Janos Zempleni, PhD

Professor

  • 4191 Citations
  • 37 h-Index
1974 …2019
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Research Output 1989 2019

2019
4 Citations (Scopus)
Dust
Macrophages
Milk
Nutrition
Polarization

Bovine milk extracellular vesicles (EVs) modification elicits skeletal muscle growth in rats

Parry, H. A., Brooks Mobley, C., Mumford, P. W., Romero, M. A., Haun, C. T., Zhang, Y., Roberson, P. A., Zempleni, J., Ferrando, A. A., Vechetti, I. J., McCarthy, J. J., Young, K. C., Roberts, M. D. & Kavazis, A. N., Jan 1 2019, In : Frontiers in Physiology. 10, MAR, 436.

Research output: Contribution to journalArticle

Open Access
Milk
Skeletal Muscle
Growth
Diet
Sonication
Exosome Multienzyme Ribonuclease Complex
Exosomes
Inbred C57BL Mouse
Milk
Cecum
5 Citations (Scopus)

Milk-Derived Exosomes and Metabolic Regulation

Zempleni, J., Sukreet, S., Zhou, F., Wu, D. & Mutai, E., Feb 15 2019, In : Annual Review of Animal Biosciences. 7, p. 245-262 18 p.

Research output: Contribution to journalReview article

exosomes
Exosomes
Milk
milk
MicroRNAs
1 Citation (Scopus)

NIH workshop on human milk composition: Summary and visions

Casavale, K. O., Ahuja, J. K. C., Wu, X., Li, Y., Quam, J., Olson, R., Pehrsson, P., Allen, L., Balentine, D., Hanspal, M., Hayward, D., Hines, E. P., McClung, J. P., Perrine, C. G., Belfort, M. B., Dallas, D., German, B., Kim, J., McGuire, M., McGuire, M. & 6 others, Morrow, A. L., Neville, M., Nommsen-Rivers, L., Rasmussen, K. M., Zempleni, J. & Lynch, C. J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 769-779 11 p.

Research output: Contribution to journalArticle

Open Access
Human Milk
Education
Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Consensus Development Conferences
2018

A cell death assay for assessing the mitochondrial targeting of proteins

Camara Teixeira, D., Cordonier, E. L., Wijeratne, S. S. K., Huebbe, P., Jamin, A., Jarecke, S., Wiebe, M. S. & Zempleni, J., Jun 2018, In : Journal of Nutritional Biochemistry. 56, p. 48-54 7 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Cell death
Assays
Cell Death
Mitochondrial Membranes
9 Citations (Scopus)
Exosome Multienzyme Ribonuclease Complex
Exosomes
Hand Strength
Nutrition
Inbred C57BL Mouse
1 Citation (Scopus)

Concentrations of purine metabolites are elevated in fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos

Aguilar-Lozano, A., Baier, S., Grove, R., Shu, J., Giraud, D., Leiferman, A., Mercer, K. E., Cui, J., Badger, T. M., Adamec, J., Andres, A. & Zempleni, J., Jan 1 2018, In : Journal of Nutrition. 148, 12, p. 1886-1894 9 p.

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
Milk
Diet
Liver
Urine
26 Citations (Scopus)

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Manca, S., Upadhyaya, B., Mutai, E., Desaulniers, A. T., Cederberg, R. A., White, B. R. & Zempleni, J., Dec 1 2018, In : Scientific reports. 8, 1, 11321.

Research output: Contribution to journalArticle

Exosomes
Tissue Distribution
MicroRNAs
Milk
Transfer RNA
1 Citation (Scopus)

Reply to B Fromm et al

Cui, J. & Zempleni, J., Sep 1 2018, In : The Journal of nutrition. 148, 9, 1 p.

