Lynell Warren Klassen, MD

Professor

  • 4659 Citations
  • 36 h-Index
1972 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020
2019
3 Scopus citations

Malondialdehyde–Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis–Associated Interstitial Lung Disease

England, B. R., Duryee, M. J., Roul, P., Mahajan, T. D., Singh, N., Poole, J. A., Ascherman, D. P., Caplan, L., Demoruelle, M. K., Deane, K. D., Klassen, L. W., Thiele, G. M. & Mikuls, T. R., Sep 1 2019, In : Arthritis and Rheumatology. 71, 9, p. 1483-1493 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology

Khadge, S., Sharp, J. G., Thiele, G. M., McGuire, T. R., Klassen, L. W., Duryee, M. J., Britton, H. C., Dafferner, A. J., Beck, J., Black, P. N., DiRusso, C. C. & Talmadge, J. E., Feb 2018, In : Journal of Nutritional Biochemistry. 52, p. 92-102 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation

Duryee, M. J., Wiese, B. M., Bowman, J. R., Vanlandingham, J. D., Klassen, L. W., Thiele, G. E., Hunter, C. D., Anderson, D. R., Mikuls, T. R. & Thiele, G. M., Mar 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 3, p. G418-G430

Research output: Contribution to journalArticle

7 Scopus citations
2 Scopus citations
4 Scopus citations

Novel antioxidant properties of doxycycline

Clemens, D. L., Duryee, M. J., Sarmiento, C., Chiou, A., McGowan, J. D., Hunter, C. D., Schlichte, S. L., Tian, J., Klassen, L. W., O'Dell, J. R., Thiele, G. M., Mikuls, T. R., Zimmerman, M. C. & Anderson, D. R., Jan 1 2018, In : International journal of molecular sciences. 19, 12, 4078.

Research output: Contribution to journalArticle

5 Scopus citations
2017
14 Scopus citations

Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint

Mikuls, T. R., Duryee, M. J., Rahman, R., Anderson, D. R., Sayles, H. R., Hollins, A., Michaud, K. D., Wolfe, F., Thiele, G. E., Sokolove, J., Robinson, W. H., Lingampalli, N., Nicholas, A. P., Talmon, G. A., Su, K., Zimmerman, M. C., Klassen, L. W. & Thiele, G. M., Oct 1 2017, In : Rheumatology (Oxford, England). 56, 10, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
3 Scopus citations

Systemic IL-6 effector response in mediating systemic bone loss following inhalation of organic dust

Wells, A., Romberger, D., Thiele, G. M., Wyatt, T. A., Staab, E., Heires, A. J., Klassen, L. W., Duryee, M. J., Mikuls, T. R., Dusad, A., West, W. W., Wang, D. & Poole, J. A., Jan 1 2017, In : Journal of Interferon and Cytokine Research. 37, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Autoantibodies from Single Circulating Plasmablasts React with Citrullinated Antigens and Porphyromonas gingivalis in Rheumatoid Arthritis

Li, S., Yu, Y., Yue, Y., Liao, H., Xie, W., Thai, J., Mikuls, T. R., Thiele, G. M., Duryee, M. J., Sayles, H., Payne, J. B., Klassen, L. W., O'Dell, J. R., Zhang, Z. & Su, K., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 614-626 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Toll-like receptor 4 signaling pathway mediates inhalant organic dust-induced bone loss

Staab, E., Thiele, G. M., Clarey, D., Wyatt, T. A., Romberger, D., Wells, A. D., Dusad, A., Wang, D., Klassen, L. W., Mikuls, T. R., Duryee, M. J. & Poole, J. A., Aug 1 2016, In : PloS one. 11, 8, e0158735.

