Lynell Warren Klassen, MD

Professor

  • 4659 Citations
  • 36 h-Index
1972 …2021

Research output per year

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Research Output

2005

Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins

Duryee, M. J., Freeman, T. L., Willis, M. S., Hunter, C. D., Hamilton, B. C., Suzuki, H., Tuma, D. J., Klassen, L. W. & Thiele, G. M., Nov 1 2005, In : Molecular pharmacology. 68, 5, p. 1423-1430 8 p.

Research output: Contribution to journalArticle

39 Scopus citations
2004

Immunologic mechanisms of alcoholic liver injury

Thiele, G. M., Freeman, T. L. & Klassen, L. W., Aug 1 2004, In : Seminars in liver disease. 24, 3, p. 273-287 15 p.

Research output: Contribution to journalReview article

76 Scopus citations
48 Scopus citations

Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage

Willis, M. S., Klassen, L. W., Carlson, D. L., Brouse, C. F. & Thiele, G. M., Jul 1 2004, In : International Immunopharmacology. 4, 7, p. 885-899 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.

Duryee, M. J., Willis, M. S., Freeman, T. L., Kuszynski, C. A., Tuma, D. J., Klassen, L. W. & Thiele, G. M., Sep 1 2004, In : Frontiers in bioscience : a journal and virtual library. 9, p. 3145-3155 11 p.

Research output: Contribution to journalReview article

23 Scopus citations

N-(methylamino)isobutyric acid inhibits proliferation of CFSC-2C hepatic stellate cells

Freeman, T. L., Thiele, G. M., Klassen, L. W., Klassen, B. T. & Mailliard, M. E., Jul 15 2004, In : Biochemical Pharmacology. 68, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

2003

Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells

Duryee, M. J., Klassen, L. W., Freeman, T. L., Willis, M. S., Tuma, D. J. & Thiele, G. M., Sep 15 2003, In : Biochemical Pharmacology. 66, 6, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated

Willis, M. S., Thiele, G. M., Tuma, D. J. & Klassen, L. W., Oct 2003, In : International Immunopharmacology. 3, 10-11, p. 1381-1399 19 p.

Research output: Contribution to journalArticle

34 Scopus citations
2002
46 Scopus citations
11 Scopus citations

Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells

Willis, M. S., Klassen, L. W., Tuma, D. J. & Thiele, G. M., Mar 5 2002, In : International Immunopharmacology. 2, 4, p. 519-535 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: Results of a two-year, randomized, double-blind, placebo-controlled trial

O'Dell, J. R., Leff, R., Paulsen, G., Haire, C., Mallek, J., Eckhoff, P. J., Fernandez, A., Blakely, K., Wees, S., Stoner, J., Hadley, S., Felt, J., Palmer, W., Waytz, P., Churchill, M., Klassen, L. & Moore, G., May 28 2002, In : Arthritis and rheumatism. 46, 5, p. 1164-1170 7 p.

Research output: Contribution to journalArticle

250 Scopus citations
2001

Elucidation of reaction scheme describing malondialdehyde - Acetaldehyde - Protein adduct formation

Tuma, D. J., Kearley, M. L., Thiele, G. M., Worrall, S., Haver, A., Klassen, L. W. & Sorrell, M. F., Jul 30 2001, In : Chemical Research in Toxicology. 14, 7, p. 822-832 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Intensive immunoablation and autologous blood stem cell transplantation in patients with refractory rheumatoid arthritis: The University of Nebraska experience

Pavletic, S. Z., O'Dell, J. R., Pirruccello, S. J., Ursick, M. M., Haire, C. E., Sharp, J. G., Kessinger, A. & Klassen, L. W., Jan 1 2001, In : Journal of Rheumatology. 28, SUPPL. 64, p. 13-20 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2 Scopus citations

The chemistry and biological effects of malondialdehyde-acetaldehyde adducts

Thiele, G. M., Worrall, S., Tuma, D. J., Klassen, L. W., Wyatt, T. A. & Nagata, N., Jun 27 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 218S-224S

Research output: Contribution to journalArticle

40 Scopus citations

Treatment of early seropositive rheumatoid arthritis: A two-year, double-blind comparison of minocycline and hydroxychloroquine

O'Dell, J. R., Blakely, K. W., Mallek, J. A., Eckhoff, P. J., Leff, R. D., Wees, S. J., Sems, K. M., Fernandez, A. M., Palmer, W. R., Klassen, L. W., Paulsen, G. A., Haire, C. E. & Moore, G. F., Oct 29 2001, In : Arthritis and rheumatism. 44, 10, p. 2235-2241 7 p.

