• 4163 Citations
  • 33 h-Index
1978 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 4163 Citations
  • 33 h-Index
  • 71 Article
  • 6 Review article
  • 2 Comment/debate
Filter
Article
2020

Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer

Leiphrakpam, P. D., Lazenby, A. J., Chowdhury, S., Smith, L. M., Mathiesen, M., Brattain, M. G., Wang, J., Black, J. D. & Are, C., Mar 1 2020, In : Journal of Surgical Oncology. 121, 3, p. 547-560 14 p.

Research output: Contribution to journalArticle

2019

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

Robb, C. M., Kour, S., Contreras, J. I., Agarwal, E., Barger, C. J., Rana, S., Sonawane, Y., Neilsen, B. K., Taylor, M., Kizhake, S., Thakare, R. N., Chowdhury, S., Wang, J., Black, J. D., Hollingsworth, M. A., Brattain, M. G. & Natarajan, A., Jan 1 2018, In : Oncotarget. 9, 4, p. 5216-5232 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium

Hsu, A. H., Lum, M. A., Shim, K. S., Frederick, P. J., Morrison, C. D., Chen, B., Lele, S. M., Sheinin, Y. M., Daikoku, T., Dey, S. K., Leone, G., Black, A. R. & Black, J. D., Jul 17 2018, In : Cell Reports. 24, 3, p. 655-669 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

TGF and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells

Leiphrakpam, P. D., Brattain, M. G., Black, J. D. & Wang, J., May 25 2018, In : Journal of Biological Chemistry. 293, 21, p. 8242-8254 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis

Agarwal, E., Robb, C. M., Smith, L. M., Brattain, M. G., Wang, J., Black, J. D. & Chowdhury, S., Jun 1 2017, In : Oncogene. 36, 22, p. 3104-3118 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

Bailey, K. L., Agarwal, E., Chowdhury, S., Luo, J., Brattain, M. G., Black, J. D. & Wang, J., Apr 2017, In : PloS one. 12, 4, e0176096.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Protein Kinase Cα (PKCα) is resistant to long term desensitization/down-regulation by prolonged diacylglycerol stimulation

Lum, M. A., Barger, C. J., Hsu, A. H., Leontieva, O. V., Black, A. R. & Black, J. D., Mar 18 2016, In : Journal of Biological Chemistry. 291, 12, p. 6331-6346 16 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Breast cancer resistance protein (BCRP) and excision repair cross complement-1 (ERCC1) expression in esophageal cancers and response to cisplatin and irinotecan based chemotherapy

Bharthuar, A., Rehman, S. S. U., Black, J. D., Levea, C., Malhotra, U., Mashtare, T. L. & Iyer, R., Jan 1 2014, In : Journal of Gastrointestinal Oncology. 5, 4, p. 253-258 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells

Pysz, M. A., Hao, F., Hizli, A. A., Lum, M. A., Swetzig, W. M., Black, A. R. & Black, J. D., Aug 8 2014, In : Journal of Biological Chemistry. 289, 32, p. 22268-22283 16 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Agonist-induced down-regulation of endogenous protein kinase C α through an endolysosomal mechanism

Lum, M. A., Pundt, K. E., Paluch, B. E., Black, A. R. & Black, J. D., May 3 2013, In : Journal of Biological Chemistry. 288, 18, p. 13093-13109 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C

Lum, M. A., Balaburski, G. M., Murphy, M. E., Black, A. R. & Black, J. D., Sep 20 2013, In : Journal of Biological Chemistry. 288, 38, p. 27112-27127 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ubiquitin-dependent regulation of phospho-AKT Dynamics by the ubiquitin E3 LIGASE, NEDD4-1, in the insulin-like growth factor-1 response

Fan, C. D., Lum, M. A., Xu, C., Black, J. D. & Wang, X., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1674-1684 11 p.

Research output: Contribution to journalArticle

62 Scopus citations
2012

Elevated Expression of the Serine-Arginine Protein Kinase 1 Gene in Ovarian Cancer and Its Role in Cisplatin Cytotoxicity In Vitro

Odunsi, K., Mhawech-Fauceglia, P., Andrews, C., Beck, A., Amuwo, O., Lele, S., Black, J. D. & Huang, R. Y., Dec 7 2012, In : PloS one. 7, 12, e51030.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis

Gogada, R., Amadori, M., Zhang, H., Jones, A., Verone, A., Pitarresi, J., Jandhyam, S., Prabhu, V., Black, J. D. & Chandra, D., Dec 1 2011, In : Cell Cycle. 10, 23, p. 4128-4137 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium

Hao, F., Pysz, M. A., Curry, K. J., Haas, K. N., Seedhouse, S. J., Black, A. R. & Black, J. D., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 18104-18117 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer

Khoury, T., Alrawi, S., Ramnath, N., Li, Q., Grimm, M., Black, J. & Tan, D., Jan 2009, In : Clinical Lung Cancer. 10, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

PKCα tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1

Pysz, M. A., Leontieva, O. V., Bateman, N. W., Uronis, J. M., Curry, K. J., Threadgill, D. W., Janssen, K. P., Robine, S., Velcich, A., Augenlicht, L. H., Black, A. R. & Black, J. D., May 1 2009, In : Experimental Cell Research. 315, 8, p. 1415-1428 14 p.

