Kaustubh Datta, PhD

Associate Professor

  • 1762 Citations
  • 24 h-Index
20002020
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Research Output 2000 2019

  • 1762 Citations
  • 24 h-Index
  • 43 Article
  • 4 Review article
  • 3 Chapter
  • 1 Short survey
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Article
2019

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Monomeric GTP-Binding Proteins
Prostatic Neoplasms
Mevalonic Acid
zoledronic acid

Neuropilin-2 is an independent prognostic factor for shorter cancer-specific survival in patients with acinar adenocarcinoma of the prostate

Borkowetz, A., Froehner, M., Rauner, M., Conrad, S., Erdmann, K., Mayr, T., Datta, K., Hofbauer, L. C., Baretton, G. B., Wirth, M., Fuessel, S., Toma, M. & Muders, M. H., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Open Access
Neuropilin-2
Prostate
Adenocarcinoma
Survival
Prostatic Neoplasms

Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects

Borchardt, H., Schulz, A., Datta, K., Muders, M. H. & Aigner, A., Dec 1 2019, In : Scientific reports. 9, 1, 15471.

Research output: Contribution to journalArticle

Open Access
Neuropilins
Adenocarcinoma
Neuropilin-2
Neuropilin-1
Semaphorins
2018
6 Citations (Scopus)

Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft

Souchek, J. J., Wojtynek, N. E., Payne, W. M., Holmes, M. B., Dutta, S., Qi, B., Datta, K., LaGrange, C. A. & Mohs, A. M., Jul 15 2018, In : Acta Biomaterialia. 75, p. 323-333 11 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Fluorophores
Hyaluronic Acid
Heterografts
Tumors
5 Citations (Scopus)

Macrophage-derived neuropilin-2 exhibits novel tumor-promoting functions

Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., Singh, R. K., Talmadge, J. E., Muders, M. H., Batra, S. K. & Datta, K., Oct 1 2018, In : Cancer Research. 78, 19, p. 5600-5617 18 p.

Research output: Contribution to journalArticle

Neuropilin-2
Macrophages
Neoplasms
Neuropilins
Cytophagocytosis
2016
7 Citations (Scopus)

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Haney, S. L., Upchurch, G. M., Opavska, J., Klinkebiel, D. L., Hlady, R. A., Roy, S., Dutta, S., Datta, K. & Opavsky, R., Sep 2016, In : PLoS genetics. 12, 9, e1006334.

Research output: Contribution to journalArticle

Peripheral T-Cell Lymphoma
lymphoma
tumor
T-lymphocytes
neoplasms
18 Citations (Scopus)

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development

Bhattacharyya, S., Rainey, M. A., Arya, P., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., Todd, G. L., Gould, K. A., Datta, K., Waes, J. G. V., Band, V. & Band, H., Feb 17 2016, In : Scientific reports. 6, 20727.

Research output: Contribution to journalArticle

Neural Tube
Cilia
Morphogenesis
Embryonic Structures
Proteins
21 Citations (Scopus)

Neuropilin-2 regulates endosome maturation and EGFR trafficking to support cancer cell pathobiology

Dutta, S., Roy, S., Polavaram, N. S., Stanton, M. J., Zhang, H., Bhola, T., Hönscheid, P., Donohue, T., Band, H., Batra, S. K., Muders, M. H. & Datta, K., Jan 15 2016, In : Cancer Research. 76, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

Neuropilin-2
Endosomes
Neoplasms
Endocytosis
Drug Resistance
7 Citations (Scopus)

NRP2 transcriptionally regulates its downstream effector WDFY1

Dutta, S., Roy, S., Polavaram, N. S., Baretton, G. B., Muders, M. H., Batra, S. K. & Datta, K., Mar 30 2016, In : Scientific reports. 6, 23588.

Research output: Contribution to journalArticle

Neuropilin-2
Neuropilins
Neoplasms
Vascular Endothelial Growth Factor Receptor
Membrane Glycoproteins
2015
15 Citations (Scopus)

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Mimeault, M., Rachagani, S., Muniyan, S., Seshacharyulu, P., Johansson, S. L., Datta, K., Lin, M-F. & Batra, S. K., Jan 1 2015, In : Oncotarget. 6, 6, p. 3887-3903 17 p.

Research output: Contribution to journalArticle

Open Access
docetaxel
HhAntag691
Anticarcinogenic Agents
Prostatic Neoplasms
Side-Population Cells
13 Citations (Scopus)

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Haney, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D. L., Pirruccello, S. J., Dutta, S., Datta, K., Simpson, M. A., Wu, L. & Opavsky, R., Oct 1 2015, In : Oncogene. 34, 43, p. 5436-5446 11 p.

