Karen A Gould, PhD

Associate Professor

  • 3553 Citations
  • 26 h-Index
1992 …2018
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Research Output 1992 2017

  • 3553 Citations
  • 26 h-Index
  • 46 Article
  • 3 Review article
  • 1 Editorial
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Article
2017
11 Citations (Scopus)

Estrogen receptor alpha promotes lupus in (NZB × NZW)F1 mice in a B cell intrinsic manner

Tabor, D. E. & Gould, K. A., Jan 1 2017, In : Clinical Immunology. 174, p. 41-52 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
B-Lymphocytes
Lupus Nephritis
Autoantibodies
Sexism
1 Citation (Scopus)

Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk

Otterpohl, K. L. & Gould, K. A., Mar 2017, In : PloS one. 12, 3, e0172247.

Research output: Contribution to journalArticle

Intestinal Neoplasms
modifiers (genes)
carcinogenesis
Carcinogenesis
neoplasms
2016
4 Citations (Scopus)

An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice

Nelson, R. K. & Gould, K. A., Feb 1 2016, In : Lupus. 25, 2, p. 137-154 18 p.

Research output: Contribution to journalArticle

Transgenes
Autoantibodies
T-Lymphocytes
Apoptosis
Nuclear Antigens
19 Citations (Scopus)

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development

Bhattacharyya, S., Rainey, M. A., Arya, P., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., Todd, G. L., Gould, K. A., Datta, K., Waes, J. G. V., Band, V. & Band, H., Feb 17 2016, In : Scientific reports. 6, 20727.

Research output: Contribution to journalArticle

Neural Tube
Cilia
Morphogenesis
Embryonic Structures
Proteins
2015
5 Citations (Scopus)
Congenic Mice
Safe Sex
Sexism
Immune Tolerance
Estrogen Receptor alpha
4 Citations (Scopus)

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes

Otterpohl, K. L. & Gould, K. A., Jun 2 2015, In : Mammalian Genome. 26, 5-6, p. 235-247 13 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Dissection
Adenoma
Genes
Colonic Neoplasms
2013
11 Citations (Scopus)

Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Ma, S., Shukla, V., Fang, L., Gould, K. A., Joshi, S. S. & Lu, R., Sep 13 2013, In : Journal of Biological Chemistry. 288, 37, p. 26430-26440 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
B-Cell Chronic Lymphocytic Leukemia
New Zealand
Single Nucleotide Polymorphism
Cell Survival
8 Citations (Scopus)

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In : PloS one. 8, 11, e81483.

Research output: Contribution to journalArticle

nephritis
Lupus Nephritis
Macrophages
Prodrugs
dexamethasone
2012
19 Citations (Scopus)

Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects

Yuan, F., Nelson, R. K., Tabor, D. E., Zhang, Y., Akhter, M. P., Gould, K. A. & Wang, D., Dec 1 2012, In : Arthritis and rheumatism. 64, 12, p. 4029-4039 11 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Prodrugs
Dexamethasone
Glucocorticoids
Albuminuria
20 Citations (Scopus)

Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans

Mikuls, T. R., LeVan, T. D., Gould, K. A., Yu, F., Thiele, G. M., Bynote, K. K., Conn, D., Jonas, B. L., Callahan, L. F., Smith, E., Brasington, R., Moreland, L. W., Reynolds, R., Gaffo, A. & Bridges, S. L., Mar 1 2012, In : Arthritis and rheumatism. 64, 3, p. 655-664 10 p.

Research output: Contribution to journalArticle

African Americans
Rheumatoid Arthritis
Smoking
Genes
Single Nucleotide Polymorphism
2010
30 Citations (Scopus)

Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: Influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study

Mikuls, T. R., Gould, K. A., Bynoté, K. K., Yu, F., LeVan, T. D., Thiele, G. M., Michaud, K. D., O'Dell, J. R., Reimold, A. M., Hooker, R., Caplan, L., Johnson, D. S., Kerr, G., Richards, J. S., Cannon, G. W., Criswell, L. A., Noble, J. A., Bridges, L. S., Hughes, L. & Gregersen, P. K., Nov 18 2010, In : Arthritis Research and Therapy. 12, 6, R213.

