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1977 …2020
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Research Output 1977 2019

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2019

Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure

Andrade, D. C., Toledo, C., Díaz, H. S., Lucero, C., Arce-Álvarez, A., Oliveira, L. M., Takakura, A. C., Moreira, T. S., Schultz, H. D., Marcus, N. J., Alcayaga, J. & Del Rio, R., Feb 14 2019, In : Clinical science (London, England : 1979). 133, 3, p. 393-405 13 p.

Research output: Contribution to journalArticle

Brain Stem
Heart Failure
Neurons
Mixed Function Oxygenases
Dopamine
2 Citations (Scopus)

Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle

Wafi, A. M., Hong, J., Rudebush, T. L., Yu, L., Hackfort, B., Wang, H., Schultz, H. D., Zucker, I. H. & Gao, L., Feb 1 2019, In : Journal of Applied Physiology. 126, 2, p. 477-486 10 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Curcumin
Ligation
Coronary Vessels
Skeletal Muscle
Ankyrins
Heart Failure
Reflex
Lung
Arterial Pressure
2018
2 Citations (Scopus)

KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure

Marcus, N. J., Del Rio, R., Ding, Y. & Schultz, H. D., Aug 1 2018, In : Journal of Physiology. 596, 15, p. 3171-3185 15 p.

Research output: Contribution to journalArticle

Carotid Body
Respiration
Heart Failure
Cardiac Arrhythmias
Kidney
2 Citations (Scopus)

Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats

Shanks, J., Xia, Z., Lisco, S. J., Rozanski, G. J., Schultz, H. D., Zucker, I. H. & Wang, H., Jun 1 2018, In : Physiological Reports. 6, 12, e13742.

Research output: Contribution to journalArticle

Lung
Pleura
Reflex
Bradykinin
Capsaicin
2017
8 Citations (Scopus)

Cardiac diastolic and autonomic dysfunction are aggravated by central chemoreflex activation in heart failure with preserved ejection fraction rats

Toledo, C., Andrade, D. C., Lucero, C., Arce-Alvarez, A., Díaz, H. S., Aliaga, V., Schultz, H. D., Marcus, N. J., Manríquez, M., Faúndez, M. & Del Rio, R., Apr 15 2017, In : Journal of Physiology. 595, 8, p. 2479-2495 17 p.

Research output: Contribution to journalArticle

Heart Failure
Cardiac Arrhythmias
Respiration
Incidence
Hypercapnia
3 Citations (Scopus)

Carotid Body-Mediated Chemoreflex Drive in the Setting of low and High Output Heart Failure

Del Rio, R., Andrade, D. C., Toledo, C., Diaz, H. S., Lucero, C., Arce-Alvarez, A., Marcus, N. J. & Schultz, H. D., Dec 1 2017, In : Scientific Reports. 7, 1, 8035.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Kruppel-Like Transcription Factors
Body Regions
Venae Cavae

Epigenetic influences on carotid body function: a new snag in the road to treating sleep apnoea

Schultz, H. D., Feb 1 2017, In : Journal of Physiology. 595, 3, p. 629-630 2 p.

Research output: Contribution to journalArticle

Carotid Body
Sleep Apnea Syndromes
Epigenomics
3 Citations (Scopus)

Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure

Andrade, D. C., Arce-Alvarez, A., Toledo, C., Díaz, H. S., Lucero, C., Schultz, H. D., Marcus, N. J. & Rio, R. D., Sep 1 2017, In : Journal of Applied Physiology. 123, 3, p. 567-577 11 p.

Research output: Contribution to journalArticle

Heart Failure
Exercise
Oxidative Stress
Brain Stem
NADPH Oxidase
18 Citations (Scopus)

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

van Bilsen, M., Patel, H. C., Bauersachs, J., Böhm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G. W., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., Ruschitzka, F. & 10 others, Sabbah, H. N., Schultz, H. D., Seferovic, P., Slart, R. H. J. A., Taggart, P., Tocchetti, C. G., Van Laake, L. W., Zannad, F., Heymans, S. & Lyon, A. R., Nov 1 2017, In : European Journal of Heart Failure. 19, 11, p. 1361-1378 18 p.