Research output: Contribution to journalArticle

Methylation
Lymphoma
T-Lymphocytes
Up-Regulation
Tumor Suppressor Genes
20 Citations (Scopus)

Neuropilin-2 and its ligand VEGF-C predict treatment response after transurethral resection and radiochemotherapy in bladder cancer patients

Keck, B., Wach, S., Taubert, H., Zeiler, S., Ott, O. J., Kunath, F., Hartmann, A., Bertz, S., Weiss, C., Hönscheid, P., Schellenburg, S., Rödel, C., Baretton, G. B., Sauer, R., Fietkau, R., Wullich, B., Krause, F. S., Datta, K. & Muders, M. H., Jan 15 2015, In : International Journal of Cancer. 136, 2, p. 443-451 9 p.

Research output: Contribution to journalArticle

Neuropilin-2
Vascular Endothelial Growth Factor C
Chemoradiotherapy
Urinary Bladder Neoplasms
Ligands
58 Citations (Scopus)

The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells

Zhang, L., Yang, S., Chen, X., Stauffer, S., Yu, F., Lele, S. M., Fu, K., Datta, K., Palermo, N., Chen, Y. & Dong, J., Jan 1 2015, In : Molecular and cellular biology. 35, 8, p. 1350-1362 13 p.

Research output: Contribution to journalArticle

Molecular Motor Proteins
Castration
Prostatic Neoplasms
Androgens
Growth
2014
52 Citations (Scopus)

Autophagy: Detection, regulation and its role in cancer and therapy response

Hönscheid, P., Datta, K. & Muders, M. H., Aug 2014, In : International Journal of Radiation Biology. 90, 8, p. 628-635 8 p.

Research output: Contribution to journalArticle

Autophagy
Neoplasms
Therapeutics
Neuropilin-2
Physiological Stress
18 Citations (Scopus)

The role of Factor Inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme

Wang, E., Zhang, C., Polavaram, N., Liu, F., Wu, G., Schroeder, M. A., Lau, J. S., Mukhopadhyay, D., Jiang, S. W., O'Neill, B. P., Datta, K. & Li, J., Jan 23 2014, In : PloS one. 9, 1, e86102.

Research output: Contribution to journalArticle

Transcription
Glioblastoma
Vascular Endothelial Growth Factor A
Tumors
hypoxia
2013
13 Citations (Scopus)

Angiogenic growth factor axis in autophagy regulation

Stanton, M. J., Dutta, S., Polavaram, N. S., Roy, S., Muders, M. H. & Datta, K., May 2013, In : Autophagy. 9, 5, p. 789-790 2 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Autophagy
Intercellular Signaling Peptides and Proteins
Neoplasms
Combination Drug Therapy
43 Citations (Scopus)

Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance

Stanton, M. J., Dutta, S., Zhang, H., Polavaram, N. S., Leontovich, A. A., Hönscheid, P., Sinicrope, F. A., Tindall, D. J., Muders, M. H. & Datta, K., Jan 1 2013, In : Cancer Research. 73, 1, p. 160-171 12 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Autophagy
Neoplasms
Cell Survival
Cell Death
24 Citations (Scopus)

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

Pandey, P., Seshacharyulu, P., Das, S., Rachagani, S., Palanimuthu Ponnusamy, M., Yan, Y., Johansson, S. L., Datta, K., Lin, M-F. & Batra, S. K., Jun 25 2013, In : British journal of cancer. 108, 12, p. 2590-2600 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Prostatic Neoplasms
Androgens
Prostate
Catalytic Domain
44 Citations (Scopus)

Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo

Mandal, C., Sarkar, S., Dutta, D., Samanta, S. K., Bhattacharya, K., Pal, B. C., Li, J., Datta, K. & Mandal, C., Feb 1 2013, In : International Journal of Cancer. 132, 3, p. 695-706 12 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatic Neoplasms
Reactive Oxygen Species
Apoptosis
Proteolysis
2011
33 Citations (Scopus)

HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells

Khurana, A., Liu, P., Mellone, P., Lorenzon, L., Vincenzi, B., Datta, K., Yang, B., Linhardt, R. J., Lingle, W., Chien, J., Baldi, A. & Shridhar, V., Mar 15 2011, In : Cancer Research. 71, 6, p. 2152-2161 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Breast Neoplasms
Cell Movement
Intercellular Signaling Peptides and Proteins
Receptor, Fibroblast Growth Factor, Type 2
19 Citations (Scopus)

Lymphangiogenesis in regional lymph nodes is an independent prognostic marker in rectal cancer patients after neoadjuvant treatment

Jakob, C., Aust, D. E., Liebscher, B., Baretton, G. B., Datta, K. & Muders, M. H., Nov 7 2011, In : PloS one. 6, 11, e27402.