Research output: Contribution to journalComment/debate

Biological Transport
MicroRNAs
Milk
Diet
16 Citations (Scopus)
Ribonucleases
MicroRNAs
Milk
Polymerase Chain Reaction
Hemolysis
2017
47 Citations (Scopus)

Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

Zempleni, J., Aguilar-Lozano, A., Sadri, M., Sukreet, S., Manca, S., Wu, D., Zhou, F. & Mutai, E., Jan 1 2017, In : Journal of Nutrition. 147, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Exosomes
Human Milk
Milk
MicroRNAs
Extracellular Vesicles
11 Citations (Scopus)

Milk exosomes: beyond dietary microRNAs

Zempleni, J., Jun 22 2017, In : Genes and Nutrition. 12, 1, 12.

Research output: Contribution to journalComment/debate

Exosomes
MicroRNAs
Milk
Biological Availability
Research
31 Citations (Scopus)

Nutrition, microRNAs, and human health

Cui, J., Zhou, B., Ross, S. A. & Zempleni, J., Jan 1 2017, In : Advances in Nutrition. 8, 1, p. 105-112 8 p.

Research output: Contribution to journalReview article

MicroRNAs
microRNA
human health
nutrition
Health
2016
8 Citations (Scopus)

Glucocorticoid cell priming enhances transfection outcomes in adult human mesenchymal stem cells

Kelly, A. M., Plautz, S. A., Zempleni, J. & Pannier, A. K., Feb 1 2016, In : Molecular Therapy. 24, 2, p. 331-341 11 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Glucocorticoids
Transfection
Transgenes
DNA
50 Citations (Scopus)

Human vascular endothelial cells transport foreign exosomes from cow’s milk by endocytosis

Kusuma, R. J., Manca, S., Frieme, T., Sukreet, S., Nguyen, C. & Zempleni, J., May 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 10, p. C800-C807

Research output: Contribution to journalArticle

Exosomes
Endocytosis
Milk
Endothelial Cells
MicroRNAs
4 Citations (Scopus)

Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells

Cordonier, E. L., Jarecke, S. K., Hollinger, F. E. & Zempleni, J., Jun 5 2016, In : European Journal of Pharmacology. 780, p. 202-208 7 p.

Research output: Contribution to journalArticle

3T3-L1 Cells
Acetyl-CoA Carboxylase
Adipocytes
Malonyl Coenzyme A
Fatty Acids
1 Citation (Scopus)

Molecular aspects of physical performance and nutritional assessment

Hassan, Y. I. & Zempleni, J., Apr 19 2016, Nutritional Assessment of Athletes: Second Edition. CRC Press, p. 213-232 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nutrition Assessment
10 Citations (Scopus)

Riboflavin

Pinto, J. T. & Zempleni, J., Jan 1 2016, In : Advances in Nutrition. 7, 5, p. 973-975 3 p.

Research output: Contribution to journalArticle

2015
27 Citations (Scopus)

Computational characterization of exogenous microRNAs that can be transferred into human circulation

Shu, J., Chiang, K., Zempleni, J. & Cui, J., Nov 3 2015, In : PloS one. 10, 11, e0140587.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
Milk
Lonicera
exosomes
18 Citations (Scopus)

Dietary microRNA database (DMD): An archive database and analytic tool for food-borne microRNAs

Chiang, K., Shu, J., Zempleni, J. & Cui, J., Jun 1 2015, In : PloS one. 10, 6, e0128089.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
Databases
Food
Genes
17 Citations (Scopus)

Diet-responsive MicroRNAs are likely exogenous

Zempleni, J., Baier, S. R. & Hirschi, K., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, 1 p.

Research output: Contribution to journalLetter

Nutrition
MicroRNAs
Milk
Animals
Diet
24 Citations (Scopus)

Gene regulation by dietary microRNAs

Zempleni, J., Baier, S. R., Howard, K. M. & Cui, J., Sep 25 2015, In : Canadian journal of physiology and pharmacology. 93, 12, p. 1097-1102 6 p.