Research output: Contribution to journalArticle

4 Scopus citations
2015
8 Scopus citations

Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation

Yu, Y., Koehn, C. D., Yue, Y., Li, S., Thiele, G. M., Hearth-Holmes, M. P., Mikuls, T. R., O’Dell, J. R., Klassen, L. W., Zhang, Z. & Su, K., Jan 1 2015, In : Current Molecular Medicine. 15, 4, p. 401-410 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis

Thiele, G. M., Duryee, M. J., Anderson, D. R., Klassen, L. W., Mohring, S. M., Young, K. A., Benissan-Messan, D., Sayles, H., Dusad, A., Hunter, C. D., Sokolove, J., Robinson, W. H., O'Dell, J. R., Nicholas, A. P., Tuma, D. J. & Mikuls, T. R., Mar 1 2015, In : Arthritis and Rheumatology. 67, 3, p. 645-655 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice

Dusad, A., Thiele, G. M., Klassen, L. W., Wang, D., Duryee, M. J., Mikuls, T. R., Staab, E. B., Wyatt, T. A., West, W. W., Reynolds, S. J., Romberger, D. & Poole, J. A., May 1 2015, In : Immunologic Research. 62, 1, p. 46-59 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant

Dusad, A., Duryee, M. J., Shaw, A. T., Klassen, L. W., Anderson, D. R., Wang, D., Ren, K., Gravallese, E. M., O'Dell, J. R., Mikuls, T. R. & Thiele, G. M., Jan 1 2014, In : Immunologic Research. 58, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
11 Scopus citations

Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease

Anderson, D. R., Duryee, M. J., Shurmur, S. W., Um, J. Y., Bussey, W. D., Hunter, C. D., Garvin, R. P., Sayles, H. R., Mikuls, T. R., Klassen, L. W. & Thiele, G. M., Sep 1 2014, In : PloS one. 9, 9, 0107440.

Research output: Contribution to journalArticle

27 Scopus citations
2013

IL-6 and its receptors in coronary artery disease and acute myocardial infarction

Anderson, D. R., Poterucha, J. T., Mikuls, T. R., Duryee, M. J., Garvin, R. P., Klassen, L. W., Shurmur, S. W. & Thiele, G. M., Jun 1 2013, In : Cytokine. 62, 3, p. 395-400 6 p.

Research output: Contribution to journalArticle

45 Scopus citations
17 Scopus citations

Polyclonal antibody to soman-tyrosine

Li, B., Duysen, E. G., Froment, M. T., Masson, P., Nachon, F., Jiang, W., Schopfer, L. M., Thiele, G. M., Klassen, L. W., Cashman, J., Williams, G. R. & Lockridge, O., Apr 15 2013, In : Chemical Research in Toxicology. 26, 4, p. 584-592 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

A method for the making and utility of gadolinium-labeled albumin microbubbles

Anderson, D. R., Duryee, M. J., Garvin, R. P., Boska, M. D., Thiele, G. M. & Klassen, L. W., Jan 1 2012, In : Magnetic Resonance Imaging. 30, 1, p. 96-103 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
16 Scopus citations

High-pressure distention of the saphenous vein during preparation results in increased markers of inflammation: A potential mechanism for graft failure

Khaleel, M. S., Dorheim, T. A., Duryee, M. J., Durbin, H. E., Bussey, W. D., Garvin, R. P., Klassen, L. W., Thiele, G. M. & Anderson, D. R., Feb 1 2012, In : Annals of Thoracic Surgery. 93, 2, p. 552-558 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Ultrasound Imaging in an Animal Model of Vascular Inflammation Following Balloon Injury

Garvin, R. P., Duryee, M. J., Klassen, L. W., Thiele, G. M. & Anderson, D. R., Sep 1 2012, In : Ultrasound in Medicine and Biology. 38, 9, p. 1552-1558 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2010

Albumin-based microbubbles bind up-regulated scavenger receptors following vascular injury

Anderson, D. R., Duryee, M. J., Anchan, R. K., Garvin, R. P., Johnston, M. D., Porter, T. R., Thiele, G. M. & Klassen, L. W., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52, p. 40645-40653 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites

Thiele, G. M., Duryee, M. J., Willis, M. S., Tuma, D. J., Radio, S. J., Hunter, C. D., Schaffert, C. S. & Klassen, L. W., Dec 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 12, p. 2126-2136 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis

Schaffert, C. S., Duryee, M. J., Bennett, R. G., DeVeney, A. L., Tuma, D. J., Olinga, P., Easterling, K. C., Thiele, G. M. & Klassen, L. W., Sep 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 3, p. G661-G668

