• 3554 Citations
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1970 …2019
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Research Output 1970 2019

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Article
2019
osteoblasts
Osteoblasts
apoptosis
Cell death
Ion beam assisted deposition

Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

McGuire, T. R., Coulter, D. W., Bai, D., Sughroue, J. A., Li, J., Yang, Z., Qiao, Z., Liu, Y., Murry, D. J., Chhonker, Y. S., McIntyre, E. M., Alexander, G., Sharp, J. G. & Li, R., Aug 27 2019, In : BMC cancer. 19, 1, 837.

Research output: Contribution to journalArticle

Open Access
Neuroblastoma
Cell Line
Toxicology
Inhibitory Concentration 50
Neoplasms

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Chaturvedi, N. K., Mahapatra, S., Kesherwani, V., Kling, M. J., Shukla, M., Ray, S., Kanchan, R., Perumal, N., McGuire, T. R., Graham Sharp, J., Joshi, S. S. & Coulter, D. W., Nov 6 2019, In : BMC cancer. 19, 1, 1056.

Research output: Contribution to journalArticle

Open Access
Protein-Arginine N-Methyltransferases
Medulloblastoma
Proteins
Tumor Cell Line
Brain Neoplasms
2018
9 Citations (Scopus)

Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology

Khadge, S., Sharp, J. G., Thiele, G. M., McGuire, T. R., Klassen, L. W., Duryee, M. J., Britton, H. C., Dafferner, A. J., Beck, J., Black, P. N., DiRusso, C. C. & Talmadge, J. E., Feb 2018, In : Journal of Nutritional Biochemistry. 52, p. 92-102 11 p.

Research output: Contribution to journalArticle

Omega-6 Fatty Acids
Pathology
Nutrition
Unsaturated Fatty Acids
Diet
5 Citations (Scopus)

Improved therapy for medulloblastoma: Targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy

Chaturvedi, N. K., Kling, M. J., Coulter, D. W., McGuire, T. R., Ray, S., Kesherwani, V., Joshi, S. S. & Sharp, J. G., Mar 30 2018, In : Oncotarget. 9, 24, p. 16619-16633 15 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hedgehogs
Combination Drug Therapy
Phosphatidylinositol 3-Kinases
HhAntag691
7 Citations (Scopus)
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Breast Neoplasms
Neoplasm Metastasis
Survival
2 Citations (Scopus)
Omega-3 Fatty Acids
Human Mammary Glands
Unsaturated Fatty Acids
Diet
Inflammation
1 Citation (Scopus)

Suppression of STAT3 NH2-terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de-repression by microRNA-21

Ray, S., Coulter, D. W., Gray, S. D., Sughroue, J. A., Roychoudhury, S., Mcintyre, E. M., Chaturvedi, N. K., Bhakat, K. K., Joshi, S. S., McGuire, T. R. & Sharp, J. G., Apr 2018, In : Molecular Carcinogenesis. 57, 4, p. 536-548 13 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Medulloblastoma
MicroRNAs
Proteins
Down-Regulation
2016
10 Citations (Scopus)

Improved therapy for neuroblastoma using a combination approach: Superior efficacy with vismodegib and topotecan

Chaturvedi, N. K., McGuire, T. R., Coulter, D. W., Shukla, A., McIntyre, E. M., Sharp, J. G. & Joshi, S. S., Mar 22 2016, In : Oncotarget. 7, 12, p. 15215-15229 15 p.

Research output: Contribution to journalArticle

HhAntag691
Topotecan
Neuroblastoma
Hedgehogs
NF-kappa B

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Coulter, D. W., McGuire, T. R., Sharp, J. G., McIntyre, E. M., Dong, Y., Wang, X., Gray, S., Alexander, G. R., Chatuverdi, N. K., Joshi, S. S., Chen, X. & Vennerstrom, J. L., Nov 8 2016, In : BMC cancer. 16, 1, 867.

