Luwen Zhang, PhD

Professor

  • 1610 Citations
  • 23 h-Index
19922017
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Research Output 1992 2017

  • 1610 Citations
  • 23 h-Index
  • 35 Article
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Review article
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Article
2017
5 Citations (Scopus)

Tumor suppressor p53 stimulates the expression of Epstein-Barr virus latent membrane protein 1

Wang, Q., Lingel, A., Geiser, V., Kwapnoski, Z. & Zhang, L., Oct 1 2017, In : Journal of virology. 91, 20, e00312-17.

Research output: Contribution to journalArticle

Human herpesvirus 4
membrane proteins
Membrane Proteins
neoplasms
Interferon Regulatory Factors
2016
5 Citations (Scopus)

Kaposi's sarcoma-associated herpesvirus reduces cellular myeloid differentiation primaryresponse gene 88 (MyD88) expression via modulation of its RNA

Lingel, A., Ehlers, E., Wang, Q., Cao, M., Wood, C., Lin, R. & Zhang, L., Jan 1 2016, In : Journal of virology. 90, 1, p. 180-188 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
Herpesviridae
transcription (genetics)
interleukin-1
2015
3 Citations (Scopus)

Interferon regulatory factor 7 is involved in the growth of Epstein-Barr virus-transformed human B lymphocytes

Xu, D., Zhang, Y., Zhao, L., Cao, M., Lingel, A. & Zhang, L., Jan 2 2015, In : Virus Research. 195, p. 112-118 7 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Human Herpesvirus 4
B-Lymphocytes
Growth
Oncogene Proteins
2013
4 Citations (Scopus)

CD20 Antibody Primes B Lymphocytes for Type I Interferon Production

Xu, D., Staedman, A. & Zhang, L., Jun 18 2013, In : PloS one. 8, 6, e67900.

Research output: Contribution to journalArticle

Interferon Type I
Lymphocytes
interferons
B-lymphocytes
B-Lymphocytes
11 Citations (Scopus)

TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator

Meyer, F., Ehlers, E., Steadman, A., Waterbury, T., Cao, M. & Zhang, L., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20435-20442 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Toll-Like Receptors
Transcription
Innate Immunity
Receptor-Interacting Protein Serine-Threonine Kinases
2012
15 Citations (Scopus)

Toll-Like Receptor 7 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1

Valente, R. M., Ehlers, E., Xu, D., Ahmad, H., Steadman, A., Blasnitz, L., Zhou, Y., Kastanek, L., Meng, B. & Zhang, L., Aug 31 2012, In : PloS one. 7, 8, e43317.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Human herpesvirus 4
membrane proteins
interferons
Chemical activation
2011
26 Citations (Scopus)

Interferon Regulatory Factor 4 (IRF-4) targets IRF-5 to regulate Epstein-Barr virus transformation

Xu, D., Meyer, F., Ehlers, E., Blasnitz, L. & Zhang, L., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 18261-18267 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Viruses
Growth
interferon regulatory factor-4
Lymphocytes
44 Citations (Scopus)

Kaposi sarcoma-associated herpesvirus degrades cellular toll-interleukin-1 receptor domain-containing adaptor-inducing β-interferon (TRIF)

Ahmad, H., Gubbels, R., Ehlers, E., Meyer, F., Waterbury, T., Lin, R. & Zhang, L., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 7865-7872 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Interleukin-1 Receptors
Transcription
Interferons
Ubiquitin
2010
8 Citations (Scopus)

Dual functions of interferon regulatory factors 7C in Epstein-Barr virus-mediated transformation of human B lymphocytes

Zhao, Y., Xu, D., Jiang, Y. & Zhang, L., Mar 4 2010, In : PloS one. 5, 3, e9459.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Human herpesvirus 4
Lymphocytes
Human Herpesvirus 4
Viruses
1 Citation (Scopus)

Viral transformation for production of personalized type I interferons

Xu, D. & Zhang, L., Jun 1 2010, In : Biotechnology Journal. 5, 6, p. 578-581 4 p.

