clinical trial participation: a retrospective single provider review

Jirka, G. W., Bisselou, K. S. M., Smith, L. M. & Shonka, N., Apr 1 2019, In : Medical Oncology. 36, 4, 34.

Research output: Contribution to journalArticle

Glioma
Clinical Trials
Glioblastoma
Telemedicine
Marital Status

Factors Predictive of Reoperation After Pancreaticoduodenectomy for Pancreatic Cancer

Hall, B. R., Sleightholm, R., Smith, L., Sayles, H. & Are, C., Jan 1 2019, In : Indian Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Pancreaticoduodenectomy
Operating Rooms
Pancreatic Neoplasms
Reoperation
Pylorus

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Monomeric GTP-Binding Proteins
Prostatic Neoplasms
Mevalonic Acid
zoledronic acid
2 Citations (Scopus)

HPV status and survival in non-oropharyngeal squamous cell carcinoma of the head and neck

Wookey, V. B., Appiah, A. K., Kallam, A., Ernani, V., Smith, L. M. & Ganti, A. K., Apr 2019, In : Anticancer Research. 39, 4, p. 1907-1914 8 p.

Research output: Contribution to journalArticle

Survival
Nasopharynx
Gingiva
Lip
Mouth Floor
4 Citations (Scopus)

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Adenocarcinoma
Mucins
Unfolded Protein Response
Terpenes
Dust
Zinc
Pneumonia
Macrophages
Nutrition
2 Citations (Scopus)
Farnesyltranstransferase
Triazoles
Terpenes
Diphosphonates
Alkenes
2 Citations (Scopus)

L-type cav 1.2 calcium channel-a-1C regulates response to rituximab in diffuse large B-cell lymphoma

Zhang, J. Y., Zhang, P. P., Zhou, W. P., Yu, J. Y., Yao, Z. H., Chu, J. F., Yao, S. N., Wang, C., Lone, W., Xia, Q. X., Ma, J., Yang, S. J., Liu, K. D., Dong, Z. G., Guo, Y. J., Smith, L. M., McKeithan, T. W., Chan, W. C., Iqbal, J. & Liu, Y. Y., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 4168-4178 11 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Calcium Channels
Vincristine
Prednisone
Doxorubicin

Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Yuan, J., Li, S., Liu, X., Su, R. J., Chen, M., Wu, X., Zheng, G., Smith, L. M., Wang, L., Li, Y., Liu, C., Zhou, J., Shen, Q., Zhang, L., Wang, E., Xu, M. L. & Pan, Z., Jul 5 2019, In : American journal of clinical pathology. 152, 2, p. 132-145 14 p.

Research output: Contribution to journalArticle

Open Access
Mantle-Cell Lymphoma
Growth
Cyclin D1
Cell Biology
Lymph Nodes
8 Citations (Scopus)

Morbidity and Mortality Rates Following Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy Compared With Other High-Risk Surgical Oncology Procedures

Foster, J. M., Sleightholm, R., Patel, A., Shostrom, V., Hall, B., Neilsen, B., Bartlett, D. & Smith, L., Jan 4 2019, In : JAMA Network Open. 2, 1, p. e186847

Research output: Contribution to journalArticle

Open Access
Hepatectomy
Esophagectomy
Morbidity
Drug Therapy
Mortality
1 Citation (Scopus)

n-3 Docosapentaenoic Acid Intake and Relationship with Plasma Long-Chain n-3 Fatty Acid Concentrations in the United States: NHANES 2003–2014

Richter, C. K., Bisselou, K. S., Nordgren, T. M., Smith, L., Appiah, A. K., Hein, N., Anderson-Berry, A., Kris-Etherton, P., Hanson, C. & Skulas-Ray, A. C., Apr 2019, In : Lipids. 54, 4, p. 221-230 10 p.

Research output: Contribution to journalArticle

Nutrition Surveys
Omega-3 Fatty Acids
Nutrition
Eicosapentaenoic Acid
Health
6 Citations (Scopus)

No survival advantage exists for patients undergoing loop ileostomy for clostridium difficile colitis

Hall, B. R., Leinicke, J. A., Armijo, P. R., Smith, L. M., Langenfeld, S. J. & Oleynikov, D., Jan 2019, In : American journal of surgery. 217, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Ileostomy
Clostridium difficile
Colitis
Colectomy
Survival
7 Citations (Scopus)

Omega-3 fatty acid intake by age, gender, and pregnancy status in the United States: National health and nutrition examination survey 2003–2014

Thompson, M., Hein, N., Hanson, C. K., Smith, L. M., Anderson Berry, A. L., Richter, C. K., Bisselou, K. S., Appiah, A. K., Kris-Etherton, P., Skulas-Ray, A. C. & Nordgren, T. M., Jan 1 2019, In : Nutrients. 11, 1, 177.