Research output: Contribution to journalArticle

19 Scopus citations

Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis

Duryee, M. J., Klassen, L. W., Schaffert, C. S., Tuma, D. J., Hunter, C. D., Garvin, R. P., Anderson, D. R. & Thiele, G. M., Nov 30 2010, In : Free Radical Biology and Medicine. 49, 10, p. 1480-1486 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
2009

Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease

Schaffert, C. S., Duryee, M. J., Hunter, C. D., Hamilton, B. C., DeVeney, A. L., Hueter, M. M., Klassen, L. W. & Thiele, G. M., Mar 14 2009, In : World Journal of Gastroenterology. 15, 10, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
2008

An in vitro method of alcoholic liver injury using precision-cut liver slices from rats

Klassen, L. W., Thiele, G. M., Duryee, M. J., Schaffert, C. S., DeVeney, A. L., Hunter, C. D., Olinga, P. & Tuma, D. J., Aug 1 2008, In : Biochemical Pharmacology. 76, 3, p. 426-436 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde

Duryee, M. J., Klassen, L. W., Jones, B. L., Willis, M. S., Tuma, D. J. & Thiele, G. M., Aug 1 2008, In : International Immunopharmacology. 8, 8, p. 1112-1118 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2007

Immunological response in alcoholic liver disease

Duryee, M. J., Klassen, L. W. & Thiele, G. M., Oct 7 2007, In : World Journal of Gastroenterology. 13, 37, p. 4938-4946 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2005

Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines

Freeman, T. L., Haver, A., Duryee, M. J., Tuma, D. J., Klassen, L. W., Hamel, F. G., White, R. L., Rennard, S. I. & Thiele, G. M., May 1 2005, In : Chemical Research in Toxicology. 18, 5, p. 817-824 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Halothane potentiates the alcohol-adduct induced TNF-alpha release in heart endothelial cells

Thiele, G. M., Hill, G. E., Pavlik, J. A., Freeman, T. L., Tuma, D. J., Duryee, M. J. & Klassen, L. W., Apr 12 2005, In : BMC Anesthesiology. 5, 3.

Research output: Contribution to journalArticle

1 Scopus citations

Modulation of oxidative stress by alcohol

Zima, T., Albano, E., Ingelman-Sundberg, M., Arteel, G. E., Thiele, G. M., Klassen, L. W. & Sun, A. Y., Jun 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 6, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
30 Scopus citations

Recent advances in alcohol-induced adduct formation

Freeman, T. L., Tuma, D. J., Thiele, G. M., Klassen, L. W., Worrall, S., Niemelä, O., Parkkila, S., Emery, P. W. & Preedy, V. R., Jul 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 7, p. 1310-1316 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins

Duryee, M. J., Freeman, T. L., Willis, M. S., Hunter, C. D., Hamilton, B. C., Suzuki, H., Tuma, D. J., Klassen, L. W. & Thiele, G. M., Nov 1 2005, In : Molecular pharmacology. 68, 5, p. 1423-1430 8 p.

Research output: Contribution to journalArticle

39 Scopus citations
2004
48 Scopus citations

Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage

Willis, M. S., Klassen, L. W., Carlson, D. L., Brouse, C. F. & Thiele, G. M., Jul 1 2004, In : International Immunopharmacology. 4, 7, p. 885-899 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

N-(methylamino)isobutyric acid inhibits proliferation of CFSC-2C hepatic stellate cells

Freeman, T. L., Thiele, G. M., Klassen, L. W., Klassen, B. T. & Mailliard, M. E., Jul 15 2004, In : Biochemical Pharmacology. 68, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

2003

Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells

Duryee, M. J., Klassen, L. W., Freeman, T. L., Willis, M. S., Tuma, D. J. & Thiele, G. M., Sep 15 2003, In : Biochemical Pharmacology. 66, 6, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated

Willis, M. S., Thiele, G. M., Tuma, D. J. & Klassen, L. W., Oct 2003, In : International Immunopharmacology. 3, 10-11, p. 1381-1399 19 p.

Research output: Contribution to journalArticle

34 Scopus citations
2002
46 Scopus citations
11 Scopus citations