John Louis Colombo, MD

Professor

  • 1465 Citations
  • 21 h-Index
1979 …2017
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Research Output 1979 2017

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Article
2017
74 Citations (Scopus)

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6–11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial

on behalf of the, VX14-809-109 investigator group & VX14-809-109 investigator group, Jul 2017, In : The Lancet Respiratory Medicine. 5, 7, p. 557-567 11 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Placebos
Safety
ivacaftor drug combination lumacaftor
2016
22 Citations (Scopus)

Forced Expiratory Volume in 1 Second Variability Helps Identify Patients with Cystic Fibrosis at Risk of Greater Loss of Lung Function

Morgan, W. J., Vandevanter, D. R., Pasta, D. J., Foreman, A. J., Wagener, J. S., Konstan, M. W., Liou, T., McColley, S., McMullen, A., Quittner, A., Regelmann, W., Ren, C., Rosenfeld, M., Sawicki, G., Schechter, M., Woo, M., Brasfield, D., Lyrene, R., Sindel, L., Roberts, D. & 315 others, Carroll, J., Warren, R., Nassri, L., Anderson, P., Brown, M., Silverthorn, A., Radford, P., Gong, G., Legris, G., Greene, G., Sudhakar, R., Platzker, A., Nickerson, B., Hardy, K., Harwood, I., Shay, G., Quick, B., Lieberthal, A., Moss, R., Landon, C., Fanous, Y., Lieberman, J., Spiritus, E., Chipps, B., McDonald, R., Pian, M., Cropp, G., Lewis, N., Nielson, D., Shapiro, B., Accurso, F., Saavedra, M., Daigle, K., Hen, J., Palazzo, R., Dodds, K., Pad-Man, R., Goodill, J., Winnie, G., Davies, L., Kriseman, T., Sallent, J., Chiaro, J., Kubiet, M., Goldfinger, S., Schwartzman, M., Diaz, C., Maupin, K., Riff, E., Geller, D., Livingston, F., Mavunda, K., Birriel, J., Faverio, L., Rosenberg, D., Schaeffer, D., Sherman, J., Wagner, M., Light, M., Schnapf, B., Montgomery, G., Kirchner, K., Weatherly, M., Caplan, D., Guill, M., Hudson, V., Akhter, J., Davison, D., Boas, S., Chung, Y., Latner, R., Aljadeff, G., Chan, Y., Kraut, J., Stone, A., Still, J. L., Sharma, G., Eagleton, L., Hopkins, P., Chatrath, U., Lester, L., Kim, Y. J., Anthony, V., Eigan, H., Howenstine, M., James, P., Gergesha, E., Harris, J., Plant, R., Zivkovich, V., Collins, A., Nassif, E., Ahrens, R., Doornbos, D., Kanarek, J., Leff, R., Shaw, P., Demoss, E., Riva, M., Sullivan, L., Anstead, M., Kanga, J., Eid, N., Morton, R., Hilman, B., Jones, K., Davis, S., Harder, R., Lever, T., Cairns, A. M., Caldwell, E., Zuckerman, J., Mogayzel, P., Rosenstein, B., McQuestion, J., Perry, D., Rosenberg, S., Gerstle, R., Colin, A., Wohl, M. E., Lapey, A., Yee, W., O'Sullivan, B., Zwerdling, R., Abdulhamid, I., O'Hagan, A., Schuen, J., Kurlandsky, L., Honicky, R., Homnick, D., Marks, J., Pichurko, B., Maxvold, N., Nasr, S., Simon, R., Tsai, W., Kissner, D., McNamara, J., Henry, N., Marker, S., Pryor, M., Walker, L., Woodward, J., Mizell, L., Miller, S., Rosenbluth, D., Black, P., McCubbin, M., Cohen, A., Ferkol, T., Mallory, G., Rejent, A., Rubin, B., Graff, G., Konig, P., Colombo, J. L., Murphy, P. J., Boyle, W., Parker, W., Patton, C., Zanni, R., Atlas, A., Turcios, N., Laraya-Cuasay, L., Bisberg, D., Aguila, H., Allen, S., James, D., Perkett, E., Thompson, M., Budhecha, S., Diaz, R., Rosen, J., Kaslovsky, R., Percciacante, R., Borowitz, D., Cronin, J., McMahon, C., Quittell, L., Giusti, R., Cohen, R., Decelie-Germana, J., Gorvoy, J., Patel, K., Kattan, M., Dozor, A., Dimango, E., Berdella, M., Anbar, R., Ianuzzi, D., Sexton, J., Tayag-Kier, C., McBride, J., Voter, K., Dimaio, M., Georgitis, J., Majure, J. M., Martinez, M., McIntosh, C., Leigh, M., Black, H., Hughes, J., Kantak, A., Wilmott, R., Omlor, G., Stone, R., McCoy, K., Acton, J., Doershuk, C., Fink, R., Steffan, M., Vauthy, P., Joseph, P., Reyes, S., Kramer, J., Royall, J., Eisenberg, J., Wall, M., Fiel, S., Scanlin, T., Phadke, S., Weinberg, J., Sexauer, W., Wolf, S., Holsclaw, D., Klein, D., Warren, S., Kinsey, R., Perez, C., Ganeshanathan, M., Shinnick, J., Panitch, H., Varlotta, L., Robinson, C., Santana, J. R., Passero, M. A., Gwinn, J., Baker, R., Bowman, M., Flume, P., Brown, D., Marville, R., Wallace, J., Parry, R., Ellenburg, D., Rogers, J., Mohon, R., Ledbetter, J., Hanissian, A., Schoumacher, R., Campbell, P., Harris, C., Slovis, B., Stokes, D., Hale, K., Katz, M., Seilheimer, D., Sockrider, M., Frank, A., Daniel, J., Cunningham, J., Browning, I., Bray, J., Dove, A., Mandujano, F., Tremper, L., Morse, M., Willey-Courand, D., Copenhaver, S., Pohl, J., McWilliams, B., Martine-Logvinoff, M., Wallace, M., Klein, R., Amaro, R., Couch, L., Brown, M., Prestidge, C., Inscore, S., Lipton, A., Chatfield, B., Liou, T., Marshall, B., Lahiri, T., Swartz, D., Whittaker, L., Karlson, K., Ropoll, I., Rubio, T., Schmidt, J., Thomas, D., Osborn, J., Froh, D., Gaston, B., Elliott, G., Gibson, R., Ramsey, B., McCarthy, M., Larson, L., Ricker, D., Robbins, M., Aitken, M., Emerson, J., Aronoff, S., Moffett, K., Biller, J., Splaingard, M., Sullivan, B., Pritchard, P., Adair, S., Holzwarth, P., Dopico, G., Meyer, K., Green, C. & Rock, M., May 1 2016, In : Journal of Pediatrics. 169, p. 116-121.e2

