Luca Brunelli, MD, PhD

Associate Professor

  • 548 Citations
  • 10 h-Index
19952020

Research output per year

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Research Output

  • 548 Citations
  • 10 h-Index
  • 21 Article
  • 2 Letter
  • 1 Review article
2020

Live-cell PCR and one-step purification streamline DNA engineering

Lyozin, G. T. & Brunelli, L., Mar 1 2020, In : FASEB Journal. 34, 3, p. 3448-3460 13 p.

Research output: Contribution to journalArticle

Open Access
2019

Many newborns in level IV NICUs are eligible for rapid DNA sequencing

Kapil, S., Fishler, K. P., Euteneuer, J. C. & Brunelli, L., Feb 1 2019, In : American Journal of Medical Genetics, Part A. 179, 2, p. 280-284 5 p.

Research output: Contribution to journalLetter

2 Scopus citations

Targeted gene panel sequencing for the rapid diagnosis of acutely ill infants

Brunelli, L., Jenkins, S. M., Gudgeon, J. M., Bleyl, S. B., Miller, C. E., Tvrdik, T., Dames, S. A., Ostrander, B., Daboub, J. A. F., Zielinski, B. A., Zinkhan, E. K., Underhill, H. R., Wilson, T., Bonkowsky, J. L., Yost, C. C., Botto, L. D., Jenkins, J., Pysher, T. J., Bayrak-Toydemir, P. & Mao, R., Jul 2019, In : Molecular Genetics and Genomic Medicine. 7, 7, e00796.

Research output: Contribution to journalArticle

Open Access
2018

Germline but not somatic de novo mutations are common in human congenital diaphragmatic hernia

Matsunami, N., Shanmugam, H., Baird, L., Stevens, J., Byrne, J. L., Barnhart, D. C., Rau, C., Feldkamp, M. L., Yoder, B. A., Leppert, M. F., Yost, H. J. & Brunelli, L., Apr 17 2018, In : Birth Defects Research. 110, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

2017

A rapid gene sequencing panel strategy to facilitate precision neonatal medicine

Brunelli, L., Mao, R., Jenkins, S. M., Bleyl, S. B., Dames, S. A., Miller, C. E., Ostrander, B., Tvrdik, T., Andrews, S., Flores, J., Patel, S., Gudgeon, J. M. & Schaefer, S., Jul 2017, In : American Journal of Medical Genetics, Part A. 173, 7, p. 1979-1982 4 p.

Research output: Contribution to journalLetter

4 Scopus citations

Direct isolation of seamless mutant bacterial artificial chromosomes

Lyozin, G. T., Kosaka, Y., Bhattacharje, G., Yost, H. J. & Brunelli, L., Apr 1 2017, In : Current Protocols in Molecular Biology. 2017, p. 8.6.1-8.6.29

Research output: Contribution to journalArticle

1 Scopus citations

Epidemiology and Prognosis of Congenital Diaphragmatic Hernia: A Population-Based Cohort Study in Utah

Shanmugam, H., Brunelli, L., Botto, L. D., Krikov, S. & Feldkamp, M. L., Nov 1 2017, In : Birth Defects Research. 109, 18, p. 1451-1459 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

14-3-3epsilon controls multiple developmental processes in the mouse heart

Gittenberger-de Groot, A. C., Hoppenbrouwers, T., Miquerol, L., Kosaka, Y., Poelmann, R. E., Wisse, L. J., Yost, H. J., Jongbloed, M. R. M., Deruiter, M. C. & Brunelli, L., Nov 1 2016, In : Developmental Dynamics. 245, 11, p. 1107-1123 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Micro-computed tomography for the quantitative 3-dimensional assessment of the compact myocardium in the mouse embryo

Merchant, S. S., Kosaka, Y., Yost, H. J., Hsu, E. W. & Brunelli, L., Jan 1 2016, In : Circulation Journal. 80, 8, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Isolation of rare recombinants without using selectable markers for one-step seamless BACmutagenesis

Lyozin, G. T., Bressloff, P. C., Kumar, A., Kosaka, Y., Demarest, B. L., Yost, H. J., Kuehn, M. R. & Brunelli, L., Jan 1 2014, In : Nature Methods. 11, 9, p. 966-970 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

14-3-3ε Gene variants in a Japanese patient with left ventricular noncompaction and hypoplasia of the corpus callosum

Chang, B., Gorbea, C., Lezin, G., Li, L., Shan, L., Sakai, N., Kogaki, S., Otomo, T., Okinaga, T., Hamaoka, A., Yu, X., Hata, Y., Nishida, N., Yost, H. J., Bowles, N. E., Brunelli, L. & Ichida, F., Feb 15 2013, In : Gene. 515, 1, p. 173-180 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Family-based studies to identify genetic variants that cause congenital heart defects

Arrington, C. B., Bleyl, S. B., Brunelli, L. & Bowles, N. E., Jul 1 2013, In : Future Cardiology. 9, 4, p. 507-518 12 p.

