Jean L Grem, MD

Professor

  • 7610 Citations
  • 49 h-Index
1985 …2019
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Research Output 1985 2019

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Article
2019
Nelfinavir
Radiosurgery
gemcitabine
Adenocarcinoma
Antigens
1 Citation (Scopus)
Nelfinavir
Radiosurgery
gemcitabine
Adenocarcinoma
Survival
2018
61 Citations (Scopus)

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., Lacomb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. C., Johnson, M., Arora, K. & 50 others, Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., DiMaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O’kane, G. M., Notta, F., Kim, E., Crawford, J. M., Devoe, C., Ocean, A., Wolfgang, C. L., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S. & Tuveson, D. A., Sep 2018, In : Cancer Discovery. 8, 9, p. 1112-1129 18 p.

Research output: Contribution to journalArticle

Organoids
Pancreatic Neoplasms
Drug Therapy
Therapeutics
Precision Medicine

Phase 2 study of treatment selection based on tumor thymidylate synthase expression in previously untreated patients with metastatic colorectal cancer: A trial of the ECOG-ACRIN Cancer Research Group (E4203)

Meropol, N. J., Feng, Y., Grem, J. L., Mulcahy, M. F., Catalano, P. J., Kauh, J. S., Hall, M. J., Saltzman, J. N., George, T. J., Zangmeister, J., Chiorean, E. G., Cheema, P. S., O'Dwyer, P. J. & Benson, A. B., Feb 15 2018, In : Cancer. 124, 4, p. 688-697 10 p.

Research output: Contribution to journalArticle

oxaliplatin
irinotecan
Thymidylate Synthase
Colorectal Neoplasms
Research
2017
16 Citations (Scopus)

De Novo lipid synthesis facilitates gemcitabine resistance through endoplasmic reticulum stress in pancreatic cancer

Tadros, S., Shukla, S. K., King, R. J., Gunda, V., Vernucci, E., Abrego, J., Chaika, N. V., Yu, F., Lazenby, A. J., Berim, L., Grem, J. L., Sasson, A. R. & Singh, P., Oct 15 2017, In : Cancer Research. 77, 20, p. 5503-5517 15 p.

Research output: Contribution to journalArticle

gemcitabine
Endoplasmic Reticulum Stress
Pancreatic Neoplasms
Lipids
Fatty Acid Synthases
69 Citations (Scopus)

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

Roe, J. S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M. & 4 others, Egeblad, M., Park, Y., Tuveson, D. A. & Vakoc, C. R., Aug 24 2017, In : Cell. 170, 5, p. 875-888.e20

Research output: Contribution to journalArticle

Transcription
Pancreatic Neoplasms
Adenocarcinoma
Chemical activation
Neoplasm Metastasis
74 Citations (Scopus)

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Sarkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P., Jul 10 2017, In : Cancer Cell. 32, 1, p. 71-87.e7

Research output: Contribution to journalArticle

gemcitabine
Hypoxia-Inducible Factor 1
Pancreatic Neoplasms
Glucose
Tumor Burden
6 Citations (Scopus)

Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice

Dutta, R., Kumar, V., Peng, Y., Evande, R. E., Grem, J. L. & Mahato, R. I., Mar 1 2017, In : Pharmaceutical Research. 34, 3, p. 564-578 15 p.

Research output: Contribution to journalArticle

HhAntag691
Pharmacokinetics
Micelles
Liver
Hepatic Stellate Cells
2016
18 Citations (Scopus)

Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

Clausen, T. M., Pereira, M. A., Nakouzi, N. A., Oo, H. Z., Agerbæk, M., Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, P. J., Theander, T., Sorensen, P. H., Daugaard, M. & Salanti, A., Dec 1 2016, In : Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.

Research output: Contribution to journalArticle

Integrins
Cell Movement
Neoplasms
Proteoglycans
chondroitin sulfate glycosaminoglycan
2015
2 Citations (Scopus)

A multicenter, open-label, phase 1 study evaluating the safety and tolerability of pegaspargase in combination with gemcitabine in advanced metastatic solid tumors and lymphoma

Borad, M. J., Babiker, H. M., Anthony, S., Mita, M., Buchbinder, A., Keilani, T. & Grem, J. L., May 28 2015, In : Cancer Investigation. 33, 5, p. 172-179 8 p.