Research output: Contribution to journalArticle

Forced Expiratory Volume
Cystic Fibrosis
Lung
Demography
Lung Diseases
92 Citations (Scopus)
Cystic Fibrosis
Pharmacokinetics
Safety
Mutation
Sweat
2011
54 Citations (Scopus)

Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function

Accurso, F. J., Moss, R. B., Wilmott, R. W., Anbar, R. D., Schaberg, A. E., Durham, T. A., Ramsey, B. W., Ahrens, R., Anbar, R., Lindner, D., Anderson, P., Atlas, A., Berthiaume, Y., Beaudoin, N., Bisberg, D., Pock, P., Boas, S., Borowitz, D., Smith, J., Chidekel, A. S. & 89 others, Chipps, B., Chmiel, J. F., Ksenich, B., Clancy, J. P., Colombo, J. L., Heimes, D., Daines, C., DeCelie-Germana, J., Galvin, S., Deterding, R., DiMango, E., Dorkin, H., Dozor, A., Gherson, I., Dunitz, J., Egan, M., Young, J., Elliott, G., Gadd, J., Fornos, P., Franco, M., Froh, D., Kelly, R., Geller, D., Cook, D., Gibson, R., Genatossio, A., Gong, G., Graff, G., Hardy, K., Robles, A., Hicks, D., Howenstine, M., Bendy, L., Jones, K., Gardner, A., Kanga, J., Owsley, B., Kreindler, J., Lapin, C., Drapeau, G., Lee, R., Dillard, M., Liou, T., McCoy, K. S., Olson, P., Millard, S., Moss, R., Dunn, C., Davies, Z., Nakamura, C., Brascia, T., Nasr, S., Oermann, C., Traplena, L., Prestidge, C., Prestridge, A., Delute, D., Ren, C., Retsch-Bogart, G., Towle, D., Barlow, C., Reyes, S., Roberts, D., Roberts, V., Rock, M., Makholm, L., Rubenstein, R., Kubrak, C., Murray, C., Schaeffer, D., DeLuca, E., Schechter, M., Peabody, J., Schellhase, D., Walker, P., Grece, C., Wall, M., Guzik, A., Weiner, D., Horn, A., Willey-Courand, D. B., Kociela, V., Woo, M., Wooldridge, J., Duan, L., Zeitlin, P., Zuckerman, J. & Kennedy-DuDevoir, R., Mar 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 183, 5, p. 627-634 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Lung
Placebos
Lung Diseases
Mucociliary Clearance
2009
169 Citations (Scopus)

Genetic modifiers of liver disease in cystic fibrosis

Bartlett, J. R., Friedman, K. J., Ling, S. C., Pace, R. G., Bell, S. C., Bourke, B., Castaldo, G., Castellani, C., Cipolli, M., Colombo, C., Colombo, J. L., Debray, D., Fernandez, A., Lacaille, F., Macek, M., Rowland, M., Salvatore, F., Taylor, C. J., Wainwright, C., Wilschanski, M. & 14 others, Zemková, D., Hannah, W. B., Phillips, M. J., Corey, M., Zielenski, J., Dorfman, R., Wang, Y., Zou, F., Silverman, L. M., Drumm, M. L., Wright, F. A., Lange, E. M., Durie, P. R. & Knowles, M. R., Sep 9 2009, In : JAMA - Journal of the American Medical Association. 302, 10, p. 1076-1083 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Liver Diseases
Alleles
Odds Ratio
Portal Hypertension
2007
165 Citations (Scopus)

Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: A randomized placebo-controlled phase 2B trial

Moss, R. B., Milla, C., Colombo, J. L., Accurso, F., Zeitlin, P. L., Clancy, J. P., Spencer, L. T., Pilewski, J., Waltz, D. A., Dorkin, H. L., Ferkol, T., Plan, M., Ramsey, B., Carter, B. J., Martin, D. B. & Heald, A. E., Aug 1 2007, In : Human gene therapy. 18, 8, p. 726-732 7 p.

Research output: Contribution to journalArticle

Dependovirus
Cystic Fibrosis
Placebos
Lung
Sputum
2003
73 Citations (Scopus)

Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: A multi-center trial in children with cystic fibrosis

Piedra, P. A., Cron, S. G., Jewell, A., Hamblett, N., McBride, R., Palacio, M. A., Ginsberg, R., Oermann, C. M., Hiatt, P. W., McColley, S., Bowman, M., Borowitz, D., Castile, R., McCoy, K., Prestige, C., Brown, M. E., Stevens, J., Regelmann, W., Milla, C., Sammut, P. H. & 17 others, Colombo, J. L., Eisenberg, J., Murphy, T. D., Finder, J., Kurland, G., Winnie, G., Orenstein, D., Voter, K., Light, M., Pian, M. S., Harris, C., Stokes, D., Fink, R., Ren, C., Gorvoy, J., Varlotta, L. & Dyson, M., Jun 2 2003, In : Vaccine. 21, 19-20, p. 2448-2460 13 p.

