Janet M Guthmiller, DDS, PhD

Dean

  • 2372 Citations
  • 22 h-Index
1985 …2019
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Research Output 1990 2019

  • 2372 Citations
  • 22 h-Index
  • 38 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter
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Article
2019

Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer

Fischer, C. L., Bates, A. M., Lanzel, E. A., Guthmiller, J. M., Johnson, G. K., Singh, N. K., Kumar, A., Vidva, R., Abbasi, T., Vali, S., Xie, X. J., Zeng, E. & Brogden, K. A., Dec 1 2019, In : Scientific reports. 9, 1, 10877.

Research output: Contribution to journalArticle

Open Access
Chemokines
Biomarkers
Inflammation
Dendritic Cells
Cytokines

Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B

Abhyankar, V. P., Bates, A. M., Fischer, C. L., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A. & Brogden, K. A., Feb 2019, In : Data in Brief. 22, p. 964-970 7 p.

Research output: Contribution to journalArticle

Chemokines
Cell Culture Techniques
Cytokines
Matrix Metalloproteinases
Keratinocytes
2018
1 Citation (Scopus)

Matrix metalloproteinase response of dendritic cell, gingival epithelial keratinocyte, and T-cell transwell co-cultures treated with porphyromonas gingivalis hemagglutinin-B

Bates, A. M., Fischer, C. L., Abhyankar, V. P., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A. & Brogden, K. A., Dec 2018, In : International journal of molecular sciences. 19, 12, 3923.

Research output: Contribution to journalArticle

T-cells
Hemagglutinins
Coculture Techniques
Matrix Metalloproteinases
Keratinocytes
5 Citations (Scopus)

Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections

Garaicoa, J. L., Fischer, C. L., Bates, A. M., Holloway, J., Avila-Ortiz, G., Guthmiller, J. M., Johnson, G. K., Stanford, C. & Brogden, K. A., Oct 2018, In : Journal of Prosthodontics. 27, 8, p. 755-762 8 p.

Research output: Contribution to journalArticle

Antifungal Agents
Dentures
Candida
Adhesives
Infection
2016
11 Citations (Scopus)

Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models

Lanzel, E. A., Paula Gomez Hernandez, M., Bates, A. M., Treinen, C. N., Starman, E. E., Fischer, C. L., Parashar, D., Guthmiller, J. M., Johnson, G. K., Abbasi, T., Vali, S. & Brogden, K. A., Dec 1 2016, In : Cancer Immunology, Immunotherapy. 65, 12, p. 1511-1522 12 p.

Research output: Contribution to journalArticle

Ligands
Neoplasms
Immunohistochemistry
Cell Line
Workflow
2015
3 Citations (Scopus)

Coordinated Pediatric and Periodontal Dental Care of a Child with Down syndrome

Byrd, G., Quinonez, R. B., Offenbacher, S., Keels, M. A. & Guthmiller, J. M., Jul 1 2015, In : Pediatric dentistry. 37, 4, p. 381-385 5 p.

Research output: Contribution to journalArticle

Dental Care for Children
Down Syndrome
Pediatrics
Mixed Dentition
Tooth Extraction
5 Citations (Scopus)

Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions

Leelakanok, N., Fischer, C. L., Bates, A. M., Guthmiller, J. M., Johnson, G. K., Salem, A. K., Brogden, K. A. & Brogden, N. K., Dec 3 2015, In : Toxicology Letters. 239, 2, p. 90-96 7 p.

Research output: Contribution to journalArticle

Cytotoxicity
Keratinocytes
Cell culture
Dendritic Cells
Cell Culture Techniques
2 Citations (Scopus)

Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells

Mehalick, L. A., Poulsen, C., Fischer, C. L., Lanzel, E. A., Bates, A. M., Walters, K. S., Cavanaugh, J. E., Guthmiller, J. M., Johnson, G. K., Wertz, P. W. & Brogden, K. A., Dec 1 2015, In : Data in Brief. 5, p. 285-291 7 p.