Research output: Contribution to journalArticle

Interferon Type I
Interferons
Virus Diseases
Human Herpesvirus 4
Hepacivirus
2009
31 Citations (Scopus)

Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages

Huang, Y., Walstrom, A., Zhang, L., Zhao, Y., Cui, M., Ye, L. & Zheng, J. C., Apr 30 2009, In : PloS one. 4, 4, e5397.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
TNF-Related Apoptosis-Inducing Ligand
Interferon Type I
Macrophages
interferons
2008
53 Citations (Scopus)

Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes

Xu, D., Zhao, L., Del Valle, L., Miklossy, J. & Zhang, L., Jul 1 2008, In : Journal of virology. 82, 13, p. 6251-6258 8 p.

Research output: Contribution to journalArticle

Human herpesvirus 4
Human Herpesvirus 4
B-lymphocytes
B-Lymphocytes
membrane proteins
18 Citations (Scopus)
Human herpesvirus 8
Primary Effusion Lymphoma
Human herpesvirus 4
Human Herpesvirus 8
Virus Replication
7 Citations (Scopus)

The interaction between KSHV RTA and cellular RBP-Jκ and their subsequent DNA binding are not sufficient for activation of RBP-Jκ

Papugani, A., Coleman, T., Jones, C. & Zhang, L., Jan 1 2008, In : Virus Research. 131, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Protein Sorting Signals
Genetic Recombination
Carrier Proteins
DNA
47 Citations (Scopus)

The Viral Etiology of AIDS-Associated Malignancies

Angeletti, P. C., Zhang, L. & Wood, C., 2008, In : Advances in Pharmacology. 56, p. 509-557 49 p.

Research output: Contribution to journalArticle

AIDS-Related Lymphoma
Papillomavirus Infections
Kaposi's Sarcoma
Non-Hodgkin's Lymphoma
Acquired Immunodeficiency Syndrome
2007
36 Citations (Scopus)

Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas

Xu, D., Coleman, T., Zhang, J., Fagot, A., Kotalik, C., Zhao, L., Trivedi, P., Jones, C. & Zhang, L., Jun 1 2007, In : Journal of virology. 81, 11, p. 6068-6078 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Primary Effusion Lymphoma
Human herpesvirus 4
Human Herpesvirus 8
lymphoma
2006
17 Citations (Scopus)

GenomeBlast: A web tool for small genome comparison

Lu, G., Jiang, L., Helikar, R. M. K., Rowley, T. W., Zhang, L., Chen, X. & Moriyama, E., Dec 1 2006, In : BMC bioinformatics. 7, SUPPL.4, S18.

Research output: Contribution to journalArticle

Genome
Genes
Gene
Phylogeny
Comparative Analysis
33 Citations (Scopus)

The latent membrane protein 1 of Epstein-Barr virus (EBV) primes EBV latency cells for type I interferon production

Xu, D., Brumm, K. & Zhang, L., Apr 7 2006, In : Journal of Biological Chemistry. 281, 14, p. 9163-9169 7 p.

Research output: Contribution to journalArticle

Virus Latency
Interferon Type I
Human Herpesvirus 4
Viruses
Membrane Proteins
2005
30 Citations (Scopus)
Human herpesvirus 8
Human Herpesvirus 8
Viral Genes
response elements
Response Elements
34 Citations (Scopus)
Interferon Regulatory Factor-7
Human herpesvirus 8
Human Herpesvirus 8
transcriptional activation
Transcriptional Activation
2004
47 Citations (Scopus)

Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties

Zhang, L., Zhang, J., Lambert, Q., Der, C. J., Del Valle, L., Miklossy, J., Khalili, K., Zhou, Y. & Pagano, J. S., Dec 1 2004, In : Journal of virology. 78, 23, p. 12987-12995 9 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Human herpesvirus 4
lymphoma
Human Herpesvirus 4
central nervous system
34 Citations (Scopus)

Multiple signal transducers and activators of transcription are induced by EBV LMP-1

Zhang, L., Hong, K., Zhang, J. & Pagano, J. S., May 20 2004, In : Virology. 323, 1, p. 141-152 12 p.

Research output: Contribution to journalArticle

STAT1 Transcription Factor
Transducers
STAT2 Transcription Factor
Human Herpesvirus 4
Virus Latency
40 Citations (Scopus)

The latent membrane protein 1 of Epstein-Barr virus establishes an antiviral state via induction of interferon-stimulated genes

Zhang, J., Das, S. C., Kotalik, C., Pattnaik, A. K. & Zhang, L., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 46335-46342 8 p.

