Jixin Dong, PhD

Associate Professor

  • 5006 Citations
  • 25 h-Index
19972019
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Research Output 1997 2019

  • 5006 Citations
  • 25 h-Index
  • 42 Article
  • 4 Review article
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Article
2019
3 Citations (Scopus)

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
Uterine Cervical Neoplasms
Carcinogenesis
Animals
Animal Models
Infection

Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression

Stauffer, S., Zeng, Y., Santos, M., Zhou, J., Chen, Y. & Dong, J., Jan 1 2019, In : Journal of cell science. 132, 20, jcs236000.

Research output: Contribution to journalArticle

Open Access
CDC2 Protein Kinase
AMP-Activated Protein Kinases
Chromosomes
Phosphorylation
Mitosis

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
CDC2 Protein Kinase
Serine
Protein Isoforms
Phosphorylation
Mitosis
4 Citations (Scopus)

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Song, L., Tang, S., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y. & Du, Y., Dec 1 2019, In : Nature communications. 10, 1, 1639.

Research output: Contribution to journalArticle

Open Access
Exosomes
secretions
Cell membranes
Multivesicular Bodies
degradation

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Mar 2019, In : FEBS Journal. 286, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Mitosis
Tumors
bis(2,3,3,3-tetrachloropropyl) ether
Lung Neoplasms

The neuroprotection of KIBRA in promoting neuron survival and against amyloid β-induced apoptosis

Song, L., Tang, S., Dong, L., Han, X., Cong, L., Dong, J., Han, X., Zhang, Q., Wang, Y. & Du, Y., Apr 12 2019, In : Frontiers in Cellular Neuroscience. 13, 137.

Research output: Contribution to journalArticle

Open Access
Amyloid
Apoptosis
Neurons
Alzheimer Disease
Knockout Mice
3 Citations (Scopus)

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J., Chen, X., Ma, B., Timm, B. K., Maclin, V., Dong, J., Rueda, B. R., Davis, J. S. & Wang, C., Sep 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 10049-10064 16 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Granulosa Cells
Chemical activation
Proteins
Luteal Cells
1 Citation (Scopus)

YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P. C., Dong, J., Zhou, J., Wang, Z., Rueda, B. R., Davis, J. S. & Wang, C., Mar 2019, In : EMBO Reports. 20, 3, e44948.

Research output: Contribution to journalArticle

Tissue homeostasis
Tumors
Homeostasis
Feedback
Neoplasms
2018
1 Citation (Scopus)

Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy

Wang, Z., Chen, X., Zhong, M. Z., Yang, S., Zhou, J., Klinkebiel, D. L., Karpf, A. R., Chen, Y. & Dong, J., Dec 2018, In : Cellular Signalling. 52, p. 137-146 10 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Phosphorylation
Apoptosis
Mitosis
Drug Therapy
6 Citations (Scopus)

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation

Zhou, J., Zeng, Y., Cui, L., Chen, X., Stauffer, S., Wang, Z., Yu, F., Lele, S. M., Talmon, G. A., Black, A. R., Chen, Y. & Dong, J., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6760-E6769

Research output: Contribution to journalArticle

Zyxin
Colonic Neoplasms
Carcinogenesis
Phosphorylation
Cell Movement
2017
9 Citations (Scopus)

CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity

Stauffer, S., Zeng, Y., Zhou, J., Chen, X., Chen, Y. & Dong, J., Nov 2017, In : Cellular Signalling. 39, p. 74-83 10 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Cytokinesis
Phosphorylation
Threonine
Carcinogenesis
7 Citations (Scopus)

Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity

Zeng, Y., Stauffer, S., Zhou, J., Chen, X., Chen, Y. & Dong, J., Jan 1 2017, In : Journal of Biological Chemistry. 292, 36, p. 15028-15038 11 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Co-Repressor Proteins
Phosphorylation
Tumors
Tissue homeostasis
8 Citations (Scopus)

G-1 Inhibits breast cancer cell growth via targeting colchicine-binding site of tubulin to interfere with microtubule assembly

Lv, X., He, C., Huang, C., Hua, G., Wang, Z., Remmenga, S. W., Rodabough, K. J., Karpf, A. R., Dong, J., Davis, J. S. & Wang, C., Jun 2017, In : Molecular cancer therapeutics. 16, 6, p. 1080-1091 12 p.

Research output: Contribution to journalArticle

Colchicine
Tubulin
Microtubules
Binding Sites
Breast Neoplasms
2016
20 Citations (Scopus)

Ajuba phosphorylation by CDK1 promotes cell proliferation and tumorigenesis

Chen, X., Stauffer, S., Chen, Y. & Dong, J., Jul 8 2016, In : Journal of Biological Chemistry. 291, 28, p. 14761-14772 12 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Phosphorylation
Cell proliferation
Carcinogenesis
Cells
4 Citations (Scopus)

MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity

Chen, X., Chen, Y. & Dong, J., Dec 1 2016, In : Cellular Signalling. 28, 12, p. 1826-1832 7 p.