Research output: Contribution to journalArticle

Antimalarials
Neuroblastoma
Cell Cycle
Cell Line
Neoplasms
2014
5 Citations (Scopus)

Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site

Farrell, T. L., McGuire, T. R., Bilek, L. D., Brusnahan, S. K., Jackson, J. D., Lane, J. T., Garvin, K. L., O'Kane, B. J., Berger, A. M., Tuljapurkar, S. R., Kessinger, M. A. & Sharp, J. G., Feb 1 2014, In : Experimental Hematology. 42, 2, p. 146-154 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Bone Marrow
Thigh
Stem Cells
Granulocyte-Macrophage Progenitor Cells
2013
6 Citations (Scopus)

Heterogeneity of functional properties of clone 66 murine breast cancer cells expressing various stem cell phenotypes

Mukhopadhyay, P., Farrell, T., Sharma, G., McGuire, T. R., O'Kane, B. & Sharp, J. G., Nov 12 2013, In : PloS one. 8, 11, e78725.

Research output: Contribution to journalArticle

Stem cells
breast neoplasms
functional properties
stem cells
Stem Cells
2012
11 Citations (Scopus)

Novel therapy for therapy-resistant mantle cell lymphoma: Multipronged approach with targeting of hedgehog signaling

Hegde, G. V., Nordgren, T. M., Munger, C. M., Mittal, A. K., Bierman, P. J., Weisenburger, D. D., Vose, J. M., Sharp, J. G. & Joshi, S. S., Dec 15 2012, In : International Journal of Cancer. 131, 12, p. 2951-2960 10 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Hedgehogs
Therapeutics
Drug Therapy
Inbred NOD Mouse
8 Citations (Scopus)

Nucleic Acid and Non-Nucleic Acid-Based Reprogramming of Adult Limbal Progenitors to Pluripotency

Parameswaran, S., Balasubramanian, S., Babai, N., DelDebbio, C. B., Harms, D. W., Gurumurthy, C. B., Rao, M. S., Sharp, J. G. & Ahmad, I., Oct 8 2012, In : PloS one. 7, 10, e46734.

Research output: Contribution to journalArticle

Nucleic Acids
nucleic acids
Acids
acids
Gene expression
2011
50 Citations (Scopus)

Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging

Tuljapurkar, S. R., McGuire, T. R., Brusnahan, S. K., Jackson, J. D., Garvin, K. L., Kessinger, M. A., Lane, J. T., O'Kane, B. J. & Sharp, J. G., Nov 1 2011, In : Journal of Anatomy. 219, 5, p. 574-581 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
bone marrow
fat
bone
cytokines
14 Citations (Scopus)

Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type i collagen gel cultures

Togo, S., Sato, T., Sugiura, H., Wang, X., Basma, H. E., Nelson, A., Liu, X., Bargar, T. W., Sharp, J. G. & Rennard, S. I., Feb 1 2011, In : In Vitro Cellular and Developmental Biology - Animal. 47, 2, p. 114-124 11 p.

Research output: Contribution to journalArticle

Fibroblasts
Embryonic Stem Cells
Stem cells
Cell culture
Collagen
6 Citations (Scopus)

IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells

Sato, T., Liu, X., Basma, H. E., Togo, S., Sugiura, H., Nelson, A., Nakanishi, M., Kanaji, N., Wang, X., Kim, M., Li, Y., Michalski, J., Farid, M., Sharp, J. G. & Rennard, S. I., Jun 2011, In : Journal of Allergy and Clinical Immunology. 127, 6, p. 1595-1603.e9

Research output: Contribution to journalArticle

Interleukin-4
Fibroblasts
Phenotype
Stem Cells
Fibronectins
19 Citations (Scopus)

Inflammation associated with obesity: Relationship with blood and bone marrow endothelial cells

McGuire, T. R., Brusnahan, S. K., Bilek, L. D., Jackson, J. D., Kessinger, M. A., Berger, A. M., Garvin, K. L., O'Kane, B. J., Tuljapurkar, S. R. & Sharp, J. G., Nov 1 2011, In : Obesity. 19, 11, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Endothelial Cells
Obesity
Inflammation
Bone Marrow
2010
34 Citations (Scopus)

Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines

Brusnahan, S. K., McGuire, T. R., Jackson, J. D., Lane, J. T., Garvin, K. L., O'Kane, B. J., Berger, A. M., Tuljapurkar, S. R., Kessinger, M. A. & Sharp, J. G., Nov 1 2010, In : Mechanisms of Ageing and Development. 131, 11-12, p. 718-722 5 p.

