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Haizhen Andrew Zhong, PhD

Associate Professor

  • 801 Citations
  • 16 h-Index
20042019
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Research Output 2004 2019

  • 801 Citations
  • 16 h-Index
  • 36 Article
  • 4 Review article
  • 2 Chapter
  • 2 Editorial
2019
2 Citations (Scopus)

Conformational studies of glucose transporter 1 (GLUT1) as an anticancer drug target

Almahmoud, S., Wang, X., Vennerstrom, J. L. & Zhong, H. A., Jun 7 2019, In : Molecules. 24, 11, 2159.

Research output: Contribution to journal › Article

Open Access
transporter
Facilitative Glucose Transport Proteins
glucose
drugs
Conformations
2 Citations (Scopus)

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Daszynski, D. M., Santhoshkumar, P., Phadte, A. S., Sharma, K. K., Zhong, H. A., Lou, M. F. & Kador, P. F., Dec 1 2019, In : Scientific reports. 9, 1, 8459.

Research output: Contribution to journal › Article

Open Access
Lanosterol
Crystallins
Cataract
Lenses
Adenosine Triphosphate

Ligand-based drug design: Synthesis and biological evaluation of substituted benzoin derivatives as potential antitumor agents

Sabbah, D. A., Ibrahim, A. H., Talib, W. H., Alqaisi, K. M., Sweidan, K., Bardaweel, S. K., Sheikha, G. A., Zhong, H. A., Al-Shalabi, E., Khalaf, R. A. & Mubarak, M. S., Jan 1 2019, In : Medicinal Chemistry. 15, 4, p. 417-429 13 p.

Research output: Contribution to journal › Article

Benzoin
1-Phosphatidylinositol 4-Kinase
Drug Design
Antineoplastic Agents
Adenocarcinoma

Molecular modeling studies on the binding mode of the PD-1/PD-L1 complex inhibitors

Almahmoud, S. & Zhong, H. A., Sep 2 2019, In : International journal of molecular sciences. 20, 18, 4654.

Research output: Contribution to journal › Article

Open Access
CD274 Antigen
Molecular modeling
Programmed Cell Death 1 Receptor
apoptosis
Cell death
2018
3 Citations (Scopus)

Benzoin schiff bases: Design, synthesis, and biological evaluation as potential antitumor agents

Sabbah, D. A., Al-Tarawneh, F., Talib, W. H., Sweidan, K., Bardaweel, S. K., Al-Shalabi, E., Zhong, H. A., Sheikha, G. A., Khalaf, R. A. & Mubarak, M. S., Jan 1 2018, In : Medicinal Chemistry. 14, 7, p. 695-708 14 p.

Research output: Contribution to journal › Article

Benzoin
1-Phosphatidylinositol 4-Kinase
Schiff Bases
Antineoplastic Agents
Adenocarcinoma
1 Citation (Scopus)

Free-Energy-Based Protein Design: Re-Engineering Cellular Retinoic Acid Binding Protein II Assisted by the Moveable-Type Approach

Zhong, H. A., Santos, E. M., Vasileiou, C., Zheng, Z., Geiger, J. H., Borhan, B. & Merz, K. M., Mar 14 2018, In : Journal of the American Chemical Society. 140, 10, p. 3483-3486 4 p.

Research output: Contribution to journal › Article

Tretinoin
Free energy
Proteins
Protein Engineering
Acids
6 Citations (Scopus)

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

Sabbah, D. A., Hishmah, B., Sweidan, K., Bardaweel, S., AlDamen, M., Zhong, H. A., Khalaf, R. A., Hasan Ibrahim, A., Al-Qirim, T., Abu Sheikha, G. & Mubarak, M. S., Jan 1 2018, In : Anti-Cancer Agents in Medicinal Chemistry. 18, 2, p. 263-276 14 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase
X Ray Crystallography
Cytotoxins
Caspase 3
HCT116 Cells
2 Citations (Scopus)

The simple system of fixing CO 2 to synthesize benzimidazolones at atmospheric pressure

Cao, X., Zhong, H. A., Zhang, P. & Zheng, H., Mar 2018, In : Journal of CO2 Utilization. 24, p. 250-255 6 p.

Research output: Contribution to journal › Article

Carbon Monoxide
atmospheric pressure
Atmospheric pressure
quantum mechanics
Carbonylation
2017

ADMET properties: Overview and current topics

Zhong, H. A., Aug 9 2017, Drug Design: Principles and Applications. Springer Singapore, p. 113-133 21 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

12 Citations (Scopus)

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Kumar, V., Chaudhary, A. K., Dong, Y., Zhong, H. A., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., Dec 1 2017, In : Scientific reports. 7, 1, 1665.