Research output: Contribution to journalArticle

National Health and Nutrition Examination Survey
Nutrition Surveys
Omega-3 Fatty Acids
omega-3 fatty acids
pregnancy
2 Citations (Scopus)

Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma

Umakanthan, J. M., Iqbal, J., Batlevi, C. L., Bouska, A., Smith, L. M., Shostrom, V., Nutsch, H., William, B. M., Bociek, R. G., Lunning, M. A., Bierman, P. J., Younes, A., Armitage, J. O. & Vose, J. M., Mar 2019, In : British Journal of Haematology. 184, 5, p. 744-752 9 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Follicular Lymphoma
Peripheral T-Cell Lymphoma
Mutation
Lymphoma, Large B-Cell, Diffuse

Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer

Leiphrakpam, P. D., Lazenby, A. J., Chowdhury, S., Smith, L. M., Mathiesen, M., Brattain, M. G., Wang, J., Black, J. D. & Are, C., Jan 1 2019, (Accepted/In press) In : Journal of Surgical Oncology. 121, 3, p. 547-560 14 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Therapeutics
Somatomedin Receptors
sodium-hydrogen exchanger regulatory factor
Cell Survival

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Histone Deacetylases
Pancreatic Neoplasms
Adenocarcinoma
Histone Deacetylase Inhibitors
1 Citation (Scopus)
Open Access
Cryosurgery
Electrocoagulation
Non-Small Cell Lung Carcinoma
Lasers
Radiotherapy

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer

Jahan, R., Ganguly, K., Smith, L. M., Atri, P., Carmicheal, J., Sheinin, Y., Rachagani, S., Natarajan, G., Brand, R. E., Macha, M. A., Grandgenett, P. M., Kaur, S. & Batra, S. K., Apr 2019, In : EBioMedicine. 42, p. 375-385 11 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Early Detection of Cancer
Chronic Pancreatitis
Biomarkers
Tissue
2018
5 Citations (Scopus)

Abnormal T cell frequencies, including cytomegalovirus - Associated expansions, distinguish seroconverted subjects at risk for type 1 diabetes

Harms, R. Z., Lorenzo-Arteaga, K. M., Ostlund, K. R., Smith, V. B., Smith, L. M., Gottlieb, P. & Sarvetnick, N. E., Oct 22 2018, In : Frontiers in immunology. 9, OCT, 2332.

Research output: Contribution to journalArticle

Cytomegalovirus
Type 1 Diabetes Mellitus
T-Lymphocytes
Autoantibodies
T-Lymphocyte Subsets
7 Citations (Scopus)

Advanced pancreatic cancer: A meta-analysis of clinical trials over thirty years

Hall, B. R., Cannon, A., Atri, P., Wichman, C. S., Smith, L. M., Ganti, A. K. P., Are, C., Sasson, A. R., Kumar, S. & Batra, S. K., Apr 10 2018, In : Oncotarget. 9, 27, p. 19396-19405 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Meta-Analysis
gemcitabine
Clinical Trials
Adenocarcinoma
1 Citation (Scopus)

A Simple and Effective Method for Flow Cytometric Study of Lymphoid Malignancies Using Needle Core Biopsy Specimens

Chi, P. D., Freed, N. S., Wake, L., Page, C., Smith, L. M., Amador, C., Naushad Qureishi, H., Greiner, T. C., Rodig, S. J., Pirruccello, S. J., Yuan, J. & Fu, K., Sep 2018, In : Cytometry Part B - Clinical Cytometry. 94, 5, p. 637-643 7 p.

Research output: Contribution to journalArticle

Large-Core Needle Biopsy
Suspensions
Flow Cytometry
Neoplasms
Needle Biopsy
2 Citations (Scopus)

Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway

Jahan, R., Macha, M. A., Rachagani, S., Das, S., Smith, L. M., Kaur, S. & Batra, S. K., Aug 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 8, p. 2538-2549 12 p.

