• 803 Citations
  • 14 h-Index
1986 …2019
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Research Output 1986 2019

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Article
2019
Open Access
Cartilage
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Hydrogel

Continuous low-intensity ultrasound promotes native-to-native cartilage integration

Sahu, N., Miller, A., Viljoen, H. J. & Subramanian, A., Nov 2019, In : Tissue Engineering - Part A. 25, 21-22, p. 1538-1549 12 p.

Research output: Contribution to journalArticle

Cartilage
Ultrasonics
Repair
Hydrogel
Hydrogels

Stability analysis of a thin film on a rotating cylinder with low airflow

Newell, H. & Viljoen, H., Mar 1 2019, In : Physics of Fluids. 31, 3, 034106.

Research output: Contribution to journalArticle

rotating cylinders
angular velocity
interfacial tension
thin films
pesticides
2018
3 Citations (Scopus)

Automated Expansion of Primary Human T Cells in Scalable and Cell-Friendly Hydrogel Microtubes for Adoptive Immunotherapy

Lin, H., Li, Q., Wang, O., Rauch, J., Harm, B., Viljoen, H. J., Zhang, C., Van Wyk, E., Zhang, C. & Lei, Y., Aug 8 2018, In : Advanced Healthcare Materials. 7, 15, 1701297.

Research output: Contribution to journalArticle

Adoptive Immunotherapy
T-cells
Hydrogel
Cell culture
Hydrogels
7 Citations (Scopus)

Scalable Culturing of Primary Human Glioblastoma Tumor-Initiating Cells with a Cell-Friendly Culture System

Li, Q., Lin, H., Rauch, J., Deleyrolle, L. P., Reynolds, B. A., Viljoen, H. J., Zhang, C., Gu, L., Van Wyk, E. & Lei, Y., Dec 1 2018, In : Scientific reports. 8, 1, 3531.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Glioblastoma
Cell Culture Techniques
Drug Discovery
Costs and Cost Analysis
2017
2 Citations (Scopus)

A nonlinear model of cell interaction with an acoustic field

Miller, A. D., Subramanian, A. & Viljoen, H. J., May 3 2017, In : Journal of Biomechanics. 56, p. 83-88 6 p.

Research output: Contribution to journalArticle

Nonlinear Dynamics
Acoustic fields
Acoustics
Cell Communication
Natural frequencies
3 Citations (Scopus)

Frequency sensitive mechanism in low-intensity ultrasound enhanced bioeffects

Miller, A. D., Chama, A., Louw, T. M., Subramanian, A. & Viljoen, H. J., Aug 2017, In : PloS one. 12, 8, e0181717.

Research output: Contribution to journalArticle

Chondrocytes
Ultrasonics
chondrocytes
Gene Expression
Theoretical Models
1 Citation (Scopus)
Cartilage
Resonant Frequency
Ultrasound
Chondrocytes
Restoration
2016
4 Citations (Scopus)

FA mathematical model of recombinase polymerase amplification under continuously stirred conditions

Moody, C., Newell, H. & Viljoen, H. J., Aug 15 2016, In : Biochemical Engineering Journal. 112, p. 193-201 9 p.

Research output: Contribution to journalArticle

Recombinases
Amplification
Theoretical Models
Mathematical models
Chemical Phenomena
1 Citation (Scopus)

Long-term culture of human mesenchymal stem cell-seeded constructs under ultrasound stimulation: Evaluation of chondrogenesis

Thakurta, S. G., Sahu, N., Miller, A., Budhiraja, G., Akert, L., Viljoen, H. J. & Subramanian, A., Sep 20 2016, In : Biomedical Physics and Engineering Express. 2, 5, 055016.

Research output: Contribution to journalArticle

Chondrogenesis
Mesenchymal Stromal Cells
Dexamethasone
Cartilage
Polyurethanes
5 Citations (Scopus)

Modeling nanoparticle delivery of TB drugs to granulomas

Grobler, A., Perez Sierra, Z. & Viljoen, H. J., Jan 7 2016, In : Journal of Theoretical Biology. 388, p. 85-95 11 p.