Research output: Contribution to journalArticle

Respiratory Syncytial Virus Vaccines
cystic fibrosis
Respiratory Syncytial Viruses
Cystic Fibrosis
Vaccines
2002
19 Citations (Scopus)

Effectiveness and tolerability of high-dose salmeterol in cystic fibrosis

Hordvik, N. L., Sammut, P. H., Gerald Judy, C. & Colombo, J. L., Oct 1 2002, In : Pediatric Pulmonology. 34, 4, p. 287-296 10 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Albuterol
Therapeutics
Salmeterol Xinafoate
Vital Capacity
2000
18 Citations (Scopus)

Airway reactivity following repeated milk aspiration in rabbits

Colombo, J. L. & Hallberg, T. K., Feb 1 2000, In : Pediatric Pulmonology. 29, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Methacholine Chloride
Milk
Gastroesophageal Reflux
Rabbits
Eosinophils
1999
23 Citations (Scopus)

Effects of standard and high doses of salmeterol on lung function of hospitalized patients with cystic fibrosis

Hordvik, N. L., Sammut, P. H., Judy, C. G. & Colombo, J. L., Jan 1 1999, In : Pediatric Pulmonology. 27, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Albuterol
Lung
Placebos
Nebulizers and Vaporizers
1997

The effects of albuterol on the lung function of hospitalized patients with cystic fibrosis

Hordvik, N. L., Sammut, P. H., Judy, C. G., Strizek, S. J. & Colombo, J. L., Dec 1 1997, In : Pediatric Pulmonology. 23, 4, 1 p.

Research output: Contribution to journalArticle

Albuterol
Cystic Fibrosis
Placebos
Lung
Spirometry
1996
42 Citations (Scopus)

Anabolic effect of biosynthetic growth hormone in cystic fibrosis patients

Huseman, C. A., Colombo, J. L., Brooks, M. A., Smay, J. R., Greger, N. G., Sammut, P. H. & Bier, D. M., Aug 1 1996, In : Pediatric Pulmonology. 22, 2, p. 90-95 6 p.

Research output: Contribution to journalArticle

Anabolic Agents
Cystic Fibrosis
Growth Hormone
Human Growth Hormone
Nitrogen

Analysis of factors associated with the development of tobramycin (TO) resistance in Cystic Fibrosis (CF) patients

Stratbucker, W., Colombo, J. L., Hallberg, T. & Sammut, P. H., Oct 1 1996, In : Chest. 110, 4 SUPPL., p. 155S

Research output: Contribution to journalArticle

Tobramycin
Cystic Fibrosis
Statistical Factor Analysis
Ciprofloxacin
Anti-Bacterial Agents

Inhaled clindamycin in CF patients with chronic infection with Pseudomonas

Thompson, A. B., Sammut, P. H., Judy, C. G., Floreani, A., Acquazzino, D., Rennard, S. I. & Colombo, J. L., Oct 1 1996, In : Chest. 110, 4 SUPPL., p. 155S

Research output: Contribution to journalArticle

Pseudomonas Infections
Clindamycin
Sputum
Pseudomonas
Spirometry
26 Citations (Scopus)

The effects of albuterol on the lung function of hospitalized patients with cystic fibrosis

Hordvik, N. L., Sammut, P. H., Judy, C. G., Strizek, S. J. & Colombo, J. L., Jan 1 1996, In : American Journal of Respiratory and Critical Care Medicine. 154, 1, p. 156-160 5 p.

