Larisa Y Poluektova, MD, PhD

Professor

  • 2357 Citations
  • 30 h-Index
19952019
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Research Output 1995 2019

  • 2357 Citations
  • 30 h-Index
  • 79 Article
  • 7 Review article
  • 2 Chapter
  • 1 Comment/debate
2019
2 Citations (Scopus)

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

Acetaldehyde
Major Histocompatibility Complex
Hepatitis B virus
Hepatocytes
Cytotoxic T-Lymphocytes
Nanofibers
Calcifediol
Immune system
Scaffolds
Immune System

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Dagur, R. S., Wang, W., Makarov, E., Sun, Y. & Poluektova, L. Y., Sep 11 2019, In : Journal of visualized experiments : JoVE. 151

Research output: Contribution to journalArticle

Liver
HIV
Viruses
Immune system
treosulfan
1 Citation (Scopus)
Comorbidity
HIV
Viruses
Liver
Hepatitis B virus
3 Citations (Scopus)

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

Mathews, S., Branch Woods, A., Katano, I., Makarov, E., Thomas, M. B., Gendelman, H. E., Poluektova, L. Y., Ito, M. & Gorantla, S., Mar 5 2019, In : Molecular neurodegeneration. 14, 1, 12.

Research output: Contribution to journalArticle

Microglia
HIV Infections
HIV-1
Cell Differentiation
Brain

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection 11 Medical and Health Sciences 1107 Immunology

Dagur, R. S., Branch-Woods, A., Mathews, S., Joshi, P. S., Quadros, R. M., Harms, D. W., Cheng, Y., Miles, S. M., Pirruccello, S. J., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., Jan 7 2019, In : BMC Immunology. 20, 1, 2.

Research output: Contribution to journalArticle

Allergy and Immunology
HIV Infections
HIV-1
Glycoproteins
Lymphocytes
1 Citation (Scopus)

Immune activations and viral tissue compartmentalization during progressive HIV-1 infection of humanized mice

Su, H., Cheng, Y., Sravanam, S., Mathews, S., Gorantla, S., Poluektova, L. Y., Dash, P. K. & Gendelman, H. E., Jan 1 2019, In : Frontiers in immunology. 10, FEB, 340.

Research output: Contribution to journalArticle

Open Access
Virus Activation
HIV Infections
HIV-1
Hematopoietic Stem Cells
Virus Diseases
16 Citations (Scopus)

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Dash, P. K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T. M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., Donadoni, M., Robinson, J. A., Sillman, B., Lin, Z., Hilaire, J. R., Banoub, M., Elango, M., Gautam, N., Mosley, R. L., Poluektova, L. Y. & 12 others, McMillan, J. E., Bade, A. N., Gorantla, S., Sariyer, I. K., Burdo, T. H., Young, W. B., Amini, S., Gordon, J., Jacobson, J. M., Edagwa, B., Khalili, K. & Gendelman, H. E., Dec 1 2019, In : Nature communications. 10, 1, 2753.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
human immunodeficiency virus
Viruses
set theory
Antiviral Agents

Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL

Zhao, R., Li, Y., Gorantla, S., Poluektova, L. Y., Lin, H., Gao, F., Wang, H., Zhao, J., Zheng, J. C. & Huang, Y., Aug 2019, In : Antiviral Research. 168, p. 134-145 12 p.

Research output: Contribution to journalArticle

Open Access
HIV-1
Macrophages
Brain
Blood-Brain Barrier
TIC10 compound
2018
3 Citations (Scopus)

Antiretroviral drug metabolism in humanized PXR-CAR-CYP3A-NOG mice

McMillan, J. M., Cobb, D. A., Lin, Z., Banoub, M. G., Dagur, R. S., Branch Woods, A. A., Wang, W., Makarov, E., Kocher, T., Joshi, P. S., Quadros, R. M., Harms, D. W., Cohen, S. M., Gendelman, H. E., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., May 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Ritonavir
Pharmaceutical Preparations
Liver
Virus Diseases
27 Citations (Scopus)

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., McMillan, J. M., Gautam, N., Alnouti, Y., Edagwa, B. J. & Gendelman, H. E., Dec 1 2018, In : Nature communications. 9, 1, 443.

Research output: Contribution to journalArticle

human immunodeficiency virus
drugs
mice
macrophages
viruses
26 Citations (Scopus)

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

Zhou, T., Su, H., Dash, P., Lin, Z., Dyavar Shetty, B. L., Kocher, T., Szlachetka, A., Lamberty, B., Fox, H. S., Poluektova, L. Y., Gorantla, S., McMillan, J. M., Gautam, N., Mosley, R. L., Alnouti, Y., Edagwa, B. J. & Gendelman, H. E., Jan 2018, In : Biomaterials. 151, p. 53-65 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Lymphocytes
Macrophages
Body fluids
Prodrugs
7 Citations (Scopus)

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. Y., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

Hepacivirus
Interferons
Ethanol
Methylation
Acetaldehyde
1 Citation (Scopus)
Hepatic Stellate Cells
Macrophages
Viruses
Hepacivirus
Liver Cirrhosis
5 Citations (Scopus)

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Dagur, R. S., Wang, W., Cheng, Y., Makarov, E., Ganesan, M., Suemizu, H., Gebhart, C. L., Gorantla, S., Osna, N. A. & Poluektova, L. Y., Jan 1 2018, In : Biology Open. 7, 2, bio029785.