Research output: Contribution to journalArticle

Lymphangiogenesis
Neoadjuvant Therapy
Rectal Neoplasms
colorectal neoplasms
Surgery
2009
30 Citations (Scopus)

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth

Muders, M. H., Vohra, P. K., Dutta, S. K., Wang, E., Ikeda, Y., Wang, L., Udugamasooriya, D. G., Memic, A., Rupashinghe, C. N., Baretton, G. B., Aust, D. E., Langer, S., Datta, K., Simons, M., Spaller, M. R. & Mukhopadhyay, D., Jun 15 2009, In : Clinical Cancer Research. 15, 12, p. 4095-4103 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
PDZ Domains
Growth
Neoplasms
IGF Type 1 Receptor
46 Citations (Scopus)

Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of rapamycin complex-2 and AKT-1

Muders, M. H., Zhang, H., Wang, E., Tindall, D. J. & Datta, K., Aug 1 2009, In : Cancer Research. 69, 15, p. 6042-6048 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Prostatic Neoplasms
Oxidative Stress
Vascular Endothelial Growth Factor A
Neoplasms
24 Citations (Scopus)

Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: Impact on vascular endothelial growth factor expression in hypoxia

Sinha, S., Dutta, S., Datta, K., Ghosh, A. K. & Mukhopadhyay, D., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32610-32618 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Genes
Cells
Gene expression
2008
23 Citations (Scopus)

Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer

Zhang, H., Muders, M. H., Li, J., Rinaldo, F., Tindall, D. J. & Datta, K., Nov 1 2008, In : Cancer Research. 68, 21, p. 8770-8778 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Prostatic Neoplasms
Lymph Nodes
Histone Deacetylase 1
Lymphangiogenesis
2007
2 Citations (Scopus)

Ist GIPC ein neuer Kandidat für die Therapie des Pankreaskarzinoms?

Translated title of the contribution: GIPC: a new target for therapy in pancreatic adenocarcinoma?Muders, M. H., Baretton, G. B., Aust, D. E., Dutta, S. K., Wang, E., Ikeda, Y., Spaller, M. R., Datta, K. & Mukhopadhyay, D., 2007, In : Verhandlungen der Deutschen Gesellschaft für Pathologie. 91, p. 286-293 8 p.

Research output: Contribution to journalArticle

PDZ Domains
Adenocarcinoma
Pancreatic Neoplasms
Peptides
Protein Stability
11 Citations (Scopus)

Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux

Li, J., Wang, E., Dutta, S., Lau, J. S., Jiang, S. W., Datta, K. & Mukhopadhyay, D., Oct 1 2007, In : Molecular and cellular biology. 27, 20, p. 7345-7353 9 p.

Research output: Contribution to journalArticle

Cytidine Diphosphate
Homeodomain Proteins
Protein Kinase C
Renal Cell Carcinoma
Hypoxia-Inducible Factor 1
27 Citations (Scopus)

RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation

Rinaldo, F., Li, J., Wang, E., Muders, M. & Datta, K., Mar 15 2007, In : Oncogene. 26, 12, p. 1731-1738 8 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Androgens
Prostatic Neoplasms
Androgen Receptors
Phenotype
2006
37 Citations (Scopus)

Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma

Muders, M. H., Dutta, S. K., Wang, L., Lau, J. S., Bhattacharya, R., Smyrk, T. C., Chari, S. T., Datta, K. & Mukhopadhyay, D., Nov 1 2006, In : Cancer Research. 66, 21, p. 10264-10268 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
IGF Type 1 Receptor
Proteins
Pancreatic Neoplasms
GTP-Binding Protein Regulators
2005
39 Citations (Scopus)

Role of elongin-binding domain of von hippel lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma

Datta, K., Mondal, S., Sinha, S., Li, J., Wang, E., Knebelmann, B., Karumanchi, S. A. & Mukhopadhyay, D., Nov 24 2005, In : Oncogene. 24, 53, p. 7850-7858 9 p.