Research output: Contribution to journalArticle

Virus Latency
Viruses
Interferons
Human Herpesvirus 4
Antiviral Agents
2002

Structure and function of IRF-7

Zhang, L. & Pagano, J. S., 2002, In : Journal of Interferon and Cytokine Research. 22, 1, p. 95-101 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Virus Latency
Interferon Regulatory Factors
Innate Immunity
Interferons
2001
23 Citations (Scopus)

Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation

Zhang, L. & Pagano, J. S., Jan 1 2001, In : Seminars in Cancer Biology. 11, 6, p. 445-453 9 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Virus Latency
Membrane Proteins
Human Herpesvirus 4
Epstein-Barr Virus Infections
51 Citations (Scopus)

Interferon regulatory factor 7 mediates activation of Tap-2 by Epstein-Barr virus latent membrane protein 1

Zhang, L. & Pagano, J. S., Jan 1 2001, In : Journal of virology. 75, 1, p. 341-350 10 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Human herpesvirus 4
Antigen Presentation
membrane proteins
transporters
58 Citations (Scopus)

Intracellular signaling molecules activated by Epstein-Barr virus for induction of interferon regulatory factor 7

Zhang, L., Wu, L., Hong, K. & Pagano, J. S., Dec 17 2001, In : Journal of virology. 75, 24, p. 12393-12401 9 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Virus Activation
Human herpesvirus 4
Human Herpesvirus 4
membrane proteins
2000
8 Citations (Scopus)
Ribonucleases
Thermal gradients
Assays
RNA
Temperature
74 Citations (Scopus)

Interferon regulatory factor 7 is induced by Epstein-Barr virus latent membrane protein 1

Zhang, L. & Pagano, J. S., Jan 24 2000, In : Journal of virology. 74, 3, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Human herpesvirus 4
membrane proteins
Membrane Proteins
promoter regions
1999
46 Citations (Scopus)

Interferon regulatory factor 2 represses the Epstein-Barr virus BamHI Q latency promoter in type III latency

Zhang, L. & Pagano, J. S., Apr 1999, In : Molecular and cellular biology. 19, 4, p. 3216-3223 8 p.

Research output: Contribution to journalArticle

Open Access
Interferon Regulatory Factor-2
Human Herpesvirus 4
Epstein-Barr Virus Nuclear Antigens
Response Elements
Interferons
1997
211 Citations (Scopus)

IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency

Zhang, L. & Pagano, J. S., Oct 1997, In : Molecular and cellular biology. 17, 10, p. 5748-5757 10 p.

Research output: Contribution to journalArticle

Open Access
Interferon Regulatory Factor-7
Interferon Regulatory Factors
Virus Latency
Human Herpesvirus 4
Interferons
1996
94 Citations (Scopus)

Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A

Ide, Y., Zhang, L., Chen, M., Inchauspe, G., Bahl, C., Sasaguri, Y. & Padmanabhan, R., Dec 5 1996, In : Gene. 182, 1-2, p. 203-211 9 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Hepacivirus
Cytoplasm
Proteins
Galactosidases
1995
249 Citations (Scopus)

Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5

Kapoor, M., Zhang, L., Ramachandra, M., Kusukawa, J., Ebner, K. E. & Padmanabhan, R., Jan 1 1995, In : Journal of Biological Chemistry. 270, 32, p. 19100-19106 7 p.

Research output: Contribution to journalArticle

RNA Replicase
Phosphorylation
Polyproteins
Viruses
Dengue Virus
63 Citations (Scopus)

Synthesis and characterization of an infectious dengue virus type-2 RNA genome (New Guinea C strain)

Kapoor, M., Zhang, L., Mohan, P. M. & Padmanabhan, R., Sep 11 1995, In : Gene. 162, 2, p. 175-180 6 p.

Research output: Contribution to journalArticle

New Guinea
Dengue Virus
Complementary DNA
Genome
RNA
1993
21 Citations (Scopus)

Role of protein conformation in the processing of dengue virus type 2 nonstructural polyprotein precursor

Zhang, L. & Padmanabhan, R., Jul 30 1993, In : Gene. 129, 2, p. 197-205 9 p.

Research output: Contribution to journalArticle

Polyproteins
Protein Conformation
Dengue Virus
Peptide Hydrolases
Diamino Amino Acids