Research output: Contribution to journalArticle

granuloma
nanoparticles
Granuloma
Nanoparticles
Macrophage
2015
6 Citations (Scopus)

Development and evaluation of a rapid multiplex-PCR based system for Mycobacterium tuberculosis diagnosis using sputum samples

Mutingwende, I., Vermeulen, U., Steyn, F., Viljoen, H. J. & Grobler, A., Sep 1 2015, In : Journal of Microbiological Methods. 116, p. 37-43 7 p.

Research output: Contribution to journalArticle

Multiplex Polymerase Chain Reaction
Sputum
Mycobacterium tuberculosis
Tuberculosis
Microscopy
1 Citation (Scopus)
bioacoustics
bioreactors
acoustics
fluids
transducers
4 Citations (Scopus)

Theoretical Evaluation of the Acoustic Field in an Ultrasonic Bioreactor

Louw, T. M., Subramanian, A. & Viljoen, H. J., Jun 1 2015, In : Ultrasound in Medicine and Biology. 41, 6, p. 1766-1778 13 p.

Research output: Contribution to journalArticle

bioreactors
Bioreactors
Acoustics
Ultrasonics
tissue engineering
2014
2 Citations (Scopus)

A model of isoniazid treatment of tuberculosis

Lemmer, Y., Grobler, A., Moody, C. & Viljoen, H. J., Dec 21 2014, In : Journal of Theoretical Biology. 363, p. 367-373 7 p.

Research output: Contribution to journalArticle

isoniazid
Tuberculosis
Isoniazid
Cell Wall
tuberculosis
15 Citations (Scopus)
Chitosan
Bioreactors
Chondrocytes
Scaffolds
Ultrasonics

Mathematical modeling of functionalized-microsphere based assays for rapid DNA detection: From sample preparation to results

Louw, T. M., Gomez-Duarte, O. G., Subramanian, A. & Viljoen, H. J., Jul 15 2014, In : Biochemical Engineering Journal. 88, p. 50-60 11 p.

Research output: Contribution to journalArticle

Microspheres
Assays
DNA
Chitosan
Fibers
2013
2 Citations (Scopus)

Mathematical modeling of pathogen trajectory in a patient care environment

Hewlett, A. L., Whitney, S. E., Gibbs, S. G., Smith, P. W. & Viljoen, H. J., Nov 1 2013, In : Infection Control and Hospital Epidemiology. 34, 11, p. 1181-1188 8 p.

Research output: Contribution to journalArticle

Patients' Rooms
Patient Care
Infection Control
Delivery of Health Care
Hydrodynamics
26 Citations (Scopus)

Mechanotransduction of Ultrasound is Frequency Dependent Below the Cavitation Threshold

Louw, T. M., Budhiraja, G., Viljoen, H. J. & Subramanian, A., Jul 2013, In : Ultrasound in Medicine and Biology. 39, 7, p. 1303-1319 17 p.

Research output: Contribution to journalArticle

Chondrocytes
cavitation flow
fos Genes
thresholds
Cell Nucleus Active Transport
2012
8 Citations (Scopus)

A new rapid method for clostridium difficile DNA extraction and detection in stool: Toward point-of-care diagnostic testing

Freifeld, A. G., Simonsen, K. A., Booth, C. S., Zhao, X., Whitney, S. E., Karre, T., Iwen, P. C. & Viljoen, H. J., May 1 2012, In : Journal of Molecular Diagnostics. 14, 3, p. 274-279 6 p.

Research output: Contribution to journalArticle

Clostridium difficile
Glutamate Dehydrogenase
Polymerase Chain Reaction
Immunoenzyme Techniques
DNA

A state-time epidemiology model of tuberculosis: Importance of re-infection

Viljoen, S., Pienaar, E. & Viljoen, H. J., Feb 1 2012, In : Computational Biology and Chemistry. 36, p. 15-22 8 p.