Research output: Contribution to journalReview article

MicroRNAs
Genes
Milk
Food
Protein Biosynthesis
38 Citations (Scopus)

Loss of miRNAs during processing and storage of cow's (Bos taurus) milk

Howard, K. M., Jati Kusuma, R., Baier, S. R., Friemel, T., Markham, L., Vanamala, J. & Zempleni, J., Jan 21 2015, In : Journal of Agricultural and Food Chemistry. 63, 2, p. 588-592 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Milk
microwave treatment
microRNA
food processing

Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster

Cordonier, E. L., Adjam, R., Teixeira, D. C., Onur, S., Zbasnik, R., Read, P. E., Döring, F., Schlegel, V. L. & Zempleni, J., Nov 2015, In : Journal of Nutritional Biochemistry. 26, 11, p. 1379-1384 6 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Phenotype
Vitis
Metabolism
Adipose Tissue
84 Citations (Scopus)
Exosomes
Caco-2 Cells
Endocytosis
Colon
Milk
2014
8 Citations (Scopus)
Histone Deacetylase 1
Co-Repressor Proteins
Terminal Repeat Sequences
Chromatin
Genes
14 Citations (Scopus)
Jurkat Cells
Riboflavin
Transcriptome
Lysine
Lymphoma
7 Citations (Scopus)
Biotinylation
Heat-Shock Proteins
Cell culture
Methionine
Lysine
169 Citations (Scopus)
HEK293 Cells
MicroRNAs
Blood Cells
Milk
Cell Culture Techniques
7 Citations (Scopus)

Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism

Zempleni, J., Liu, D., Teixeira Camara, D. & Cordonier, E. L., Jun 2014, In : Nutrition Reviews. 72, 6, p. 369-376 8 p.

Research output: Contribution to journalArticle

Biotinylation
biotin carboxylase
HSP72 Heat-Shock Proteins
Genes
Gluconeogenesis
20 Citations (Scopus)

Nuclear receptors and epigenetic regulation: Opportunities for nutritional targeting and disease prevention

Romagnolo, D. F., Zempleni, J. & Selmin, O. I., Jan 1 2014, In : Advances in Nutrition. 5, 4, p. 373-385 13 p.

Research output: Contribution to journalReview article

disease prevention
Cytoplasmic and Nuclear Receptors
Epigenomics
epigenetics
receptors
9 Citations (Scopus)

Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events

Baier, S. R., Zbasnik, R., Schlegel, V. L. & Zempleni, J., Jun 2014, In : Journal of Nutritional Biochemistry. 25, 6, p. 665-668 4 p.

Research output: Contribution to journalArticle

Acetylation
Terminal Repeat Sequences
Histones
Genes
Brassica
4 Citations (Scopus)

Reply to witwer

Baier, S. R., Nguyen, C., Xie, F., Wood, J. R. & Zempleni, J., Jan 1 2014, In : Journal of Nutrition. 144, 11, 1 p.

Research output: Contribution to journalArticle

Reply to Witwer

Baier, S. R., Xie, F. & Zempleni, J., Nov 1 2014, In : The Journal of nutrition. 144, 11, p. 1882 1 p.

Research output: Contribution to journalArticle

Mononuclear Leukocytes
MicroRNAs
Milk
Gene Expression
5 Citations (Scopus)
Histone Code
Flavin-Adenine Dinucleotide
Monoamine Oxidase
Methylation
Lysine
7 Citations (Scopus)

β-Keto and β-hydroxyphosphonate analogs of biotin-5′-AMP are inhibitors of holocarboxylase synthetase

Sittiwong, W., Cordonier, E. L., Zempleni, J. & Dussault, P. H., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5568-5571 4 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Inhibitory Concentration 50
Biotin
Histones
Molecules
2013
11 Citations (Scopus)

Biotinylation of lysine 16 in histone H4 contributes toward nucleosome condensation

Singh, M. P., Wijeratne, S. S. K. & Zempleni, J., Jan 15 2013, In : Archives of Biochemistry and Biophysics. 529, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

Biotinylation
Nucleosomes
Histones
Lysine
Condensation
1 Citation (Scopus)

Enrichment of meiotic recombination hotspot sequences by avidin capture technology

Camara Teixeira, D., Malkaram, S. A. & Zempleni, J., Mar 1 2013, In : Gene. 516, 1, p. 101-106 6 p.