Research output: Contribution to journalArticle

Virus Diseases
Human immunodeficiency virus 1
Viruses
hepatocytes
HIV-1
4 Citations (Scopus)

Liver as a target of human immunodeficiency virus infection

Ganesan, M., Poluektova, L. Y., Kharbanda, K. & Osna, N. A., Nov 14 2018, In : World Journal of Gastroenterology. 24, 42, p. 4728-4737 10 p.

Research output: Contribution to journalReview article

Virus Diseases
HIV
Liver
Alcohols
Wounds and Injuries
3 Citations (Scopus)
Stiffness matrix
Cell death
Liver Cirrhosis
Liver
Hepatocytes
3 Citations (Scopus)

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

Olson, K. E., Bade, A. N., Namminga, K. L., Potash, M. J., Mosley, R. L., Poluektova, L. Y., Volsky, D. J. & Gendelman, H. E., Aug 1 2018, In : Journal of neurovirology. 24, 4, p. 398-410 13 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Substantia Nigra
HIV
Virus Diseases
Parkinson Disease
2017
44 Citations (Scopus)
HIV-1
Macrophages
Rilpivirine
Hematopoietic Stem Cells
Therapeutics
7 Citations (Scopus)

Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection

Singh, V. B., Singh, M. V., Piekna-Przybylska, D., Gorantla, S., Poluektova, L. Y. & Maggirwar, S. B., Dec 1 2017, In : Scientific reports. 7, 1, 9578.

Research output: Contribution to journalArticle

Hedgehogs
Virus Diseases
Leukocytes
HIV
Blood-Brain Barrier
7 Citations (Scopus)

Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains

Li, W., Gorantla, S., Gendelman, H. E. & Poluektova, L. Y., Dec 1 2017, In : DMM Disease Models and Mechanisms. 10, 12, p. 1489-1502 14 p.

Research output: Contribution to journalArticle

Neuroglia
HIV Infections
HIV-1
Brain
Animals
2016
12 Citations (Scopus)
Acetaldehyde
Viruses
Interferon-alpha
Hepacivirus
Liver
32 Citations (Scopus)

HIV-1 cellular and tissue replication patterns in infected humanized mice

Araínga, M., Su, H., Poluektova, L. Y., Gorantla, S. & Gendelman, H. E., Mar 21 2016, In : Scientific reports. 6, 23513.

Research output: Contribution to journalArticle

HIV-1
Stem Cells
Monocyte-Macrophage Precursor Cells
Virology
Macaca

Human lymphocyte biology and its application to humanized mice

Poluektova, L. Y., Jan 1 2016, Neuroimmune Pharmacology. Springer International Publishing, p. 201-216 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peripheral Nervous System
Lymphocytes
Animal Disease Models
Brain
Adaptive Immunity
26 Citations (Scopus)

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "meet the Experts" 2015 Workshop Summary

Akkina, R., Allam, A., Balazs, A. B., Blankson, J. N., Burnett, J. C., Casares, S., Garcia, J. V., Hasenkrug, K. J., Kashanchi, F., Kitchen, S. G., Klein, F., Kumar, P., Luster, A. D., Poluektova, L. Y., Rao, M., Sanders-Beer, B. E., Shultz, L. D. & Zack, J. A., Feb 2016, In : AIDS Research and Human Retroviruses. 32, 2, p. 109-119 11 p.

Research output: Contribution to journalArticle

National Institute of Allergy and Infectious Diseases (U.S.)
HIV
Education
Research
HLA Antigens
6 Citations (Scopus)

Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice

Bade, A. N., Gorantla, S., Dash, P. K., Makarov, E., Sajja, B. R., Poluektova, L. Y., Luo, J., Gendelman, H. E., Boska, M. D. & Liu, Y., Jul 1 2016, In : Molecular Neurobiology. 53, 5, p. 3286-3297 12 p.

Research output: Contribution to journalArticle

Virus Diseases
Manganese
Magnetic Resonance Imaging
Pathology
Brain
10 Citations (Scopus)

Neuropharmacologic Approaches to Restore the Brain’s Microenvironment

Li, W., Tong, H. I., Gorantla, S., Poluektova, L. Y., Gendelman, H. E. & Lu, Y., Sep 1 2016, In : Journal of Neuroimmune Pharmacology. 11, 3, p. 484-494 11 p.

