Karen A Gould, PhD

Associate Professor

  • 3597 Citations
  • 26 h-Index
1992 …2018

Research output per year

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Research Output

  • 3597 Citations
  • 26 h-Index
  • 46 Article
  • 3 Review article
  • 1 Editorial
Article

Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Ma, S., Shukla, V., Fang, L., Gould, K. A., Joshi, S. S. & Lu, R., Sep 13 2013, In : Journal of Biological Chemistry. 288, 37, p. 26430-26440 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Action of Min and Mom1 on neoplasia in ectopic intestinal grafts

Gould, K. A. & Dove, W. F., Nov 7 1996, In : Cell Growth and Differentiation. 7, 10, p. 1361-1368 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In : PloS one. 8, 11, e81483.

Research output: Contribution to journalArticle

8 Scopus citations

Analysis of the mom1 modifier of intestinal neoplasia in mice

Gould, K. A. & Dove, W. F., Jan 1 1998, In : Experimental Lung Research. 24, 4, p. 437-453 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice

Nelson, R. K. & Gould, K. A., Feb 1 2016, In : Lupus. 25, 2, p. 137-154 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: Influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study

Mikuls, T. R., Gould, K. A., Bynoté, K. K., Yu, F., LeVan, T. D., Thiele, G. M., Michaud, K. D., O'Dell, J. R., Reimold, A. M., Hooker, R., Caplan, L., Johnson, D. S., Kerr, G., Richards, J. S., Cannon, G. W., Criswell, L. A., Noble, J. A., Bridges, L. S., Hughes, L. & Gregersen, P. K., Nov 18 2010, In : Arthritis Research and Therapy. 12, 6, R213.

Research output: Contribution to journalArticle

30 Scopus citations

ApcMin: A mouse model for intestinal and mammary tumorigenesis

Moser, A. R., Luongo, C., Gould, K. A., McNeley, M. K., Shoemaker, A. R. & Dove, W. F., Jan 1 1995, In : European Journal of Cancer. 31, 7-8, p. 1061-1064 4 p.

Research output: Contribution to journalArticle

177 Scopus citations

Associations of cigarette smoking with rheumatoid arthritis in African Americans

Mikuls, T. R., Sayles, H., Yu, F., Levan, T., Gould, K. A., Thiele, G. M., Conn, D. L., Jonas, B. L., Callahan, L. F., Smith, E., Brasington, R., Moreland, L. W., Reynolds, R. J. & Bridges, S. L., Dec 1 2010, In : Arthritis Care and Research. 62, 12, p. 3560-3568 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

DES action in the thymus: inhibition of cell proliferation and genetic variation

Gould, K. A., Shull, J. D. & Gorski, J., Dec 22 2000, In : Molecular and Cellular Endocrinology. 170, 1-2, p. 31-39 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects

Yuan, F., Nelson, R. K., Tabor, D. E., Zhang, Y., Akhter, M. P., Gould, K. A. & Wang, D., Dec 1 2012, In : Arthritis and rheumatism. 64, 12, p. 4029-4039 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Disruption of estrogen receptor signaling enhances intestinal neoplasia in ApcMin/+ mice

Cleveland, A. G., Oikarinen, S. I., Bynoté, K. K., Marttinen, M., Rafter, J. J., Gustafsson, J. Å., Roy, S. K., Pitot, H. C., Korach, K. S., Lubahn, D. B., Mutanen, M. & Gould, K. A., Sep 18 2009, In : Carcinogenesis. 30, 9, p. 1581-1590 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development

Bhattacharyya, S., Rainey, M. A., Arya, P., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., Todd, G. L., Gould, K., Datta, K., Waes, J. G. V., Band, V. & Band, H., Feb 17 2016, In : Scientific reports. 6, 20727.

Research output: Contribution to journalArticle

21 Scopus citations

Estrogen receptor alpha promotes lupus in (NZB × NZW)F1 mice in a B cell intrinsic manner

Tabor, D. E. & Gould, K. A., Jan 1 2017, In : Clinical Immunology. 174, p. 41-52 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
5 Scopus citations

Estrogen receptor-α deficiency attenuates autoimmune disease in (NZB × NZW)F1 mice

Bynoté, K. K., Hackenberg, J. M., Korach, K. S., Lubahn, D. B., Lane, P. H. & Gould, K. A., Mar 1 2008, In : Genes and Immunity. 9, 2, p. 137-152 16 p.

Research output: Contribution to journalArticle

95 Scopus citations

Estrogen receptor α-mediated events promote sex-specific diabetic glomerular hypertrophy

Lovegrove, A. S., Sun, J., Gould, K. A., Lubahn, D. B., Korach, K. S. & Lane, P. H., Sep 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 3 56-3, p. F586-F591

Research output: Contribution to journalArticle

30 Scopus citations

Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk

Otterpohl, K. L. & Gould, K. A., Mar 2017, In : PloS one. 12, 3, e0172247.