Research output: Contribution to journalArticle

HLA-DRB1 Chains
Glutathione Transferase
Epitopes
Rheumatoid Arthritis
Cross-Sectional Studies
37 Citations (Scopus)

Associations of cigarette smoking with rheumatoid arthritis in African Americans

Mikuls, T. R., Sayles, H., Yu, F., LeVan, T. D., Gould, K. A., Thiele, G. M., Conn, D. L., Jonas, B. L., Callahan, L. F., Smith, E., Brasington, R., Moreland, L. W., Reynolds, R. J. & Bridges, S. L., Dec 1 2010, In : Arthritis Care and Research. 62, 12, p. 3560-3568 9 p.

Research output: Contribution to journalArticle

African Americans
Rheumatoid Arthritis
Smoking
Epitopes
Autoantibodies
40 Citations (Scopus)

Gender-dependent expression of murine Irf5 gene: Implications for sex bias in autoimmunity

Shen, H., Panchanathan, R., Rajavelu, P., Duan, X., Gould, K. A. & Choubey, D., Dec 1 2010, In : Journal of Molecular Cell Biology. 2, 5, p. 284-290 7 p.

Research output: Contribution to journalArticle

Sexism
Interferon Regulatory Factors
Autoimmunity
Estrogen Receptor alpha
Messenger RNA
2009
27 Citations (Scopus)

Disruption of estrogen receptor signaling enhances intestinal neoplasia in ApcMin/+ mice

Cleveland, A. G., Oikarinen, S. I., Bynoté, K. K., Marttinen, M., Rafter, J. J., Gustafsson, J. Å., Roy, S. K., Pitot, H. C., Korach, K. S., Lubahn, D. B., Mutanen, M. & Gould, K. A., Sep 18 2009, In : Carcinogenesis. 30, 9, p. 1581-1590 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Catenins
Neoplasms
Carcinogenesis
Wnt Signaling Pathway
49 Citations (Scopus)

Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval

Panchanathan, R., Shen, H., Bupp, M. G., Gould, K. A. & Choubey, D., Dec 1 2009, In : Journal of Immunology. 183, 11, p. 7031-7038 8 p.

Research output: Contribution to journalArticle

Gonadal Steroid Hormones
Interferons
Estrogen Receptors
Systemic Lupus Erythematosus
Genes
8 Citations (Scopus)

Genetic mapping of Mom5, a novel modifier of ApcMin-induced intestinal tumorigenesis

Oikarinen, S. I., Cleveland, A. G., Cork, K. M., Bynoté, K. K., Rafter, J. J., Gustafsson, J. Å., Mutanen, M. & Gould, K. A., Sep 18 2009, In : Carcinogenesis. 30, 9, p. 1591-1596 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Carcinogenesis
Alleles
Neoplasms
Chromosomes, Human, Pair 5
2008
90 Citations (Scopus)

Estrogen receptor-α deficiency attenuates autoimmune disease in (NZB × NZW)F1 mice

Bynoté, K. K., Hackenberg, J. M., Korach, K. S., Lubahn, D. B., Lane, P. H. & Gould, K. A., Mar 1 2008, In : Genes and Immunity. 9, 2, p. 137-152 16 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Autoimmune Diseases
Glomerulonephritis
Antibodies
Estrogens
19 Citations (Scopus)

Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat

Kurz, S. G., Hansen, K. K., McLaughlin, M. T., Shivaswamy, V., Schaffer, B. S., Gould, K. A., McComb, R. D., Meza, J. L. & Shull, J. D., Aug 1 2008, In : Endocrinology. 149, 8, p. 3850-3859 10 p.