Research output: Contribution to journalArticle

RNA Stability
Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Genes
elongin
49 Citations (Scopus)

Upregulation of VEGF-C by androgen depletion: The involvement of IGF-IR-FOXO pathway

Li, J., Wang, E., Rinaldo, F. & Datta, K., Aug 18 2005, In : Oncogene. 24, 35, p. 5510-5520 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Androgens
Up-Regulation
Prostatic Neoplasms
Forkhead Transcription Factors
2004
79 Citations (Scopus)

Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer

Stephan, S., Datta, K., Wang, E., Li, J., Brekken, R. A., Parangi, S., Thorpe, P. E. & Mukhopadhyay, D., Oct 15 2004, In : Clinical Cancer Research. 10, 20, p. 6993-7000 8 p.

Research output: Contribution to journalArticle

Sirolimus
Pancreatic Neoplasms
Neoplasms
Therapeutics
Cell Proliferation
30 Citations (Scopus)

Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on α6β1 integrin in breast carcinoma cells

Chung, J., Yoon, S., Datta, K., Bachelder, R. E. & Mercurio, A. M., Jul 15 2004, In : Cancer Research. 64, 14, p. 4711-4716 6 p.

Research output: Contribution to journalArticle

Integrins
Vascular Endothelial Growth Factor A
Apoptosis
Breast Neoplasms
Cell Hypoxia
47 Citations (Scopus)

Protein Kinase C ζ Transactivates Hypoxia-Inducible Factor α by Promoting Its Association with p300 in Renal Cancer

Datta, K., Li, J., Bhattacharya, R., Gasparian, L., Wang, E. & Mukhopadhyay, D., Jan 15 2004, In : Cancer Research. 64, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Protein Kinase C
Renal Cell Carcinoma
Hypoxia-Inducible Factor 1
Asparagine
21 Citations (Scopus)

Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes

Datta, K., Li, J., Ananth Karumanchi, S., Wang, E., Rondeau, E. & Mukhopadhyay, D., Oct 2004, In : Kidney International. 66, 4, p. 1471-1478 8 p.

Research output: Contribution to journalArticle

Podocytes
Vascular Endothelial Growth Factor A
Kidney Glomerulus
Glomerular Filtration Barrier
Laminin Receptors
43 Citations (Scopus)

Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells

Neid, M., Datta, K., Stephan, S., Khanna, I., Pal, S., Shaw, L., White, M. & Mukhopadhyay, D., Feb 6 2004, In : Journal of Biological Chemistry. 279, 6, p. 3941-3948 8 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Pancreatic Neoplasms
Protein Kinase C
Vascular Endothelial Growth Factor A
Cells
2003
59 Citations (Scopus)

Heterotrimeric Gαq/Gα11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling

Zeng, H., Zhao, D., Yang, S., Datta, K. & Mukhopadhyay, D., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20738-20745 8 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Vascular Endothelial Growth Factor Receptor-2
Phosphorylation
Vascular Endothelial Growth Factor A
Endothelial cells
58 Citations (Scopus)
IGF Type 1 Receptor
Vascular Endothelial Growth Factor A
Cells
Cell Line
Cell proliferation
2001
6 Citations (Scopus)

A comparative study of the winged bean protease inhibitors and their interaction with proteases

Datta, K., Usha, R., Dutta, S. K. & Singh, M., Jan 1 2001, In : Plant Physiology and Biochemistry. 39, 11, p. 949-959 11 p.

Research output: Contribution to journalArticle

Psophocarpus tetragonolobus
Trypsin Inhibitors
chymotrypsin
trypsin inhibitors
proteinase inhibitors
166 Citations (Scopus)

Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma

Pal, S., Datta, K. & Mukhopadhyay, D., Sep 15 2001, In : Cancer Research. 61, 18, p. 6952-6957 6 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Breast Neoplasms
src-Family Kinases
Angiogenic Proteins
src Genes
65 Citations (Scopus)

Role of Protein Kinase Cζ in Ras-mediated Transcriptional Activation of Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression

Pal, S., Datta, K., Khosravi-Far, R. & Mukhopadhyay, D., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Vascular Endothelial Growth Factor A
Transcriptional Activation
Chemical activation
Transcription
79 Citations (Scopus)

The 104-123 amino acid sequence of the β-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion

Datta, K., Sundberg, C., Karumanchi, S. A. & Mukhopadhyay, D., Mar 1 2001, In : Cancer Research. 61, 5, p. 1768-1775 8 p.

Research output: Contribution to journalArticle

Amino Acid Sequence
Renal Cell Carcinoma
Kidney
Peptides
Growth
2000
74 Citations (Scopus)

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

Datta, K., Nambudripad, R., Pal, S., Zhou, M., Cohen, H. T. & Mukhopadhyay, D., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20700-20706 7 p.

Research output: Contribution to journalArticle

Cell signaling
Kidney Neoplasms
Insulin-Like Growth Factor I
Tumors
Genes