Research output: Contribution to journalArticle

Avidin
Oligonucleotides
Genetic Recombination
Technology
DNA
7 Citations (Scopus)

Epigenetic Synergies Between Biotin and Folate in the Regulation of Pro-Inflammatory Cytokines and Repeats

Xue, J. & Zempleni, J., Nov 1 2013, In : Scandinavian Journal of Immunology. 78, 5, p. 419-425 7 p.

Research output: Contribution to journalArticle

Biotin
Folic Acid
Epigenomics
Cytokines
Terminal Repeat Sequences
6 Citations (Scopus)
HSP72 Heat-Shock Proteins
Biotinylation
HEK293 Cells
Mass Spectrometry
Biotin
14 Citations (Scopus)
Histone-Lysine N-Methyltransferase
Biotinylation
Methylation
Histones
Histone Code
14 Citations (Scopus)

Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

Xue, J., Wijeratne, S. S. K. & Zempleni, J., May 2013, In : Epigenetics. 8, 5, p. 504-511 8 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Terminal Repeat Sequences
Methyltransferases
DNA
Chromatin
14 Citations (Scopus)

Identification and assessment of markers of biotin status in healthy adults

Eng, W. K., Giraud, D., Schlegel, V. L., Wang, D., Lee, B. H. & Zempleni, J., Jul 28 2013, In : British Journal of Nutrition. 110, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

Biotin
Methylmalonyl-CoA Decarboxylase
biotin carboxylase
methylcrotonoyl-CoA carboxylase
Lymphocytes

Mechanisms of gene transcriptional regulation through biotin and biotin-binding proteins in mammals

Zempleni, J., Liu, D., Teixeira, D. C. & Singh, M. P., Jan 1 2013, Vitamin-Binding Proteins: Functional Consequences. CRC Press, p. 219-228 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

biotin-binding proteins
Acetyl-CoA Carboxylase
acetyl-CoA carboxylase
Mammals
biotin
3 Citations (Scopus)

Three promoters regulate the transcriptional activity of the human holocarboxylase synthetase gene

Xia, M., Malkaram, S. A. & Zempleni, J., Nov 1 2013, In : Journal of Nutritional Biochemistry. 24, 11, p. 1963-1969 7 p.

Research output: Contribution to journalArticle

Human Activities
Genes
Biotin
Cells
Cell Line
2012
19 Citations (Scopus)

Biotin

Zempleni, J. & Kuroishi, T., Mar 1 2012, In : Advances in Nutrition. 3, 2, p. 213-214 2 p.

Research output: Contribution to journalComment/debate

Carbon-Nitrogen Ligases
carbon-nitrogen ligases
Biotinidase Deficiency
nutrition policy
Nutrition Policy
12 Citations (Scopus)

Biotin

Zempleni, J., Wijeratne, S. S. K. & Kuroishi, T., Jun 18 2012, Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, p. 359-374 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biotin
Biotinidase
Histones
Methylmalonyl-CoA Decarboxylase
Biotinylation
16 Citations (Scopus)

Biotin requirements for DNA damage prevention

Zempleni, J., Teixeira, D. C., Kuroishi, T., Cordonier, E. L. & Baier, S., May 1 2012, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 733, 1-2, p. 58-60 3 p.

Research output: Contribution to journalReview article

Biotin
Histones
DNA Damage
Biotinylation
Genomic Instability
8 Citations (Scopus)
Biotinylation
Methylation
Cytosine
Histones
Genes