• 4581 Citations
  • 42 h-Index
1977 …2020
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Research Output 1977 2019

2019

Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure

Andrade, D. C., Toledo, C., Díaz, H. S., Lucero, C., Arce-Álvarez, A., Oliveira, L. M., Takakura, A. C., Moreira, T. S., Schultz, H. D., Marcus, N. J., Alcayaga, J. & Del Rio, R., Feb 14 2019, In : Clinical science (London, England : 1979). 133, 3, p. 393-405 13 p.

Research output: Contribution to journalArticle

Brain Stem
Heart Failure
Neurons
Mixed Function Oxygenases
Dopamine
2 Citations (Scopus)

Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle

Wafi, A. M., Hong, J., Rudebush, T. L., Yu, L., Hackfort, B., Wang, H., Schultz, H. D., Zucker, I. H. & Gao, L., Feb 1 2019, In : Journal of Applied Physiology. 126, 2, p. 477-486 10 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Curcumin
Ligation
Coronary Vessels
Skeletal Muscle
Ankyrins
Heart Failure
Reflex
Lung
Arterial Pressure
2018

Advances in cellular and integrative control of oxygen and carbon dioxide homeostasis

Schultz, H. D., Aug 1 2018, In : Journal of Physiology. 596, 15, p. 2933-2934 2 p.

Research output: Contribution to journalEditorial

Carbon Dioxide
Homeostasis
Oxygen
1 Citation (Scopus)

Chronic Heart Failure Abolishes Circadian Rhythms in Resting and Chemoreflex Breathing

Lewis, R., Hackfort, B. T. & Schultz, H. D., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 129-136 8 p. (Advances in Experimental Medicine and Biology; vol. 1071).

Research output: Chapter in Book/Report/Conference proceedingChapter

Circadian Rhythm
Respiration
Heart Failure
Light
Ligation
2 Citations (Scopus)

KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure

Marcus, N. J., Del Rio, R., Ding, Y. & Schultz, H. D., Aug 1 2018, In : Journal of Physiology. 596, 15, p. 3171-3185 15 p.

Research output: Contribution to journalArticle

Carotid Body
Respiration
Heart Failure
Cardiac Arrhythmias
Kidney
1 Citation (Scopus)

Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: Does ejection fraction matter?

Andrade, D. C., Arce-Alvarez, A., Toledo, C., Díaz, H. S., Lucero, C., Quintanilla, R. A., Schultz, H. D., Marcus, N. J., Amann, M. & Del Rio, R., Mar 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 3, p. H464-H474

Research output: Contribution to journalReview article

Heart Failure
Exercise
Baroreflex
Survival
Hypersensitivity
2 Citations (Scopus)

Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats

Shanks, J., Xia, Z., Lisco, S. J., Rozanski, G. J., Schultz, H. D., Zucker, I. H. & Wang, H., Jun 1 2018, In : Physiological Reports. 6, 12, e13742.

Research output: Contribution to journalArticle

Lung
Pleura
Reflex
Bradykinin
Capsaicin

Visualizing data in research articles

Schultz, H. D., Aug 15 2018, In : Journal of Physiology. 596, 16, p. 3431-3432 2 p.

Research output: Contribution to journalEditorial

Research
2017
8 Citations (Scopus)

Cardiac diastolic and autonomic dysfunction are aggravated by central chemoreflex activation in heart failure with preserved ejection fraction rats

Toledo, C., Andrade, D. C., Lucero, C., Arce-Alvarez, A., Díaz, H. S., Aliaga, V., Schultz, H. D., Marcus, N. J., Manríquez, M., Faúndez, M. & Del Rio, R., Apr 15 2017, In : Journal of Physiology. 595, 8, p. 2479-2495 17 p.

Research output: Contribution to journalArticle

Heart Failure
Cardiac Arrhythmias
Respiration
Incidence
Hypercapnia
3 Citations (Scopus)

Carotid Body-Mediated Chemoreflex Drive in the Setting of low and High Output Heart Failure

Del Rio, R., Andrade, D. C., Toledo, C., Diaz, H. S., Lucero, C., Arce-Alvarez, A., Marcus, N. J. & Schultz, H. D., Dec 1 2017, In : Scientific Reports. 7, 1, 8035.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Kruppel-Like Transcription Factors
Body Regions
Venae Cavae
10 Citations (Scopus)

Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure

Toledo, C., Andrade, D. C., Lucero, C., Schultz, H. D., Marcus, N., Retamal, M., Madrid, C. & Del Rio, R., Jan 1 2017, In : Journal of Physiology. 595, 1, p. 43-51 9 p.

