Haizhen Andrew Zhong, PhD

Associate Professor

  • 793 Citations
  • 16 h-Index
20042019
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Research Output 2004 2019

  • 793 Citations
  • 16 h-Index
  • 36 Article
  • 4 Review article
  • 2 Chapter
  • 2 Editorial
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Article
2019
2 Citations (Scopus)

Conformational studies of glucose transporter 1 (GLUT1) as an anticancer drug target

Almahmoud, S., Wang, X., Vennerstrom, J. L. & Zhong, H. A., Jun 7 2019, In : Molecules. 24, 11, 2159.

Research output: Contribution to journalArticle

Open Access
transporter
Facilitative Glucose Transport Proteins
glucose
drugs
Conformations
1 Citation (Scopus)

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Daszynski, D. M., Santhoshkumar, P., Phadte, A. S., Sharma, K. K., Zhong, H. A., Lou, M. F. & Kador, P. F., Dec 1 2019, In : Scientific reports. 9, 1, 8459.

Research output: Contribution to journalArticle

Open Access
Lanosterol
Crystallins
Cataract
Lenses
Adenosine Triphosphate

Ligand-based drug design: Synthesis and biological evaluation of substituted benzoin derivatives as potential antitumor agents

Sabbah, D. A., Ibrahim, A. H., Talib, W. H., Alqaisi, K. M., Sweidan, K., Bardaweel, S. K., Sheikha, G. A., Zhong, H. A., Al-Shalabi, E., Khalaf, R. A. & Mubarak, M. S., Jan 1 2019, In : Medicinal Chemistry. 15, 4, p. 417-429 13 p.

Research output: Contribution to journalArticle

Benzoin
1-Phosphatidylinositol 4-Kinase
Drug Design
Antineoplastic Agents
Adenocarcinoma

Molecular modeling studies on the binding mode of the PD-1/PD-L1 complex inhibitors

Almahmoud, S. & Zhong, H. A., Sep 2 2019, In : International journal of molecular sciences. 20, 18, 4654.

Research output: Contribution to journalArticle

Open Access
CD274 Antigen
Molecular modeling
Programmed Cell Death 1 Receptor
apoptosis
Cell death
2018
3 Citations (Scopus)

Benzoin schiff bases: Design, synthesis, and biological evaluation as potential antitumor agents

Sabbah, D. A., Al-Tarawneh, F., Talib, W. H., Sweidan, K., Bardaweel, S. K., Al-Shalabi, E., Zhong, H. A., Sheikha, G. A., Khalaf, R. A. & Mubarak, M. S., Jan 1 2018, In : Medicinal Chemistry. 14, 7, p. 695-708 14 p.

Research output: Contribution to journalArticle

Benzoin
1-Phosphatidylinositol 4-Kinase
Schiff Bases
Antineoplastic Agents
Adenocarcinoma
1 Citation (Scopus)

Free-Energy-Based Protein Design: Re-Engineering Cellular Retinoic Acid Binding Protein II Assisted by the Moveable-Type Approach

Zhong, H. A., Santos, E. M., Vasileiou, C., Zheng, Z., Geiger, J. H., Borhan, B. & Merz, K. M., Mar 14 2018, In : Journal of the American Chemical Society. 140, 10, p. 3483-3486 4 p.

Research output: Contribution to journalArticle

Tretinoin
Free energy
Proteins
Protein Engineering
Acids
6 Citations (Scopus)

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

Sabbah, D. A., Hishmah, B., Sweidan, K., Bardaweel, S., AlDamen, M., Zhong, H. A., Khalaf, R. A., Hasan Ibrahim, A., Al-Qirim, T., Abu Sheikha, G. & Mubarak, M. S., Jan 1 2018, In : Anti-Cancer Agents in Medicinal Chemistry. 18, 2, p. 263-276 14 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
X Ray Crystallography
Cytotoxins
Caspase 3
HCT116 Cells
2 Citations (Scopus)

The simple system of fixing CO 2 to synthesize benzimidazolones at atmospheric pressure

Cao, X., Zhong, H. A., Zhang, P. & Zheng, H., Mar 2018, In : Journal of CO2 Utilization. 24, p. 250-255 6 p.

Research output: Contribution to journalArticle

Carbon Monoxide
atmospheric pressure
Atmospheric pressure
quantum mechanics
Carbonylation
2017
12 Citations (Scopus)

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Kumar, V., Chaudhary, A. K., Dong, Y., Zhong, H. A., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., Dec 1 2017, In : Scientific reports. 7, 1, 1665.

Research output: Contribution to journalArticle

HhAntag691
Hedgehogs
Pancreatic Neoplasms
Neoplastic Stem Cells
Neoplasms
11 Citations (Scopus)

Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents

Conda Sheridan, M., Udumula, V., Endres, J. L., Harper, C. N., Jaramillo, L., Zhong, H. A. & Bayles, K. W., Jan 1 2017, In : European Journal of Medicinal Chemistry. 125, p. 710-721 12 p.