Research output: Contribution to journalArticle

gemcitabine
Lymphoma
Safety
Neoplasms
Asparaginase
1 Citation (Scopus)
Clinical Trials, Phase I
Fluorouracil
Neoplasms
Disease-Free Survival
Folic Acid Antagonists
8 Citations (Scopus)

Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer

Kattel, K., Evande, R., Tan, C., Mondal, G., Grem, J. L. & Mahato, R. I., Aug 1 2015, In : British Journal of Clinical Pharmacology. 80, 2, p. 267-275 9 p.

Research output: Contribution to journalArticle

Nelfinavir
Pancreatic Neoplasms
Pharmacokinetics
Area Under Curve
Genotype
120 Citations (Scopus)

Rectal cancer, version 2.2015: Featured updates to the NCCN guidelines

Benson, A. B., Venook, A. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Cooper, H. S., Engstrom, P. F., Enzinger, P. C., Fenton, M. J., Fuchs, C. S., Grem, J. L., Grothey, A., Hochster, H. S., Hunt, S., Kamel, A., Kirilcuk, N., Leong, L. A., Lin, E., Messersmith, W. A., Mulcahy, M. F. & 14 others, Murphy, J. D., Nurkin, S., Rohren, E., Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Gregory, K. M. & Freedman-Cass, D., Jun 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 6, p. 719-728 10 p.

Research output: Contribution to journalArticle

Open Access
Rectal Neoplasms
Guidelines
Primary Care Physicians
Publications
Survival Rate
2014
145 Citations (Scopus)

Colon cancer, version 3.2014

Benson, A. B., Venook, A. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Cooper, H. S., Engstrom, P. F., Enzinger, P. C., Fenton, M. J., Fuchs, C. S., Grem, J. L., Hunt, S., Kamel, A., Leong, L. A., Lin, E., Messersmith, W., Mulcahy, M. F., Murphy, J. D., Nurkin, S., Rohren, E. & 11 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Gregory, K. M. & Freedman-Cass, D. A., Jul 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 7, p. 1028-1059 32 p.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms
Guidelines
Therapeutics
Continuity of Patient Care
Patient Preference
2013
55 Citations (Scopus)

Localized Colon Cancer, version 3.2013

Benson, A. B., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Engstrom, P. F., Enzinger, P. C., Fakih, M. G., Fenton, M. J., Fuchs, C. S., Grem, J. L., Hunt, S., Kamel, A., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 11 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P., Willett, C. G., Gregory, K. M. & Freedman-Cass, D. A., Jan 1 2013, In : JNCCN Journal of the National Comprehensive Cancer Network. 11, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Guidelines
Primary Care Physicians
Practice Guidelines
Survival Rate
111 Citations (Scopus)

Metastatic colon cancer, version 3.2013: Featured updates to the NCCN guidelines

Benson, A. B., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Engstrom, P. F., Enzinger, P. C., Fakih, M. G., Fenton, M. J., Fuchs, C. S., Grem, J. L., Hunt, S., Kamel, A., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 11 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Jr, W. S., Sofocleous, C. T., Venook, A. P., Willett, C. G., Gregory, K. M. & Freedman-Cass, D. A., Feb 1 2013, In : JNCCN Journal of the National Comprehensive Cancer Network. 11, 2, p. 141-152 12 p.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms
Guidelines
Continuity of Patient Care
Primary Care Physicians
Practice Guidelines
23 Citations (Scopus)

Nccam/nci phase 1 study of mistletoe extract and gemcitabine in patients with advanced solid tumors

Mansky, P. J., Wallerstedt, D. B., Sannes, T. S., Stagl, J., Johnson, L. L., Blackman, M. R., Grem, J. L., Swain, S. M. & Monahan, B. P., Dec 4 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 964592.