Research output: Contribution to journalReview article

Heart Failure
Carotid Body
Ventilation
Respiration
Animal Models

Epigenetic influences on carotid body function: a new snag in the road to treating sleep apnoea

Schultz, H. D., Feb 1 2017, In : Journal of Physiology. 595, 3, p. 629-630 2 p.

Research output: Contribution to journalArticle

Carotid Body
Sleep Apnea Syndromes
Epigenomics
3 Citations (Scopus)

Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure

Andrade, D. C., Arce-Alvarez, A., Toledo, C., Díaz, H. S., Lucero, C., Schultz, H. D., Marcus, N. J. & Rio, R. D., Sep 1 2017, In : Journal of Applied Physiology. 123, 3, p. 567-577 11 p.

Research output: Contribution to journalArticle

Heart Failure
Exercise
Oxidative Stress
Brain Stem
NADPH Oxidase
18 Citations (Scopus)

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

van Bilsen, M., Patel, H. C., Bauersachs, J., Böhm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G. W., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., Ruschitzka, F. & 10 others, Sabbah, H. N., Schultz, H. D., Seferovic, P., Slart, R. H. J. A., Taggart, P., Tocchetti, C. G., Van Laake, L. W., Zannad, F., Heymans, S. & Lyon, A. R., Nov 1 2017, In : European Journal of Heart Failure. 19, 11, p. 1361-1378 18 p.

Research output: Contribution to journalArticle

Translational Medical Research
Autonomic Nervous System
Heart Failure
Therapeutics
Equipment and Supplies
2016
2 Citations (Scopus)

Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: Role of the α1-adrenergic receptor

Pugge, C., Mediratta, J., Marcus, N. J., Schultz, H. D., Schiller, A. M. & Zucker, I. H., Feb 1 2016, In : Journal of Applied Physiology. 120, 3, p. 334-343 10 p.

Research output: Contribution to journalArticle

Renal Circulation
Adrenergic Receptors
Heart Failure
Exercise
Kidney
33 Citations (Scopus)

Translational neurocardiology: preclinical models and cardioneural integrative aspects

Ardell, J. L., Andresen, M. C., Armour, J. A., Billman, G. E., Chen, P. S., Foreman, R. D., Herring, N., O'Leary, D. S., Sabbah, H. N., Schultz, H. D., Sunagawa, K. & Zucker, I. H., Jul 15 2016, In : Journal of Physiology. 594, 14, p. 3877-3909 33 p.

Research output: Contribution to journalArticle

Nervous System
Regional Blood Flow
Cardiac Output
Cerebral Cortex
Heart Diseases
2015

Comment on "Precedence and autocracy in breathing control" [2]

Del Rio, R., Andrade, D. C. & Schultz, H. D., Jun 15 2015, In : Journal of Applied Physiology. 118, 12, p. 1558-1559 2 p.

Research output: Contribution to journalArticle

Respiration
6 Citations (Scopus)

Editorial: Carotid body: A new target for rescuing neural control of cardiorespiratory balance in disease

Del Rio, R., Iturriaga, R. & Schultz, H. D., Jan 1 2015, In : Frontiers in Physiology. 6, JUN, 181.

Research output: Contribution to journalEditorial

Carotid Body
Sympathetic Nervous System
Sleep Apnea Syndromes
Insulin Resistance
Heart Failure
9 Citations (Scopus)

Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure

Marcus, N. J., Pügge, C., Mediratta, J., Schiller, A. M., del Rio, R., Zucker, I. H. & Schultz, H. D., Jul 15 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 2, p. H259-H266

Research output: Contribution to journalArticle

Renal Circulation
Heart Failure
Exercise
Carotid Body
Denervation

In adult female hamsters hypothyroidism stimulates D1 receptor-mediated breathing without altering D1 receptor expression

Schlenker, E. H., Del Rio, R. & Schultz, H. D., Nov 1 2015, In : Respiratory Physiology and Neurobiology. 218, p. 32-39 8 p.