Research output: Contribution to journalArticle

1 Scopus citations

Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval

Panchanathan, R., Shen, H., Bupp, M. G., Gould, K. A. & Choubey, D., Dec 1 2009, In : Journal of Immunology. 183, 11, p. 7031-7038 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Gender-dependent expression of murine Irf5 gene: Implications for sex bias in autoimmunity

Shen, H., Panchanathan, R., Rajavelu, P., Duan, X., Gould, K. A. & Choubey, D., Dec 1 2010, In : Journal of Molecular Cell Biology. 2, 5, p. 284-290 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Genetic bases of estrogen-induced pituitary tumorigenesis: Identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains

Strecker, T. E., Spady, T. J., Schaffer, B. S., Gould, K. A., Kaufman, A. E., Shen, F., McLaughlin, M. T., Pennington, K. L., Meza, J. L. & Shull, J. D., Apr 1 2005, In : Genetics. 169, 4, p. 2189-2197 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genetic bases of estrogen-induced tumorigenesis in the rat: Mapping of loci controlling susceptibility to mammary cancer in a Brown Norway × ACI intercross

Schaffer, B. S., Lachel, C. M., Pennington, K. L., Murrin, C. R., Strecker, T. E., Tochacek, M., Gould, K. A., Meza, J. L., McComb, R. D. & Shull, J. D., Aug 1 2006, In : Cancer Research. 66, 15, p. 7793-7800 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Genetic bases of renal agenesis in the ACI rat: Mapping of Renag1 to chromosome 14

Shull, J. D., Lachel, C. M., Strecker, T. E., Spady, T. J., Tochacek, M., Pennington, K. L., Murrin, C. R., Meza, J. L., Schaffer, B. S., Flood, L. A. & Gould, K. A., Jul 1 2006, In : Mammalian Genome. 17, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic control of estrogen action in the rat: Mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross

Shull, J. D., Lachel, C. M., Murrin, C. R., Pennington, K. L., Schaffer, B. S., Strecker, T. E. & Gould, K. A., Sep 1 2007, In : Mammalian Genome. 18, 9, p. 657-669 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: Mapping of Emca1 and Emca2 to chromosomes 5 and 18

Gould, K. A., Tochacek, M., Schaffer, B. S., Reindl, T. M., Murrin, C. R., Lachel, C. M., VanderWoude, E. A., Pennington, K. L., Flood, L. A., Bynote, K. K., Meza, J. L., Newton, M. A. & Shull, J. D., Dec 1 2004, In : Genetics. 168, 4, p. 2113-2125 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes

Otterpohl, K. L. & Gould, K. A., Jun 2 2015, In : Mammalian Genome. 26, 5-6, p. 235-247 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice

Gould, K. A., Luongo, C., Moser, A. R., McNeley, M. K., Borenstein, N., Shedlovsky, A., Dove, W. F., Hong, K., Dietrich, W. F. & Lander, E. S., Dec 1 1996, In : Genetics. 144, 4, p. 1777-1785 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

Dietrich, W. F., Lander, E. S., Smith, J. S., Moser, A. R., Gould, K. A., Luongo, C., Borenstein, N. & Dove, W., Nov 19 1993, In : Cell. 75, 4, p. 631-639 9 p.

Research output: Contribution to journalArticle

580 Scopus citations

Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5

Gould, K. A., Pandey, J., Lachel, C. M., Murrin, C. R., Flood, L. A., Pennington, K. L., Schaffer, B. S., Tochacek, M., McComb, R. D., Meza, J. L., Wendell, D. L. & Shull, J. D., Nov 1 2005, In : Mammalian Genome. 16, 11, p. 854-864 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat

Gould, K. A., Strecker, T. E., Hansen, K. K., Bynoté, K. K., Peterson, K. A. & Shull, J. D., May 1 2006, In : Mammalian Genome. 17, 5, p. 451-464 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic mapping of Mom5, a novel modifier of ApcMin-induced intestinal tumorigenesis

Oikarinen, S. I., Cleveland, A. G., Cork, K. M., Bynoté, K. K., Rafter, J. J., Gustafsson, J. Å., Mutanen, M. & Gould, K. A., Sep 18 2009, In : Carcinogenesis. 30, 9, p. 1591-1596 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation

Moser, A. R., Shoemaker, A. R., Connelly, C. S., Clipson, L., Gould, K. A., Luongo, C., Dove, W. F., Siggers, P. H. & Gardner, R. L., Aug 1995, In : Developmental Dynamics. 203, 4, p. 422-433 12 p.