Research output: Contribution to journalArticle

Translational Medical Research
Autonomic Nervous System
Heart Failure
Therapeutics
Equipment and Supplies
2016
2 Citations (Scopus)

Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: Role of the α1-adrenergic receptor

Pugge, C., Mediratta, J., Marcus, N. J., Schultz, H. D., Schiller, A. M. & Zucker, I. H., Feb 1 2016, In : Journal of Applied Physiology. 120, 3, p. 334-343 10 p.

Research output: Contribution to journalArticle

Renal Circulation
Adrenergic Receptors
Heart Failure
Exercise
Kidney
33 Citations (Scopus)

Translational neurocardiology: preclinical models and cardioneural integrative aspects

Ardell, J. L., Andresen, M. C., Armour, J. A., Billman, G. E., Chen, P. S., Foreman, R. D., Herring, N., O'Leary, D. S., Sabbah, H. N., Schultz, H. D., Sunagawa, K. & Zucker, I. H., Jul 15 2016, In : Journal of Physiology. 594, 14, p. 3877-3909 33 p.

Research output: Contribution to journalArticle

Nervous System
Regional Blood Flow
Cardiac Output
Cerebral Cortex
Heart Diseases
2015

Comment on "Precedence and autocracy in breathing control" [2]

Del Rio, R., Andrade, D. C. & Schultz, H. D., Jun 15 2015, In : Journal of Applied Physiology. 118, 12, p. 1558-1559 2 p.

Research output: Contribution to journalArticle

Respiration
9 Citations (Scopus)

Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure

Marcus, N. J., Pügge, C., Mediratta, J., Schiller, A. M., del Rio, R., Zucker, I. H. & Schultz, H. D., Jul 15 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 2, p. H259-H266

Research output: Contribution to journalArticle

Renal Circulation
Heart Failure
Exercise
Carotid Body
Denervation

In adult female hamsters hypothyroidism stimulates D1 receptor-mediated breathing without altering D1 receptor expression

Schlenker, E. H., Del Rio, R. & Schultz, H. D., Nov 1 2015, In : Respiratory Physiology and Neurobiology. 218, p. 32-39 8 p.

Research output: Contribution to journalArticle

Hypothyroidism
Cricetinae
Respiration
Ventilation
Air
33 Citations (Scopus)

Mechanisms of carotid body chemoreflex dysfunction during heart failure

Schultz, H. D., Marcus, N. J. & Del Rio, R., Feb 1 2015, In : Experimental Physiology. 100, 2, p. 124-129 6 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Reflex
Disease Management
21 Citations (Scopus)
Angiotensin II
Heart Failure
Exercise
Adrenergic Agents
Carotid Body
10 Citations (Scopus)

Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure

Andrade, D. C., Lucero, C., Toledo, C., Madrid, C., Marcus, N. J., Schultz, H. D. & Del Rio, R., 2015, In : BioMed Research International. 2015, 467597.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Theoretical Models
Physiology
13 Citations (Scopus)

Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies

Schultz, H. D., Marcus, N. J. & del Rio, R., 2015, In : Advances in Experimental Medicine and Biology. 860, p. 167-185 19 p.

Research output: Contribution to journalArticle

Carotid Body
Animals
Heart Failure
Respiration
Pulmonary diseases
14 Citations (Scopus)

Selective carotid body ablation in experimental heart failure: A new therapeutic tool to improve cardiorespiratory control

Del Rio, R., Andrade, D. C., Marcus, N. J. & Schultz, H. D., Feb 1 2015, In : Experimental Physiology. 100, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Therapeutics
Baroreflex
2014
87 Citations (Scopus)

Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure

Marcus, N. J., Del Rio, R., Schultz, E. P., Xia, X. H. & Schultz, H. D., Jan 1 2014, In : Journal of Physiology. 592, 2, p. 391-408 18 p.