Research output: Contribution to journalArticle

27 Scopus citations
2008

Pilot study of gefitinib, oxaliplatin, and radiotherapy for esophageal adenocarcinoma tissue effect predicts clinical response

Javle, M., Pande, A., Iyer, R., Yang, G., LeVea, C., Wilding, G., Black, J., Nava, H. & Nwogu, C., Aug 1 2008, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 31, 4, p. 329-334 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors

Fakih, M. G., Trump, D. L., Muindi, J. R., Black, J. D., Bernardi, R. J., Creaven, P. J., Schwartz, J., Brattain, M. G., Hutson, A., French, R. & Johnson, C. S., Feb 15 2007, In : Clinical Cancer Research. 13, 4, p. 1216-1223 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival

Foster, J., Black, J., LeVea, C., Khoury, T., Kuvshinoff, B., Javle, M. & Gibbs, J. F., Feb 1 2007, In : Annals of Surgical Oncology. 14, 2, p. 752-758 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Epithelial-Mesenchymal Transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer

Javle, M. M., Gibbs, J. F., Iwata, K. K., Pak, Y., Rutledge, P., Yu, J., Black, J. D., Tan, D. & Khoury, T., Dec 1 2007, In : Annals of Surgical Oncology. 14, 12, p. 3527-3533 7 p.

Research output: Contribution to journalArticle

125 Scopus citations
39 Scopus citations

Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma

Ailawadhi, S., Nagase, H., Khoury, T., Yu, J., Tan, D., Black, J., Brattain, M. & Javle, M., Jul 1 2007, In : Hepato-Gastroenterology. 54, 77, p. 1339-1344 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
64 Scopus citations
2006

Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma

Chadha, K. S., Khoury, T., Yu, J., Black, J. D., Gibbs, J. F., Kuvshinoff, B. W., Tan, D., Brattain, M. G. & Javle, M. M., Jul 1 2006, In : Annals of Surgical Oncology. 13, 7, p. 933-939 7 p.

Research output: Contribution to journalArticle

97 Scopus citations

Akt expression may predict favorable prognosis in cholangiocarcinoma

Javle, M. M., Yu, J., Khoury, T., Chadha, K. C., Iyer, R. V., Foster, J., Kuvshinoff, B. W., Gibbs, J. F., Geradts, J., Black, J. D. & Brattain, M. G., Nov 2006, In : Journal of Gastroenterology and Hepatology (Australia). 21, 11, p. 1744-1751 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Protein kinase C α signaling inhibits cyclin D1 translation in intestinal epithelial cells

Hizli, A. A., Black, A. R., Pysz, M. A. & Black, J. D., May 26 2006, In : Journal of Biological Chemistry. 281, 21, p. 14596-14603 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Temporal and spatial expression of TACC1 in the mouse and human

Lauffart, B., DiMatteo, A., Vaughan, M. M., Cincotta, M. A., Black, J. D. & Still, I. H., Jun 1 2006, In : Developmental Dynamics. 235, 6, p. 1638-1647 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2005

Aberrations of TACC1 and TACC3 are associated with ovarian cancer

Lauffart, B., Vaughan, M. M., Eddy, R., Chervinsky, D., DiCioccio, R. A., Black, J. D. & Still, I. H., May 26 2005, In : BMC Women's Health. 5, 8.

Research output: Contribution to journalArticle

63 Scopus citations
2004

Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells

Frey, M. R., Clark, J. A., Bateman, N. W., Kazanietz, M. G., Black, A. R. & Black, J. D., May 15 2004, In : Biochemical Pharmacology. 67, 10, p. 1873-1886 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinoma

Wilkinson, N. W., Black, J. D., Roukhadze, E., Driscoll, D., Smiley, S., Hoshi, H., Geradts, J., Javle, M. & Brattain, M., May 1 2004, In : Journal of Gastrointestinal Surgery. 8, 4, p. 448-453 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Identification of Two Distinct Pathways of Protein Kinase Cα Down-regulation in Intestinal Epithelial Cells

Leontieva, O. V. & Black, J. D., Feb 13 2004, In : Journal of Biological Chemistry. 279, 7, p. 5788-5801 14 p.

