Lawrence J Parkhurst, PhD

Professor

  • 2064 Citations
  • 25 h-Index
1963 …2013
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Research Output 1963 2013

  • 2064 Citations
  • 25 h-Index
  • 79 Article
  • 2 Letter
  • 2 Review article
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Article
2013
16 Citations (Scopus)

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A

Glanzer, J. G., Carnes, K. A., Soto, P., Liu, S., Parkhurst, L. J. & Oakley, G. G., Feb 1 2013, In : Nucleic acids research. 41, 3, p. 2047-2059 13 p.

Research output: Contribution to journalArticle

Replication Protein A
Transcriptional Activation
Tryptophan
DNA Repair
DNA Damage
2010
16 Citations (Scopus)

Spectroscopic properties of fluorescein and rhodamine dyes attached to DNA

Delgadillo, R. F. & Parkhurst, L. J., Mar 1 2010, In : Photochemistry and Photobiology. 86, 2, p. 261-272 12 p.

Research output: Contribution to journalArticle

Rhodamines
rhodamine
Fluorescein
Coloring Agents
deoxyribonucleic acid
2009
30 Citations (Scopus)

The TATA-binding protein core domain in solution variably bends TATA sequences via a three-step binding mechanism

Delgadillo, R. F., Whittington, J. E., Parkhurst, L. K. & Parkhurst, L. J., Mar 3 2009, In : Biochemistry. 48, 8, p. 1801-1809 9 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
DNA
Yeast
Yeasts
Protein Domains
2008
17 Citations (Scopus)

TATA-binding protein recognition and bending of a consensus promoter are protein species dependent

Whittington, J. E., Delgadillo, R. F., Attebury, T. J., Parkhurst, L. K., Daugherty, M. A. & Parkhurst, L. J., Jul 8 2008, In : Biochemistry. 47, 27, p. 7264-7273 10 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Consensus
Proteins
TATA Box
Fluorescence Polarization
2006
20 Citations (Scopus)

Changes in DNA bending and flexing due to tethered cations detected by fluorescence resonance energy transfer

Williams, S. L., Parkhurst, L. K. & Parkhurst, L. J., Mar 20 2006, In : Nucleic acids research. 34, 3, p. 1028-1035 8 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Energy Transfer
Cations
DNA
Static Electricity
2004
16 Citations (Scopus)
Energy Transfer
Entropy
Thermodynamics
Energy transfer
DNA
5 Citations (Scopus)

Efficient Integration of Kinetic Differential Equation Sets Using Matrix Exponentiation

Matheson, I. B. C., Parkhurst, L. J. & DeSa, R. J., Jan 1 2004, In : Methods in enzymology. 384, p. 18-39 22 p.

Research output: Contribution to journalArticle

Differential equations
Kinetics
2003
29 Citations (Scopus)

Native human TATA-binding protein simultaneously binds and bends promoter DNA without a slow isomerization step or TFIIB requirement

Masters, K. M., Parkhurst, K. M., Daugherty, M. A. & Parkhurst, L. J., Aug 22 2003, In : Journal of Biological Chemistry. 278, 34, p. 31685-31690 6 p.

Research output: Contribution to journalArticle

Transcription Factor TFIIB
TATA-Box Binding Protein
Isomerization
Population Groups
DNA
2002
33 Citations (Scopus)

Comparison of TATA-binding protein recognition of a variant and consensus DNA promoters

Powell, R. M., Parkhurst, K. M. & Parkhurst, L. J., Mar 8 2002, In : Journal of Biological Chemistry. 277, 10, p. 7776-7784 9 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Transcription
DNA
Bearings (structural)
Fluorescence Resonance Energy Transfer
21 Citations (Scopus)

DNA bending by bZIP charge variants: A unified study using electrophoretic phasing and fluorescence resonance energy transfer

Hardwidge, P. R., Wu, J., Williams, S. L., Parkhurst, K. M., Parkhurst, L. J. & Maher, L. J., Jun 18 2002, In : Biochemistry. 41, 24, p. 7732-7742 11 p.

Research output: Contribution to journalArticle

Leucine Zippers
Fluorescence Resonance Energy Transfer
DNA
Transcription Factor AP-1
Static Electricity
2001
66 Citations (Scopus)

DNA Bends in TATA-binding Protein·TATA Complexes in Solution Are DNA Sequence-dependent

Wu, J., Parkhurst, K. M., Powell, R. M., Brenowitz, M. & Parkhurst, L. J., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 14614-14622 9 p.