Research output: Contribution to journalArticle

Epidemiology
Tuberculosis
Infection
Person
Age-structured Model
5 Citations (Scopus)

Evaluation of the real-time protein adsorption kinetics on albumin-binding surfaces by dynamic in situ spectroscopic ellipsometry

Guha Thakurta, S., Viljoen, H. J. & Subramanian, A., Jan 1 2012, In : Thin Solid Films. 520, 6, p. 2200-2207 8 p.

Research output: Contribution to journalArticle

Spectroscopic ellipsometry
albumins
ellipsometry
Albumins
proteins
7 Citations (Scopus)

Forced wave motion with internal and boundary damping

Louw, T., Whitney, S., Subramanian, A. & Viljoen, H. J., Jan 1 2012, In : Journal of Applied Physics. 111, 1, 014702.

Research output: Contribution to journalArticle

damping
boundary conditions
bioreactors
pulse detonation engines
transient response
3 Citations (Scopus)

Rapid cell lysis and DNA capture in a lysis microreactor

Grobler, A., Levanets, O., Whitney, S., Booth, C. & Viljoen, H. J., Oct 22 2012, In : Chemical Engineering Science. 81, p. 311-318 8 p.

Research output: Contribution to journalArticle

Microreactor
DNA
Cell
Strip
Diagnostics
2011
2 Citations (Scopus)

Experimental validation of a fundamental model for PCR efficiency

Louw, T. M., Booth, C. S., Pienaar, E., TerMaat, J. R., Whitney, S. E. & Viljoen, H. J., Apr 15 2011, In : Chemical Engineering Science. 66, 8, p. 1783-1789 7 p.

Research output: Contribution to journalArticle

Experimental Validation
Annealing
Template
Midpoint
Model
2 Citations (Scopus)

Oligonucleotide optimization for DNA synthesis

Louw, T. M., Whitney, S. E., Termaat, J. R., Pienaar, E. & Viljoen, H. J., Jul 1 2011, In : AIChE Journal. 57, 7, p. 1912-1918 7 p.

Research output: Contribution to journalArticle

Oligonucleotides
DNA
Freezing
Temperature
Melting point
2010
7 Citations (Scopus)

A model of tuberculosis transmission and intervention strategies in an urban residential area

Pienaar, E., Fluitt, A. M., Whitney, S. E., Freifeld, A. G. & Viljoen, H. J., Apr 1 2010, In : Computational Biology and Chemistry. 34, 2, p. 86-96 11 p.

Research output: Contribution to journalArticle

Tuberculosis
Urban Areas
Population
Commute
Ambulatory Care
10 Citations (Scopus)

Efficiency of the polymerase chain reaction

Booth, C. S., Pienaar, E., Termaat, J. R., Whitney, S. E., Louw, T. M. & Viljoen, H. J., Sep 1 2010, In : Chemical Engineering Science. 65, 17, p. 4996-5006 11 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Polymerase chain reaction
Ternary
Biochemistry
Molecular biology
2009
6 Citations (Scopus)

A kinetic study of in vitro lysis of mycobacterium smegmatis

Valente, W. J., Pienaar, E., Fast, A., Fluitt, A., Whitney, S. E., Fenton, R. J., Barletta, R. G., Chacon, O. & Viljoen, H. J., May 1 2009, In : Chemical Engineering Science. 64, 9, p. 1944-1952 9 p.

Research output: Contribution to journalArticle

Kinetics
Cell
DNA
Tuberculosis
Cells
4 Citations (Scopus)

A model of the complex response of Staphylococcus aureus to methicillin

Pienaar, E., Whitney, S. E., Viljoen, H. J. & van Rensburg, N. F. J., Apr 7 2009, In : Journal of Theoretical Biology. 257, 3, p. 438-445 8 p.

