Gregory G Oakley, PhD

Associate Professor

  • 1660 Citations
  • 22 h-Index
19962019
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Research Output 1996 2019

  • 1660 Citations
  • 22 h-Index
  • 35 Article
  • 3 Review article
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Article
2019
1 Citation (Scopus)

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

Simhadri, S., Vincelli, G., Huo, Y., Misenko, S., Foo, T. K., Ahlskog, J., Sørensen, C. S., Oakley, G. G., Ganesan, S., Bunting, S. F. & Xia, B., Mar 7 2019, In : Oncogene. 38, 10, p. 1585-1596 12 p.

Research output: Contribution to journalArticle

Maintenance
Homologous Recombination
DNA Damage
M Phase Cell Cycle Checkpoints
Tumor Suppressor Proteins
2018
3 Citations (Scopus)

Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress

Wang, F., Zhu, S., Fisher, L. A., Wang, W., Oakley, G. G., Li, C. & Peng, A., Dec 1 2018, In : Scientific reports. 8, 1, 2683.

Research output: Contribution to journalArticle

Replication Protein A
Protein Phosphatase 2
Cell Division
DNA Replication
Phosphorylation
2017
5 Citations (Scopus)

S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas

Rector, J., Kapil, S., Treude, K. J., Kumm, P., Glanzer, J. G., Byrne, B. M., Liu, S., Smith, L. M., DiMaio, D. J., Giannini, P. J., Smith, R. B. & Oakley, G. G., Jan 1 2017, In : Oncotarget. 8, 6, p. 9243-9250 8 p.

Research output: Contribution to journalArticle

Replication Protein A
Squamous Cell Carcinoma
Phosphorylation
DNA Damage
Neoplasms
2016
7 Citations (Scopus)

Identification of inhibitors for single-stranded DNA-binding proteins in eubacteria

Glanzer, J. G., Endres, J. L., Byrne, B. M., Liu, S., Bayles, K. W. & Oakley, G. G., Jan 1 2016, In : Journal of Antimicrobial Chemotherapy. 71, 12, p. 3432-3440 9 p.

Research output: Contribution to journalArticle

Open Access
DNA-Binding Proteins
Francisella tularensis
Bacillus anthracis
Gram-Positive Bacteria
Bacteria
6 Citations (Scopus)

In silico and in vitro methods to identify ebola virus VP35-dsRNA inhibitors

Glanzer, J. G., Byrne, B. M., McCoy, A. M., James, B. J., Frank, J. D. & Oakley, G. G., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5388-5392 5 p.

Research output: Contribution to journalArticle

Viruses
Computer Simulation
Inhibitory Concentration 50
Antiviral Agents
Ebolavirus
2015
17 Citations (Scopus)

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

Kijas, A. W., Lim, Y. C., Bolderson, E., Cerosaletti, K., Gatei, M., Jakob, B., Tobias, F., Taucher-Scholz, G., Gueven, N., Oakley, G. G., Concannon, P., Wolvetang, E., Khanna, K. K., Wiesmüller, L. & Lavin, M. F., Sep 30 2015, In : Nucleic acids research. 43, 17, p. 8352-8367 16 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Phosphorylation
DNA Repair
Double-Stranded DNA Breaks
Cell Survival
1 Citation (Scopus)

Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae

Ghospurkar, P. L., Wilson, T. M., Liu, S., Herauf, A., Steffes, J., Mueller, E. N., Oakley, G. G. & Haring, S. J., Feb 1 2015, In : Experimental Cell Research. 331, 1, p. 183-199 17 p.

Research output: Contribution to journalArticle

Saccharomycetales
Replication Protein A
Saccharomyces cerevisiae
Yeasts
Phosphorylation
2014
46 Citations (Scopus)

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

Ashley, A. K., Shrivastav, M., Nie, J., Amerin, C., Troksa, K., Glanzer, J. G., Liu, S., Opiyo, S. O., Dimitrova, D. D., Le, P., Sishc, B., Bailey, S. M., Oakley, G. G. & Nickoloff, J. A., Sep 2014, In : DNA Repair. 21, p. 131-139 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Homologous Recombination
Replication Protein A
Chemical activation
Phosphatidylinositol 3-Kinase
7 Citations (Scopus)

Interplay of DNA damage and cell cycle signaling at the level of human replication protein A

Borgstahl, G. E., Brader, K., Mosel, A., Liu, S., Kremmer, E., Goettsch, K. A., Kolar, C., Nasheuer, H. P. & Oakley, G. G., Sep 2014, In : DNA Repair. 21, p. 12-23 12 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA Damage
Phosphorylation
Cell Cycle
Cells
26 Citations (Scopus)

RPA inhibition increases replication stress and suppresses tumor growth

Glanzer, J. G., Liu, S., Wang, L., Mosel, A., Peng, A. & Oakley, G. G., Jul 28 2014, In : Cancer Research. 74, 18, p. 5165-5172 8 p.