Research output: Contribution to journalArticle

Albuterol
Cystic Fibrosis
Placebos
Lung
Spirometry
1995
70 Citations (Scopus)

Clinical denouement and mutation analysis of patients with cystic fibrosis undergoing liver transplantation for biliary cirrhosis

Mack, D. R., Traystman, M. D., Colombo, J. L., Sammut, P. H., Kaufman, S. S., Vanderhoof, J. A., Antonson, D. L., Markin, R. S., Shaw, B. W. & Langnas, A. N., Dec 1995, In : The Journal of Pediatrics. 127, 6, p. 881-887 7 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Cystic Fibrosis
Liver Transplantation
Mutation
Transplantation
40 Citations (Scopus)

Comparison of three jet nebulizer aerosol delivery systems used to administer recombinant human DNase I to patients with cystic fibrosis

Fiel, S. B., Fuchs, H. J., Johnson, C., Gonda, I., Clark, A. R., Cipolla, C. C., Colin, A., Colombo, J., Denning, C., Dozor, A., Eigen, H., Eisenberg, J., Fink, R., Geller, D., Glasser, L., Gerstle, L., Green, C., Hernried, L. & Johnson, G., Jan 1 1995, In : Chest. 108, 1, p. 153-156 4 p.

Research output: Contribution to journalArticle

Nebulizers and Vaporizers
Deoxyribonuclease I
Aerosols
Cystic Fibrosis
Lung
1993
4 Citations (Scopus)

Mutation analysis and haplotype correlation for 139 cystic fibrosis patients from the Nebraska Regional Cystic Fibrosis Center

Traystman, M. D., Schulte, N., Colombo, J. L., Sammut, P. H., Reilly, P., Patel, C., Acquazzino, D., Simanek, B., Anderson, R., Kimberling, W. J., Bradley Schaefer, G. & Sanger, W. G., 1993, In : Human mutation. 2, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Haplotypes
Mutation
Chromosomes
Sequence Deletion
9 Citations (Scopus)

Unusual form of endobronchial aspergillosis in a patient with cystic fibrosis

Sammut, P. H., Howard, S. T., Linder, J. & Colombo, J. L., Jul 1993, In : Pediatric Pulmonology. 16, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

Aspergillus fumigatus
Aspergillosis
Cystic Fibrosis
Allergic Bronchopulmonary Aspergillosis
Cyanosis
1992
27 Citations (Scopus)
Serum Amyloid A Protein
Cystic Fibrosis
Pneumonia
Adrenal Cortex Hormones
Proteins
32 Citations (Scopus)

The spectrum of Pneumocystis carinii infection after liver transplantation in children

Colombo, J. L., Sammut, P. H., Langnas, A. N. & Shaw, B. W., Oct 1992, In : Transplantation. 54, 4, p. 621-624 4 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Liver Transplantation
Transplantation
Dimercaprol
Chemoprevention
28 Citations (Scopus)

Time course of lipid‐laden pulmonary macrophages with acute and recurrent milk aspiration in rabbits

Colombo, J. L., Hallberg, T. K. & Sammut, P. H., Feb 1992, In : Pediatric Pulmonology. 12, 2, p. 95-98 4 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Milk
Rabbits
Lipids
Macrophages
37 Citations (Scopus)

Treatment of life-threatening primary pulmonary hemosiderosis with cyclophosphamide

Colombo, J. L. & Stolz, S. M., Jan 1 1992, In : Chest. 102, 3, p. 959-960 2 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Hemorrhage
Lung
Azathioprine
Therapeutics
1990
10 Citations (Scopus)

Refractory congestive heart failure after ribavirin in infants with heart disease and respiratory syncytial virus.

Martin, J. T., Kugler, J. D., Gumbiner, C. H., Brown, J. C., Murphy, K. R., Colombo, J. L. & McManus, B. M., Feb 1990, In : The Nebraska medical journal. 75, 2, p. 23-26 4 p.

Research output: Contribution to journalArticle

Respiratory Syncytial Viruses
Ribavirin
Heart Diseases
Heart Failure
Pulmonary Edema
1987
37 Citations (Scopus)

Chlorine inhalation toxicity from vapors generated by swimming pool chlorinator tablets

Wood, B. R., Colombo, J. L. & Benson, B. E., Jan 1 1987, In : Pediatrics. 79, 3, p. 427-430 4 p.