Research output: Contribution to journalArticle

Methicillin
methicillin
Cell Wall
Autolysis
Staphylococcus aureus
2008
69 Citations (Scopus)

A fundamental study of the PCR amplification of GC-rich DNA templates

Mamedov, T. G., Pienaar, E., Whitney, S. E., TerMaat, J. R., Carvill, G., Goliath, R., Subramanian, A. & Viljoen, H. J., Dec 1 2008, In : Computational Biology and Chemistry. 32, 6, p. 452-457 6 p.

Research output: Contribution to journalArticle

Annealing
Amplification
Template
DNA
Polymerase Chain Reaction
8 Citations (Scopus)

The tri-frame model

Pienaar, E. & Viljoen, H. J., Apr 21 2008, In : Journal of Theoretical Biology. 251, 4, p. 616-627 12 p.

Research output: Contribution to journalArticle

codons
Codon
Reading Frames
ribosomes
Ribosomes
2007
11 Citations (Scopus)

Rational de novo gene synthesis by rapid polymerase chain assembly (PCA) and expression of endothelial protein-C and thrombin receptor genes

Mamedov, T. G., Padhye, N. V., Viljoen, H. J. & Subramanian, A., Sep 30 2007, In : Journal of Biotechnology. 131, 4, p. 379-387 9 p.

Research output: Contribution to journalArticle

Thrombin Receptors
Protein C
Genes
Proteins
Thrombomodulin
82 Citations (Scopus)

Ribosome kinetics and aa-tRNA competition determine rate and fidelity of peptide synthesis

Fluitt, A., Pienaar, E. & Viljoen, H. J., Oct 1 2007, In : Computational Biology and Chemistry. 31, 5-6, p. 335-346 12 p.

Research output: Contribution to journalArticle

ribosomes
Transfer RNA
Ribosomes
Peptides
Fidelity
2006
26 Citations (Scopus)

A quantitative model of error accumulation during PCR amplification

Pienaar, E., Theron, M., Nelson, M. & Viljoen, H. J., Apr 1 2006, In : Computational Biology and Chemistry. 30, 2, p. 102-111 10 p.

Research output: Contribution to journalArticle

polymerase chain reaction
Polymerase Chain Reaction
Polymerase chain reaction
Amplification
Hot Temperature
9 Citations (Scopus)

DNA polymerase chain reaction: A model of error frequencies and extension rates

Griep, M. A., Whitney, S., Nelson, M. & Viljoen, H. J., Jan 1 2006, In : AIChE Journal. 52, 1, p. 384-392 9 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
DNA-Directed DNA Polymerase
DNA
Nucleotides
Polymerase Chain Reaction
8 Citations (Scopus)

Kinetics of the DNA polymerase pyrococcus kodakaraensis

Griep, M. A., Kotera, C. A., Nelson, R. M. & Viljoen, H. J., Jun 1 2006, In : Chemical Engineering Science. 61, 12, p. 3885-3892 8 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
DNA
Kinetics
Polymerase chain reaction
Nucleotides
3 Citations (Scopus)

Thermal analysis of the vortex tube based thermocycler for fast DNA amplification: Experimental and two-dimensional numerical results

Raghavan, V., Whitney, S. E., Ebmeier, R. J., Padhye, N. V., Nelson, M., Viljoen, H. J. & Gogos, G., Oct 9 2006, In : Review of Scientific Instruments. 77, 9, 094301.

Research output: Contribution to journalArticle

vortex tubes
Thermoanalysis
Amplification
Polymerase chain reaction
thermal analysis
2005
8 Citations (Scopus)

A macroscopic kinetic model for DNA polymerase elongation and high-fidelity nucleotide selection

Viljoen, S., Griep, M. A., Nelson, M. & Viljoen, H. J., Apr 1 2005, In : Computational Biology and Chemistry. 29, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

nucleotides
DNA-Directed DNA Polymerase
Kinetic Model
Nucleotides
Elongation

Reaction of thermics in a Bridgman anvil. II. Fracture and reaction

Gordopolov, A., Dzenis, O. & Viljoen, H. J., Oct 25 2005, In : Khimicheskaya Fizika. 24, 4, p. 61-66 6 p.