Research output: Contribution to journalArticle

Autonomic Denervation
Carotid Body
Respiration
Heart Failure
Cardiac Arrhythmias
14 Citations (Scopus)

Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure

Marcus, N. J., Del Rio, R. & Schultz, H. D., Jan 1 2014, In : Frontiers in Physiology. 5, Nov, 438.

Research output: Contribution to journalArticle

Carotid Body
Respiration
Heart Failure
Kidney
Respiratory System

Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression

Schlenker, E. H., Del Rio, R. & Schultz, H. D., Mar 1 2014, In : Respiratory Physiology and Neurobiology. 193, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Hypothyroidism
Cricetinae
Respiration
Bromocriptine
Ventilation
22 Citations (Scopus)

Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure

Haack, K. K. V., Marcus, N. J., Del Rio, R., Zucker, I. H. & Schultz, H. D., Jan 1 2014, In : Hypertension. 63, 5, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

Carotid Body
Simvastatin
Apnea
Heart Failure
Cardiac Arrhythmias

The arterial chemoreflex and cardiac stress in heart failure: Nothing to be sheepish about

Schultz, H. D., Aug 1 2014, In : Experimental Physiology. 99, 8, p. 1029-1030 2 p.

Research output: Contribution to journalArticle

Chemoreceptor Cells
Sympathetic Nervous System
Heart Failure
2013
90 Citations (Scopus)

Carotid chemoreceptor ablation improves survival in heart failure: Rescuing autonomic control of cardiorespiratory function

Del Rio, R., Marcus, N. J. & Schultz, H. D., Dec 24 2013, In : Journal of the American College of Cardiology. 62, 25, p. 2422-2430 9 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Ventricular Remodeling
Baroreflex
Denervation
28 Citations (Scopus)

Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure

Del Rio, R., Marcus, N. J. & Schultz, H. D., May 1 2013, In : Journal of Applied Physiology. 114, 9, p. 1141-1150 10 p.

Research output: Contribution to journalArticle

Carotid Body
Hydrogen Sulfide
Respiration
Heart Failure
Blood Pressure
11 Citations (Scopus)
Mitochondria
Superoxides
Angiotensin II
Neurons
Superoxide Dismutase
34 Citations (Scopus)

Role of the carotid body in the pathophysiology of heart failure

Schultz, H. D., Marcus, N. J. & Del Rio, R., Aug 1 2013, In : Current Hypertension Reports. 15, 4, p. 356-362 7 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Reflex
Animal Models
2012
27 Citations (Scopus)

Effect of AT 1 receptor blockade on intermittent hypoxia-induced endothelial dysfunction

Marcus, N. J., Philippi, N. R., Bird, C. E., Li, Y., Schultz, H. D. & Morgan, B. J., Aug 15 2012, In : Respiratory Physiology and Neurobiology. 183, 2, p. 67-74 8 p.

Research output: Contribution to journalArticle

Losartan
Nitroprusside
Superoxides
Angiotensin II
Acetylcholine
5 Citations (Scopus)
Carotid Body
Hypothyroidism
Cricetinae
Respiration
Brain
2011
40 Citations (Scopus)
Potassium
Nitric Oxide
Nitric Oxide Synthase
7-Ala-angiotensin (1-7)
Neurons
11 Citations (Scopus)
Carotid Body
Hypothyroidism
Cricetinae
Respiration
Hypercapnia
68 Citations (Scopus)

Role of blood flow in carotid body chemoreflex function in heart failure

Ding, Y., Li, Y. & Schultz, H. D., Jan 1 2011, In : Journal of Physiology. 589, 1, p. 245-258 14 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Carotid Arteries
Rabbits
Sympathetic Nervous System
2010
84 Citations (Scopus)

Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: Role of the angiotensin II type 1 receptor