Research output: Contribution to journalArticle

Inbred ACI Rats
Estrogens
Pituitary Gland
Quantitative Trait Loci
Thymus Gland
2007
14 Citations (Scopus)

Genetic control of estrogen action in the rat: Mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross

Shull, J. D., Lachel, C. M., Murrin, C. R., Pennington, K. L., Schaffer, B. S., Strecker, T. E. & Gould, K. A., Sep 1 2007, In : Mammalian Genome. 18, 9, p. 657-669 13 p.

Research output: Contribution to journalArticle

Lactotrophs
Quantitative Trait Loci
Norway
Hyperplasia
Estrogens
2006
46 Citations (Scopus)

Genetic bases of estrogen-induced tumorigenesis in the rat: Mapping of loci controlling susceptibility to mammary cancer in a Brown Norway × ACI intercross

Schaffer, B. S., Lachel, C. M., Pennington, K. L., Murrin, C. R., Strecker, T. E., Tochacek, M., Gould, K. A., Meza, J. L., McComb, R. D. & Shull, J. D., Aug 1 2006, In : Cancer Research. 66, 15, p. 7793-7800 8 p.

Research output: Contribution to journalArticle

Norway
Estrogens
Carcinogenesis
Breast Neoplasms
Inbred ACI Rats
10 Citations (Scopus)

Genetic bases of renal agenesis in the ACI rat: Mapping of Renag1 to chromosome 14

Shull, J. D., Lachel, C. M., Strecker, T. E., Spady, T. J., Tochacek, M., Pennington, K. L., Murrin, C. R., Meza, J. L., Schaffer, B. S., Flood, L. A. & Gould, K. A., Jul 1 2006, In : Mammalian Genome. 17, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

Inbred ACI Rats
Chromosomes, Human, Pair 14
Hereditary renal agenesis
Genetic Crosses
Genetic Loci
11 Citations (Scopus)

Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat

Gould, K. A., Strecker, T. E., Hansen, K. K., Bynoté, K. K., Peterson, K. A. & Shull, J. D., May 1 2006, In : Mammalian Genome. 17, 5, p. 451-464 14 p.

Research output: Contribution to journalArticle

Diethylstilbestrol
Genetic Loci
Atrophy
Estrogens
Thymocytes
2005
26 Citations (Scopus)

Genetic bases of estrogen-induced pituitary tumorigenesis: Identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains

Strecker, T. E., Spady, T. J., Schaffer, B. S., Gould, K. A., Kaufman, A. E., Shen, F., McLaughlin, M. T., Pennington, K. L., Meza, J. L. & Shull, J. D., Apr 1 2005, In : Genetics. 169, 4, p. 2189-2197 9 p.

Research output: Contribution to journalArticle

Inbred ACI Rats
Genetic Loci
Estrogens
Carcinogenesis
Diethylstilbestrol
20 Citations (Scopus)

Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5

Gould, K. A., Pandey, J., Lachel, C. M., Murrin, C. R., Flood, L. A., Pennington, K. L., Schaffer, B. S., Tochacek, M., McComb, R. D., Meza, J. L., Wendell, D. L. & Shull, J. D., Nov 1 2005, In : Mammalian Genome. 16, 11, p. 854-864 11 p.

Research output: Contribution to journalArticle

Estrogens
Norway
Chromosomes, Human, Pair 5
Suppuration
Genetic Predisposition to Disease
14 Citations (Scopus)

Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain

Pandey, J., Gould, K. A., McComb, R. D., Shull, J. D. & Wendell, D. L., Nov 1 2005, In : Mammalian Genome. 16, 11, p. 865-872 8 p.