Research output: Contribution to journalArticle

DNA sequences
Transcription
DNA
TATA-Box Binding Protein
TATA Box
30 Citations (Scopus)

DNA Sequence-dependent Differences in TATA-binding Protein-induced DNA Bending in Solution Are Highly Sensitive to Osmolytes

Wu, J., Parkhurst, K. M., Powell, R. M. & Parkhurst, L. J., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 14623-14627 5 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
DNA sequences
DNA
TATA Box
RNA Polymerase II
30 Citations (Scopus)

Marked Stepwise Differences within a Common Kinetic Mechanism Characterize TATA-binding Protein Interactions with Two Consensus Promoters

Powell, R. M., Parkhurst, K. M., Brenowitz, M. & Parkhurst, L. J., Aug 10 2001, In : Journal of Biological Chemistry. 276, 32, p. 29782-29791 10 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Kinetics
DNA
Adenoviridae
Bearings (structural)
2000
12 Citations (Scopus)

Near-ultraviolet magnetic circular dichroism spectroscopy of protein conformational states: Correlation of tryptophan band position and intensity with hemoglobin allostery

Vitale, D. J., Goldbeck, R. A., Kim-Shapiro, D. B., Esquerra, R. M., Parkhurst, L. J. & Kliger, D. S., Jun 20 2000, In : Biochemistry. 39, 24, p. 7145-7152 8 p.

Research output: Contribution to journalArticle

Circular dichroism spectroscopy
Circular Dichroism
Tryptophan
Spectrum Analysis
Hemoglobins
1999
70 Citations (Scopus)

Intermediate species possessing bent DNA are present along the pathway to formation of a final TBP-TATA complex

Parkhurst, K. M., Richards, R. M., Brenowitz, M. & Parkhurst, L. J., Jun 25 1999, In : Journal of Molecular Biology. 289, 5, p. 1327-1341 15 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
DNA
Entropy
Protein Binding
Transcription Factor TFIIB
1996
12 Citations (Scopus)

Detection of point mutations in DNA by fluorescence energy transfer

Parkhurst, K. M. & Parkhurst, L. J., Jan 1 1996, In : Journal of Biomedical Optics. 1, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

Open Access
Fluorescence Resonance Energy Transfer
Energy Transfer
mutations
Point Mutation
complement
115 Citations (Scopus)

Simultaneous binding and bending of promoter DNA by the TATA binding protein: Real time kinetic measurements

Parkhurst, K. M., Brenowitz, M. & Parkhurst, L. J., Jun 11 1996, In : Biochemistry. 35, 23, p. 7459-7465 7 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
DNA-Binding Proteins
Fluorescein
Kinetics
DNA
1995
1 Citation (Scopus)

A nanosecond ORD study of hemoglobin.

Parkhurst, L. J., Feb 1995, In : Biophysical journal. 68, 2, p. 399-400 2 p.

Research output: Contribution to journalArticle

Open Access
73 Citations (Scopus)
Fluorescein
Oligonucleotides
Fluorometers
Deoxyribonucleotides
B-Form DNA
92 Citations (Scopus)
Fluorescence Resonance Energy Transfer
Single-Stranded DNA
Fluorescein
Oligonucleotides
Rhodamines
1994
4 Citations (Scopus)

Effects of wavelength on fitting Adair constants for binding of oxygen to human hemoglobin

Parkhurst, L. J., Larsen, T. M. & Lee, H. Y., Jan 1 1994, In : Methods in enzymology. 232, C, p. 606-632 27 p.

Research output: Contribution to journalArticle

Electrodes
Hemoglobins
Oxygen
Wavelength
Myoglobin
11 Citations (Scopus)

Synthesis and Characterization of Conjugates Formed between Periodate-Oxidized Ribonucleotides and Amine-Containing Fluorophores

Hileman, R. E., Parkhurst, K. M., Gupta, N. K. & Parkhurst, L. J., Sep 1 1994, In : Bioconjugate Chemistry. 5, 5, p. 436-444 9 p.

Research output: Contribution to journalArticle

Ribonucleotides
Fluorophores
Amines
Ribose
Adenosinetriphosphate
8 Citations (Scopus)

Thermodynamic Characterization of the Cooperativity of 40S Complex Formation during the Initiation of Eukaryotic Protein Synthesis

Parkhurst, K. M., Hileman, R. E., Saha, D., Gupta, N. K. & Parkhurst, L. J., Dec 1 1994, In : Biochemistry. 33, 50, p. 15168-15177 10 p.