Research output: Contribution to journalArticle

Chlorine Compounds
Swimming Pools
Chlorine
Inhalation
Tablets
133 Citations (Scopus)

Recurrent aspiration in children: Lipid‐laden alveolar macrophage quantitation

Colombo, J. L. & Hallberg, T. K., Jan 1 1987, In : Pediatric Pulmonology. 3, 2, p. 86-89 4 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Macrophages
Food
1986
16 Citations (Scopus)

Circulating immune complexes in cystic fibrosis and their correlation to clinical parameters

Disis, M. L., McDonald, T. L., Colombo, J. L., Kobayashi, R. H., Angle, C. R. & Murray, S., May 1986, In : Pediatric Research. 20, 5, p. 385-390 6 p.

Research output: Contribution to journalArticle

Open Access
Antigen-Antibody Complex
Cystic Fibrosis
Immunoglobulin G
Peak Expiratory Flow Rate
Vital Signs
11 Citations (Scopus)

Cystic fibrosis complicated by acute leukemia

Biggs, B. G., Vaughan, W., Colombo, J. L., Sanger, W. & Purtilo, D. T., Jun 15 1986, In : Cancer. 57, 12, p. 2441-2443 3 p.

Research output: Contribution to journalArticle

Open Access
Cystic Fibrosis
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Survival
1984
1 Citation (Scopus)

Isolated endocardial fibroelastosis of the right ventricle associated with pulmonary hypertension

Larson, J. E., McManus, B. M., Hofschire, P. J., Colombo, J. L. & Look, C. E., Jun 1984, In : American Heart Journal. 107, 6, p. 1286-1290 5 p.

Research output: Contribution to journalArticle

Endocardial Fibroelastosis
Pulmonary Hypertension
Heart Ventricles
Echocardiography
1983
12 Citations (Scopus)

Evidence for modification of pulmonary cyclooxygenase activity by endotoxin in the dog

Spannhake, E. W., Colombo, J. L., Craigo, P. A., McNamara, D. B., Hyman, A. L. & Kadowitz, P. J., May 26 1983, In : Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 54, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Endotoxins
Arachidonic Acid
Dogs
Lung
1982

Contribution of thromboxane A2 to the airway and pulmonary vascular responses to arachidonic acid in normal and endotoxin-treated dogs

Spannhake, E. W., Colombo, J. L. & Craigo, P. A., Jan 1 1982, In : Federation Proceedings. 41, 5, 1 p.

Research output: Contribution to journalArticle

Thromboxanes
Arachidonic Acid
Endotoxins
Blood Vessels
Dogs

Evidence for modification of cyclooxygenase activity following E. coli endotoxin in the dog

Spannhake Wm., E., Colombo, J. L. & Craigo, P. A., Jan 1 1982, In : American Review of Respiratory Disease. 125, 4 II, 1 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Endotoxins
Dogs
Escherichia coli
1981

Modification of the airway response to arachidonic acid by endotoxin in the dog

Craigo, P. A., Spannhake Wm., E. & Colombo, J. L., Jan 1 1981, In : Clinical Research. 29, 5, p. 845 A

Research output: Contribution to journalArticle

Arachidonic Acid
Endotoxins
Dogs
8 Citations (Scopus)

Steam vaporizer injuries

Colombo, J. L., Hopkins, R. L. & Waring, W. W., Jan 1 1981, In : Pediatrics. 67, 5, p. 661-663 3 p.

Research output: Contribution to journalArticle

Nebulizers and Vaporizers
Steam
Burns
Wounds and Injuries
Hospital Departments
1979

Phenytoin and hyperglycemic complex.

Colombo, J. L. & Lohff, M. R., May 1 1979, In : The Nebraska medical journal. 64, 5, p. 146-148 3 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Infant, Premature, Diseases
Phenytoin
Hyperglycemia
Seizures