Research output: Contribution to journalArticle

Diethylstilbestrol
Inflammation
Norway
Incidence
Estrogens
2004
30 Citations (Scopus)

Estrogen receptor α-mediated events promote sex-specific diabetic glomerular hypertrophy

Lovegrove, A. S., Sun, J., Gould, K. A., Lubahn, D. B., Korach, K. S. & Lane, P. H., Sep 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 3 56-3, p. F586-F591

Research output: Contribution to journalArticle

Estrogen Receptors
Hypertrophy
Kidney
Genotype
Transforming Growth Factors
46 Citations (Scopus)

Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: Mapping of Emca1 and Emca2 to chromosomes 5 and 18

Gould, K. A., Tochacek, M., Schaffer, B. S., Reindl, T. M., Murrin, C. R., Lachel, C. M., VanderWoude, E. A., Pennington, K. L., Flood, L. A., Bynote, K. K., Meza, J. L., Newton, M. A. & Shull, J. D., Dec 1 2004, In : Genetics. 168, 4, p. 2113-2125 13 p.

Research output: Contribution to journalArticle

Inbred ACI Rats
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 5
Genetic Predisposition to Disease
Estrogens
2003
7 Citations (Scopus)

Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction

Harvell, D. M. E., Buckles, L. K., Gould, K. A., Pennington, K. L., McComb, R. D. & Shull, J. D., Jul 1 2003, In : Endocrine. 21, 2, p. 175-183 9 p.

Research output: Contribution to journalArticle

Inbred ACI Rats
Anterior Pituitary Gland
Estrogens
Carcinogenesis
Prolactin
2000
25 Citations (Scopus)

DES action in the thymus: inhibition of cell proliferation and genetic variation

Gould, K. A., Shull, J. D. & Gorski, J., Dec 22 2000, In : Molecular and Cellular Endocrinology. 170, 1-2, p. 31-39 9 p.

Research output: Contribution to journalArticle

Thymus
Diethylstilbestrol
Cell proliferation
Thymus Gland
Estrogens
88 Citations (Scopus)

The Mom1(AKR) intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64

Cormier, R. T., Bilger, A., Lillich, A. J., Halberg, R. B., Hong, K. H., Gould, K. A., Borenstein, N., Lander, E. S. & Dove, W. F., Jun 29 2000, In : Oncogene. 19, 28, p. 3182-3192 11 p.

Research output: Contribution to journalArticle

Open Access
Small Intestine
Carcinogenesis
Inbred AKR Mouse
Chromosomes, Human, Pair 4
Goblet Cells
1998
8 Citations (Scopus)

Analysis of the mom1 modifier of intestinal neoplasia in mice

Gould, K. A. & Dove, W. F., Jan 1 1998, In : Experimental Lung Research. 24, 4, p. 437-453 17 p.

Research output: Contribution to journalArticle

Phospholipases
Quantitative Trait Loci
Organism Cloning
Genes
Cloning
10 Citations (Scopus)
E-Box Elements
Transcription Factors
Nucleotides
Hematopoiesis
DNA
35 Citations (Scopus)

The intestinal epithelium and its neoplasms: Genetic, cellular and tissue interactions

Dove, W. F., Cormier, R. T., Gould, K. A., Halberg, R. B., Merritt, A. J., Newton, M. A. & Shoemaker, A. R., Jun 29 1998, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 353, 1370, p. 915-923 9 p.

Research output: Contribution to journalArticle

Intestinal Mucosa
intestinal mucosa
allele
Genes
Tissue
1997
113 Citations (Scopus)

Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status

Dove, W. F., Clipson, L., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., Newton, M. A. & Jacoby, R. F., Jan 1 1997, In : Cancer Research. 57, 5, p. 812-814 3 p.

Research output: Contribution to journalArticle

Adenoma
Neoplasms
Adenomatous Polyposis Coli
Internal-External Control
Enterobacteriaceae
33 Citations (Scopus)

Localized gene action controlling intestinal neoplasia in mice

Gould, K. A. & Dove, W. F., May 27 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 11, p. 5848-5853 6 p.

Research output: Contribution to journalArticle

Adenoma
Cell Polarity
Phospholipases
Cell Lineage
Cell Adhesion
82 Citations (Scopus)
Adenoma
Neoplasms
Epithelium
Clone Cells
Cell Lineage
1996
32 Citations (Scopus)

Action of Min and Mom1 on neoplasia in ectopic intestinal grafts

Gould, K. A. & Dove, W. F., Nov 7 1996, In : Cell Growth and Differentiation. 7, 10, p. 1361-1368 8 p.