Research output: Contribution to journalArticle

gemcitabine
Mistletoe
Neoplasms
Maximum Tolerated Dose
Viscum album
3 Citations (Scopus)

Sequencing of treatment in advanced unresectable colorectal cancer

Grem, J. L., Sep 1 2013, In : JNCCN Journal of the National Comprehensive Cancer Network. 11, SUPPL.4, p. S28-S37

Research output: Contribution to journalArticle

Colorectal Neoplasms
Therapeutics
Disease Progression
Drug Therapy
Patient Preference
2012

Why we should not treat patients with stage II colon cancer

Subbiah, S. P. & Grem, J. L., Sep 1 2012, In : Current Colorectal Cancer Reports. 8, 3, p. 204-209 6 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Adjuvant Chemotherapy
Molecular Biology
Prospective Studies
Recurrence
2011
7 Citations (Scopus)

Brain metastasis and leptomeningeal carcinomatosis in a patient with cholangiocarcinoma

William, B. M. & Grem, J. L., Jul 1 2011, In : Gastrointestinal Cancer Research. 4, 4, p. 144-145 2 p.

Research output: Contribution to journalArticle

Meningeal Carcinomatosis
Cholangiocarcinoma
Neoplasm Metastasis
Brain
25 Citations (Scopus)

Colon cancer.

Benson, A. B., Arnoletti, J. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Engstrom, P. F., Enzinger, P. C., Fleshman, J. W., Fuchs, C. S., Grem, J. L., Knol, J. A., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 10 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P., Willett, C. & National Comprehensive Cancer Network, C. C. N., Nov 1 2011, In : Journal of the National Comprehensive Cancer Network : JNCCN. 9, 11, p. 1238-1290 53 p.

Research output: Contribution to journalArticle

Digestive System Surgical Procedures
Antineoplastic Combined Chemotherapy Protocols
Maintenance Chemotherapy
Combined Modality Therapy
Neoadjuvant Therapy
2010
39 Citations (Scopus)

Anal carcinoma: Clinical practice guidelines in oncology™

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Berlin, J. D., Berry, J. M., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Early, D. S., Enzinger, P. C., Fakih, M. G., Fleshman, J., Fuchs, C., Grem, J. L., Knol, J. A., Leong, L. A., Lin, E., Mulcahy, M. F., Rohren, E. & 9 others, Ryan, D. P., Saltz, L., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C., Thomas, J., Venook, A. P. & Willett, C., Jan 2010, In : JNCCN Journal of the National Comprehensive Cancer Network. 8, 1, p. 106-120 15 p.

Research output: Contribution to journalArticle

Open Access
Practice Guidelines
Groin
Carcinoma
Dissection
Clinical Trials
40 Citations (Scopus)

Fatigue and other variables during adjuvant chemotherapy for colon and rectal cancer.

Berger, A. M., Grem, J. L., Visovsky, C., Marunda, H. A. & Yurkovich, J. M., Nov 1 2010, In : Oncology nursing forum. 37, 6, p. E359-369

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Rectal Neoplasms
Colonic Neoplasms
Fatigue
Sleep
2009
79 Citations (Scopus)

National Institutes of Health consensus development conference statement: Management of hepatitis B

Sorrell, M. F., Belongia, E. A., Costa, J., Gareen, I. F., Grem, J. L., Inadomi, J. M., Kern, E. R., McHugh, J. A., Petersen, G. M., Rein, M. F., Strader, D. B. & Trotter, H. T., May 1 2009, In : Hepatology. 49, SUPPL. 5, p. S4-S12

Research output: Contribution to journalArticle

Consensus Development Conferences
Chronic Hepatitis B
National Institutes of Health (U.S.)
Hepatitis B
Research
199 Citations (Scopus)

National Institutes of Health consensus development conference statement: Management of hepatitis B

Sorrell, M. F., Belongia, E. A., Costa, J., Gareen, I. F., Grem, J. L., Inadomi, J. M., Kern, E. R., McHugh, J. A., Petersen, G. M., Rein, M. F., Strader, D. B. & Trotter, H. T., Jan 20 2009, In : Annals of internal medicine. 150, 2, p. 104-110 7 p.