Research output: Contribution to journalArticle

112 Scopus citations

Treatment of relapse after autologous blood stem cell transplantation for severe rheumatoid arthritis

Pavletic, S. Z., Klassen, L. W., Pope, R., O'Dell, J. R., Traynor, A. E., Haire, C. E., Graziano, F., Schuening, F., Oyama, Y., Barr, W. & Burt, R. K., Jan 1 2001, In : Journal of Rheumatology. 28, SUPPL. 64, p. 28-31 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
2000

Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease

Rolla, R., Vay, D., Mottaran, E., Parodi, M., Traverso, N., Aricó, S., Sartori, M., Bellomo, G., Klassen, L. W., Thiele, G. M., Tuma, D. J. & Albano, E., Jan 1 2000, In : Hepatology. 31, 4, p. 878-884 7 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations
1999

Combination therapy in rheumatoid arthritis: A comment [2]

O'Dell, J. R., Moore, G. F. & Klassen, L. W., Nov 9 1999, In : Rheumatology. 38, 6, 1 p.

Research output: Contribution to journalLetter

6 Scopus citations

Immune reactivity to proteins biotransformed by alcohol metabolites

Klassen, L. W. & Thiele, G. M., Dec 1 1999, In : Alcoholism: Clinical and Experimental Research. 23, 5 SUPPL., p. 204S-207S

Research output: Contribution to journalArticle

1 Scopus citations

Treatment of early seropositive rheumatoid arthritis with minocycline: Four-year followup of a double-blind, placebo-controlled trial

O'Dell, J. R., Paulsen, G., Haire, C. E., Blakely, K., Palmer, W., Wees, S., Eckhoff, P. J., Klassen, L. W., Churchill, M., Doud, D., Weaver, A. & Moore, G. F., Aug 1 1999, In : Arthritis and rheumatism. 42, 8, p. 1691-1695 5 p.

Research output: Contribution to journalArticle

95 Scopus citations
1998

Association of malondialdehyde-acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injury

Hill, G. E., Miller, J. A., Baxter, B. T., Klassen, L. W., Duryee, M. J., Tuma, D. J. & Thiele, G. M., Oct 5 1998, In : Atherosclerosis. 141, 1, p. 107-116 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats

Xu, D., Thiele, G. M., Beckenhauer, J. L., Klassen, L. W., Sorrell, M. F. & Tuma, D. J., Jan 1 1998, In : Gastroenterology. 115, 3, p. 686-692 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

HLA-DRB1 typing in rheumatoid arthritis: Predicting response to specific treatments

O'Dell, J. R., Nepom, B. S., Haire, C., Gersuk, V. H., Gaur, L., Moore, G. F., Drymalski, W., Palmer, W., Eckhoff, P. J., Klassen, L. W., Wees, S., Thiele, G. M. & Nepom, G. T., Jan 1 1998, In : Annals of the rheumatic diseases. 57, 4, p. 209-213 5 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Immune reactivity to proteins biotransformed by alcohol metabolites

Klassen, L. W. & Thiele, G. M., Aug 1 1998, In : Alcoholism: Clinical and Experimental Research. 22, 5 SUPPL., p. 204S-207S

Research output: Contribution to journalArticle

7 Scopus citations

Monoclonal and polyclonal antibodies recognizing acetaldehyde-protein adducts

Thiele, G. M., Tuma, D. J., Miller, J. A., Wegter, K. M., McDonald, T. L. & Klassen, L. W., Dec 1 1998, In : Biochemical Pharmacology. 56, 11, p. 1515-1523 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant

Thiele, G. M., Tuma, D. J., Willis, M. S., Miller, J. A., McDonald, T. L., Sorrell, M. F. & Klassen, L. W., Nov 1998, In : Alcoholism: Clinical and Experimental Research. 22, 8, p. 1731-1739 9 p.

Research output: Contribution to journalArticle

82 Scopus citations
1997

Epitope characterization of malondialdehyde-acetaldehyde adducts using an enzyme-Linked immunosorbent assay

Xu, D., Thiele, G. M., Kearley, M. L., Haugen, M. D., Klassen, L. W., Sorrell, M. F. & Turna, D. J., Sep 1 1997, In : Chemical Research in Toxicology. 10, 9, p. 978-986 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Treatment of early rheumatoid arthritis with minocycline or placebo: Results of a randomized, double-blind, placebo-controlled trial

O'Dell, J. R., Haire, C. E., Palmer, W., Drymalski, W., Wees, S., Blakely, K., Churchill, M., James Eckhoff, P., Weaver, A., Doud, D., Erikson, N., Dietz, F., Olson, R., Maloley, P., Klassen, L. W. & Moore, G. F., Jan 1 1997, In : Arthritis and rheumatism. 40, 5, p. 842-848 7 p.