Research output: Contribution to journalArticle

Mucin-4
MAP Kinase Signaling System
Integrins
Pancreatic Neoplasms
Phenotype
12 Citations (Scopus)

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D. R., Ouellette, M. M., Batra, S. K. & Palanimuthu Ponnusamy, M., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Smoke
Tobacco Products
Stem Cells
Nicotine
7 Citations (Scopus)

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Chugh, S., Barkeer, S., Rachagani, S., Nimmakayala, R. K., Perumal, N., Pothuraju, R., Atri, P., Mahapatra, S., Thapa, I., Talmon, G. A., Smith, L. M., Yu, X., Neelamegham, S., Fu, J., Xia, L., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 2018, In : Gastroenterology. 155, 5, p. 1608-1624 17 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
Genes
Polysaccharides
Lectins
4 Citations (Scopus)

Driving safety and real-time glucose monitoring in insulin-dependent diabetes

Merickel, J., High, R., Smith, L., Wichman, C., Frankel, E., Smits, K., Drincic, A., Desouza, C., Gunaratne, P., Ebe, K. & Rizzo, M., Jan 1 2018, In : International Journal of Automotive Engineering. 10, 1, p. 34-40 7 p.

Research output: Contribution to journalArticle

Insulin
Medical problems
chronic illness
Glucose
driver
5 Citations (Scopus)

Effect of increasing doses of vitamin D on bone mineral density and serum N-terminal telopeptide in elderly women: a randomized controlled trial

Smith, L. M., Gallagher, J. C., Kaufmann, M. & Jones, G., Dec 2018, In : Journal of Internal Medicine. 284, 6, p. 685-693 9 p.

Research output: Contribution to journalArticle

Vitamin D
Bone Density
Randomized Controlled Trials
Cholecalciferol
Serum

Follicular large cleaved cell (centrocytic) lymphoma: an unrecognized variant of follicular lymphoma

El Behery, R., Laurini, J. A., Weisenburger, D. D., Smith, L. M., Dave, B. J., Yuan, J., Fu, K., Chan, W. C., Nathwani, B. N., Bierman, P. J., Bociek, R. G., Vose, J. M., Armitage, J. O., Greiner, T. C. & Aoun, P., Feb 2018, In : Human Pathology. 72, p. 180-190 11 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Lymphoma
Anthracyclines
Chromatin
Cytoplasm
4 Citations (Scopus)

Global curriculum in research literacy for the surgical oncologist

Are, C., Yanala, U., Malhotra, G., Hall, B., Smith, L. M., Cummings, C., Lecoq, C., Wyld, L., Audisio, R. A. & Berman, R. S., Jan 2018, In : European Journal of Surgical Oncology. 44, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

Curriculum
Research
Neoplasms
Oncologists
Literacy
4 Citations (Scopus)

Global Curriculum in Research Literacy for the Surgical Oncologist

Are, C., Yanala, U., Malhotra, G., Hall, B., Smith, L. M., Wyld, L., Cummings, C., Lecoq, C., Audisio, R. A. & Berman, R. S., Mar 1 2018, In : Annals of Surgical Oncology. 25, 3, p. 604-616 13 p.

Research output: Contribution to journalArticle

Curriculum
Research
Neoplasms
Evidence-Based Practice
Oncologists
4 Citations (Scopus)

Global variations in the level of cancer-related research activity and correlation to cancer-specific mortality: Proposal for a global curriculum

Are, C., Caniglia, A., Malik, M., Smith, L. M., Cummings, C., Lecoq, C., Berman, R., Audisio, R. & Wyld, L., Jan 2018, In : European Journal of Surgical Oncology. 44, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Curriculum
Mortality
Research
Neoplasms
Geographic Locations
2 Citations (Scopus)

Global Variations in the Level of Cancer-Related Research Activity and Correlation to Cancer-Specific Mortality: Proposal for a Global Curriculum

Are, C., Caniglia, A., Mohammed, M., Smith, L. M., Cummings, C., Lecoq, C., Berman, R., Audisio, R. & Wyld, L., Mar 1 2018, In : Annals of Surgical Oncology. 25, 3, p. 594-603 10 p.

Research output: Contribution to journalArticle

Curriculum
Mortality
Research
Neoplasms
Geographic Locations
1 Citation (Scopus)
Fee-for-Service Plans
Medicaid
Hospital Emergency Service
Tooth
Dentists
2 Citations (Scopus)

Preoperative pulmonary function tests (PFTs) and outcomes from resected early stage non-small cell lung cancer (NSCLC)

Almquist, D., Khanal, N., Smith, L. M. & Ganti, A. K. P., May 2018, In : Anticancer Research. 38, 5, p. 2903-2907 5 p.