Research output: Contribution to journalReview article

Brain
Neuroglia
Parasitic Diseases
Aptitude
Wounds and Injuries
11 Citations (Scopus)
Acetaldehyde
Hepacivirus
Hepatocytes
Apoptosis
Alcohols
1 Citation (Scopus)

Simple and reliable genotyping protocol for mouse PrkdcSCID mutation

Quadros, R. M., Poluektova, L. Y. & Gurumurthy, C. B., Apr 1 2016, In : Journal of Immunological Methods. 431, p. 60-62 3 p.

Research output: Contribution to journalArticle

Mutation
Restriction Fragment Length Polymorphisms
Transplantation Immunology
Biomedical Research
Polymerase Chain Reaction
20 Citations (Scopus)

Smoothened agonist reduces human immunodeficiency virus type-1-induced blood-brain barrier breakdown in humanized mice

Singh, V. B., Singh, M. V., Gorantla, S., Poluektova, L. Y. & Maggirwar, S. B., May 31 2016, In : Scientific reports. 6, 26876.

Research output: Contribution to journalArticle

Hedgehogs
Blood-Brain Barrier
HIV-1
Virus Diseases
Occludin
17 Citations (Scopus)

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

Zhang, G., Guo, D., Dash, P. K., Araínga, M., Wiederin, J. L., Haverland, N. A., Knibbe-Hollinger, J., Martinez-Skinner, A., Ciborowski, P. S., Goodfellow, V. S., Wysocki, T. A., Wysocki, B. J., Poluektova, L. Y., Liu, X. M., McMillan, J. M., Gorantla, S., Gelbard, H. A. & Gendelman, H. E., Jan 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

T-cells
Recycling
Tissue
Crystalline materials
Pharmaceutical Preparations
2015
20 Citations (Scopus)
Acetaldehyde
Innate Immunity
Hepacivirus
Methylation
Liver
7 Citations (Scopus)

Amphiphilic Cationic Nanogels as Brain-Targeted Carriers for Activated Nucleoside Reverse Transcriptase Inhibitors

Warren, G., Makarov, E., Lu, Y., Senanayake, T., Rivera, K., Gorantla, S., Poluektova, L. Y. & Vinogradov, S. V., Feb 20 2015, In : Journal of Neuroimmune Pharmacology. 10, 1, p. 88-101 14 p.

Research output: Contribution to journalArticle

Reverse Transcriptase Inhibitors
Nucleosides
Central Nervous System
Brain
Antiviral Agents
4 Citations (Scopus)

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Proteins
Oxidative stress
Hepatocytes
7 Citations (Scopus)

Influence of age, irradiation and humanization on NSG mouse phenotypes

Knibbe-Hollinger, J. S., Fields, N. R., Chaudoin, T. R., Epstein, A. A., Makarov, E., Akhter, S. P., Gorantla, S., Bonasera, S. J., Gendelman, H. E. & Poluektova, L. Y., Jan 1 2015, In : Biology Open. 4, 10, p. 1243-1252 10 p.

Research output: Contribution to journalArticle

irradiation
Irradiation
Phenotype
phenotype
mice
10 Citations (Scopus)

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics

Zhang, J., Garrison, J. C., Poluektova, L. Y., Bronich, T. K. & Osna, N. A., Nov 1 2015, In : Biomaterials. 70, p. 37-47 11 p., 17009.

Research output: Contribution to journalArticle

Liver
Peptides
Antiviral Agents
Therapeutics
Cytotoxicity
16 Citations (Scopus)

Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice

Puligujja, P., Araínga, M., Dash, P., Palandri, D., Mosley, R. L., Gorantla, S., Poluektova, L. Y., McMillan, J. M. & Gendelman, H. E., Jan 1 2015, In : Antiviral Research. 120, 1, p. 85-88 4 p.

Research output: Contribution to journalArticle

Folic Acid
HIV-1
Ritonavir
Intramuscular Injections
Viral RNA
47 Citations (Scopus)

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations

Puligujja, P., Balkundi, S. S., Kendrick, L. M., Baldridge, H. M., Hilaire, J. R., Bade, A. N., Dash, P. K., Zhang, G., Poluektova, L. Y., Gorantla, S., Liu, X. M., Ying, T., Feng, Y., Wang, Y., Dimitrov, D. S., McMillan, J. M. & Gendelman, H. E., Feb 1 2015, In : Biomaterials. 41, p. 141-150 10 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Ritonavir
Folic Acid
Acids
Macrophages
2014
27 Citations (Scopus)

Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice

Boska, M. D., Dash, P. K., Knibbe, J., Epstein, A. A., Akhter, S. P., Fields, N., High, R., Makarov, E., Bonasera, S. J., Gelbard, H. A., Poluektova, L. Y., Gendelman, H. E. & Gorantla, S., Jan 1 2014, In : Molecular neurodegeneration. 9, 1 p.