Research output: Contribution to journalArticle

Thermodynamics
Codon
Eukaryotic Small Ribosome Subunits
Oligoribonucleotides
Messenger RNA
1993
Photolysis
hemoglobin
photolysis
Hemoglobins
Equilibrium constants
5 Citations (Scopus)
Prokaryotic Initiation Factor-2
Ribonucleotides
Fluorescence Polarization
Histones
Anisotropy
1992
8 Citations (Scopus)
Heme
Isotherms
Hemoglobins
Carps
Oxygen
18 Citations (Scopus)

Rapid preparation of native alpha and beta chains of human hemoglobin

Parkhurst, K. M. & Parkhurst, L. J., Jun 1992, In : International Journal of Biochemistry. 24, 6, p. 993-998 6 p.

Research output: Contribution to journalArticle

Hemoglobins
Contamination
Mercaptoethanol
Photolysis
Carbon Monoxide
1991
18 Citations (Scopus)

Use of dual wavelength spectrophotometry and continuous enzymatic depletion of oxygen for determination of the oxygen binding constants of hemoglobin

Larsen, T. M., Mueser, T. C. & Parkhurst, L. J., Aug 15 1991, In : Analytical Biochemistry. 197, 1, p. 231-246 16 p.

Research output: Contribution to journalArticle

Spectrophotometry
Hemoglobins
Oxygen
Wavelength
Hemeproteins
1990
13 Citations (Scopus)

A combined nuclear magnetic resonance and absorbance stopped-flow apparatus for biochemical studies

McGee, W. A. & Parkhurst, L. J., Sep 1990, In : Analytical Biochemistry. 189, 2, p. 267-273 7 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Hemoglobins
Light
Protein Unfolding
6 Citations (Scopus)

A multipass cuvette for laser photolysis studies and its uses in studying hemoglobin kinetics and equilibria

Martin, K. D. & Parkhurst, L. J., May 1 1990, In : Analytical Biochemistry. 186, 2, p. 288-295 8 p.

Research output: Contribution to journalArticle

Photolysis
Hemoglobins
Lasers
Hemeproteins
Tromethamine
17 Citations (Scopus)

Kinetics and thermodynamics of oxygen, CO, and azide binding by the subcomponents of soybean leghemoglobin

Martin, K. D., Saari, L., Guang-Xin, W., Wang, T., Parkhurst, L. J. & Klucas, R. V., Nov 15 1990, In : Journal of Biological Chemistry. 265, 32, p. 19588-19593 6 p.

Research output: Contribution to journalArticle

Leghemoglobin
Azides
Carbon Monoxide
Thermodynamics
Soybeans
9 Citations (Scopus)

Kinetics and Thermodynamics of Oxygen and Carbon Monoxide Binding to the T-State Hemoglobin of Urechis caupo

Martin, K. D. & Parkhurst, L. J., Jun 19 1990, In : Biochemistry. 29, 24, p. 5718-5726 9 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Thermodynamics
Ligation
Oxygen
Kinetics
1989
13 Citations (Scopus)

A matrix series method for the integration of rate equations in a reaction network. An alternative to Runge-Kutta methods

Zamis, T. M., Parkhurst, L. J. & Gallup, G. A., 1989, In : Computers and Chemistry. 13, 3, p. 165-171 7 p.

Research output: Contribution to journalArticle

Reaction Network
Runge Kutta methods
Rate Equations
Runge-Kutta Methods
Series
1986
41 Citations (Scopus)

Movement of Fe with respect to the heme plane in the R-T transition of carp hemoglobin. An extended x-ray absorption fine structure study.

Chance, M. R., Parkhurst, L. J., Powers, L. S. & Chance, B., May 5 1986, In : The Journal of biological chemistry. 261, 13, p. 5689-5692 4 p.

Research output: Contribution to journalArticle

Carps
Heme
Hemoglobins
Iron
X-Rays
64 Citations (Scopus)
Guanine Nucleotide Exchange Factors
Reticulocytes
NADP
Rabbits
Peptides
1984
6 Citations (Scopus)

Cooperative Interactions in the System Ribosomes-Ribosomal Protein S1-Polynucleotide Triplets

Goss, D. J., Parkhurst, L. J., Mehta, A. M. & Wahba, A. J., Dec 1984, In : Biochemistry. 23, 26, p. 6522-6529 8 p.

