Jixin Dong, PhD

Associate Professor

  • 5109 Citations
  • 25 h-Index
19972020

Research output per year

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Research Output

  • 5109 Citations
  • 25 h-Index
  • 44 Article
  • 4 Review article
2020

Cyclin-dependent kinase 1-mediated phosphorylation of protein kinase N1 promotes anchorage-independent growth and migration

Zeng, R., Wang, Z., Li, X., Chen, Y., Yang, S. & Dong, J., May 2020, In : Cellular Signalling. 69, 109546.

Research output: Contribution to journalArticle

2019

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression

Stauffer, S., Zeng, Y., Santos, M., Zhou, J., Chen, Y. & Dong, J., Jan 1 2019, In : Journal of cell science. 132, 20, jcs236000.

Research output: Contribution to journalArticle

Open Access

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Song, L., Tang, S., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y. & Du, Y., Dec 1 2019, In : Nature communications. 10, 1, 1639.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Mar 2019, In : FEBS Journal. 286, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

The neuroprotection of KIBRA in promoting neuron survival and against amyloid β-induced apoptosis

Song, L., Tang, S., Dong, L., Han, X., Cong, L., Dong, J., Han, X., Zhang, Q., Wang, Y. & Du, Y., Apr 12 2019, In : Frontiers in Cellular Neuroscience. 13, 137.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J., Chen, X., Ma, B., Timm, B. K., Maclin, V., Dong, J., Rueda, B. R., Davis, J. S. & Wang, C., Sep 1 2019, In : FASEB Journal. 33, 9, p. 10049-10064 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P. C., Dong, J., Zhou, J., Wang, Z., Rueda, B. R., Davis, J. S. & Wang, C., Mar 2019, In : EMBO Reports. 20, 3, e44948.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy

Wang, Z., Chen, X., Zhong, M. Z., Yang, S., Zhou, J., Klinkebiel, D. L., Karpf, A. R., Chen, Y. & Dong, J., Dec 2018, In : Cellular Signalling. 52, p. 137-146 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation

Zhou, J., Zeng, Y., Cui, L., Chen, X., Stauffer, S., Wang, Z., Yu, F., Lele, S. M., Talmon, G. A., Black, A. R., Chen, Y. & Dong, J., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6760-E6769

Research output: Contribution to journalArticle

7 Scopus citations
2017

CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity

Stauffer, S., Zeng, Y., Zhou, J., Chen, X., Chen, Y. & Dong, J., Nov 2017, In : Cellular Signalling. 39, p. 74-83 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity

Zeng, Y., Stauffer, S., Zhou, J., Chen, X., Chen, Y. & Dong, J., Jan 1 2017, In : Journal of Biological Chemistry. 292, 36, p. 15028-15038 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

G-1 Inhibits breast cancer cell growth via targeting colchicine-binding site of tubulin to interfere with microtubule assembly

Lv, X., He, C., Huang, C., Hua, G., Wang, Z., Remmenga, S. W., Rodabough, K. J., Karpf, A. R., Dong, J., Davis, J. S. & Wang, C., Jun 2017, In : Molecular cancer therapeutics. 16, 6, p. 1080-1091 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Ajuba phosphorylation by CDK1 promotes cell proliferation and tumorigenesis

Chen, X., Stauffer, S., Chen, Y. & Dong, J., Jul 8 2016, In : Journal of Biological Chemistry. 291, 28, p. 14761-14772 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Pandey, P., Sliker, B., Peters, H. L., Tuli, A., Herskovitz, J., Smits, K., Purohit, A., Singh, R. K., Dong, J., Batra, S. K., Coulter, D. W. & Solheim, J. C., Apr 12 2016, In : Oncotarget. 7, 15, p. 19430-19444 15 p.

Research output: Contribution to journalReview article

35 Scopus citations

KIBRA promotes prostate cancer cell proliferation and motility

Stauffer, S., Chen, X., Zhang, L., Chen, Y. & Dong, J., May 1 2016, In : FEBS Journal. 283, 10, p. 1800-1811 12 p.