Research output: Contribution to journalArticle

Open Access
Consensus Development Conferences
National Institutes of Health (U.S.)
Hepatitis B
Health Services Research
Contracts
2008
54 Citations (Scopus)

NIH consensus development statement on management of hepatitis B

Belongia, E. A., Costa, J., Gareen, I. F., Grem, J. L., Inadomi, J. M., Kern, E. R., McHugh, J. A., Petersen, G. M., Rein, M. F., Sorrell, M. F., Strader, D. B. & Trotter, H. T., Jan 1 2008, In : NIH consensus and state-of-the-science statements. 25, 2, p. 1-29 29 p.

Research output: Contribution to journalArticle

Hepatitis B
Consensus
Fibrosis
Hepatocellular Carcinoma
DNA
68 Citations (Scopus)

Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of liver dysfunction: A study by the national cancer institute organ dysfunction working group

Ramanathan, R. K., Egorin, M. J., Takimoto, C. H. M., Remick, S. C., Doroshow, J. H., LoRusso, P. A., Mulkerin, D. L., Grem, J. L., Hamilton, A., Murgo, A. J., Potter, D. M., Belani, C. P., Hayes, M. J., Peng, B. & Ivy, S. P., Feb 1 2008, In : Journal of Clinical Oncology. 26, 4, p. 563-569 7 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Liver Diseases
Pharmacokinetics
Neoplasms
Nausea
73 Citations (Scopus)

Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: A study by the national cancer institute organ dysfunction working group

Gibbons, J., Egorin, M. J., Ramanathan, R. K., Fu, P., Mulkerin, D. L., Shibata, S., Takimoto, C. H. M., Mani, S., LoRusso, P. A., Grem, J. L., Pavlick, A., Lenz, H. J., Flick, S. M., Reynolds, S., Lagattuta, T. F., Parise, R. A., Wang, Y., Murgo, A. J., Ivy, S. P. & Remick, S. C., Feb 1 2008, In : Journal of Clinical Oncology. 26, 4, p. 570-576 7 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Pharmacokinetics
Kidney
Neoplasms
Creatinine
43 Citations (Scopus)
oxaliplatin
Dihydrouracil Dehydrogenase (NADP)
Thymidine Phosphorylase
Thymidylate Synthase
Adenocarcinoma
2007
50 Citations (Scopus)

Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function

Takimoto, C. H., Graham, M. A., Lockwood, G., Ng, C. M., Goetz, A., Greenslade, D., Remick, S. C., Sharma, S., Mani, S., Ramanathan, R. K., Synold, T. W., Doroshow, J. H., Hamilton, A., Mulkerin, D. L., Ivy, P., Egorin, M. J. & Grem, J. L., Aug 15 2007, In : Clinical Cancer Research. 13, 16, p. 4832-4839 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Creatinine
Pharmacokinetics
Kidney
Neoplasms
2005
4 Citations (Scopus)

A phase II and pharmacologic study of fluorouracil given by a 1-hour infusion daily for 5 days with leucovorin and interferon α-2a in adenocarcinoma of the large bowel

Ismail, A. S. A., Quinn, M. G., Wright, M. A., Ernst, A., Kao, V., Grogan, L., Parr, A., Grollman, F., Kirsch, I. R. & Grem, J. L., Jun 1 2005, In : Oncology reports. 13, 6, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

Leucovorin
Fluorouracil
Interferons
Adenocarcinoma
Microsatellite Instability
5 Citations (Scopus)

A phase I pharmacologic and pharmacogenetic trial of sequential 24-hour infusion of irinotecan followed by leucovorin and a 48-hour infusion of fluorouracil in adult patients with solid tumors

Wright, M. A., Morrison, G., Lin, P., Leonard, G. D., Nguyen, D., Guo, X., Szabo, E., Hopkins, J. L., Leguizamo, J. P., Harold, N., Fioravanti, S., Schuler, B., Monahan, B. P., Saif, M. W., Quinn, M. G., Pang, J. & Grem, J. L., Jun 1 2005, In : Clinical Cancer Research. 11, 11, p. 4144-4150 7 p.