Marcus, N. J., Li, Y., Bird, C. E., Schultz, H. D. & Morgan, B. J., Apr 15 2010, In : Respiratory Physiology and Neurobiology. 171, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Carotid Body
Nitric Oxide Synthase Type I
Losartan
NADPH Oxidase
40 Citations (Scopus)
Angiotensin II
Down-Regulation
Heart Failure
Voltage-Gated Potassium Channels
4-Aminopyridine
26 Citations (Scopus)
Carotid Body
Superoxides
Superoxide Dismutase
Heart Failure
Rabbits
18 Citations (Scopus)
Carotid Body
Nitric Oxide Synthase Type I
Potassium
Rabbits
Large-Conductance Calcium-Activated Potassium Channels
44 Citations (Scopus)

Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current

Yin, J. X., Yang, R. F., Li, S., Renshaw, A. O., Li, Y., Schultz, H. D. & Zimmerman, M. C., Apr 1 2010, In : American Journal of Physiology - Cell Physiology. 298, 4

Research output: Contribution to journalArticle

Superoxides
Angiotensin II
Potassium
Mitochondria
Neurons
56 Citations (Scopus)

The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase

Rosenbaugh, E. G., Roat, J. W., Gao, L., Yang, R. F., Manickam, D. S., Yin, J. X., Schultz, H. D., Bronich, T. K., Batrakova, E. V., Kabanov, A. V., Zucker, I. H. & Zimmerman, M. C., Jul 1 2010, In : Biomaterials. 31, 19, p. 5218-5226 9 p.

Research output: Contribution to journalArticle

Angiotensin II
Neurons
Superoxide Dismutase
Zinc
Copper
2009
42 Citations (Scopus)

Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits

Ding, Y., Li, Y., Zimmerman, M. C., Davisson, R. L. & Schultz, H. D., Mar 1 2009, In : Cardiovascular Research. 81, 4, p. 678-685 8 p.

Research output: Contribution to journalArticle

Carotid Body
Superoxide Dismutase
Heart Failure
Rabbits
Superoxides
2008
23 Citations (Scopus)
Pressoreceptors
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Type 1 Diabetes Mellitus
Neurons
Nodose Ganglion
26 Citations (Scopus)
Carbon Monoxide
Hypersensitivity
Nitric Oxide
Down-Regulation
Heart Failure
47 Citations (Scopus)

Exercise training improves peripheral chemoreflex function in heart failure rabbits

Li, Y., Ding, Y., Agnew, C. & Schultz, H. D., Sep 1 2008, In : Journal of Applied Physiology. 105, 3, p. 782-790 9 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Exercise
Rabbits
Nitric Oxide Synthase Type I
64 Citations (Scopus)
Paraventricular Hypothalamic Nucleus
Glutamic Acid
Heart Failure
Exercise
N-Methylaspartate
2007
23 Citations (Scopus)
Carotid Body
Paraventricular Hypothalamic Nucleus
Nitric Oxide
Heart Failure
Phrenic Nerve
29 Citations (Scopus)

Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats

Gao, L., Pan, Y. X., Wang, W. Z., Li, Y., Schultz, H. D., Zucker, I. H. & Wang, W., Jan 1 2007, In : Journal of Applied Physiology. 102, 1, p. 37-43 7 p.

Research output: Contribution to journalArticle

Reflex
Chemical Stimulation
Electric Stimulation
Solitary Nucleus
Losartan
75 Citations (Scopus)

Carotid body function in heart failure

Schultz, H. D. & Li, Y., Jul 1 2007, In : Respiratory Physiology and Neurobiology. 157, 1, p. 171-185 15 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Angiotensin II
Central Nervous System
Rabbits
89 Citations (Scopus)
Carotid Body
NADPH Oxidase
Superoxides
Angiotensin II
Heart Failure
2006
81 Citations (Scopus)

Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits

Li, Y., Xia, X. H., Zheng, H., Gao, L., Li, Y. F., Liu, D., Patel, K. P., Wang, W. & Schultz, H. D., Jul 1 2006, In : Cardiovascular Research. 71, 1, p. 129-138 10 p.

Research output: Contribution to journalArticle

Carotid Body
Angiotensin II
Heart Failure
Rabbits
Kidney