Research output: Contribution to journalArticle

Side-Population Cells
Mesenchymal Stromal Cells
Stem Cells
Cell Count
Bone Marrow
59 Citations (Scopus)

Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function

Simet Chadwick, S. M., Sisson, J. H., Pavlik, J. A., DeVasure, J. M., Boyer, C., Liu, X., Kawasaki, S., Sharp, J. G., Rennard, S. I. & Wyatt, T. A., Dec 1 2010, In : American journal of respiratory cell and molecular biology. 43, 6, p. 635-640 6 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Epithelial Cells
Protein Kinase C
Cell Count
2009
36 Citations (Scopus)

Non cell-autonomous reprogramming of adult ocular progenitors: Generation of pluripotent stem cells without exogenous transcription factors

Balasubramanian, S., Babai, N., Chaudhuri, A., Qui, F., Bhattacharya, S., Dave, B. J., Parameswaran, S., Carson, S. D., Thoreson, W. B., Sharp, J. G., Rao, M. & Ahmad, I., Dec 1 2009, In : STEM CELLS. 27, 12, p. 3053-3062 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Transcription Factors
Stem Cells
Virus Integration
2008
1 Citation (Scopus)

A comparative evaluation of teaching methods in an introductory neuroscience course for physical therapy students.

Willett, G. M., Sharp, J. G. & Smith, L. M., Jan 1 2008, In : Journal of allied health. 37, 3, p. e177-198

Research output: Contribution to journalArticle

Neurosciences
Teaching
Students
Therapeutics
Costs and Cost Analysis
47 Citations (Scopus)

Effects of exercise on hematological parameters, circulating side population cells, and cytokines

Wardyn, G. G., Rennard, S. I., Brusnahan, S. K., McGuire, T. R., Carlson, M. L., Smith, L. M., McGranaghan, S. & Sharp, J. G., Feb 1 2008, In : Experimental Hematology. 36, 2, p. 216-223 8 p.

Research output: Contribution to journalArticle

Side-Population Cells
Cytokines
Interleukin-6
Hematocrit
Vascular Endothelial Growth Factor A
2007
28 Citations (Scopus)
Side-Population Cells
Bone Marrow Cells
Stem Cells
Bone Marrow
Tacrine
95 Citations (Scopus)

Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-γc-/- mice

Gorantla, S., Sneller, H., Walters, L., Sharp, J. G., Pirruccello, S. J., West, J. T., Wood, C., Dewhurst, S., Gendelman, H. E. & Poluektova, L. Y., Mar 1 2007, In : Journal of virology. 81, 6, p. 2700-2712 13 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
mice
Thymus Gland
busulfan
2006
2 Citations (Scopus)

Novel engineered nanocrystalline ultra-hydrophilic hard ceramic coatings for attachment and growth of bone marrow stromal cells

Namavar, F., Jackson, J. D., Sharp, J. G., Varma, S., Haider, H., Feschuk, C. & Garvin, K. L., Dec 1 2006, In : MCB Molecular and Cellular Biomechanics. 3, 4, p. 171-172 2 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Hardness
Ceramics
Titanium
Aluminum
2005
1 Citation (Scopus)

An ex vivo model of hematopoietic stem cell mobilization

Kessinger, A., O'Kane, M. B., Jackson, J. D. & Sharp, J. G., Dec 1 2005, In : Cytotherapy. 7, 6, p. 463-469 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Mobilization
Stem Cells
Cytokines
Cell Count
Bone Marrow
25 Citations (Scopus)

Evidence for a qualitative hierarchy within the Hoechst-33342 'side population' (SP) of murine bone marrow cells

Robinson, S. N., Seina, S. M., Gohr, J. C., Kuszynski, C. A. & Sharp, J. G., Apr 1 2005, In : Bone marrow transplantation. 35, 8, p. 807-818 12 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Population
Coloring Agents
Bone Marrow
Side-Population Cells
9 Citations (Scopus)

Hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor and erythropoietin in the absence of matrix metalloproteinase-9

