Jean L Grem, MD

Professor

  • 7610 Citations
  • 49 h-Index
1985 …2019
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Research Output 1985 2019

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Review article
2019

Small bowel adenocarcinoma, version 1.2020

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Arain, M. A., Chen, Y. J., Ciombor, K. K., Cohen, S. A., Cooper, H. S., Deming, D. A., Garrido-Laguna, I., Grem, J. L., Hoffe, S. E., Hubbard, J., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J., Miller, E. D. & 17 others, Mulcahy, M. F., Steven Nurkin, Md, Ms, N. M. M., Overman, M. J., Parikh, A., Patel, H., Pedersen, K. S., Saltz, L. B., Schneider, C., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Johnson-Chilla, A., Gregory, K. M. & Gurski, L. A., Jan 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 9, p. 1109-1133 25 p.

Research output: Contribution to journalReview article

Open Access
Adenocarcinoma
Colorectal Neoplasms
Therapeutics
Guidelines
Standard of Care
2018
17 Citations (Scopus)

Anal Carcinoma, version 2.2018 clinical practice guidelines in Oncology

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J. & 14 others, Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Gregory, K. M. & Freedman-Cass, D. A., Jul 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 7, p. 852-871 20 p.

Research output: Contribution to journalReview article

Practice Guidelines
Anus Neoplasms
Carcinoma
Radiation Oncology
Medical Oncology
37 Citations (Scopus)

Rectal cancer, version 2.2018 clinical practice guidelines in Oncology

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J. & 15 others, Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Freedman-Cass, D. A., Gregory, K. M. & Gurski, L., Jul 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 7, p. 874-901 28 p.

Research output: Contribution to journalReview article

Rectal Neoplasms
Practice Guidelines
Guidelines
Disease Management
Patient Selection
2017
214 Citations (Scopus)

Colon cancer, version 1.2017: Clinical practice guidelines in oncology

Benson, A. B., Venook, A. P., Cederquist, L., Chan, E., Chen, Y. J., Cooper, H. S., Deming, D., Engstrom, P. F., Enzinger, P. C., Fichera, A., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Mulcahy, M. F. & 13 others, Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wu, C. S., Gregory, K. M. & Freedman-Cass, D., Mar 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 3, p. 370-398 29 p.

Research output: Contribution to journalReview article

Open Access
Practice Guidelines
Colonic Neoplasms
Patient Preference
Microsatellite Repeats
Comorbidity
2016
7 Citations (Scopus)

Biochemistry and Clinical Activity of N-(Phosphonacety1)-L-aspartate: A Review

Grem, J. L., King, S. A., O'Dwyer, P. J. & Leyland-Jones, B., Jan 1 2016, In : Cancer Research. 48, 16, p. 4441-4454 14 p.

Research output: Contribution to journalReview article

NSC 224131
Biochemistry
Pharmacology
Antimetabolites
National Cancer Institute (U.S.)
2012
57 Citations (Scopus)

Anal carcinoma, version 2.2012: Featured updates to the NCCN guidelines

Benson, A. B., Arnoletti, J. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Engstrom, P. F., Enzinger, P. C., Fakih, M. G., Fleshman, J. W., Fuchs, C. S., Grem, J. L., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 10 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P., Willett, C. & Freedman-Cass, D. A., Apr 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 4, p. 449-454 6 p.

Research output: Contribution to journalReview article

Open Access
Anus Neoplasms
Guidelines
Carcinoma
Radiotherapy
Anal Canal
108 Citations (Scopus)

Rectal cancer

Benson, A. B., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Engstrom, P. F., Enzinger, P. C., Fakih, M. G., Fuchs, C. S., Grem, J. L., Hunt, S., Leong, L. A., Lin, E., Martin, M. G., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E., Ryan, D. P. & 10 others, Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P., Willett, C. G., Freedman-Cass, D. A. & Gregory, K. M., Dec 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 12, p. 1528-1564 37 p.

Research output: Contribution to journalReview article

Rectal Neoplasms
Radiation Oncology
Neoadjuvant Therapy
Medical Oncology
Primary Care Physicians
2011
9 Citations (Scopus)

Clinical practice guidelines in oncology

Benson, A. B., Arnoletti, J. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Engstrom, P. F., Enzinger, P. C., Fleshman, J. W., Fuchs, C. S., Grem, J. L., Knol, J. A., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 9 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P. & Willett, C., Nov 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 11, p. 1238-1289 52 p.

Research output: Contribution to journalReview article

Practice Guidelines
oxaliplatin
Therapeutics
Drug Therapy
Fluorouracil
2009
236 Citations (Scopus)

Colon cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Covey, A., Dilawari, R. A., Early, D. S., Enzinger, P. C., Fakih, M. G., Fleshman, J., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Lin, E., Mulcahy, M. F., Rao, S. & 8 others, Ryan, D. P., Saltz, L., Shibata, D., Skibber, J. M., Sofocleous, C., Thomas, J., Venook, A. P. & Willett, C., Sep 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 8, p. 778-831 54 p.