Research output: Contribution to journalArticle

damages
death
5 Citations (Scopus)

Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells

Poulsen, C., Mehalick, L. A., Fischer, C. L., Lanzel, E. A., Bates, A. M., Walters, K. S., Cavanaugh, J. E., Guthmiller, J. M., Johnson, G. K., Wertz, P. W. & Brogden, K. A., Aug 9 2015, In : Toxicology Letters. 237, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Fibroblasts
Cytotoxicity
Keratinocytes
Dendritic Cells
phytosphingosine
2 Citations (Scopus)

Educators' and applicants' views of the postdoctoral pediatric dentistry admission process: A qualitative study

Ricker, K., Mihas, P., Lee, J. Y., Guthmiller, J. M., Roberts, M. W. & Divaris, K., Nov 1 2015, In : Journal of dental education. 79, 11, p. 1272-1278 7 p.

Research output: Contribution to journalArticle

Pediatric Dentistry
dentistry
applicant
educator
Interviews
2014
1 Citation (Scopus)

Empowerment through mentorship and leadership

Wilder, R. S. & Guthmiller, J. M., Jun 2014, In : Journal of Evidence-Based Dental Practice. 14, SUPPL., p. 222-226 5 p.

Research output: Contribution to journalArticle

Dental Hygienists
Mentors
Oral Health
Oral Hygiene
Delivery of Health Care
30 Citations (Scopus)

The impact of oral health literacy on periodontal health status

Wehmeyer, M. M. H., Corwin, C. L., Guthmiller, J. M. & Lee, J. Y., Dec 1 2014, In : Journal of Public Health Dentistry. 74, 1, p. 80-87 8 p.

Research output: Contribution to journalArticle

Health Literacy
Oral Health
Health Status
Periodontitis
Tooth
2012
8 Citations (Scopus)

Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay

Kohlgraf, K. G., Ackermann, A. R., Burnell, K. K., Srikantha, R. N., Joly, S. A., Bartlett, J. A., Gakhar, L., Johnson, G. K., McCray, P. B., Guthmiller, J. M. & Brogden, K. A., Feb 1 2012, In : Archives of Oral Biology. 57, 2, p. 197-204 8 p.

Research output: Contribution to journalArticle

Palate
Nose
Saliva
Immunoassay
Clone Cells
2011
87 Citations (Scopus)

Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis

Tymkiw, K. D., Thunell, D. H., Johnson, G. K., Joly, S., Burnell, K. K., Cavanaugh, J. E., Brogden, K. A. & Guthmiller, J. M., Mar 1 2011, In : Journal of Clinical Periodontology. 38, 3, p. 219-228 10 p.

Research output: Contribution to journalArticle

Gingival Crevicular Fluid
Chronic Periodontitis
Smoking
Chemokines
Cytokines
2010
84 Citations (Scopus)

A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy

Thunell, D. H., Tymkiw, K. D., Johnson, G. K., Joly, S., Burnell, K. K., Cavanaugh, J. E., Brogden, K. A. & Guthmiller, J. M., Feb 1 2010, In : Journal of Periodontal Research. 45, 1, p. 148-152 5 p.

Research output: Contribution to journalArticle

Gingival Crevicular Fluid
Immunoassay
Cytokines
Interleukin-1
Chemokines
24 Citations (Scopus)

Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures

Johnson, G. K., Guthmiller, J. M., Joly, S., Organ, C. C. & Dawson, D. V., Aug 1 2010, In : Journal of Periodontal Research. 45, 4, p. 583-588 6 p.

Research output: Contribution to journalArticle

Interleukin-8
Interleukin-1
Nicotine
Keratinocytes
Lipopolysaccharides
2009
50 Citations (Scopus)

Loss of human β-defensin 1, 2, and 3 expression in oral squamous cell carcinoma

Joly, S., Compton, L. M., Pujol, C., Kurago, Z. B. & Guthmiller, J. M., Oct 1 2009, In : Oral Microbiology and Immunology. 24, 5, p. 353-360 8 p.

Research output: Contribution to journalArticle

Defensins
Squamous Cell Carcinoma
Cell Line
Single Nucleotide Polymorphism
Carcinogenesis
19 Citations (Scopus)

Periodontal-systemic disease education in U.S. and Canadian dental schools

Wilder, R. S., Iacopino, A. M., Feldman, C. A., Guthmiller, J., Linfante, J., Lavigne, S. & Paquette, D., Jan 1 2009, In : Journal of dental education. 73, 1, p. 38-52 15 p.