Research output: Contribution to journalReview article

3 Scopus citations
2012

14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle

Kosaka, Y., Cieslik, K. A., Li, L., Lezin, G., Maguire, C. T., Saijoh, Y., Toyo-oka, K., Gambello, M. J., Vatta, M., Wynshaw-Boris, A., Baldini, A., Yost, H. J. & Brunelli, L., Dec 1 2012, In : Molecular and cellular biology. 32, 24, p. 5089-5102 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

A family-based paradigm to identify candidate chromosomal regions for isolated congenital diaphragmatic hernia

Arrington, C. B., Bleyl, S. B., Matsunami, N., Bowles, N. E., Leppert, T. I., Demarest, B. L., Osborne, K., Yoder, B. A., Byrne, J. L., Schiffman, J. D., Null, D. M., Digeronimo, R., Rollins, M., Faix, R., Comstock, J., Camp, N. J., Leppert, M. F., Yost, H. J. & Brunelli, L., Dec 2012, In : American Journal of Medical Genetics, Part A. 158 A, 12, p. 3137-3147 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction

Xi, Y., Ai, T., De Lange, E., Li, Z., Wu, G., Brunelli, L., Kyle, W. B., Turker, I., Cheng, J., Ackerman, M. J., Kimura, A., Weiss, J. N., Qu, Z., Kim, J. J., Faulkner, G. & Vatta, M., Oct 1 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

A one-step miniprep for the isolation of plasmid DNA and lambda phage particles

Lezin, G., Kosaka, Y., Yost, H. J., Kuehn, M. R. & Brunelli, L., Aug 19 2011, In : PloS one. 6, 8, e23457.

Research output: Contribution to journalArticle

11 Scopus citations

Hofmeister series salts enhance purification of plasmid DNA by non-ionic detergents

Lezin, G., Kuehn, M. R. & Brunelli, L., Aug 1 2011, In : Biotechnology and Bioengineering. 108, 8, p. 1872-1882 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy

Li, Z., Ai, T., Samani, K., Xi, Y., Tzeng, H. P., Xie, M., Wu, S., Ge, S., Taylor, M. D., Dong, J. W., Cheng, J., Ackerman, M. J., Kimura, A., Sinagra, G., Brunelli, L., Faulkner, G. & Vatta, M., Dec 1 2010, In : Circulation: Arrhythmia and Electrophysiology. 3, 6, p. 646-656 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Remodeling of dystrophin and sarcomeric Z-band occurs in pediatric cardiomyopathies: A unifying mechanism for force transmission defect

Vatta, M., Sinagra, G., Brunelli, L. & Faulkner, G., Feb 1 2009, In : Journal of Cardiovascular Medicine. 10, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2007

Peroxisome proliferator-activated receptor-δ upregulates 14-3-3ε in human endothelial cells via CCAAT/enhancer binding protein-β

Brunelli, L., Cieslik, K. A., Alcorn, J. L., Vatta, M. & Baldini, A., Mar 1 2007, In : Circulation Research. 100, 5, p. e59-e71

Research output: Contribution to journalArticle

39 Scopus citations
2006

Perfluorochemical liquids enhance delivery of superoxide dismutase to the lungs of juvenile rabbits

Brunelli, L., Hamilton, E., Davis, J. M., Koo, H. C., Joseph, A., Kazzaz, J. A., Wolfson, M. R. & Shaffer, T. H., Jul 1 2006, In : Pediatric Research. 60, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2001

Modulation of catalase peroxidatic and catalatic activity by nitric oxide

Brunelli, L., Yermilov, V. & Beckman, J. S., Apr 1 2001, In : Free Radical Biology and Medicine. 30, 7, p. 709-714 6 p.

Research output: Contribution to journalArticle

99 Scopus citations
1995

Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion

Tao, S., Calza, G., Lerzo, F., Virgone, A., Camassa, N., Panizzon, G., Bertolini, A., Brunelli, L., Moretti, R., Grasso, P. & Ghiggeri, G., Jan 1995, In : Perfusion. 10, 1, p. 45-50 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

The comparative toxicity of nitric oxide and peroxynitrite to escherichia coli

Brunelli, L., Crow, J. P. & Beckman, J. S., Jan 1995, In : Archives of Biochemistry and Biophysics. 316, 1, p. 327-334 8 p.

Research output: Contribution to journalArticle

245 Scopus citations