Research output: Contribution to journalReview article

Open Access
Colonic Neoplasms
Therapeutics
Drug Therapy
Anus Neoplasms
Continuity of Patient Care
186 Citations (Scopus)

Rectal cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Covey, A., Dilawari, R. A., Early, D. S., Enzinger, P. C., Fakih, M. G., Fleshman, J., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Lin, E., Mulcahy, M. F., Rao, S. & 8 others, Ryan, D. P., Saltz, L., Shibata, D., Skibber, J. M., Sofocleous, C., Thomas, J., Venook, A. P. & Willett, C., Sep 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 8, p. 838-881 44 p.

Research output: Contribution to journalReview article

Open Access
Rectal Neoplasms
Therapeutics
Drug Therapy
Proctoscopy
Radiation Oncology
2007
9 Citations (Scopus)

Colon cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Early, D. S., Fakih, M. G., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Ludwig, K. A., Martin, E. W., Rao, S., Saltz, L., Shibata, D., Skibber, J. M. & 1 others, Venook, A. P., Oct 1 2007, In : JNCCN Journal of the National Comprehensive Cancer Network. 5, 9, p. 884-925 42 p.

Research output: Contribution to journalReview article

Colonic Neoplasms
irinotecan
Fluorouracil
Therapeutics
Drug Therapy
8 Citations (Scopus)

Rectal cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Early, D. S., Fakih, M. G., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Ludwig, K. A., Martin, E. W., Rao, S., Saltz, L., Shibata, D., Skibber, J. M. & 1 others, Venook, A. P., Oct 1 2007, In : JNCCN Journal of the National Comprehensive Cancer Network. 5, 9, p. 940-981 42 p.

Research output: Contribution to journalReview article

Rectal Neoplasms
irinotecan
Therapeutics
Drug Therapy
Fluorouracil
2004

The Gowda/Goel/Berdzik et al article reviewed

Grem, J. L., Nov 1 2004, In : ONCOLOGY. 18, 13, p. 1676+1680

Research output: Contribution to journalReview article

2003
15 Citations (Scopus)

Mistletoe and Gemcitabine in Patients with Advanced Cancer: A Model for the Phase I Study of Botanicals and Botanical-Drug Interactions in Cancer Therapy

Mansky, P. J., Grem, J., Wallerstedt, D. B., Monahan, B. P. & Blackman, M. R., Dec 1 2003, In : Integrative Cancer Therapies. 2, 4, p. 345-352 8 p.

Research output: Contribution to journalReview article

gemcitabine
Mistletoe
Drug Interactions
Viscum album
Neoplasms
2002
1 Citation (Scopus)

Oxaliplatin beim kolorektal-karzinom: Neue daten zu first-line-und adjuvanter therapie

Translated title of the contribution: Oxaliplatin in colorectal cancer: New data in first-line and adjuvant therapyGoldberg, R. M., Saltz, L., Grem, J. L., Lenz, H. J., Ajani, J. A., Blackstock, A. W., Tempero, M. A., Plunkett, W., Overmoyer, B. & Weiner, G. J., Oct 9 2002, In : Onkologie. 25, SUPPL. 3, p. 1-11 11 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Relative gene expression in normal and tumor tissue by quantitative RT-PCR.

Salonga, D. S., Danenberg, K. D., Grem, J., Park, J. M. & Danenberg, P. V., 2002, In : Methods in molecular biology (Clifton, N.J.). 191, p. 83-98 16 p.

Research output: Contribution to journalReview article

Neoplasm RNA
Neoplastic Gene Expression Regulation
Experimental Neoplasms
Nucleic Acid Denaturation
DNA Primers
2001

Thymidylate synthase inhibitors.

Ismail, A. S. & Grem, J. L., 2001, In : Cancer chemotherapy and biological response modifiers. 19, p. 1-19 19 p.

Research output: Contribution to journalReview article

Neoplasm Drug Resistance
Cultured Tumor Cells
Thymidylate Synthase
Combined Modality Therapy
Enzyme Inhibitors
2000
235 Citations (Scopus)

5-Fluorouracil: Forty-plus and still ticking. A review of its preclinical and clinical development

Grem, J. L., Oct 28 2000, In : Investigational New Drugs. 18, 4, p. 299-313 15 p.

Research output: Contribution to journalReview article

Fluorouracil
Clinical Pharmacology
Deoxyuridine
Leucovorin
Peritoneal Cavity
1999
17 Citations (Scopus)

Antimetabolites.