Research output: Contribution to journalArticle

Respiratory Function Tests
Non-Small Cell Lung Carcinoma
Length of Stay
Survival
Forced Expiratory Volume

Safety of long-term anticoagulation in patients with brain metastases

Horstman, H., Gruhl, J., Smith, L. M., Ganti, A. K. P. & Shonka, N. A., Apr 1 2018, In : Medical Oncology. 35, 4, 43.

Research output: Contribution to journalArticle

Intracranial Hemorrhages
Neoplasm Metastasis
Safety
Brain
Anticoagulants
1 Citation (Scopus)

Short term dynamics of the sputum microbiome among COPD patients

Sinha, R., Weissenburger-Moser, L. A., Clarke, J. L., Smith, L. M., Heires, A. J., Romberger, D. & LeVan, T. D., Mar 2018, In : PloS one. 13, 3, e0191499.

Research output: Contribution to journalArticle

Pulmonary diseases
Microbiota
Sputum
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
3 Citations (Scopus)

The Relationship Between Age and Chronic Kidney Disease in Patients Undergoing Pancreatic Resection

Antoniak, D., Are, C., Vokoun, C. W., Samson, K., Smith, L. M. & Shiffermiller, J., Aug 1 2018, In : Journal of Gastrointestinal Surgery. 22, 8, p. 1376-1384 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Odds Ratio
Pancreatectomy
Confidence Intervals
Mortality
2017
24 Citations (Scopus)

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

Kaur, S., Smith, L. M., Patel, A., Menning, M., Watley, D. C., Malik, S. S., Krishn, S. R., Mallya, K., Aithal, A., Sasson, A. R., Johansson, S. L., Jain, M., Singh, S., Guha, S., Are, C., Raimondo, M., Hollingsworth, M. A., Brand, R. E. & Batra, S. K., Jan 1 2017, In : American Journal of Gastroenterology. 112, 1, p. 172-183 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Multicenter Studies
Chronic Pancreatitis
Mucins
Radioimmunoassay
2 Citations (Scopus)

A double-blind, placebo-controlled randomized trial of vilazodone in the treatment of posttraumatic stress disorder and comorbid depression

Ramaswamy, S., Driscoll, D., Reist, C., Smith, L. M., Albers, L. J., Rose, J., Nguyen, L., Monga, V., Doria, R. & Hollifield, M., Jan 1 2017, In : Primary Care Companion to the Journal of Clinical Psychiatry. 19, 4, 17m02138.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
Randomized Controlled Trials
Placebos
Depression
Outcome Assessment (Health Care)
Veterans Hospitals
Insulin
Hospitalization
Hypoglycemia
Veterans
3 Citations (Scopus)

Characteristics of urban male homeless veterans and non-veterans in Omaha, Nebraska

Ramaswamy, S., Driscoll, D., Tsai, J., Rose, J., Smith, L. M. & Rosenheck, R. A., Mar 21 2017, In : Journal of Social Distress and the Homeless. 26, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

psychosocial factors
agglomeration area
housing
staff
interview
4 Citations (Scopus)

Chemoradiotherapy for locally advanced squamous cell carcinoma of the oropharynx: Does completion of systemic therapy affect outcomes?

Baine, M., Dorius, T., Bennion, N., Alam, M., Smith, L. M., Zhen, W. & Ganti, A. K. P., Oct 2017, In : Oral Oncology. 73, p. 105-110 6 p.

Research output: Contribution to journalArticle

Oropharynx
Chemoradiotherapy
Squamous Cell Carcinoma
Therapeutics
Cisplatin
3 Citations (Scopus)

Epistatic effect of TLR-1,-6 and-10 polymorphisms on organic dust-mediated cytokine response

Smith, L. M., Weissenburger-Moser, L. A., Heires, A. J., Bailey, K. L., Romberger, D. & LeVan, T. D., Mar 1 2017, In : Genes and Immunity. 18, 2, p. 67-74 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 6
Toll-Like Receptor 1
Dust
Cytokines
Multigene Family
13 Citations (Scopus)

Frequency of MYD88 and CD79B mutations, and MGMT methylation in primary central nervous system diffuse large B-cell lymphoma

Zheng, M., Perry, A. M., Bierman, P. J., Loberiza, F., Nasr, M. R., Szwajcer, D., Del Bigio, M. R., Smith, L. M., Zhang, W. & Greiner, T. C., Dec 2017, In : Neuropathology. 37, 6, p. 509-516 8 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Methylation
Central Nervous System
Mutation
Survival