Research output: Contribution to journalArticle

Phenazines
Methicillin
Methicillin-Resistant Staphylococcus aureus
Biological Products
Health
2016
14 Citations (Scopus)

Drug design targeting the CXCR4/CXCR7/CXCL12 pathway

Xu, D., Li, R., Wu, J., Jiang, L. & Zhong, H. A., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1441-1451 11 p.

Research output: Contribution to journalArticle

Drug Design
Drug Delivery Systems
Vascular Tissue Neoplasms
Neoplasms
Tumor Microenvironment
9 Citations (Scopus)

Methionine aminopeptidase type-2 inhibitors targeting angiogenesis

Ehlers, T., Furness, S., Robinson, T. P., Zhong, H. A., Goldsmith, D., Aribser, J. & Bowen, J. P., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1478-1488 11 p.

Research output: Contribution to journalArticle

Angiogenesis Inhibitors
Drug Design
Biological Products
Penicillins
Methionine
15 Citations (Scopus)
Amyloid Precursor Protein Secretases
Protonation
Molecular dynamics
molecular dynamics
inhibitors

Perspectives in medicinal chemistry: The evolution of medicinal chemistry

Phillip Bowen, J. & Zhong, H. A., Jan 1 2016, In : Current Topics in Medicinal Chemistry. 16, 9, p. 897-898 2 p.

Research output: Contribution to journalArticle

Pharmaceutical Chemistry
Drug Industry
Drug Discovery
Pharmaceutical Preparations
2014
9 Citations (Scopus)

Molecular phylogeny and evolutionary dynamics of influenza A nonstructural (NS) gene

Xu, J., Zhong, H. A., Madrahimov, A., Helikar, T. & Lu, G., Mar 1 2014, In : Infection, Genetics and Evolution. 22, p. 192-200 9 p.

Research output: Contribution to journalArticle

influenza
Phylogeny
Human Influenza
phylogeny
Swine
2013
7 Citations (Scopus)

Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors

Zhong, H. A., Arbiser, J. & Bowen, J. P., Aug 15 2013, In : Current Pharmaceutical Design. 19, 26, p. 4701-4713 13 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Zinc
Catalytic Domain
Ions
7 Citations (Scopus)

Synthesis and self-assembly of triphenylene-containing conjugated macrocycles

Dutta, T., Che, Y., Zhong, H. A., Laity, J. H., Dusevich, V., Murowchick, J. B., Zang, L. & Peng, Z., May 7 2013, In : RSC Advances. 3, 17, p. 6008-6015 8 p.

Research output: Contribution to journalArticle

Self assembly
Macrocyclic Compounds
Imines
Conformations
Optical properties
12 Citations (Scopus)

Understanding the molecular properties and metabolism of top prescribed drugs

Zhong, H. A., Mashinson, V., Woolman, T. A. & Zha, M., Aug 15 2013, In : Current Topics in Medicinal Chemistry. 13, 11, p. 1290-1307 18 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Molecular Weight
Anti-HIV Agents
Solubility
Anti-Bacterial Agents
2012
22 Citations (Scopus)

Binding selectivity studies of phosphoinositide 3-kinases using free energy calculations

Sabbah, D. A., Vennerstrom, J. L. & Zhong, H. A., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3213-3224 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
mechanic
Free energy
Phosphotransferases
Ligands
18 Citations (Scopus)

Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases

Sabbah, D. A., Simms, N. A., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Jan 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 2, p. 876-880 5 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphatidylinositol 3-Kinases
Phosphotransferases
Enzyme Inhibitors
3 Citations (Scopus)
Site selection
Vaccines
Influenza Vaccines
Hemagglutinins
Viruses
24 Citations (Scopus)

Evolutionary history and phylodynamics of influenza A and B neuraminidase (NA) genes inferred from large-scale sequence analyses

Xu, J., Davis, C. T., Christman, M. C., Rivailler, P., Zhong, H. A., Donis, R. O. & Lu, G., Jul 11 2012, In : PloS one. 7, 7, e38665.

Research output: Contribution to journalArticle

sialidase
Neuraminidase
influenza
Human Influenza
Sequence Analysis
24 Citations (Scopus)

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

Sabbah, D. A., Simms, N. A., Wang, W., Dong, Y., Ezell, E. L., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Dec 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 24, p. 7175-7183 9 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
Cell growth
Apoptosis
21 Citations (Scopus)

Synthesis and optical properties of perylene diimide derivatives with triphenylene-based dendrons linked at the bay positions through a conjugated ethynyl linkage

Bagui, M., Dutta, T., Zhong, H. A., Li, S., Chakraborty, S., Keightley, A. & Peng, Z., Apr 1 2012, In : Tetrahedron. 68, 13, p. 2806-2818 13 p.