Research output: Contribution to journalArticle

84 Scopus citations

Intestinal Tumor Progression Is Associated with Altered Function of KLF5

Bateman, N. W., Tan, D., Pestell, R. G., Black, J. D. & Black, A. R., Mar 26 2004, In : Journal of Biological Chemistry. 279, 13, p. 12093-12101 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Involvement of the ERK Signaling Cascade in Protein Kinase C-mediated Cell Cycle Arrest in Intestinal Epithelial Cells

Clark, J. A., Black, A. R., Leontieva, O. V., Frey, M. R., Pysz, M. A., Kunneva, L., Woloszynska-Read, A., Roy, D. & Black, J. D., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9233-9247 15 p.

Research output: Contribution to journalArticle

58 Scopus citations
2001

Protein kinase C isozymes in colon carcinogenesis: Guilt by omission

Black, J. D., Jan 1 2001, In : Gastroenterology. 120, 7, p. 1868-1872 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Stimulation of protein kinase C-dependent and -independent signaling pathways by bistratene A in intestinal epithelial cells

Frey, M. R., Leontieva, O., Watters, D. J. & Black, J. D., May 1 2001, In : Biochemical Pharmacology. 61, 9, p. 1093-1100 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2000

Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium

Frey, M. R., Clark, J. A., Leontieva, O., Uronis, J. M., Black, A. R. & Black, J. D., Nov 13 2000, In : Journal of Cell Biology. 151, 4, p. 763-777 15 p.

Research output: Contribution to journalArticle

84 Scopus citations

SPAF, a new AAA-protein specific to early spermatogenesis and malignant conversion

Liu, Y., Black, J., Kisiel, N. & Kulesz-Martin, M. F., Mar 16 2000, In : Oncogene. 19, 12, p. 1579-1588 10 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
1999

Dynamic association of L-selectin with the lymphocyte cytoskeletal matrix

Evans, S. S., Schleider, D. M., Bowman, L. A., Francis, M. L., Kansas, G. S. & Black, J. D., Mar 15 1999, In : Journal of Immunology. 162, 6, p. 3615-3624 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Polarized expression of immunoglobulin, spectrin, and protein kinase C beta II occurs in B cells from normal BALB/c, autoimmune lpr, and anti-ssDNA transgenic, tolerant mice

Masso-Welch, P. A., Black, J. D., Erikson, J. & Repasky, E. A., Jan 1 1999, In : Journal of Leukocyte Biology. 66, 4, p. 617-624 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Polyamine analogue induction of the p53-p21(WAF1/CIP1)-Rb pathway and G1 Ar in human melanoma cells

Kramer, D. L., Vujcic, S., Diegelman, P., Alderfer, J., Miller, J. T., Black, J. D., Bergeron, R. J. & Porter, C. W., Mar 15 1999, In : Cancer Research. 59, 6, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

104 Scopus citations
1998

Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes

Verstovsek, G., Byrd, A., Frey, M. R., Petrelli, N. J. & Black, J. D., Jan 1 1998, In : Gastroenterology. 115, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Interleukin 15 offers selective protection from irinotecan-induced intestinal toxicity in a preclinical animal model

Cao, S., Black, J. D., Troutt, A. B. & Rustum, Y. M., Aug 1 1998, In : Cancer Research. 58, 15, p. 3270-3274 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP- 48664

Kramer, D. L., Black, J. D., Mett, H., Bergeron, R. J. & Porter, C. W., Sep 1 1998, In : Cancer Research. 58, 17, p. 3883-3890 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway

Kramer, D. L., Vujcic, S., Diegelman, P., White, C., Black, J. D. & Porter, C. W., Jan 1 1998, In : Biochemical Society Transactions. 26, 4, p. 609-614 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
1997

Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells

Frey, M. R., Saxon, M. L., Zhao, X., Rollins, A., Evans, S. S. & Black, J. D., Apr 4 1997, In : Journal of Biological Chemistry. 272, 14, p. 9424-9435 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

The relationship between smoking exposure and p53 overexpression in colorectal cancer

Freedman, A. N., Michalek, A. M., Marshall, J. R., Mettlin, C. J., Petrelli, N. J., Zhang, Z. F., Black, J. D., Satchidanand, S. & Asirwatham, J. E., Apr 1996, In : British journal of cancer. 73, 8, p. 902-908 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
1995

Prolactin and epidermal growth factor regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture

Darcy, K. M., Shoemaker, S. F., Lee, PP. H., Vaughan, M. M., Black, J. D. & Ip, M. M., May 1995, In : Journal of Cellular Physiology. 163, 2, p. 346-364 19 p.

Research output: Contribution to journalArticle

26 Scopus citations