Research output: Contribution to journalReview article

17 Scopus citations

MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity

Chen, X., Chen, Y. & Dong, J., Dec 1 2016, In : Cellular Signalling. 28, 12, p. 1826-1832 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells

Hua, G., Lv, X., He, C., Remmenga, S. W., Rodabough, K. J., Dong, J., Yang, L., Lele, S. M., Yang, P., Zhou, J., Karst, A., Drapkin, R. I., Davis, J. S. & Wang, C., Apr 28 2016, In : Oncogene. 35, 17, p. 2247-2265 19 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

Yang, S., Zhang, L., Purohit, V., Shukla, S. K., Chen, X., Yu, F., Fu, K., Chen, Y., Solheim, J. C., Singh, P., Song, W. & Dong, J., Jan 1 2015, In : Oncotarget. 6, 34, p. 36019-36031 13 p.

Research output: Contribution to journalArticle

37 Scopus citations

CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity

Zhang, L., Chen, X., Stauffer, S., Yang, S., Chen, Y. & Dong, J., Jan 1 2015, In : Oncotarget. 6, 31, p. 31399-31412 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1

Yang, S., Zhang, L., Chen, X., Chen, Y. & Dong, J., Mar 6 2015, In : Journal of Biological Chemistry. 290, 10, p. 6191-6202 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

He, C., Mao, D., Hua, G., Lv, X., Chen, X., Angeletti, P. C., Dong, J., Remmenga, S. W., Rodabaugh, K. J., Zhou, J., Lambert, P. F., Yang, P., Davis, J. S. & Wang, C., Nov 2015, In : EMBO Molecular Medicine. 7, 11, p. 1426-1449 24 p.

Research output: Contribution to journalArticle

76 Scopus citations

The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells

Zhang, L., Yang, S., Chen, X., Stauffer, S., Yu, F., Lele, S. M., Fu, K., Datta, K., Palermo, N., Chen, Y. & Dong, J., Jan 1 2015, In : Molecular and cellular biology. 35, 8, p. 1350-1362 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

He, C., Lv, X., Hua, G., Lele, S. M., Remmenga, S., Dong, J., Davis, J. S. & Wang, C., Dec 10 2015, In : Oncogene. 34, 50, p. 6040-6054 15 p.

Research output: Contribution to journalArticle

46 Scopus citations
2014

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness

Jami, M. S., Hou, J., Liu, M., Varney, M. L., Hassan, H., Dong, J., Geng, L., Wang, J., Yu, F., Huang, X., Peng, H., Fu, K., Li, Y., Singh, R. K. & Ding, S. J., Mar 15 2014, In : BMC cancer. 14, 1, 194.

Research output: Contribution to journalArticle

40 Scopus citations

KIBRA: In the brain and beyond

Zhang, L., Yang, S., Wennmann, D. O., Chen, Y., Kremerskothen, J. & Dong, J., Jul 2014, In : Cellular Signalling. 26, 7, p. 1392-1399 8 p.

Research output: Contribution to journalReview article

30 Scopus citations

Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration

Yang, S., Ji, M., Zhang, L., Chen, Y., Wennmann, D. O., Kremerskothen, J. & Dong, J., Jan 1 2014, In : Cellular Signalling. 26, 2, p. 343-351 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors

Fu, D., Lv, X., Hua, G., He, C., Dong, J., Lele, S. M., Li, D. W. C., Zhai, Q., Davis, J. S. & Wang, C., Apr 2014, In : Endocrine-Related Cancer. 21, 2, p. 297-310 14 p.

Research output: Contribution to journalArticle

46 Scopus citations
2013

CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation

Yang, S., Zhang, L., Liu, M., Chong, R., Ding, S. J., Chen, Y. & Dong, J., Nov 15 2013, In : Cancer Research. 73, 22, p. 6722-6733 12 p.