Research output: Contribution to journalArticle

Replication Protein A
Growth
Neoplasms
DNA Replication
Proteins
2013
16 Citations (Scopus)

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A

Glanzer, J. G., Carnes, K. A., Soto, P., Liu, S., Parkhurst, L. J. & Oakley, G. G., Feb 1 2013, In : Nucleic acids research. 41, 3, p. 2047-2059 13 p.

Research output: Contribution to journalArticle

Replication Protein A
Transcriptional Activation
Tryptophan
DNA Repair
DNA Damage
2012
38 Citations (Scopus)

Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer

Wang, L., Mosel, A. J., Oakley, G. G. & Peng, A., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2401-2409 9 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Cisplatin
DNA Damage
Neoplasms
Squamous Cell Carcinoma
116 Citations (Scopus)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

Liu, S., Opiyo, S. O., Manthey, K., Glanzer, J. G., Ashley, A. K., Amerin, C., Troksa, K., Shrivastav, M., Nickoloff, J. A. & Oakley, G. G., Nov 1 2012, In : Nucleic acids research. 40, 21, p. 10780-10794 15 p.

Research output: Contribution to journalArticle

Replication Protein A
Ataxia Telangiectasia
DNA-Activated Protein Kinase
Phosphorylation
DNA
18 Citations (Scopus)

Transforming growth factor-β activates c-Myc to promote palatal growth

Zhu, X., Ozturk, F., Liu, C., Oakley, G. G. & Nawshad, A., Oct 1 2012, In : Journal of Cellular Biochemistry. 113, 10, p. 3069-3085 17 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Growth
myc Genes
Cell proliferation
Cell Proliferation
2011
14 Citations (Scopus)

Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Bharadwaj, A. G., Goodrich, N. P., McAtee, C. O., Haferbier, K., Oakley, G. G., Wahl, J. K. & Simpson, M. A., May 1 2011, In : Experimental Cell Research. 317, 8, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Hyaluronic Acid
Cadherins
Prostate
Cell Proliferation
26 Citations (Scopus)

Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods

Glanzer, J. G., Liu, S. & Oakley, G. G., Apr 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 8, p. 2589-2595 7 p.

Research output: Contribution to journalArticle

Replication Protein A
Protein Interaction Domains and Motifs
Computer Simulation
Molecules
Repair
2010
31 Citations (Scopus)

Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway

Liyanage, N. P. M., Manthey, K. C., Dassanayake, R. P., Kuszynski, C. A., Oakley, G. G. & Duhamel, G. E., Apr 1 2010, In : Helicobacter. 15, 2, p. 98-107 10 p.

Research output: Contribution to journalArticle

Helicobacter hepaticus
Cause of Death
Cell Death
Epithelial Cells
Caspase 7
12 Citations (Scopus)

Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines

Manthey, K. C., Glanzer, J. G., Dimitrova, D. D. & Oakley, G. G., May 1 2010, In : Head and Neck. 32, 5, p. 636-645 10 p.

Research output: Contribution to journalArticle

Replication Protein A
Cisplatin
Cell Line
Etoposide
Cell Cycle
2009
25 Citations (Scopus)

Human replication protein A-Rad52-single-stranded DNA complex: Stoichiometry and evidence for strand transfer regulation by phosphorylation

Deng, X., Prakash, A., Dhar, K., Baia, G. S., Kolar, C., Oakley, G. G. & Borgstahl, G. E., Jul 21 2009, In : Biochemistry. 48, 28, p. 6633-6643 11 p.

Research output: Contribution to journalArticle

Replication Protein A
Phosphorylation
Single-Stranded DNA
Stoichiometry
Double-Stranded DNA Breaks
33 Citations (Scopus)

Physical interaction between replication protein A (RPA) and MRN: Involvement of RPA2 phosphorylation and the N-terminus of RPA1

Oakley, G. G., Tillison, K., Opiyo, S. A., Glanzer, J. G., Horn, J. M. & Patrick, S. M., Aug 11 2009, In : Biochemistry. 48, 31, p. 7473-7481 9 p.

Research output: Contribution to journalArticle

Replication Protein A
Phosphorylation
Single-Stranded DNA
Proteins
Oligosaccharides
97 Citations (Scopus)

Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing

Bharadwaj, A. G., Kovar, J. L., Loughman, E., Elowsky, C., Oakley, G. G. & Simpson, M. A., Mar 2009, In : American Journal of Pathology. 174, 3, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Prostatic Neoplasms
Neoplasm Metastasis
Prostate
Carcinogenesis
2007
34 Citations (Scopus)

NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

Manthey, K. C., Opiyo, S., Glanzer, J. G., Dimitrova, D., Elliott, J. & Oakley, G. G., Dec 1 2007, In : Journal of cell science. 120, 23, p. 4221-4229 9 p.

Research output: Contribution to journalArticle

Replication Protein A
Nijmegen Breakage Syndrome
Phosphorylation
Hydroxyurea
DNA Damage
2006
22 Citations (Scopus)

UV-induced RPA phosphorylation is increased in the absence of DNA polymerase η and requires DNA-PK

Cruet-Hennequart, S., Coyne, S., Glynn, M. T., Oakley, G. G. & Carty, M. P., Apr 8 2006, In : DNA Repair. 5, 4, p. 491-504 14 p.