Research output: Contribution to journalArticle

Polynucleotides
Ribosomes
Free energy
Association reactions
Anisotropy
5 Citations (Scopus)

Dissociation of mitochondrial malate dehydrogenase

Muller, J., Gorisch, H. & Parkhurst, L. J., Jun 28 1984, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 787, 3, p. 258-263 6 p.

Research output: Contribution to journalArticle

Malate Dehydrogenase
Tyrosine
Chickens
Swine
Enzymes
11 Citations (Scopus)
Hemeproteins
Myoglobin
Carbon Monoxide
Ligands
Kinetics
8 Citations (Scopus)

Ligand Binding Kinetic Studies on the Hybrid Hemoglobin α(Carp):β(Human): A Hemoglobin with a Restricted Allosteric Range

Goss, D. J. & Parkhurst, L. J., May 1984, In : Biochemistry. 23, 10, p. 2174-2179 6 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Hemoglobins
Carps
Ligands
Kinetics
9 Citations (Scopus)
Carps
Conformations
Hemoglobins
Ligands
Kinetics
10 Citations (Scopus)

Oxygen Equilibrium Studies on Carp-Human Hybrid Hemoglobins

Causgrove, T., Goss, D. J. & Parkhurst, L. J., May 1984, In : Biochemistry. 23, 10, p. 2168-2173 6 p.

Research output: Contribution to journalArticle

Carps
Hemoglobins
Oxygen
hybrid hemoglobins
Salts
36 Citations (Scopus)

Studies on the role of eukaryotic nucleotide exchange factor in polypeptide chain initiation

Goss, D. J., Parkhurst, L. J., Mehta, H. B., Woodley, C. L. & Wahba, A. J., Aug 23 1984, In : Journal of Biological Chemistry. 259, 12, p. 7374-7377 4 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Prokaryotic Initiation Factor-2
Nucleotides
Peptides
Guanosine Triphosphate

Studies on the role of the eucaryotic exchange factor in polypeptide chain initiation

Goss, D. J. & Parkhurst, L. J., Jan 1 1984, In : Federation Proceedings. 43, 6, p. no. 70

Research output: Contribution to journalArticle

Peptides
1983
38 Citations (Scopus)

Kinetic and Equilibrium Studies on the Role of the β-147 Histidine in the Root Effect and Cooperativity in Carp Hemoglobin

Parkhurst, L. J., Goss, D. J. & Perutz, M. F., Jan 1 1983, In : Biochemistry. 22, 23, p. 5401-5409 9 p.

Research output: Contribution to journalArticle

Carps
Histidine
Hemoglobins
Kinetics
Carbon Monoxide
4 Citations (Scopus)

The binding of ribosomal protein SI to Sl-depleted 30S and 70S ribosomes. A fluorescence anisotropy study of the effects of Mg2+

Goss, D. J., Parkhurst, L. J., Mehta, A. M. & Wahba, A. J., Aug 25 1983, In : Nucleic acids research. 11, 16, p. 5589-5602 14 p.

Research output: Contribution to journalArticle

Fluorescence Polarization
Ribosomal Proteins
Ribosomes
Fluorescence
Anisotropy
1982
24 Citations (Scopus)

Kinetic studies on the interaction of chain initiation factor 3 with 70 S Escherichia coli ribosomes and subunits

Goss, D. J., Parkhurst, L. J. & Wahba, A. J., Dec 1 1982, In : Journal of Biological Chemistry. 257, 17, p. 10119-10127 9 p.

Research output: Contribution to journalArticle

Ribosome Subunits
Peptide Initiation Factors
Escherichia coli
Kinetics
Light scattering
12 Citations (Scopus)
Myoglobin
Heme
Substitution reactions
Azides
Oxygen
1981
48 Citations (Scopus)

Circular Dichroism Spectra of Hemoglobins

Geraci, G. & Parkhurst, L. J., Jan 1 1981, In : Methods in enzymology. 76, C, p. 262-275 14 p.

Research output: Contribution to journalArticle

Circular Dichroism
Hemoglobins
Molecules
Chromophores
Optical Rotation

Dye laser photolysis studies on a cooperative dimeric hemoglobin

Parkhurst, L. J., 1981, In : Journal of Photochemistry. 17, 1, 1 p.

Research output: Contribution to journalArticle

1980
50 Citations (Scopus)

Kinetics of Oxygen and Carbon Monoxide Binding to the Hemoglobins of Glycera Dibranchiata

Parkhurst, L. J., Sima, P. & Goss, D. J., Jun 1 1980, In : Biochemistry. 19, 12, p. 2688-2692 5 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Hemoglobins
Oxygen
Kinetics
Association reactions