Research output: Contribution to journalArticle

Mitosis
Serine
Phosphotransferases
Phosphorylation
Neoplasms
25 Citations (Scopus)

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells

Hua, G., Lv, X., He, C., Remmenga, S. W., Rodabough, K. J., Dong, J., Yang, L., Lele, S. M., Yang, P., Zhou, J., Karst, A., Drapkin, R. I., Davis, J. S. & Wang, C., Apr 28 2016, In : Oncogene. 35, 17, p. 2247-2265 19 p.

Research output: Contribution to journalArticle

Fallopian Tubes
Epithelial Cells
Carcinoma
Proteins
Fibroblast Growth Factor Receptors
2015
35 Citations (Scopus)

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

Yang, S., Zhang, L., Purohit, V., Shukla, S. K., Chen, X., Yu, F., Fu, K., Chen, Y., Solheim, J. C., Singh, P., Song, W. & Dong, J., Jan 1 2015, In : Oncotarget. 6, 34, p. 36019-36031 13 p.

Research output: Contribution to journalArticle

Lysophosphatidic Acid Receptors
Pancreatic Neoplasms
Cell Movement
Carcinogenesis
Phosphorylation
13 Citations (Scopus)

CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity

Zhang, L., Chen, X., Stauffer, S., Yang, S., Chen, Y. & Dong, J., Jan 1 2015, In : Oncotarget. 6, 31, p. 31399-31412 14 p.

Research output: Contribution to journalArticle

Mitosis
Phosphorylation
Centrosome
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
13 Citations (Scopus)

Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1

Yang, S., Zhang, L., Chen, X., Chen, Y. & Dong, J., Mar 6 2015, In : Journal of Biological Chemistry. 290, 10, p. 6191-6202 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Oncogene Proteins
Up-Regulation
Chemical activation
Proteins
70 Citations (Scopus)

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

He, C., Mao, D., Hua, G., Lv, X., Chen, X., Angeletti, P. C., Dong, J., Remmenga, S. W., Rodabaugh, K. J., Zhou, J., Lambert, P. F., Yang, P., Davis, J. S. & Wang, C., Nov 2015, In : EMBO Molecular Medicine. 7, 11, p. 1426-1449 24 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Uterine Cervical Neoplasms
Proteins
Cell Proliferation
Organ Size
60 Citations (Scopus)

The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells

Zhang, L., Yang, S., Chen, X., Stauffer, S., Yu, F., Lele, S. M., Fu, K., Datta, K., Palermo, N., Chen, Y. & Dong, J., Jan 1 2015, In : Molecular and cellular biology. 35, 8, p. 1350-1362 13 p.

Research output: Contribution to journalArticle

Molecular Motor Proteins
Castration
Prostatic Neoplasms
Androgens
Growth
44 Citations (Scopus)

YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

He, C., Lv, X., Hua, G., Lele, S. M., Remmenga, S., Dong, J., Davis, J. S. & Wang, C., Dec 10 2015, In : Oncogene. 34, 50, p. 6040-6054 15 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Proteins
Neoplasms
Carcinogenesis
Growth
2014
39 Citations (Scopus)

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness

Jami, M. S., Hou, J., Liu, M., Varney, M. L., Hassan, H., Dong, J., Geng, L., Wang, J., Yu, F., Huang, X., Peng, H., Fu, K., Li, Y., Singh, R. K. & Ding, S. J., Mar 15 2014, In : BMC cancer. 14, 1, 194.

Research output: Contribution to journalArticle

Proteomics
Breast Neoplasms
Growth
Tumor Cell Line
Nude Mice
29 Citations (Scopus)

Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration

Yang, S., Ji, M., Zhang, L., Chen, Y., Wennmann, D. O., Kremerskothen, J. & Dong, J., Jan 1 2014, In : Cellular Signalling. 26, 2, p. 343-351 9 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Extracellular Signal-Regulated MAP Kinases
Cell Movement
Phosphorylation
Cell Proliferation
44 Citations (Scopus)

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors

Fu, D., Lv, X., Hua, G., He, C., Dong, J., Lele, S. M., Li, D. W. C., Zhai, Q., Davis, J. S. & Wang, C., Apr 2014, In : Endocrine-Related Cancer. 21, 2, p. 297-310 14 p.

Research output: Contribution to journalArticle

Granulosa Cell Tumor
Cell Movement
Cell Proliferation
Proteins
Estrogens
2013
56 Citations (Scopus)

CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation

Yang, S., Zhang, L., Liu, M., Chong, R., Ding, S. J., Chen, Y. & Dong, J., Nov 15 2013, In : Cancer Research. 73, 22, p. 6722-6733 12 p.

Research output: Contribution to journalArticle

Cell Movement
Cell Cycle
Neoplastic Cell Transformation
Phosphorylation
Centrosome
2012
28 Citations (Scopus)

KIBRA regulates Aurora kinase activity and is required for precise chromosome alignment during mitosis

Zhang, L., Iyer, J., Chowdhury, A., Ji, M., Xiao, L., Yang, S., Chen, Y., Tsai, M. Y. & Dong, J., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34069-34077 9 p.