Research output: Contribution to journalArticle

Replication Protein A
Phosphorylation
DNA-Directed DNA Polymerase
DNA
DNA Damage
2005
51 Citations (Scopus)

DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage

Nuss, J. E., Patrick, S. M., Oakley, G. G., Alter, G. M., Robison, J. G., Dixon, K. & Turchi, J. J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8428-8437 10 p.

Research output: Contribution to journalArticle

Replication Protein A
Phosphorylation
DNA Damage
DNA
Gels
47 Citations (Scopus)

DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair

Patrick, S. M., Oakley, G. G., Dixon, K. & Turchi, J. J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8438-8448 11 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA-Binding Proteins
DNA Replication
DNA Repair
DNA Damage
2004
111 Citations (Scopus)

Replication protein A and the Mre11·Rad50·Nbs1 complex co-localize and interact at sites of stalled replication forks

Robison, J. G., Elliott, J., Dixon, K. & Oakley, G. G., Aug 13 2004, In : Journal of Biological Chemistry. 279, 33, p. 34802-34810 9 p.

Research output: Contribution to journalArticle

Replication Protein A
Hydroxyurea
Ultraviolet Rays
Phosphoric Monoester Hydrolases
DNA Repair
47 Citations (Scopus)

Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes

Shertzer, H. G., Clay, C. D., Genter, M. B., Chames, M. C., Schneider, S. N., Oakley, G. G., Nebert, D. W. & Dalton, T. P., Mar 1 2004, In : Free Radical Biology and Medicine. 36, 5, p. 618-631 14 p.

Research output: Contribution to journalArticle

Halogenated Hydrocarbons
Aromatic Hydrocarbons
Liver Microsomes
Microsomes
NADP
2003
91 Citations (Scopus)

RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions

Oakley, G. G., Patrick, S. M., Yao, J., Carty, M. P., Turchi, J. J. & Dixon, K., Mar 25 2003, In : Biochemistry. 42, 11, p. 3255-3264 10 p.

Research output: Contribution to journalArticle

Replication Protein A
Phosphorylation
Mitosis
Carrier Proteins
Proteins
2001
12 Citations (Scopus)

2,4,4′-Trichlorobiphenyl increases STAT5 transcriptional activity

Oakley, G. G., Roe, A. L., Blouin, R. A., Twaroski, T. P., Ganguly, T. C., Vore, M., Lehmler, H. J. & Robertson, L. W., Jan 1 2001, In : Molecular Carcinogenesis. 30, 4, p. 199-208 10 p.

Research output: Contribution to journalArticle

Polychlorinated Biphenyls
Transcription Factor AP-1
STAT6 Transcription Factor
Luciferases
Transducers
15 Citations (Scopus)

Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts

Li, Y., Carty, M. P., Oakley, G. G., Seidman, M. M., Medvedovic, M. & Dixon, K., Jan 1 2001, In : Environmental and Molecular Mutagenesis. 37, 2, p. 128-140 13 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
airborne thematic mapper
Double-Stranded DNA Breaks
Automatic teller machines
Fibroblasts
78 Citations (Scopus)

UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein

Oakley, G. G., Loberg, L. I., Yao, J., Risinger, M. A., Yunker, R. L., Zernik-Kobak, M., Khanna, K. K., Lavin, M. F., Carty, M. P. & Dixon, K., Jan 1 2001, In : Molecular biology of the cell. 12, 5, p. 1199-1213 15 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia Mutated Proteins
DNA Replication
Radiation
Ataxia Telangiectasia
Proteins
3 Citations (Scopus)

XPA protein alters the specificity of ultraviolet light-induced mutagenesis in vitro

King, N. M., Oakley, G. G., Medvedovic, M. & Dixon, K., Jul 24 2001, In : Environmental and Molecular Mutagenesis. 37, 4, p. 329-339 11 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum
Mutagenesis
Ultraviolet Rays
plasmid
hot spot
1996
74 Citations (Scopus)

Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling

Oakley, G. G., Robertson, L. W. & Gupta, R. C., Jan 1996, In : Carcinogenesis. 17, 1, p. 109-114 6 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Polychlorinated Biphenyls
Butanols
DNA
Methylcholanthrene
118 Citations (Scopus)

Metabolic activation of PCBs to quinones: Reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase

Amaro, A. R., Oakley, G. G., Bauer, U., Peter Spielmann, H. & Robertson, L. W., Apr 1 1996, In : Chemical Research in Toxicology. 9, 3, p. 623-629 7 p.

Research output: Contribution to journalArticle

Quinones
Nucleophiles
Polychlorinated Biphenyls
Sulfur
Superoxide Dismutase
147 Citations (Scopus)

Oxidative dna damage induced by activation of polychlorinated biphenyls (pcbs): Implications for pcb-induced oxidative stress in breast cancer

Oakley, G. G., Devanaboyina, D., Robertson, L. W. & Gupta, R. C., Dec 14 1996, In : Chemical Research in Toxicology. 9, 8, p. 1285-1292 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Polychlorinated Biphenyls
DNA Damage
Oxidative Stress
Chemical activation