Research output: Contribution to journalArticle

Mouth Diseases
Dental Schools
Periodontal Diseases
Disease
Education
26 Citations (Scopus)

Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture

Franzman, M. R., Burnell, K. K., Dehkordi-Vakil, F. H., Guthmiller, J. M., Dawson, D. V. & Brogden, K. A., Jan 1 2009, In : International Journal of Antimicrobial Agents. 33, 1, p. 14-20 7 p.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Immunoglobulin G
Aggregatibacter actinomycetemcomitans
Peptostreptococcus
Peptides
2008
54 Citations (Scopus)

Human β-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response

Pingel, L. C., Kohlgraf, K. G., Hansen, C. J., Eastman, C. G., Dietrich, D. E., Burnell, K. K., Srikantha, R. N., Xiao, X., Bélanger, M., Progulske-Fox, A., Cavanaugh, J. E., Guthmiller, J. M., Johnson, G. K., Joly, S., Kurago, Z. B., Dawson, D. V. & Brogden, K. A., Nov 1 2008, In : Immunology and Cell Biology. 86, 8, p. 643-649 7 p.

Research output: Contribution to journalArticle

Defensins
Porphyromonas gingivalis
Hemagglutinins
Cytokines
Myeloid Cells
10 Citations (Scopus)

SMAP29 congeners demonstrate activity against oral bacteria and reduced toxicity against oral keratinocytes

Weistroffer, P. L., Joly, S., Srikantha, R., Tack, B. F., Brogden, K. A. & Guthmiller, J. M., Apr 1 2008, In : Oral Microbiology and Immunology. 23, 2, p. 89-95 7 p.

Research output: Contribution to journalArticle

Keratinocytes
Bacteria
Peptides
Fusobacterium nucleatum
Actinomyces
2007
16 Citations (Scopus)

Intravenous bisphosphonate-associated osteonecrosis of the jaw

Statz, T. A., Guthmiller, J. M., Humbert, L. A. & Johnson, G. K., Nov 1 2007, In : Journal of periodontology. 78, 11, p. 2203-2208 6 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Jaw
Osteonecrosis
Tooth
Diphosphonates
2005
103 Citations (Scopus)

Correlation between β-defensin expression and induction profiles in gingival keratinocytes

Joly, S., Organ, C. C., Johnson, G. K., McCray, P. B. & Guthmiller, J. M., May 2005, In : Molecular Immunology. 42, 9, p. 1073-1084 12 p.

Research output: Contribution to journalArticle

Defensins
Keratinocytes
Interleukin-1beta
Interleukin-2
Lipopolysaccharides
83 Citations (Scopus)

Factors related to utilization of dental services during pregnancy

Habashneh, R. A., Guthmiller, J. M., Levy, S., Johnson, G. K., Squier, C., Dawson, D. V. & Fang, Q., Jul 1 2005, In : Journal of Clinical Periodontology. 32, 7, p. 815-821 7 p.

Research output: Contribution to journalArticle

Tooth
Pregnancy
Oral Health
Pregnancy Outcome
Dental Care
2004
33 Citations (Scopus)

Expression and regulation of novel human β-defensins in gingival keratinocytes

Premratanachai, P., Joly, S., Johnson, G. K., McCray, P. B., Jia, H. P. & Guthmiller, J. M., Apr 1 2004, In : Oral Microbiology and Immunology. 19, 2, p. 111-117 7 p.

Research output: Contribution to journalArticle

Defensins
Keratinocytes
Interleukin-1
Candida
Adaptive Immunity
81 Citations (Scopus)

Expression of β-defensins in gingival health and in periodontal disease

Bissell, J., Joly, S., Johnson, G. K., Organ, C. C., Dawson, D., McCray, P. B. & Guthmiller, J. M., May 1 2004, In : Journal of Oral Pathology and Medicine. 33, 5, p. 278-285 8 p.

Research output: Contribution to journalArticle

Defensins
Periodontal Diseases
Messenger RNA
Health
Gingival Diseases
194 Citations (Scopus)

Human β-Defensins 2 and 3 Demonstrate Strain-Selective Activity against Oral Microorganisms

Joly, S., Maze, C., McCray, P. B. & Guthmiller, J. M., Mar 1 2004, In : Journal of clinical microbiology. 42, 3, p. 1024-1029 6 p.

Research output: Contribution to journalArticle

Defensins
Candida
Actinomyces
Peptides
Streptococcus sanguis
2003
78 Citations (Scopus)

Bacterial penetration through canals of endodontically treated teeth in the presence or absence of the smear layer

Clark-Holke, D., Drake, D., Walton, R., Rivera, E. & Guthmiller, J. M., May 2003, In : Journal of Dentistry. 31, 4, p. 275-281 7 p.