Research output: Contribution to journal › Article

HhAntag691
Hedgehogs
Pancreatic Neoplasms
Neoplastic Stem Cells
Neoplasms
12 Citations (Scopus)

Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents

Conda Sheridan, M., Udumula, V., Endres, J. L., Harper, C. N., Jaramillo, L., Zhong, H. A. & Bayles, K. W., Jan 1 2017, In : European Journal of Medicinal Chemistry. 125, p. 710-721 12 p.

Research output: Contribution to journal › Article

Phenazines
Methicillin
Methicillin-Resistant Staphylococcus aureus
Biological Products
Health
2016

Advances in drug discovery for the treatment of cancer: Many approaches, one goal

Bowen, J. P. & Zhong, H. A., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1411-1412 2 p.

Research output: Contribution to journal › Editorial

Drug Discovery
Antineoplastic Agents
Neoplasms
15 Citations (Scopus)

Advances in the development of class I phosphoinositide 3-kinase (PI3K) inhibitors

Sabbah, D. A., Hu, J. & Zhong, H. A., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1413-1426 14 p.

Research output: Contribution to journal › Review article

1-Phosphatidylinositol 4-Kinase
Drug Design
Structure-Activity Relationship
Rheumatoid Arthritis
Cell Survival
14 Citations (Scopus)

Drug design targeting the CXCR4/CXCR7/CXCL12 pathway

Xu, D., Li, R., Wu, J., Jiang, L. & Zhong, H. A., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1441-1451 11 p.

Research output: Contribution to journal › Article

Drug Design
Drug Delivery Systems
Vascular Tissue Neoplasms
Neoplasms
Tumor Microenvironment
10 Citations (Scopus)

Methionine aminopeptidase type-2 inhibitors targeting angiogenesis

Ehlers, T., Furness, S., Robinson, T. P., Zhong, H. A., Goldsmith, D., Aribser, J. & Bowen, J. P., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1478-1488 11 p.

Research output: Contribution to journal › Article

Angiogenesis Inhibitors
Drug Design
Biological Products
Penicillins
Methionine
15 Citations (Scopus)

Modeling the protonation states of β-secretase binding pocket by molecular dynamics simulations and docking studies

Sabbah, D. A. & Zhong, H. A., Jul 1 2016, In : Journal of Molecular Graphics and Modelling. 68, p. 206-215 10 p.

Research output: Contribution to journal › Article

Amyloid Precursor Protein Secretases
Protonation
Molecular dynamics
molecular dynamics
inhibitors

Perspectives in medicinal chemistry: The evolution of medicinal chemistry

Phillip Bowen, J. & Zhong, H. A., Jan 1 2016, In : Current Topics in Medicinal Chemistry. 16, 9, p. 897-898 2 p.

Research output: Contribution to journal › Article

Pharmaceutical Chemistry
Drug Industry
Drug Discovery
Pharmaceutical Preparations

Rational drug discovery, design, and development

Zhong, H. A., Güner, O. F. & Phillip, B. J., Sep 15 2016, Drug Delivery: Fundamentals and Applications: Second Edition. CRC Press, p. 443-464 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Drug Design
Drug Discovery
2014
9 Citations (Scopus)

Molecular phylogeny and evolutionary dynamics of influenza A nonstructural (NS) gene

Xu, J., Zhong, H. A., Madrahimov, A., Helikar, T. & Lu, G., Mar 1 2014, In : Infection, Genetics and Evolution. 22, p. 192-200 9 p.

Research output: Contribution to journal › Article

influenza
Phylogeny
Human Influenza
phylogeny
Swine
2013
1 Citation (Scopus)

ADME and toxicity in early drug discovery

Zhong, H. A., Aug 15 2013, In : Current Topics in Medicinal Chemistry. 13, 11, p. 1255-1256 2 p.

Research output: Contribution to journal › Editorial

Investigational Drugs
Preclinical Drug Evaluations
Drug Discovery
Treatment Failure
Biological Availability
7 Citations (Scopus)

Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors

Zhong, H. A., Arbiser, J. & Bowen, J. P., Aug 15 2013, In : Current Pharmaceutical Design. 19, 26, p. 4701-4713 13 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Zinc
Catalytic Domain
Ions
7 Citations (Scopus)

Synthesis and self-assembly of triphenylene-containing conjugated macrocycles

Dutta, T., Che, Y., Zhong, H. A., Laity, J. H., Dusevich, V., Murowchick, J. B., Zang, L. & Peng, Z., May 7 2013, In : RSC Advances. 3, 17, p. 6008-6015 8 p.