Grem, J. L., Takimoto, C. H., Multani, P., Chu, E., Ryan, D., Chabner, B. A., Allegra, C. J. & Johnston, P. G., 1999, In : Cancer chemotherapy and biological response modifiers. 18, p. 1-38 38 p.

Research output: Contribution to journalReview article

1998
2 Citations (Scopus)
Antineoplastic Antimetabolites
Neoplasm Drug Resistance
Thymidylate Synthase
Combined Modality Therapy
Pyrimidines
1997
10 Citations (Scopus)

Antimetabolites.

Johnston, P. G., Takimoto, C. H., Grem, J. L., Fidias, P., Grossbard, M. L., Chabner, B. A., Allegra, C. J. & Chu, E., 1997, In : Cancer chemotherapy and biological response modifiers. 17, p. 1-39 39 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Systemic treatment options in advanced colorectal cancer: Perspectives on combination 5-fluorouracil plus leucovorin

Grem, J. L., Dec 1 1997, In : Seminars in Oncology. 24, 5 SUPPL. 18, p. S18-8-S18-18

Research output: Contribution to journalReview article

Leucovorin
Fluorouracil
Colorectal Neoplasms
Appointments and Schedules
Therapeutics
46 Citations (Scopus)

The prognostic importance of tumor markers in adenocarcinomas of the gastrointestinal tract

Grem, J., Jan 1 1997, In : Current Opinion in Oncology. 9, 4, p. 380-387 8 p.

Research output: Contribution to journalReview article

Tumor Biomarkers
Gastrointestinal Tract
Colorectal Neoplasms
Adenocarcinoma
Pancreatic Neoplasms
1996
10 Citations (Scopus)

Antimetabolites.

Johnston, P. G., Takimoto, C. H., Grem, J. L., Chabner, B. A., Allegra, C. J. & Chu, E., 1996, In : Cancer chemotherapy and biological response modifiers. 16, p. 1-27 27 p.

Research output: Contribution to journalReview article

Antineoplastic Antimetabolites
Antimetabolites
Cytidine
Purines
Methotrexate
22 Citations (Scopus)

New concepts for the development and use of antifolates

Chu, E., Grem, J. L., Johnston, P. G. & Allegra, C. J., Jan 1 1996, In : STEM CELLS. 14, 1, p. 41-46 6 p.

Research output: Contribution to journalReview article

Open Access
Folic Acid Antagonists
Thymidylate Synthase
Fluorouracil
Interferons
Enzyme Inhibitors
1994
4 Citations (Scopus)

Antimetabolites.

Chu, E., Johnston, P. G., Grem, J. L., Takimoto, C. H., Van Groeningen, C., Chabner, B. A. & Allegra, C. J., 1994, In : Cancer chemotherapy and biological response modifiers. 15, p. 1-31 31 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

Chemotherapy of advanced gastrointestinal cancer

Geoffroy, F. & Grem, J. L., Jan 1 1994, In : Current Opinion in Oncology. 6, 4, p. 427-434 8 p.

Research output: Contribution to journalReview article

Gastrointestinal Neoplasms
Fluorouracil
Drug Therapy
Colorectal Neoplasms
irinotecan
1993
2 Citations (Scopus)

Antimetabolites.

Chu, E., Johnston, P. G., Takimoto, C. H., Politi, P. M., Grem, J. L., Chabner, B. A. & Allegra, C. J., 1993, In : Cancer chemotherapy and biological response modifiers. 14, p. 1-25 25 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Doxorubicin: role in the treatment of osteosarcoma.

Blaney, S. M., Smith, M. A. & Grem, J. L., Jan 1 1993, In : Cancer treatment and research. 62, p. 55-73 19 p.

Research output: Contribution to journalReview article

Neoplasm DNA
Antineoplastic Combined Chemotherapy Protocols
Combined Modality Therapy
Bone Neoplasms
Osteosarcoma
13 Citations (Scopus)

Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma

Alexander, H. R., Grem, J. L., Pass, H. I., Hamilton, M., McAtee, N., Fraker, D. L. & Allegra, C. J., Jan 1 1993, In : ONCOLOGY. 7, 5, p. 37-41 5 p.

Research output: Contribution to journalReview article

Stomach
Adenocarcinoma
Drug Therapy
Neoadjuvant Therapy
Leucovorin
1992
5 Citations (Scopus)

Antimetabolites

Chen, A. P. & Grem, J. L., Jan 1 1992, In : Current Opinion in Oncology. 4, 6, p. 1089-1098 10 p.

Research output: Contribution to journalReview article

Antimetabolites
Cytarabine
Drug Interactions
Drug Resistance
Methotrexate
1 Citation (Scopus)

Antimetabolites.

Chu, E., Grem, J. L., Johnston, P. G., Politi, P. M., Chabner, B. A. & Allegra, C. J., Jan 1 1992, In : Cancer chemotherapy and biological response modifiers. 13, p. 1-30 30 p.