Research output: Contribution to journalArticle

Smear Layer
Nonvital Tooth
Tooth Apex
Fusobacterium nucleatum
Bacteria
83 Citations (Scopus)

Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease

Brogden, K. A., Heidari, M., Sacco, R. E., Palmquist, D., Guthmiller, J. M., Johnson, G. K., Jia, H. P., Tack, B. F. & McCray, P. B., Apr 1 2003, In : Oral Microbiology and Immunology. 18, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

Defensins
Ovalbumin
Periodontal Diseases
Adaptive Immunity
Serum
2001
36 Citations (Scopus)
Open Access
Aggregatibacter actinomycetemcomitans
Periodontal Diseases
Aggressive Periodontitis
Virulence Factors
Microbial Genetics
227 Citations (Scopus)

Discovery of new human β-defensins using a genomics-based approach

Peng Jia, H., Schutte, B. C., Schudy, A., Linzmeier, R., Guthmiller, J. M., Johnson, G. K., Tack, B. F., Mitros, J. P., Rosenthal, A., Ganz, T. & McCray, P. B., Jan 24 2001, In : Gene. 263, 1-2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Defensins
Genomics
Genes
Complementary DNA
Keratinocytes
5 Citations (Scopus)

Molecular Analysis of Peptostreptococcus micros Isolates from Patients with Periodontitis

Alpha, C. X., Guthmiller, J. M., Cummings, H. E., Schomberg, L. L. & Noorani, S. M., Jul 1 2001, In : Journal of periodontology. 72, 7, p. 877-882 6 p.

Research output: Contribution to journalArticle

Peptostreptococcus
Periodontitis
Periodontal Diseases
Polymerase Chain Reaction
Genotype
15 Citations (Scopus)

Periodontal disease in pregnancy complicated by type 1 diabetes mellitus

Guthmiller, J. M., Hassebroek-Johnson, J. R., Weenig, D. R., Johnson, G. K., Kirchner, H. L., Kohout, F. J. & Hunter, S. K., Dec 22 2001, In : Journal of periodontology. 72, 11, p. 1485-1490 6 p.

Research output: Contribution to journalArticle

Periodontal Diseases
Type 1 Diabetes Mellitus
Inflammation
Pregnancy
Periodontal Index
55 Citations (Scopus)

Susceptibilities of oral bacteria and yeast to mammalian cathelicidins

Guthmiller, J. M., Vargas, K. G., Srikantha, R., Schomberg, L. L., Weistroffer, P. L., McCray, J. & Tack, B. F., Nov 1 2001, In : Antimicrobial Agents and Chemotherapy. 45, 11, p. 3216-3219 4 p.

Research output: Contribution to journalArticle

Cathelicidins
Yeasts
Streptococcus sanguis
Fusobacterium nucleatum
Candida tropicalis
1999
299 Citations (Scopus)

Production of β-defensin antimicrobial peptides by the oral mucosa and salivary glands

Mathews, M., Jia, H. P., Guthmiller, J. M., Losh, G., Graham, S., Johnson, G. K., Tack, B. F. & McCray, P. B., Jun 1 1999, In : Infection and immunity. 67, 6, p. 2740-2745 6 p.

Research output: Contribution to journalArticle

Defensins
Mouth Mucosa
Salivary Glands
Peptides
Interleukin-1
1996
12 Citations (Scopus)

Development and evaluation of a selective and differential medium for the primary isolation of Peptostreptococcus micros

Turng, B. F., Guthmiller, J. M., Minah, G. E. & Falkler, W. A., Oct 1996, In : Oral Microbiology and Immunology. 11, 5, p. 356-361 6 p.

Research output: Contribution to journalArticle

Peptostreptococcus
Gram-Positive Cocci
Chronic Periodontitis
Phenylethyl Alcohol
Aggressive Periodontitis
1995
28 Citations (Scopus)

Mutational analysis of the putative leukotoxin transport genes in actinobacillus actinomycetemcomitans

Guthmiller, J. M., Kolodrubetz, D. & Kraig, E., May 1995, In : Microbial Pathogenesis. 18, 5, p. 307-321 15 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Camellia
Genes
Proteins
Hemolysin Proteins
1993
15 Citations (Scopus)
Aggregatibacter actinomycetemcomitans
DNA Probes
Primates
Periodontal Diseases
Haplorhini