Research output: Contribution to journalArticle

Hypothyroidism
Cricetinae
Respiration
Ventilation
Air
33 Citations (Scopus)

Mechanisms of carotid body chemoreflex dysfunction during heart failure

Schultz, H. D., Marcus, N. J. & Del Rio, R., Feb 1 2015, In : Experimental Physiology. 100, 2, p. 124-129 6 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Reflex
Disease Management
21 Citations (Scopus)
Angiotensin II
Heart Failure
Exercise
Adrenergic Agents
Carotid Body
10 Citations (Scopus)

Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure

Andrade, D. C., Lucero, C., Toledo, C., Madrid, C., Marcus, N. J., Schultz, H. D. & Del Rio, R., 2015, In : BioMed Research International. 2015, 467597.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Theoretical Models
Physiology
13 Citations (Scopus)

Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies

Schultz, H. D., Marcus, N. J. & del Rio, R., 2015, In : Advances in Experimental Medicine and Biology. 860, p. 167-185 19 p.

Research output: Contribution to journalArticle

Carotid Body
Animals
Heart Failure
Respiration
Pulmonary diseases
14 Citations (Scopus)

Selective carotid body ablation in experimental heart failure: A new therapeutic tool to improve cardiorespiratory control

Del Rio, R., Andrade, D. C., Marcus, N. J. & Schultz, H. D., Feb 1 2015, In : Experimental Physiology. 100, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Therapeutics
Baroreflex
2014
87 Citations (Scopus)

Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure

Marcus, N. J., Del Rio, R., Schultz, E. P., Xia, X. H. & Schultz, H. D., Jan 1 2014, In : Journal of Physiology. 592, 2, p. 391-408 18 p.

Research output: Contribution to journalArticle

Autonomic Denervation
Carotid Body
Respiration
Heart Failure
Cardiac Arrhythmias
14 Citations (Scopus)

Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure

Marcus, N. J., Del Rio, R. & Schultz, H. D., Jan 1 2014, In : Frontiers in Physiology. 5, Nov, 438.

Research output: Contribution to journalArticle

Carotid Body
Respiration
Heart Failure
Kidney
Respiratory System

Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression

Schlenker, E. H., Del Rio, R. & Schultz, H. D., Mar 1 2014, In : Respiratory Physiology and Neurobiology. 193, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Hypothyroidism
Cricetinae
Respiration
Bromocriptine
Ventilation
1 Citation (Scopus)

Reply from Noah J. Marcus, Rodrigo Del Rio and Harold D. Schultz

Marcus, N. J., Del Rio, R. & Schultz, H. D., Apr 15 2014, In : Journal of Physiology. 592, 8, p. 1905-1906 2 p.

Research output: Contribution to journalLetter

Carotid Body
Ventricular Function
Sympathetic Nervous System
Apnea
Respiration
22 Citations (Scopus)

Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure

Haack, K. K. V., Marcus, N. J., Del Rio, R., Zucker, I. H. & Schultz, H. D., Jan 1 2014, In : Hypertension. 63, 5, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

Carotid Body
Simvastatin
Apnea
Heart Failure
Cardiac Arrhythmias

The arterial chemoreflex and cardiac stress in heart failure: Nothing to be sheepish about

Schultz, H. D., Aug 1 2014, In : Experimental Physiology. 99, 8, p. 1029-1030 2 p.

Research output: Contribution to journalArticle

Chemoreceptor Cells
Sympathetic Nervous System
Heart Failure
2013
16 Citations (Scopus)

Angiotensin peptides and nitric oxide in cardiovascular disease

Patel, K. P. & Schultz, H. D., Oct 1 2013, In : Antioxidants and Redox Signaling. 19, 10, p. 1121-1132 12 p.

Research output: Contribution to journalReview article

Angiotensins
Renin-Angiotensin System
Nitric Oxide
Cardiovascular Diseases
Peptides
90 Citations (Scopus)

Carotid chemoreceptor ablation improves survival in heart failure: Rescuing autonomic control of cardiorespiratory function

Del Rio, R., Marcus, N. J. & Schultz, H. D., Dec 24 2013, In : Journal of the American College of Cardiology. 62, 25, p. 2422-2430 9 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Ventricular Remodeling
Baroreflex
Denervation
28 Citations (Scopus)

Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure

Del Rio, R., Marcus, N. J. & Schultz, H. D., May 1 2013, In : Journal of Applied Physiology. 114, 9, p. 1141-1150 10 p.