Research output: Contribution to journal › Article

Self assembly
Macrocyclic Compounds
Imines
Conformations
Optical properties
12 Citations (Scopus)

Understanding the molecular properties and metabolism of top prescribed drugs

Zhong, H. A., Mashinson, V., Woolman, T. A. & Zha, M., Aug 15 2013, In : Current Topics in Medicinal Chemistry. 13, 11, p. 1290-1307 18 p.

Research output: Contribution to journal › Article

Pharmaceutical Preparations
Molecular Weight
Anti-HIV Agents
Solubility
Anti-Bacterial Agents
2012
22 Citations (Scopus)

Binding selectivity studies of phosphoinositide 3-kinases using free energy calculations

Sabbah, D. A., Vennerstrom, J. L. & Zhong, H. A., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3213-3224 12 p.

Research output: Contribution to journal › Article

Phosphatidylinositols
mechanic
Free energy
Phosphotransferases
Ligands
18 Citations (Scopus)

Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases

Sabbah, D. A., Simms, N. A., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Jan 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 2, p. 876-880 5 p.

Research output: Contribution to journal › Article

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphatidylinositol 3-Kinases
Phosphotransferases
Enzyme Inhibitors
3 Citations (Scopus)

Computational analysis of adaptive antigenic mutations of the human influenza hemagglutinin for vaccine strain selection

Rickert, J. D., Herpy, T. A., Zhong, H. A. & Lu, G., Mar 1 2012, In : International Journal of Bioinformatics Research and Applications. 8, 1-2, p. 81-98 18 p.

Research output: Contribution to journal › Article

Site selection
Vaccines
Influenza Vaccines
Hemagglutinins
Viruses
24 Citations (Scopus)

Evolutionary history and phylodynamics of influenza A and B neuraminidase (NA) genes inferred from large-scale sequence analyses

Xu, J., Davis, C. T., Christman, M. C., Rivailler, P., Zhong, H. A., Donis, R. O. & Lu, G., Jul 11 2012, In : PloS one. 7, 7, e38665.

Research output: Contribution to journal › Article

sialidase
Neuraminidase
influenza
Human Influenza
Sequence Analysis
24 Citations (Scopus)

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

Sabbah, D. A., Simms, N. A., Wang, W., Dong, Y., Ezell, E. L., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Dec 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 24, p. 7175-7183 9 p.

Research output: Contribution to journal › Article

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
Cell growth
Apoptosis
23 Citations (Scopus)

Synthesis and optical properties of perylene diimide derivatives with triphenylene-based dendrons linked at the bay positions through a conjugated ethynyl linkage

Bagui, M., Dutta, T., Zhong, H. A., Li, S., Chakraborty, S., Keightley, A. & Peng, Z., Apr 1 2012, In : Tetrahedron. 68, 13, p. 2806-2818 13 p.

Research output: Contribution to journal › Article

Perylene
Dendrimers
Optical properties
Derivatives
Absorption spectra
2011
40 Citations (Scopus)

Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: Which way shall we go?

Sabbah, D. A., Brattain, M. G. & Zhong, H. A., Dec 1 2011, In : Current medicinal chemistry. 18, 36, p. 5528-5544 17 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase
Pharmacologic Actions
Oncology
Chemotherapy
Drug Design
37 Citations (Scopus)

Recent advances in small molecule inhibitors of VEGFR and EGFR signaling pathways

Zhong, H. A. & Phillip Bowen, J., Jun 1 2011, In : Current Topics in Medicinal Chemistry. 11, 12, p. 1571-1590 20 p.

Research output: Contribution to journal › Review article

Protein-Tyrosine Kinases
Clinical Trials, Phase I
Renal Cell Carcinoma
Drug Resistance
Non-Small Cell Lung Carcinoma
27 Citations (Scopus)

Synthesis and optical properties of triphenylene-based dendritic donor perylene diimide acceptor systems

Bagui, M., Dutta, T., Chakraborty, S., Melinger, J. S., Zhong, H. A., Keightley, A. & Peng, Z., Mar 10 2011, In : Journal of Physical Chemistry A. 115, 9, p. 1579-1592 14 p.