Research output: Contribution to journalArticle

irinotecan
Leucovorin
Pharmacogenetics
Fluorouracil
Neoplasms
13 Citations (Scopus)

Intratumoral molecular or genetic markers as predictors of clinical outcome with chemotherapy in colorectal cancer

Grem, J. L., Feb 2005, In : Seminars in Oncology. 32, 1 SPEC. ISS., p. 120-127 8 p.

Research output: Contribution to journalArticle

Genetic Markers
Molecular Biology
Colorectal Neoplasms
Drug Therapy
Fluorouracil
94 Citations (Scopus)

Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels

Webster, R. G., Brain, K. L., Wilson, R. H., Grem, J. L. & Vincent, A., Dec 1 2005, In : British Journal of Pharmacology. 146, 7, p. 1027-1039 13 p.

Research output: Contribution to journalArticle

oxaliplatin
Voltage-Gated Sodium Channels
Neuromuscular Junction
Diaphragm
Vas Deferens
217 Citations (Scopus)

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors

Grem, J. L., Morrison, G., Guo, X. D., Agnew, E., Takimoto, C. H., Thomas, R., Szabo, E., Grochow, L., Grollman, F., Hamilton, J. M., Neckers, L. & Wilson, R. H., Dec 1 2005, In : Journal of Clinical Oncology. 23, 9, p. 1885-1893 9 p.

Research output: Contribution to journalArticle

tanespimycin
Neoplasms
Proteins
HSP70 Heat-Shock Proteins
Body Surface Area
95 Citations (Scopus)

Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer

Leonard, G. D., Wright, M. A., Quinn, M. G., Fioravanti, S., Harold, N., Schuler, B., Thomas, R. R. & Grem, J. L., Sep 16 2005, In : BMC cancer. 5, 116.

Research output: Contribution to journalArticle

oxaliplatin
Colorectal Neoplasms
Interviews
Paresthesia
Muscle Cramp
2004
31 Citations (Scopus)
gemcitabine
Plasma (human)
Deoxyuridine
Liquid chromatography
Metabolites
209 Citations (Scopus)

Oxaliplatin-induced neurotoxicity: Acute hyperexcitability and chronic neuropathy

Lehky, T. J., Leonard, G. D., Wilson, R. H., Grem, J. L. & Floeter, M. K., Mar 2004, In : Muscle and Nerve. 29, 3, p. 387-392 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Platinum
Action Potentials
Colorectal Neoplasms
Channelopathies
12 Citations (Scopus)

Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy

Leonard, G. D., Wagner, M. R., Quinn, M. G. & Grem, J. L., Aug 1 2004, In : Anti-Cancer Drugs. 15, 7, p. 733-735 3 p.

Research output: Contribution to journalArticle

oxaliplatin
Polyneuropathies
Drug Therapy
Colorectal Neoplasms
Wheelchairs
2003
29 Citations (Scopus)

Administration of oxaliplatin to patients with renal dysfunction: A preliminary report of the National Cancer Institute Organ Dysfunction Working Group

Takimoto, C. H., Remick, S. C., Sharma, S., Mani, S., Ramanathan, R. K., Doroshow, J. H., Hamilton, A., Mulkerin, D., Graham, M., Lockwood, G. F., Ivy, P., Egorin, M., Greenslade, D., Goetz, A. & Grem, J. L., Aug 2003, In : Seminars in Oncology. 30, 4 SUPPL. 15, p. 20-25 6 p.

Research output: Contribution to journalArticle

oxaliplatin
National Cancer Institute (U.S.)
Kidney
Creatinine
Pharmacokinetics
4 Citations (Scopus)

A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin

Grem, J. L., Quinn, M. G., Keith, B., Monahan, B. P., Hamilton, J. M., Xu, Y., Harold, N., Nguyen, D., Takimoto, C. H., Rowedder, A., Pang, J., Morrison, G. & Chen, A., Dec 1 2003, In : Cancer Chemotherapy and Pharmacology. 52, 6, p. 487-496 10 p.