Research output: Contribution to journalArticle

57 Scopus citations
2012

KIBRA regulates Aurora kinase activity and is required for precise chromosome alignment during mitosis

Zhang, L., Iyer, J., Chowdhury, A., Ji, M., Xiao, L., Yang, S., Chen, Y., Tsai, M. Y. & Dong, J., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34069-34077 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression

Ji, M., Yang, S., Chen, Y., Xiao, L., Zhang, L. & Dong, J., Oct 1 2012, In : Biochemical Journal. 447, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011

Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274

Hou, J., Dong, J., Sun, L., Geng, L., Wang, J., Zheng, J. C., Li, Y., Bridge, J., Hinrichs, S. H. & Ding, S. J., May 16 2011, In : Journal of Translational Medicine. 9, 64.

Research output: Contribution to journalArticle

19 Scopus citations

KIBRA protein phosphorylation is regulated by mitotic kinase Aurora and protein phosphatase 1

Xiao, L., Chen, Y., Ji, M., Volle, D. J., Lewis, R. E., Tsai, M. Y. & Dong, J., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36304-36315 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

KIBRA regulates hippo signaling activity via interactions with large tumor suppressor kinases

Xiao, L., Chen, Y., Ji, M. & Dong, J., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 7788-7796 9 p.

Research output: Contribution to journalArticle

110 Scopus citations
2010

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W. M. & Pan, D., Feb 16 2010, In : Developmental cell. 18, 2, p. 288-299 12 p.

Research output: Contribution to journalArticle

304 Scopus citations

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A. & Pan, D., Jul 1 2010, In : Developmental cell. 19, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

389 Scopus citations
2008

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 1 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

372 Scopus citations

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

Wu, S., Liu, Y., Zheng, Y., Dong, J. & Pan, D., Mar 2008, In : Developmental cell. 14, 3, p. 388-398 11 p.

Research output: Contribution to journalArticle

395 Scopus citations
2007

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, MF. F., Anders, R. A., Maitra, A. & Pan, D., Sep 21 2007, In : Cell. 130, 6, p. 1120-1133 14 p.

Research output: Contribution to journalArticle

1320 Scopus citations
2006

The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: A novel oncogenic pathway

Lam-Himlin, D. M., Daniels, J. A., Gayyed, M. F., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Dec 1 2006, In : International Journal of Gastrointestinal Cancer. 37, 4, p. 103-109 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
2004

Tsc2 is not a critical target of Akt during normal Drosophila development

Dong, J. & Pan, D., Oct 15 2004, In : Genes and Development. 18, 20, p. 2479-2484 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Tuberous sclerosis complex: From Drosophila to human disease

Pan, D., Dong, J., Zhang, Y. & Gao, X., Feb 2004, In : Trends in Cell Biology. 14, 2, p. 78-85 8 p.

Research output: Contribution to journalReview article

127 Scopus citations
2003

Expression profiles of the Arabidopsis WRKY gene superfamily during plant defense response

Dong, J., Chen, C. & Chen, Z., Jan 1 2003, In : Plant Molecular Biology. 51, 1, p. 21-37 17 p.

Research output: Contribution to journalArticle

542 Scopus citations

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Wu, S., Huang, J., Dong, J. & Pan, D., Aug 22 2003, In : Cell. 114, 4, p. 445-456 12 p.

Research output: Contribution to journalArticle

646 Scopus citations
2000

The rice Rim2 transcript accumulates in response to Magnaporthe grisea and its predicted protein product shares similarity with TNP2-like proteins encoded by CACTA transposons

He, Z. H., Dong, H. T., Dong, J. X., Li, D. B. & Ronald, P. C., Jan 1 2000, In : Molecular and General Genetics. 264, 1-2, p. 2-10 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
1997

Molecular cloning of differentially expressed novel rice genes induced by Magnaporthe grisea

He, Z., Dong, H., Cheng, S., Wu, Y., Dong, J. & Li, D., Jan 1 1997, In : Chinese Science Bulletin. 42, 20, p. 1748-1750 3 p.

Research output: Contribution to journalArticle