Research output: Contribution to journalArticle

Myelin-Associated Glycoprotein
Virus Diseases
Myelin-Oligodendrocyte Glycoprotein
HIV-1
Synaptophysin
3 Citations (Scopus)

Deficient synthesis of class-switched, HIVneutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen

Planque, S. A., Mitsuda, Y., Chitsazzadeh, V., Gorantla, S., Poluektova, L., Nishiyama, Y., Ochsenbauer, C., Morris, M. K., Sapparapu, G., Hanson, C. V., Massey, R. J. & Paul, S., Jan 1 2014, In : AIDS. 28, 15, p. 2201-2211 11 p.

Research output: Contribution to journalArticle

Binding Sites
HIV
Antibodies
Immunoglobulin G
Epitopes
7 Citations (Scopus)

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K., Sun, Y., Simpson, R. L., Poluektova, L. Y., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

Hepatitis C
Ethanol
Viral RNA
Liver
Oxidative stress
39 Citations (Scopus)

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice

Gutti, T. L., Knibbe, J. S., Makarov, E., Zhang, J., Yannam, G. R., Gorantla, S., Sun, Y., Mercer, D. F., Suemizu, H., Wisecarver, J. L., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

treosulfan
Hepatocytes
Transplantation
Urokinase-Type Plasminogen Activator
Severe Combined Immunodeficiency
27 Citations (Scopus)

Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain

Gerson, T., Makarov, E., Senanayake, T. H., Gorantla, S., Poluektova, L. Y. & Vinogradov, S. V., Jan 1 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 1, p. 177-185 9 p.

Research output: Contribution to journalArticle

Reverse Transcriptase Inhibitors
Nucleosides
HIV Infections
Antiviral Agents
Brain
2013
18 Citations (Scopus)

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

Zhang, J., Mulvenon, A., Makarov, E., Wagoner, J., Knibbe, J., Kim, J. O., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., May 1 2013, In : Biomaterials. 34, 15, p. 3846-3857 12 p.

Research output: Contribution to journalArticle

Virus Diseases
Coinfection
Viruses
Hepacivirus
Peptides
18 Citations (Scopus)

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection

Epstein, A. A., Narayanasamy, P., Dash, P. K., High, R., Bathena, S. P. R., Gorantla, S., Poluektova, L. Y., Alnouti, Y., Gendelman, H. E. & Boska, M. D., Dec 1 2013, In : Journal of Neuroimmune Pharmacology. 8, 5, p. 1224-1238 15 p.

Research output: Contribution to journalArticle

Metabolomics
Virus Diseases
Tissue Preservation
HIV-1
Rodentia
14 Citations (Scopus)

Improved visualization of neuronal injury following glial activation by manganese enhanced MRI

Bade, A. N., Zhou, B., Epstein, A. A., Gorantla, S., Poluektova, L. Y., Luo, J., Gendelman, H. E., Boska, M. D. & Liu, Y., Sep 1 2013, In : Journal of Neuroimmune Pharmacology. 8, 4, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

Manganese
Neuroglia
Magnetic Resonance Imaging
Wounds and Injuries
Contrast Media
2012
19 Citations (Scopus)
HIV
Virus Diseases
Aptitude
Central Nervous System Diseases
Hematopoietic Stem Cells
36 Citations (Scopus)

Cisplatin-loaded core cross-linked micelles: Comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi, H. S., Nukolova, N. V., Laquer, F. C., Poluektova, L. Y., Huang, J., Alnouti, Y., Yokohira, M., Arnold, L. L., Kabanov, A. V., Cohen, S. M. & Bronich, T. K., Dec 5 2012, In : International journal of nanomedicine. 7, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Micelles
Cisplatin
Toxicity
Platinum
16 Citations (Scopus)

IL-23 in infections, inflammation, autoimmunity and cancer: Possible role in HIV-1 and AIDS

Yannam, G. R., Gutti, T. & Poluektova, L. Y., Mar 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 1, p. 95-112 18 p.

Research output: Contribution to journalReview article

Interleukin-23
Autoimmunity
HIV-1
Acquired Immunodeficiency Syndrome
Central Nervous System Viral Diseases
76 Citations (Scopus)

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

Dash, P. K., Gendelman, H. E., Roy, U., Balkundi, S., Alnouti, Y., Mosley, R. L., Gelbard, H. A., McMillan, J. M., Gorantla, S. & Poluektova, L. Y., Nov 13 2012, In : AIDS. 26, 17, p. 2135-2144 10 p.

Research output: Contribution to journalArticle

HIV-1
Viral Load
Pharmaceutical Preparations
Therapeutics
T-Lymphocytes