Robinson, S. N., Seina, S. M., Gohr, J. C. & Sharp, J. G., Jun 1 2005, In : Stem Cells and Development. 14, 3, p. 317-328 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Granulocyte Colony-Stimulating Factor
Erythropoietin
Hematopoietic Stem Cells
Matrix Metalloproteinases
9 Citations (Scopus)

Promises and pitfalls of stem cell therapy for promotion of bone healing

Sharp, J. G., Murphy, B. O. K., Jackson, J. D., Brusnahan, S. K., Kessinger, A. & Neff, J. R., Jun 2005, In : Clinical Orthopaedics and Related Research. 435, p. 52-61 10 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem Cells
Bone and Bones
Thigh
Kidney
2004
2 Citations (Scopus)

A pilot evaluation of micrometastases for the prediction of outcome in lung cancer

Thompson, A. B., Kessinger, A. & Sharp, J. G., May 2004, In : Chest. 125, 5 SUPPL., p. 156S-157S

Research output: Contribution to journalArticle

Bone Marrow Neoplasms
Circulating Neoplastic Cells
Neoplasm Micrometastasis
Small Cell Carcinoma
Non-Small Cell Lung Carcinoma
131 Citations (Scopus)

Cells derived from the circulation contribute to the repair of lung injury

Abe, S., Boyer, C., Liu, X., Fu, Q. W., Kobayashi, T., Fang, Q., Wang, X., Hashimoto, M., Sharp, J. G. & Rennard, S. I., Dec 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 170, 11, p. 1158-1163 6 p.

Research output: Contribution to journalArticle

Lung Injury
Stem Cells
Pancreatic Elastase
Green Fluorescent Proteins
Radiation
17 Citations (Scopus)

Lung cells transplanted to irradiated recipients generate lymphohematopoietic progeny

Abe, S., Lauby, G., Boyer, C., Manouilova, L., Rennard, S. I. & Sharp, J. G., Apr 1 2004, In : American journal of respiratory cell and molecular biology. 30, 4, p. 491-499 9 p.

Research output: Contribution to journalArticle

Stem cells
Bone
Tissue
Gene therapy
Lung
2003
1 Citation (Scopus)

Regulatory issues in cellular therapies

Sharp, J. G., Jan 1 2003, In : Cytotherapy. 5, 4, p. 277-278 2 p.

Research output: Contribution to journalArticle

Therapeutics
60 Citations (Scopus)

Transplanted BM and BM side population cells contribute progeny to the lung and liver in irradiated mice

Abe, S., Lauby, G., Boyer, C., Rennard, S. I. & Sharp, J. G., Jan 1 2003, In : Cytotherapy. 5, 6, p. 523-533 11 p.

Research output: Contribution to journalArticle

Side-Population Cells
Lung
Liver
Alveolar Epithelial Cells
Kupffer Cells
2002
18 Citations (Scopus)

A murine model of bone marrow micrometastasis in breast cancer

O'Kane Murphy, B., Joshi, S., Kessinger, A., Reed, E. & Sharp, J. G., Dec 1 2002, In : Clinical and Experimental Metastasis. 19, 7, p. 561-569 9 p.

Research output: Contribution to journalArticle

Neoplasm Micrometastasis
Bone Marrow
Breast Neoplasms
Neoplasms
Bone Marrow Cells
74 Citations (Scopus)

Autologous transplantation for aggressive non-Hodgkin's lymphoma: Results of a randomized trial evaluating graft source and minimal residual disease

Vose, J. M., Sharp, G., Chan, W. C., Nichols, C., Loh, K., Inwards, D., Rifkin, R., Bierman, P. J., Lynch, J. C., Weisenburger, D. D., Kessinger, A. & Armitage, J. O., May 1 2002, In : Journal of Clinical Oncology. 20, 9, p. 2344-2352 9 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Autologous Transplantation
Residual Neoplasm
Non-Hodgkin's Lymphoma
Bone Marrow Transplantation
5 Citations (Scopus)

Effect of prior therapy and bone marrow metastases on progenitor cell content of blood stem cell harvests in breast cancer patients

Demirkazik, A., Kessinger, A., Lynch, J., Reed, E., Tarantolo, S. & Sharp, J. G., Jan 1 2002, In : Biology of Blood and Marrow Transplantation. 8, 5, p. 268-272 5 p.