Research output: Contribution to journalArticle

anvils

Reactions of thermites in a Bridgman anvil. The pre-explosion phase

Gordopolov, A. & Viljoen, H. J., Oct 25 2005, In : Khimicheskaya Fizika. 24, 3, p. 60-69 10 p.

Research output: Contribution to journalArticle

thermites
anvils
explosions
2004
20 Citations (Scopus)

Principles of rapid polymerase chain reactions: Mathematical modeling and experimental verification

Whitney, S. E., Sudhir, A., Nelson, R. M. & Viljoen, H. J., Jul 1 2004, In : Computational Biology and Chemistry. 28, 3, p. 195-209 15 p.

Research output: Contribution to journalArticle

polymerase chain reaction
Polymerase Chain Reaction
Polymerase chain reaction
Elongation
Mathematical Modeling
3 Citations (Scopus)

Ranque-hilsch vortex tube thermocycler for DNA amplification

Ebmeier, R., Whitney, S., Alugupally, S., Nelson, M., Padhye, N., Gogos, G. & Viljoen, H. J., Sep 1 2004, In : Instrumentation Science and Technology. 32, 5, p. 567-570 4 p.

Research output: Contribution to journalArticle

vortex tubes
polymerase chain reaction
Polymerase chain reaction
Amplification
vortex
6 Citations (Scopus)

Ranque-Hilsch vortex tube thermocycler for fast DMA amplification and real-time optical detection

Ebmeier, R. J., Whitney, S. E., Sarkar, A., Nelson, M., Padhye, N. V., Gogos, G. & Viljoen, H. J., Dec 1 2004, In : Review of Scientific Instruments. 75, 12, p. 5356-5359 4 p.

Research output: Contribution to journalArticle

vortex tubes
Dynamic mechanical analysis
Amplification
polymerase chain reaction
Vortex flow
2003
4 Citations (Scopus)

A Macrokinetic Study of the High-Temperature Solid-Phase Titanium-Carbon Reaction

Kostogorova, J. Y., Viljoen, H. J. & Shteinberg, A. S., Dec 24 2003, In : Industrial and Engineering Chemistry Research. 42, 26, p. 6714-6719 6 p.

Research output: Contribution to journalArticle

Titanium
titanium
Carbon
carbon
activation energy
15 Citations (Scopus)

Effective thermal conductivity estimates of particulate mixtures

Richter, C., Viljoen, H. J. & Van Rensburg, N. F. J., Mar 1 2003, In : Journal of Applied Physics. 93, 5, p. 2663-2670 8 p.

Research output: Contribution to journalArticle

particulates
thermal conductivity
estimates
coefficients
2 Citations (Scopus)

Natural convection and solid phase combustion

Whitney, S. E. & Viljoen, H. J., Mar 1 2003, In : Chemical Engineering Communications. 190, 3, p. 393-430 38 p.

Research output: Contribution to journalArticle

Natural convection
Gases
Noble Gases
Preheating
Inert gases
2002
4 Citations (Scopus)

A combinatorial approach to surface contacts in solid phase reactions

Richter, C. & Viljoen, H. J., Feb 25 2002, In : Thermochimica Acta. 384, 1-2, p. 315-328 14 p.

Research output: Contribution to journalArticle

solid phases
Particle size
Reaction rates
Aspect ratio
Platelets
6 Citations (Scopus)

Role of particle geometry and surface contacts in solid-phase reactions

Kostogorova, J., Viljoen, H. J. & Shteinberg, A., Aug 1 2002, In : AIChE Journal. 48, 8, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

Powders
Geometry
Tile
Probability distributions
Distribution functions
4 Citations (Scopus)
Toda Lattice
Solitary Waves
Explosion
solitary waves
Nonlinear Dispersion