Research output: Contribution to journal › Article

Perylene
Optical properties
optical properties
charge transfer
synthesis
7 Citations (Scopus)

The impact of ionization states of matrix metalloproteinase inhibitors on docking-based inhibitor design

Zhong, H. A., Wees, M. A., Faure, T. D., Carrillo, C., Arbiser, J. & Bowen, J. P., Jun 9 2011, In : ACS Medicinal Chemistry Letters. 2, 6, p. 455-460 6 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinase Inhibitors
Ionization
Zinc
Ions
Matrix Metalloproteinases
2010
41 Citations (Scopus)

Docking studies on isoform-specific inhibition of phosphoinositide-3- kinases

Sabbah, D. A., Vennerstrom, J. L. & Zhong, H. A., Oct 25 2010, In : Journal of Chemical Information and Modeling. 50, 10, p. 1887-1898 12 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase
Phosphatidylinositols
Protein Isoforms
Phosphotransferases
Ligands
2009
48 Citations (Scopus)

Induced-fit docking studies of the active and inactive states of protein tyrosine kinases

Zhong, H. A., Tran, L. M. & Stang, J. L., Nov 1 2009, In : Journal of Molecular Graphics and Modelling. 28, 4, p. 336-346 11 p.

Research output: Contribution to journal › Article

tyrosine
Protein-Tyrosine Kinases
Ligands
inhibitors
proteins
2008
7 Citations (Scopus)

Binding free energy calculation for duocarmycin/DNA complex based on the QPLD-derived partial charge model

Zhong, H., Kirschner, K. N., Lee, M. & Bowen, J. P., Jan 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 2, p. 542-545 4 p.

Research output: Contribution to journal › Article

Free energy
Ligands
DNA
Trajectories
2007
53 Citations (Scopus)

Molecular design and clinical development of VEGFR kinase inhibitors

Zhong, H. & Bowen, J. P., Jul 1 2007, In : Current Topics in Medicinal Chemistry. 7, 14, p. 1379-1393 15 p.

Research output: Contribution to journal › Review article

Epidermal Growth Factor Receptor
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Phosphotransferases
Receptor Protein-Tyrosine Kinases
111 Citations (Scopus)

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models

Bowman, A. L., Nikolovska-Coleska, Z., Zhong, H., Wang, S. & Carlson, H. A., Oct 24 2007, In : Journal of the American Chemical Society. 129, 42, p. 12809-12814 6 p.

Research output: Contribution to journal › Article

Proteins
Molecules
Scaffolds
Drug Discovery
Hydrogen Bonding
2006
58 Citations (Scopus)

Antiangiogenesis drug design: Multiple pathways targeting tumor vasculature

Zhong, H. & Bowen, J. P., Apr 1 2006, In : Current medicinal chemistry. 13, 8, p. 849-862 14 p.

Research output: Contribution to journal › Review article

Drug Design
Angiogenesis Inhibitors
Blood vessels
Tumors
Blood Vessels
25 Citations (Scopus)

Conformational studies of polyprolines

Zhong, H. & Carlson, H. A., Dec 1 2006, In : Journal of Chemical Theory and Computation. 2, 2, p. 342-353 12 p.

Research output: Contribution to journal › Article

oligomers
Oligomers
helices
Conformations
Proline
2005
18 Citations (Scopus)

Ab initio and DFT conformational studies of propanal, 2-butanone, and analogous imines and enamines

Zhong, H., Stewart, E. L., Kontoyianni, M. & Bowen, J. P., Dec 1 2005, In : Journal of Chemical Theory and Computation. 1, 2, p. 230-238 9 p.

Research output: Contribution to journal › Article

Imines
Discrete Fourier transforms
imines
Potential energy surfaces
Aldehydes
79 Citations (Scopus)

Computational studies and peptidomimetic design for the human p53-MDM2 complex

Zhong, H. & Carlson, H. A., Jan 1 2005, In : Proteins: Structure, Function and Genetics. 58, 1, p. 222-234 13 p.

Research output: Contribution to journal › Article

Peptidomimetics
Alanine
Free energy
Molecular Dynamics Simulation
Cell growth
3 Citations (Scopus)

Theoretical study of stereoselective reduction controlled by NADH analogs

Zhong, H. & Bowen, J. P., Sep 1 2005, In : Journal of Molecular Graphics and Modelling. 24, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article

NAD
Conformations
analogs
Potential energy surfaces
enzymes
2004
3 Citations (Scopus)

Structure and dynamics of a predicted ferredoxin-like selenoprotein in Japanese encephalitis virus

Zhong, H. & Taylor, E. W., Dec 1 2004, In : Journal of Molecular Graphics and Modelling. 23, 3, p. 223-231 9 p.

Research output: Contribution to journal › Article

encephalitis
Selenoproteins
Ferredoxins
viruses
Viruses