Kurt H Piepenbrink, PhD

Assistant Professor

  • 614 Citations
  • 15 h-Index
20082019
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Research Output 2008 2019

  • 614 Citations
  • 15 h-Index
  • 23 Article
  • 2 Review article
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Article
2019
2 Citations (Scopus)

Candida albicans quorum-sensing molecule farnesol modulates staphyloxanthin production and activates the thiol-based oxidative-stress response in Staphylococcus aureus

Vila, T., Kong, E. F., Ibrahim, A., Piepenbrink, K., Shetty, A. C., McCracken, C., Bruno, V. & Jabra-Rizk, M. A., Jan 1 2019, In : Virulence. 10, 1, p. 625-642 18 p.

Research output: Contribution to journalArticle

Open Access
Farnesol
Quorum Sensing
Candida albicans
Sulfhydryl Compounds
Staphylococcus aureus
6 Citations (Scopus)

The structure of PilA from Acinetobacter baumannii AB5075 suggests a mechanism for functional specialization in Acinetobacter type IV pili

Ronish, L. A., Lillehoj, E., Fields, J. K., Sundberg, E. J. & Piepenbrink, K. H., Jan 1 2019, In : Journal of Biological Chemistry. 294, 1, p. 218-230 13 p.

Research output: Contribution to journalArticle

Acinetobacter baumannii
Acinetobacter
Biofilms
Protein Subunits
Static Electricity
2017
10 Citations (Scopus)

How an alloreactive T-cell receptor achieves peptide and MHC specificity

Wang, Y., Singh, N. K., Spear, T. T., Hellman, L. M., Piepenbrink, K. H., McMahan, R. H., Rosen, H. R., Vander Kooi, C. W., Nishimura, M. I. & Baker, B. M., Jun 13 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 24, p. E4792-E4801

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
HLA-A2 Antigen
Peptides
Hepacivirus
21 Citations (Scopus)

Structurebased design of hepatitis C virus vaccines that elicit neutralizing antibody responses to a conserved epitope

Pierce, B. G., Boucher, E. N., Piepenbrink, K. H., Ejemel, M., Rapp, C. A., Thomas, W. D., Sundberg, E. J., Weng, Z. & Wang, Y., Oct 1 2017, In : Journal of virology. 91, 20, e01032-17.

Research output: Contribution to journalArticle

Hepatitis C virus
Neutralizing Antibodies
neutralizing antibodies
Hepacivirus
epitopes
2016
10 Citations (Scopus)

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces

Riley, T. P., Ayres, C. M., Hellman, L. M., Singh, N. K., Cosiano, M., Cimons, J. M., Anderson, M. J., Piepenbrink, K. H., Pierce, B. G., Weng, Z. & Baker, B. M., Jan 1 2016, In : Protein Engineering, Design and Selection. 29, 12, p. 595-606 12 p.

Research output: Contribution to journalArticle

Open Access
T-cells
T-Cell Antigen Receptor
Scanning
T-Cell Antigen Receptor Specificity
Mutation
16 Citations (Scopus)

Motility and adhesion through type IV pili in Gram-positive bacteria

Piepenbrink, K. H. & Sundberg, E. J., Dec 15 2016, In : Biochemical Society Transactions. 44, 6, p. 1659-1666 8 p.

Research output: Contribution to journalArticle

Fimbriae Proteins
Gram-Positive Bacteria
Bacteria
Adhesion
Gene transfer
9 Citations (Scopus)

Some of the most interesting CASP11 targets through the eyes of their authors

Kryshtafovych, A., Moult, J., Baslé, A., Burgin, A., Craig, T. K., Edwards, R. A., Fass, D., Hartmann, M. D., Korycinski, M., Lewis, R. J., Lorimer, D., Lupas, A. N., Newman, J., Peat, T. S., Piepenbrink, K. H., Prahlad, J., van Raaij, M. J., Rohwer, F., Segall, A. M., Seguritan, V. & 4 others, Sundberg, E. J., Singh, A. K., Wilson, M. A. & Schwede, T., Sep 1 2016, In : Proteins. 84, p. 34-50 17 p.

Research output: Contribution to journalArticle

Proteins
Experiments
13 Citations (Scopus)

Structural diversity in the type IV Pili of multidrug-resistant acinetobacter

Piepenbrink, K. H., Lillehoj, E., Harding, C. M., Labonte, J. W., Zuo, X., Rapp, C. A., Munson, R. S., Goldblum, S. E., Feldman, M. F., Gray, J. J. & Sundberg, E. J., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 22924-22935 12 p.

Research output: Contribution to journalArticle

Fimbriae Proteins
Acinetobacter
Acinetobacter baumannii
Bacterial Fimbriae
Gammaproteobacteria
8 Citations (Scopus)

The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo

Hyun, S. W., Liu, A., Liu, Z., Cross, A. S., Verceles, A. C., Magesh, S., Kommagalla, Y., Kona, C., Ando, H., Luzina, I. G., Atamas, S. P., Piepenbrink, K. H., Sundberg, E. J., Guang, W., Ishida, H., Lillehoj, E. P. & Goldblum, S. E., Aug 1 2016, In : Glycobiology. 26, 8, p. 834-849 16 p.

Research output: Contribution to journalArticle

Neuraminidase
Bioactivity
Amides
Lung
Endothelium
17 Citations (Scopus)

Type IV pili promote early biofilm formation by Clostridium difficile

Maldarelli, G. A., Piepenbrink, K. H., Scott, A. J., Freiberg, J. A., Song, Y., Achermann, Y., Ernst, R. K., Shirtliff, M. E., Sundberg, E. J., Donnenberg, M. S. & von Rosenvinge, E. C., Aug 1 2016, In : Pathogens and disease. 74, 6, ftw061.