Research output: Contribution to journalArticle

Perylene
Dendrimers
Optical properties
Derivatives
Absorption spectra
2011
39 Citations (Scopus)

Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: Which way shall we go?

Sabbah, D. A., Brattain, M. G. & Zhong, H. A., Dec 1 2011, In : Current medicinal chemistry. 18, 36, p. 5528-5544 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Pharmacologic Actions
Oncology
Chemotherapy
Drug Design
27 Citations (Scopus)

Synthesis and optical properties of triphenylene-based dendritic donor perylene diimide acceptor systems

Bagui, M., Dutta, T., Chakraborty, S., Melinger, J. S., Zhong, H. A., Keightley, A. & Peng, Z., Mar 10 2011, In : Journal of Physical Chemistry A. 115, 9, p. 1579-1592 14 p.

Research output: Contribution to journalArticle

Perylene
Optical properties
optical properties
charge transfer
synthesis
7 Citations (Scopus)

The impact of ionization states of matrix metalloproteinase inhibitors on docking-based inhibitor design

Zhong, H. A., Wees, M. A., Faure, T. D., Carrillo, C., Arbiser, J. & Bowen, J. P., Jun 9 2011, In : ACS Medicinal Chemistry Letters. 2, 6, p. 455-460 6 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase Inhibitors
Ionization
Zinc
Ions
Matrix Metalloproteinases
2010
41 Citations (Scopus)

Docking studies on isoform-specific inhibition of phosphoinositide-3- kinases

Sabbah, D. A., Vennerstrom, J. L. & Zhong, H. A., Oct 25 2010, In : Journal of Chemical Information and Modeling. 50, 10, p. 1887-1898 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Phosphatidylinositols
Protein Isoforms
Phosphotransferases
Ligands
2009
48 Citations (Scopus)

Induced-fit docking studies of the active and inactive states of protein tyrosine kinases

Zhong, H. A., Tran, L. M. & Stang, J. L., Nov 1 2009, In : Journal of Molecular Graphics and Modelling. 28, 4, p. 336-346 11 p.

Research output: Contribution to journalArticle

tyrosine
Protein-Tyrosine Kinases
Ligands
inhibitors
proteins
2008
7 Citations (Scopus)

Binding free energy calculation for duocarmycin/DNA complex based on the QPLD-derived partial charge model

Zhong, H., Kirschner, K. N., Lee, M. & Bowen, J. P., Jan 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 2, p. 542-545 4 p.

Research output: Contribution to journalArticle

Free energy
Ligands
DNA
Trajectories
2007
111 Citations (Scopus)

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models

Bowman, A. L., Nikolovska-Coleska, Z., Zhong, H., Wang, S. & Carlson, H. A., Oct 24 2007, In : Journal of the American Chemical Society. 129, 42, p. 12809-12814 6 p.

Research output: Contribution to journalArticle

Proteins
Molecules
Scaffolds
Drug Discovery
Hydrogen Bonding
2006
25 Citations (Scopus)

Conformational studies of polyprolines

Zhong, H. & Carlson, H. A., Dec 1 2006, In : Journal of Chemical Theory and Computation. 2, 2, p. 342-353 12 p.

Research output: Contribution to journalArticle

oligomers
Oligomers
helices
Conformations
Proline
2005
18 Citations (Scopus)

Ab initio and DFT conformational studies of propanal, 2-butanone, and analogous imines and enamines

Zhong, H., Stewart, E. L., Kontoyianni, M. & Bowen, J. P., Dec 1 2005, In : Journal of Chemical Theory and Computation. 1, 2, p. 230-238 9 p.

Research output: Contribution to journalArticle

Imines
Discrete Fourier transforms
imines
Potential energy surfaces
Aldehydes
78 Citations (Scopus)

Computational studies and peptidomimetic design for the human p53-MDM2 complex

Zhong, H. & Carlson, H. A., Jan 1 2005, In : Proteins: Structure, Function and Genetics. 58, 1, p. 222-234 13 p.

Research output: Contribution to journalArticle

Peptidomimetics
Alanine
Free energy
Molecular Dynamics Simulation
Cell growth
3 Citations (Scopus)

Theoretical study of stereoselective reduction controlled by NADH analogs

Zhong, H. & Bowen, J. P., Sep 1 2005, In : Journal of Molecular Graphics and Modelling. 24, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

NAD
Conformations
analogs
Potential energy surfaces
enzymes
2004
3 Citations (Scopus)

Structure and dynamics of a predicted ferredoxin-like selenoprotein in Japanese encephalitis virus

Zhong, H. & Taylor, E. W., Dec 1 2004, In : Journal of Molecular Graphics and Modelling. 23, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

encephalitis
Selenoproteins
Ferredoxins
viruses
Viruses