Research output: Contribution to journalArticle

Transplants
Neoplasms
Isografts
Chromosomes, Human, Pair 4
Genetic Loci
60 Citations (Scopus)

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice

Gould, K. A., Luongo, C., Moser, A. R., McNeley, M. K., Borenstein, N., Shedlovsky, A., Dove, W. F., Hong, K., Dietrich, W. F. & Lander, E. S., Dec 1 1996, In : Genetics. 144, 4, p. 1777-1785 9 p.

Research output: Contribution to journalArticle

Modifier Genes
Quantitative Trait Loci
Adenoma
GTPase-Activating Proteins
Phospholipases
65 Citations (Scopus)

Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Gould, K. A., Dietrich, W. F., Borenstein, N., Lander, E. S. & Dove, W. F., Dec 1 1996, In : Genetics. 144, 4, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

Adenoma
Alleles
Neoplasms
Genetic Background
1995
170 Citations (Scopus)

ApcMin: A mouse model for intestinal and mammary tumorigenesis

Moser, A. R., Luongo, C., Gould, K. A., McNeley, M. K., Shoemaker, A. R. & Dove, W. F., Jan 1 1995, In : European Journal of Cancer. 31, 7-8, p. 1061-1064 4 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Neoplasms
Adenomatous Polyposis Coli
Adenoma
118 Citations (Scopus)

Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation

Moser, A. R., Shoemaker, A. R., Connelly, C. S., Clipson, L., Gould, K. A., Luongo, C., Dove, W. F., Siggers, P. H. & Gardner, R. L., Aug 1995, In : Developmental Dynamics. 203, 4, p. 422-433 12 p.

Research output: Contribution to journalArticle

Open Access
Gastrulation
Neoplasms
Embryonic Structures
APC Genes
Ectoderm
1994
19 Citations (Scopus)

The adenomatous polyposis coli gene of the mouse in development and neoplasia

Dove, W. F., Luongo, C., Connelly, C. S., Gould, K. A., Shoemaker, A. R., Moser, A. R. & Gardner, R. L., Jan 1 1994, In : Cold Spring Harbor Symposia on Quantitative Biology. 59, p. 501-508 8 p.

Research output: Contribution to journalArticle

APC Genes
Neoplasms
1993
577 Citations (Scopus)

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

Dietrich, W. F., Lander, E. S., Smith, J. S., Moser, A. R., Gould, K. A., Luongo, C., Borenstein, N. & Dove, W., Nov 19 1993, In : Cell. 75, 4, p. 631-639 9 p.

Research output: Contribution to journalArticle

Tumors
Neoplasms
Chromosomes
Genes
Colonic Neoplasms
9 Citations (Scopus)

Immunolocalization of ras oncogene p21 in human liver diseases

Radosevich, J. A., Gould, K. A., Koukoulis, G. K., Haines, G. K., Rosen, S. T., Lee, I. & Gould, V. E., Jan 1 1993, In : Ultrastructural Pathology. 17, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

oncogenes
ras Genes
liver
Liver
Liver Diseases
45 Citations (Scopus)

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

Luongo, C., Gould, K. A., Su, L. K., Kinzler, K. W., Vogelstein, B., Dietrich, W., Lander, E. S. & Moser, A. R., Jan 1993, In : Genomics. 15, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 18
Colorectal Neoplasms
Neoplasms
APC Genes
Synteny
1992
1231 Citations (Scopus)

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

Su, L. K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A. & Dove, W. F., Jan 1 1992, In : Science. 256, 5057, p. 668-670 3 p.

Research output: Contribution to journalArticle

APC Genes
Adenomatous Polyposis Coli
Mutation
Colorectal Neoplasms
Neoplasms