Research output: Contribution to journalArticle

Clostridium difficile
Biofilms
Clostridium Infections
RNA Sequence Analysis
Microscopy
2015
26 Citations (Scopus)

Structural and evolutionary analyses show unique stabilization strategies in the type IV Pili of clostridium difficile

Piepenbrink, K. H., Maldarelli, G. A., Martinez De La Peña, C. F., Dingle, T. C., Mulvey, G. L., Lee, A., Von Rosenvinge, E., Armstrong, G. D., Donnenberg, M. S. & Sundberg, E. J., Feb 3 2015, In : Structure. 23, 2, p. 385-396 12 p.

Research output: Contribution to journalArticle

Fimbriae Proteins
Clostridium difficile
Gram-Negative Bacteria
Horizontal Gene Transfer
Biofilms
2014
41 Citations (Scopus)

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant clostridium difficile infection in mice

Yang, Z., Schmidt, D., Liu, W., Li, S., Shi, L., Sheng, J., Chen, K., Yu, H., Tremblay, J. M., Chen, X., Piepenbrink, K. H., Sundberg, E. J., Kelly, C. P., Bai, G., Shoemaker, C. B. & Feng, H., Jan 1 2014, In : Journal of Infectious Diseases. 210, 6, p. 964-972 9 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Clostridium Infections
Clostridium difficile
Bispecific Antibodies
Neutralizing Antibodies
22 Citations (Scopus)

Structure of clostridium difficile pilj exhibits unprecedented divergence from known type iv pilins

Piepenbrink, K. H., Maldarelli, G. A., De La Peña, C. F. M., Mulvey, G. L., Snyder, G. A., De Masi, L., Von Rosenvinge, E. C., Günther, S., Armstrong, G. D., Donnenberg, M. S. & Sundberg, E. J., Feb 14 2014, In : Journal of Biological Chemistry. 289, 7, p. 4334-4345 12 p.

Research output: Contribution to journalArticle

Fimbriae Proteins
Clostridium
Clostridium difficile
Gram-Negative Bacteria
Bacteria
2013
13 Citations (Scopus)

Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes

Smith, S. N., Sommermeyer, D., Piepenbrink, K. H., Blevins, S. J., Bernhard, H., Uckert, W., Baker, B. M. & Kranz, D. M., Nov 15 2013, In : Journal of Molecular Biology. 425, 22, p. 4496-4507 12 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Codon
26 Citations (Scopus)

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain

Piao, W., Ru, L. W., Piepenbrink, K. H., Sundberg, E. J., Vogel, S. N. & Toshchakov, V. Y., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 19036-19041 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Cytokines
Peptides
Interferon Regulatory Factor-3
Interferon Type I
22 Citations (Scopus)

The basis for limited specificity and MHC restriction in a T cell receptor interface

Piepenbrink, K. H., Blevins, S. J., Scott, D. R. & Baker, B. M., Jun 5 2013, In : Nature communications. 4, 1948.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Complementarity Determining Regions
Major Histocompatibility Complex
constrictions
peptides
2012
27 Citations (Scopus)

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

Aggen, D. H., Chervin, A. S., Schmitt, T. M., Engels, B., Stone, J. D., Richman, S. A., Piepenbrink, K. H., Baker, B. M., Greenberg, P. D., Schreiber, H. & Kranz, D. M., Apr 1 2012, In : Gene Therapy. 19, 4, p. 365-374 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
CD3 Antigens
T-Cell Receptor Genes
Virus Diseases
2011
41 Citations (Scopus)

Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics

Borbulevych, O. Y., Piepenbrink, K. H. & Baker, B. M., Mar 1 2011, In : Journal of Immunology. 186, 5, p. 2950-2958 9 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
Molecular Mimicry
Deltaretrovirus
Peptides
Tropical Spastic Paraparesis
41 Citations (Scopus)

Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism

Scott, D. R., Borbulevych, O. Y., Piepenbrink, K. H., Corcelli, S. A. & Baker, B. M., Dec 2 2011, In : Journal of Molecular Biology. 414, 3, p. 385-400 16 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Complementarity Determining Regions
Peptides
Ligands
25 Citations (Scopus)

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

Aggen, D. H., Chervin, A. S., Insaidoo, F. K., Piepenbrink, K. H., Baker, B. M. & Kranz, D. M., Apr 1 2011, In : Protein Engineering, Design and Selection. 24, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Forensic Anthropology
T-cells
Human Engineering
T-Cell Antigen Receptor
HLA-A2 Antigen
2009
24 Citations (Scopus)

Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner

Piepenbrink, K. H., Borbulevych, O. Y., Sommese, R. F., Clemens, J., Armstrong, K. M., Desmond, C., Do, P. & Baker, B. M., Nov 1 2009, In : Biochemical Journal. 423, 3, p. 353-361 9 p.

Research output: Contribution to journalArticle

Fluorine
T-Cell Antigen Receptor
Substitution reactions
Peptides
Fluorination
9 Citations (Scopus)

Methods for quantifying T cell receptor binding affinities and thermodynamics.

Piepenbrink, K. H., Gloor, B. E., Armstrong, K. M. & Baker, B. M., Dec 1 2009, In : Methods in enzymology. 466, p. 359-381 23 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thermodynamics
Major Histocompatibility Complex
Peptides
T-cells
107 Citations (Scopus)

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

Borbulevych, O. Y., Piepenbrink, K. H., Gloor, B. E., Scott, D. R., Sommese, R. F., Cole, D. K., Sewell, A. K. & Baker, B. M., Dec 18 2009, In : Immunity. 31, 6, p. 885-896 12 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
T-Cell Antigen Receptor
Antigens
Peptides
Peptide Receptors