Research output: Contribution to journalArticle

gemcitabine
Floxuridine
Leucovorin
Deoxyuridine
Neutropenia
7 Citations (Scopus)

A phase I study of 9-aminocamptothecin as a colloidal dispersion formulation given as a fortnightly 72-h infusion

Leguizamo, J., Quinn, M., Takimoto, C. H., Liang, M. D., Ismail, A. S. A., Pang, J., Dahut, W. & Grem, J. L., Oct 1 2003, In : Cancer Chemotherapy and Pharmacology. 52, 4, p. 333-338 6 p.

Research output: Contribution to journalArticle

9-aminocamptothecin
Lactones
Toxicity
Granulocytes
Area Under Curve
12 Citations (Scopus)

Cardiac toxicity associated with capecitabine therapy

Saif, M. W., Quinn, M. G., Thomas, R. R., Ernst, A. & Grem, J. L., Jul 24 2003, In : Acta Oncologica. 42, 4, p. 342-344 3 p.

Research output: Contribution to journalArticle

Antineoplastic Antimetabolites
Deoxycytidine
Prodrugs
Rectal Neoplasms
Heart Diseases
76 Citations (Scopus)

Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: A National Cancer Institute organ dysfunction working group study

Takimoto, C. H., Remick, S. C., Sharma, S., Mani, S., Ramanathan, R. K., Doroshow, J., Hamilton, A., Mulkerin, D., Graham, M., Lockwood, G. F., Ivy, P., Egorin, M., Schuler, B., Greenslade, D., Goetz, A., Knight, R., Thomas, R., Monahan, B. P., Dahut, W. & Grem, J. L., Jul 15 2003, In : Journal of Clinical Oncology. 21, 14, p. 2664-2672 9 p.

Research output: Contribution to journalArticle

oxaliplatin
National Cancer Institute (U.S.)
Pharmacology
Kidney
Creatinine
100 Citations (Scopus)

Hypersensitivity and idiosyncratic reactions to oxaliplatin

Thomas, R. R., Quinn, M. G., Schuler, B. & Grem, J. L., May 1 2003, In : Cancer. 97, 9, p. 2301-2307 7 p.

Research output: Contribution to journalArticle

oxaliplatin
Hypersensitivity
Methylprednisolone Hemisuccinate
Diphenhydramine
Histamine Receptors
49 Citations (Scopus)
Plasma (human)
Liquid chromatography
Metabolites
Nucleosides
Liquid Chromatography
32 Citations (Scopus)
gemcitabine
Plasma (human)
High performance liquid chromatography
High Pressure Liquid Chromatography
Assays
14 Citations (Scopus)

Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule

Guo, X. D., Harold, N., Wasif Saif, M., Schuler, B., Szabo, E., Hamilton, J. M., Monahan, B. P., Quinn, M. G., Cliatt, J., Nguyen, D., Grollman, F., Thomas, R. R., McQuigan, E. A., Wilson, R., Takimoto, C. H. & Grem, J. L., Jul 1 2003, In : Cancer Chemotherapy and Pharmacology. 52, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Leucovorin
Fluorouracil
Appointments and Schedules
2002
246 Citations (Scopus)

Acute oxaliplatin-induced peripheral nerve hyperexcitability

Wilson, R. H., Lehky, T., Thomas, R. R., Quinn, M. G., Floeter, M. K. & Grem, J. L., Apr 1 2002, In : Journal of Clinical Oncology. 20, 7, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nerves
Paresthesia
Neural Conduction
Carbamazepine
8 Citations (Scopus)

A Phase I pharmacologic and pharmacodynamic study of pyrazoloacridine given as a weekly 24-hour continuous intravenous infusion in adult cancer patients

Grem, J. L., Harold, N., Keith, B., Chen, A. P., Kao, V., Takimoto, C. H., Hamilton, J. M., Pang, J., Pace, M., Jasser, G. B., Quinn, M. G. & Monahan, B. P., Jan 1 2002, In : Clinical Cancer Research. 8, 7, p. 2149-2156 8 p.

Research output: Contribution to journalArticle

NSC 366140
Intravenous Infusions
Neoplasms
Agranulocytosis
Appointments and Schedules