Research output: Contribution to journalReview article

1991
3 Citations (Scopus)

Adjuvant treatment of node-positive colon carcinoma with levamisole and 5-fluorouracil

Grem, J. L., Jan 1 1991, In : ONCOLOGY. 5, 3, p. 63-74 12 p.

Research output: Contribution to journalReview article

Antineoplastic Combined Chemotherapy Protocols
Levamisole
Fluorouracil
Colonic Neoplasms
Colon
1 Citation (Scopus)

Antimetabolites.

Grem, J. L., Chabner, B. A., Chu, E., Johnson, P., Yeh, G. C. & Allegra, C. J., Jan 1 1991, In : Cancer chemotherapy and biological response modifiers. 12, p. 1-25 25 p.

Research output: Contribution to journalReview article

Floxuridine
Folic Acid Antagonists
Antimetabolites
Cytidine
Cytarabine
20 Citations (Scopus)

Clinical use of thymidine as a rescue agent from methotrexate toxicity

Grem, J. L., King, S. A., Sorensen, J. M. & Christian, M. C., Aug 1 1991, In : Investigational New Drugs. 9, 3, p. 281-290 10 p.

Research output: Contribution to journalReview article

Methotrexate
Thymidine
Kidney
Leucovorin
National Cancer Institute (U.S.)
9 Citations (Scopus)

Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model

Grem, J. L., Plowman, J., Rubinstein, L., Hawkins, M. J. & Harrison, S. D., 1991, In : Leukemia Research. 15, 4, p. 229-236 8 p.

Research output: Contribution to journalReview article

3-Deazauridine
Cytarabine
Palmitates
Leukemia
CTP synthetase
1990
3 Citations (Scopus)

Antimetabolites.

Allegra, C. J., Grem, J. L., Chu, E., Johnston, P., Yeh, G. C. & Chabner, B. A., Jan 1 1990, In : Cancer chemotherapy and biological response modifiers. 11, p. 1-28 28 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Levamisole as a therapeutic agent for colorectal carcinoma

Grem, J. L., Jan 1 1990, In : Cancer Cells. 2, 5, p. 131-137 7 p.

Research output: Contribution to journalReview article

Levamisole
Colorectal Neoplasms
Clinical Trials
Therapeutics
141 Citations (Scopus)

Metabolism and action of amino acid analog anti-cancer agents

Ahluwalia, G. S., Grem, J. L., Hao, Z. & Cooney, D. A., 1990, In : Pharmacology and Therapeutics. 46, 2, p. 243-271 29 p.

Research output: Contribution to journalReview article

alanosine
NSC 224131
acivicin
Antineoplastic Agents
Azaserine
1988
38 Citations (Scopus)

Cephalotaxine esters: Antileukemic advance or therapeutic failure?

Grem, J. L., Cheson, B. D., King, S. A., Leyland-jones, B. & Suffness, M., Sep 21 1988, In : Journal of the National Cancer Institute. 80, 14, p. 1095-1103 9 p.

Research output: Contribution to journalReview article

Esters
China
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Appointments and Schedules
13 Citations (Scopus)

Teniposide in the treatment of leukemia: A case study of conflicting priorities in the development of drugs for fatal diseases

Grem, J. L., Hoth, D. F., Leyland-Jones, B., King, S. A., Ungerleider, R. S. & Wittes, R. E., Jan 1 1988, In : Journal of Clinical Oncology. 6, 2, p. 351-379 29 p.

Research output: Contribution to journalReview article

Teniposide
Leukemia
Pharmaceutical Preparations
Cytarabine
Therapeutics
37 Citations (Scopus)

The role of methotrexate in osteosarcoma

Grem, J. L., King, S. A., Wittes, R. E. & Leyland-jones, B., Jul 6 1988, In : Journal of the National Cancer Institute. 80, 9, p. 626-655 30 p.

Research output: Contribution to journalReview article

Osteosarcoma
Methotrexate
Adjuvant Chemotherapy
History
Neoplasms
1987
22 Citations (Scopus)

Arabinosyl-5-azacytosine: A novel nucleoside entering clinical trials

Grem, J. L., Shoemaker, D. D., Hoth, D. F., King, S. A., Plowman, J., Zaharko, D., Grieshaber, C. K., Harrison, S. D., Cradock, J. C. & Leyland-Jones, B., Dec 1 1987, In : Investigational New Drugs. 5, 4, p. 315-328 14 p.

Research output: Contribution to journalReview article

fazarabine
Nucleosides
Clinical Trials
Cytarabine
Appointments and Schedules
105 Citations (Scopus)

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.

Grem, J. L., Hoth, D. F., Hamilton, J. M., King, S. A. & Leyland-Jones, B., Dec 1987, In : Cancer treatment reports. 71, 12, p. 1249-1264 16 p.

Research output: Contribution to journalReview article