Research output: Contribution to journalArticle

Open Access
120 Scopus citations

Immunolocalization of ras oncogene p21 in human liver diseases

Radosevich, J. A., Gould, K. A., Koukoulis, G. K., Haines, G. K., Rosen, S. T., Lee, I. & Gould, V. E., Jan 1 1993, In : Ultrastructural Pathology. 17, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans

Mikuls, T. R., Levan, T., Gould, K. A., Yu, F., Thiele, G. M., Bynote, K. K., Conn, D., Jonas, B. L., Callahan, L. F., Smith, E., Brasington, R., Moreland, L. W., Reynolds, R., Gaffo, A. & Bridges, S. L., Mar 1 2012, In : Arthritis and rheumatism. 64, 3, p. 655-664 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status

Dove, W. F., Clipson, L., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., Newton, M. A. & Jacoby, R. F., Jan 1 1997, In : Cancer Research. 57, 5, p. 812-814 3 p.

Research output: Contribution to journalArticle

115 Scopus citations

Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain

Pandey, J., Gould, K. A., McComb, R. D., Shull, J. D. & Wendell, D. L., Nov 1 2005, In : Mammalian Genome. 16, 11, p. 865-872 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Localized gene action controlling intestinal neoplasia in mice

Gould, K. A. & Dove, W. F., May 27 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 11, p. 5848-5853 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

Luongo, C., Gould, K. A., Su, L. K., Kinzler, K. W., Vogelstein, B., Dietrich, W., Lander, E. S. & Moser, A. R., Jan 1993, In : Genomics. 15, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Gould, K. A., Dietrich, W. F., Borenstein, N., Lander, E. S. & Dove, W. F., Dec 1 1996, In : Genetics. 144, 4, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

Su, L. K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A. & Dove, W. F., Jan 1 1992, In : Science. 256, 5057, p. 668-670 3 p.

Research output: Contribution to journalArticle

1240 Scopus citations
83 Scopus citations

Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction

Harvell, D. M. E., Buckles, L. K., Gould, K. A., Pennington, K. L., McComb, R. D. & Shull, J. D., Jul 1 2003, In : Endocrine. 21, 2, p. 175-183 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
10 Scopus citations

The adenomatous polyposis coli gene of the mouse in development and neoplasia

Dove, W. F., Luongo, C., Connelly, C. S., Gould, K. A., Shoemaker, A. R., Moser, A. R. & Gardner, R. L., Jan 1 1994, In : Cold Spring Harbor Symposia on Quantitative Biology. 59, p. 501-508 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

The intestinal epithelium and its neoplasms: Genetic, cellular and tissue interactions

Dove, W. F., Cormier, R. T., Gould, K. A., Halberg, R. B., Merritt, A. J., Newton, M. A. & Shoemaker, A. R., Jun 29 1998, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 353, 1370, p. 915-923 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

The Mom1(AKR) intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64

Cormier, R. T., Bilger, A., Lillich, A. J., Halberg, R. B., Hong, K. H., Gould, K. A., Borenstein, N., Lander, E. S. & Dove, W. F., Jun 29 2000, In : Oncogene. 19, 28, p. 3182-3192 11 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat

Kurz, S. G., Hansen, K. K., McLaughlin, M. T., Shivaswamy, V., Schaffer, B. S., Gould, K. A., McComb, R. D., Meza, J. L. & Shull, J. D., Aug 1 2008, In : Endocrinology. 149, 8, p. 3850-3859 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
Editorial

E-cadherin as tumor differentiation marker and as architectural determinant

Gould, V. E. & Gould, K. A., Jan 1 1999, In : Human Pathology. 30, 11, p. 1273-1275 3 p.

Research output: Contribution to journalEditorial

9 Scopus citations
Review article

Emergent issues in the genetics of intestinal neoplasia

Dove, W. F., Gould, K. A., Luongo, C., Moser, A. R. & Shoemaker, A. R., Dec 1 1995, In : Cancer Surveys. 25, p. 335-356 22 p.

Research output: Contribution to journalReview article

29 Scopus citations

Manipulation of the mouse germline in the study of Min-induced neoplasia

Bilger, A., Shoemaker, A. R., Gould, K. A. & Dove, W. F., Oct 1996, In : Seminars in Cancer Biology. 7, 5, p. 249-260 12 p.

Research output: Contribution to journalReview article

28 Scopus citations

Studies of neoplasia in the Min mouse

Shoemaker, A. R., Gould, K. A., Luongo, C., Moser, A. R. & Dove, W. F., Apr 18 1997, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1332, 2, p. F25-F48

Research output: Contribution to journalReview article

144 Scopus citations