Research output: Contribution to journalArticle

138 Scopus citations
1996
190 Scopus citations

Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate

O'Dell, J. R., Haire, C., Erikson, N., Drymalski, W., Palmer, W., Maloley, P., Klassen, L. W., Wees, S. & Moore, G. F., Mar 1 1996, In : Journal of Rheumatology. 23, SUPPL. 44, p. 72-74 3 p.

Research output: Contribution to journalArticle

46 Scopus citations

Intravenous immunoglobulin in rheumatic disease

Klassen, L. W., Calabrese, L. H. & Laxer, R. M., Jan 1 1996, In : Rheumatic Disease Clinics of North America. 22, 1, p. 155-173 19 p.

Research output: Contribution to journalArticle

11 Scopus citations

Long-term ethanol administration alters the degradation of acetaldehyde adducts by liver endothelial cells

Thiele, G. M., Miller, J. A., Klassen, L. W. & Tuma, D. J., Sep 1996, In : Hepatology. 24, 3, p. 643-648 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pneumococcal vaccine in rheumatoid arthritis: Decreased response while taking methotrexate

O'Dell, J. R., Gilg, J., Palmer, W., Haire, C., Klassen, L. & Moore, G., Apr 1 1996, In : Journal of Clinical Rheumatology. 2, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications

O'Dell, J. R., Haire, C. E., Erikson, N., Drymalski, W., Palmer, W., Eckhoff, P. J., Garwood, V., Maloley, P., Klassen, L. W., Wees, S., Klein, H. & Moore, G. F., May 16 1996, In : New England Journal of Medicine. 334, 20, p. 1287-1291 5 p.

Research output: Contribution to journalArticle

578 Scopus citations
1995
34 Scopus citations

Immune mechanisms of alcohol-induced liver disease

Klassen, L. W., Tuma, D. & Sorrell, M. F., Jul 1995, In : Hepatology. 22, 1, p. 355-357 3 p.

Research output: Contribution to journalEditorial

64 Scopus citations

Immunologic Effects of Levamisole in Mice and Humans: Evidence for Augmented Antibody Response Without Modulation of Cellular Cytotoxicity

Tempero, M. A., Haga, Y., Sivinski, C., Birt, D., Klassen, L. & Thiele, G., Jan 1995, In : Journal of Immunotherapy. 17, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
1994

Detection of Reduced Acetaldehyde Protein Adducts Using a Unique Monoclonal Antibody

Klassen, L. W., Tuma, D. J., Sorrell, M. F., McDonald, T. L., DeVasure, J. M. & Thiele, G. M., Feb 1994, In : Alcoholism: Clinical and Experimental Research. 18, 1, p. 164-171 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
14 Scopus citations
1993

Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin

Braddock, S. W., Kay, H. D., Maennle, D., McDonald, T. L., Pirruccello, S. J., Masih, A., Klassen, L. W. & Sawka, A. R., Jan 1 1993, In : Journal of the American Academy of Dermatology. 28, 5, p. 691-695 5 p.

Research output: Contribution to journalArticle

27 Scopus citations
19 Scopus citations

The use of outcome measures to evaluate clinical rheumatology curriculum changes

O'Dell, J. R., Klassen, L. W. & Moore, G. F., Jan 1 1993, In : Journal of Rheumatology. 20, 6, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
1992

Chronic hypervitaminosis A: A case of surreptitious use

Ruskin, J. D., Wendt, S., Klassen, L., Tu, H. K. & Markin, R. S., Jan 1 1992, In : Laboratory medicine. 23, 3, p. 187-189 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Immune responses to acetaldehyde-protein adducts: Role in alcoholic liver disease

Tuma, D. J. & Klassen, L. W., Dec 1992, In : Gastroenterology. 103, 6, p. 1969-1973 5 p.

Research output: Contribution to journalEditorial

43 Scopus citations
1991
34 Scopus citations

Serum selenium concentrations in rheumatoid arthritis

Dell, J. R. O., Lemley-Gillespie, S., Palmer, W. R., Weaver, A. L., Moore, G. F. & Klassen, L. W., Jan 1 1991, In : Annals of the rheumatic diseases. 50, 6, p. 376-378 3 p.

Research output: Contribution to journalArticle

28 Scopus citations