Research output: Contribution to journalArticle

Aurora Kinases
Chromosomes
Mitosis
Tumors
Centrosome
21 Citations (Scopus)

Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression

Ji, M., Yang, S., Chen, Y., Xiao, L., Zhang, L. & Dong, J., Oct 1 2012, In : Biochemical Journal. 447, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Cell Cycle Checkpoints
Phosphoric Monoester Hydrolases
Brain
Cells
2011
19 Citations (Scopus)

Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274

Hou, J., Dong, J., Sun, L., Geng, L., Wang, J., Zheng, J. C., Li, Y., Bridge, J., Hinrichs, S. H. & Ding, S. J., May 16 2011, In : Journal of Translational Medicine. 9, 64.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Cells
Cell Line
Molecules
Alveolar Rhabdomyosarcoma
37 Citations (Scopus)

KIBRA protein phosphorylation is regulated by mitotic kinase Aurora and protein phosphatase 1

Xiao, L., Chen, Y., Ji, M., Volle, D. J., Lewis, R. E., Tsai, M. Y. & Dong, J., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36304-36315 12 p.

Research output: Contribution to journalArticle

Aurora Kinases
Protein Phosphatase 1
Phosphorylation
Proteins
Aurora Kinase B
107 Citations (Scopus)

KIBRA regulates hippo signaling activity via interactions with large tumor suppressor kinases

Xiao, L., Chen, Y., Ji, M. & Dong, J., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 7788-7796 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Tumors
Phosphotransferases
Cells
Neoplasms
2010
299 Citations (Scopus)

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W. M. & Pan, D., Feb 16 2010, In : Developmental cell. 18, 2, p. 288-299 12 p.

Research output: Contribution to journalArticle

Neurofibromin 2
Tumor Suppressor Proteins
Tissue homeostasis
Phosphotransferases
Proteins
384 Citations (Scopus)

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A. & Pan, D., Jul 1 2010, In : Developmental cell. 19, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

Tissue homeostasis
Neurofibromin 2
Mammals
Oncogene Proteins
Tumors
2008
368 Citations (Scopus)

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 1 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

Serous Cystadenocarcinoma
Neoplasms
Proteins
Carcinoma, Ductal, Breast
Human Chromosomes
393 Citations (Scopus)

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

Wu, S., Liu, Y., Zheng, Y., Dong, J. & Pan, D., Mar 2008, In : Developmental cell. 14, 3, p. 388-398 11 p.

Research output: Contribution to journalArticle

Tissue
Gene Expression
Cell death
Missense Mutation
Growth
2007
1294 Citations (Scopus)

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, MF. F., Anders, R. A., Maitra, A. & Pan, D., Sep 21 2007, In : Cell. 130, 6, p. 1120-1133 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Mammals
Drosophila
Organ Size
Tissue homeostasis
2006
59 Citations (Scopus)

The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: A novel oncogenic pathway

Lam-Himlin, D. M., Daniels, J. A., Gayyed, M. F., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Dec 1 2006, In : International Journal of Gastrointestinal Cancer. 37, 4, p. 103-109 7 p.

Research output: Contribution to journalArticle

Stomach
Carcinoma
Stomach Diseases
Carcinogenesis
Proteins
2004
88 Citations (Scopus)

Tsc2 is not a critical target of Akt during normal Drosophila development

Dong, J. & Pan, D., Oct 15 2004, In : Genes and Development. 18, 20, p. 2479-2484 6 p.

Research output: Contribution to journalArticle

Drosophila
Growth
Insulin
Tuberous Sclerosis
Sirolimus
2003
533 Citations (Scopus)

Expression profiles of the Arabidopsis WRKY gene superfamily during plant defense response

Dong, J., Chen, C. & Chen, Z., Jan 1 2003, In : Plant Molecular Biology. 51, 1, p. 21-37 17 p.

Research output: Contribution to journalArticle

Salicylic Acid
Arabidopsis
salicylic acid
Genes
Pathogens
638 Citations (Scopus)

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Wu, S., Huang, J., Dong, J. & Pan, D., Aug 22 2003, In : Cell. 114, 4, p. 445-456 12 p.

Research output: Contribution to journalArticle

Warts
Cell proliferation
Cell death
Protein Kinases
Cell Death
2000
38 Citations (Scopus)

The rice Rim2 transcript accumulates in response to Magnaporthe grisea and its predicted protein product shares similarity with TNP2-like proteins encoded by CACTA transposons

He, Z. H., Dong, H. T., Dong, J. X., Li, D. B. & Ronald, P. C., Jan 1 2000, In : Molecular and General Genetics. 264, 1-2, p. 2-10 9 p.

Research output: Contribution to journalArticle

Magnaporthe
Proteins
Petroselinum
Retroelements
Tandem Repeat Sequences
1997

Molecular cloning of differentially expressed novel rice genes induced by Magnaporthe grisea

He, Z., Dong, H., Cheng, S., Wu, Y., Dong, J. & Li, D., Jan 1 1997, In : Chinese Science Bulletin. 42, 20, p. 1748-1750 3 p.

Research output: Contribution to journalArticle