Research output: Contribution to journalArticle

Carotid Body
Hydrogen Sulfide
Respiration
Heart Failure
Blood Pressure
11 Citations (Scopus)
Mitochondria
Superoxides
Angiotensin II
Neurons
Superoxide Dismutase
34 Citations (Scopus)

Role of the carotid body in the pathophysiology of heart failure

Schultz, H. D., Marcus, N. J. & Del Rio, R., Aug 1 2013, In : Current Hypertension Reports. 15, 4, p. 356-362 7 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Respiration
Reflex
Animal Models
2012

Be sympathetic to your nervous system

Zucker, I. H., Patel, K. P. & Schultz, H. D., Oct 15 2012, In : Journal of Applied Physiology. 113, 8, p. 1292-1293 2 p.

Research output: Contribution to journalEditorial

Sympathetic Nervous System
Nervous System
Signal Transduction
Cardiovascular Diseases
27 Citations (Scopus)

Effect of AT 1 receptor blockade on intermittent hypoxia-induced endothelial dysfunction

Marcus, N. J., Philippi, N. R., Bird, C. E., Li, Y., Schultz, H. D. & Morgan, B. J., Aug 15 2012, In : Respiratory Physiology and Neurobiology. 183, 2, p. 67-74 8 p.

Research output: Contribution to journalArticle

Losartan
Nitroprusside
Superoxides
Angiotensin II
Acetylcholine
14 Citations (Scopus)

Heart failure and carotid body chemoreception

Schultz, H. D. & Marcus, N. J., Dec 7 2012, Arterial Chemoreception: From Molecules to Systems. Nurse, C. A., Peers, C., Gonzalez, C. & Prabhakar, N. R. (eds.). p. 387-395 9 p. (Advances in Experimental Medicine and Biology; vol. 758).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carotid Body
Heart Failure
Hot Temperature
Respiration
Pulmonary diseases
5 Citations (Scopus)
Carotid Body
Hypothyroidism
Cricetinae
Respiration
Brain
68 Citations (Scopus)

Neurohumoral Stimulation

Zucker, I. H., Patel, K. P. & Schultz, H. D., Jan 1 2012, In : Heart Failure Clinics. 8, 1, p. 87-99 13 p.

Research output: Contribution to journalReview article

Heart Failure
Reflex
Disease Progression
14 Citations (Scopus)

Role of neurotransmitter gases in the control of the carotid body in heart failure

Schultz, H. D., Del Rio, R., Ding, Y. & Marcus, N. J., Nov 15 2012, In : Respiratory Physiology and Neurobiology. 184, 2, p. 197-203 7 p.

Research output: Contribution to journalReview article

Carotid Body
Neurotransmitter Agents
Heart Failure
Gases
Respiration
2 Citations (Scopus)

The paradox of carbon monoxide and the heart

Schultz, H. D., Oct 1 2012, In : American Journal of Respiratory and Critical Care Medicine. 186, 7, p. 582-583 2 p.

Research output: Contribution to journalEditorial

Voltage-Gated Sodium Channels
Carbon Monoxide Poisoning
Carbon Monoxide
Cardiac Myocytes
Cardiac Arrhythmias
2011
40 Citations (Scopus)
Potassium
Nitric Oxide
Nitric Oxide Synthase
7-Ala-angiotensin (1-7)
Neurons
24 Citations (Scopus)

Angiotensin and carotid body chemoreception in heart failure

Schultz, H. D., Jan 1 2011, In : Current Opinion in Pharmacology. 11, 2, p. 144-149 6 p.

Research output: Contribution to journalReview article

Carotid Body
Angiotensins
Heart Failure
Hot Temperature
Angiotensin I
11 Citations (Scopus)
Carotid Body
Hypothyroidism
Cricetinae
Respiration
Hypercapnia
68 Citations (Scopus)

Role of blood flow in carotid body chemoreflex function in heart failure

Ding, Y., Li, Y. & Schultz, H. D., Jan 1 2011, In : Journal of Physiology. 589, 1, p. 245-258 14 p.

Research output: Contribution to journalArticle

Carotid Body
Heart Failure
Carotid Arteries
Rabbits
Sympathetic Nervous System
2010
84 Citations (Scopus)

Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: Role of the angiotensin II type 1 receptor

Marcus, N. J., Li, Y., Bird, C. E., Schultz, H. D. & Morgan, B. J., Apr 15 2010, In : Respiratory Physiology and Neurobiology. 171, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Carotid Body
Nitric Oxide Synthase Type I
Losartan
NADPH Oxidase
40 Citations (Scopus)
Angiotensin II
Down-Regulation
Heart Failure
Voltage-Gated Potassium Channels
4-Aminopyridine