Research output: Contribution to journalArticle

Open Access
Blood Cells
Stem Cells
Bone Marrow
Breast Neoplasms
Neoplasm Metastasis
3 Citations (Scopus)

Plasma from poorly mobilizing human subjects inhibits cytokine-induced murine blood stem-cell mobilization

Sharp, J. G., McGuire, T. R., Mann, S., Murphy, B. & Kessinger, A., Jan 1 2002, In : Cytotherapy. 4, 4, p. 365-373 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Mobilization
Transforming Growth Factors
Blood Cells
Tissue Donors
Cytokines
1 Citation (Scopus)

Report of the Tumor Evaluation Committee workshops at ISHAGE 2001

Ross, A., Ruud, E. & Sharp, J. G., Jan 1 2002, In : Cytotherapy. 4, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

Education
Neoplasms
Granulocytes
Anticoagulants
Biomarkers
340 Citations (Scopus)

The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells

Kim, M., Turnquist, H., Jackson, J., Yan, Y., Cowan, K. H., Gong, M., Sharp, J. G., Sharp, J. G. & Cowan, K., Jan 1 2002, In : Clinical Cancer Research. 8, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

BRCA1 Protein
MCF-7 Cells
Multiple Drug Resistance
Hematopoietic Stem Cells
Side-Population Cells
2001
15 Citations (Scopus)

Circulating factors may be responsible for murine strain-specific responses to mobilizing cytokines

Kessinger, A., Mann, S., Murphy, B. O. K., Jackson, J. D. & Sharp, J. G., Jun 13 2001, In : Experimental Hematology. 29, 6, p. 775-778 4 p.

Research output: Contribution to journalArticle

Cytokines
Granulocytes
Macrophages
Spleen
Hematopoietic Stem Cells
7 Citations (Scopus)
Transforming Growth Factor beta
Stem Cells
Tissue Donors
Cytokines
Neoplasms
23 Citations (Scopus)

Intensive immunoablation and autologous blood stem cell transplantation in patients with refractory rheumatoid arthritis: The University of Nebraska experience

Pavletic, S. Z., O'Dell, J. R., Pirruccello, S. J., Ursick, M. M., Haire, C. E., Sharp, J. G., Kessinger, A. & Klassen, L. W., Jan 1 2001, In : Journal of Rheumatology. 28, SUPPL. 64, p. 13-20 8 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Blood Cells
Rheumatoid Arthritis
Rheumatology
Transplants
5 Citations (Scopus)

Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells

Sharp, J. G., Bishop, M. R., Copple, B., Greiner, T. C., Iversen, P. L., Jackson, J. D., Joshi, S. S., Benner, E. J., Mann, S. L., Rao, A. K. & Vose, J. M., Jan 1 2001, In : Leukemia and Lymphoma. 42, 3, p. 417-427 11 p.

Research output: Contribution to journalArticle

Idarubicin
Oligonucleotides
Lymphoma
Hematopoietic Stem Cells
Down-Regulation
21 Citations (Scopus)

Progenitor and lymphoma cells in blood stem cell harvests: Impact on survival following transplantation

Demirkazik, A., Kessinger, A., Armitage, J. O., Bierman, P. J., Lynch, J., Vose, J. M., Chan, W. & Sharp, J. G., Aug 20 2001, In : Bone marrow transplantation. 28, 2, p. 207-212 6 p.

Research output: Contribution to journalArticle

Lymphoma
Blood Cells
Stem Cells
Transplantation
Survival
21 Citations (Scopus)

VLA-4 mediated adhesion to bone marrow stromal cells confers chemoresistance to adherent lymphoma cells

Weekes, C. D., Kuszynski, C. A. & Sharp, J. G., Jan 1 2001, In : Leukemia and Lymphoma. 40, 5-6, p. 631-645 15 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Mesenchymal Stromal Cells
Lymphoma
Bone Marrow
Stromal Cells
2000
9 Citations (Scopus)

Blood stem cell transplantation: Factors influencing cellular immunological reconstitution

Sharp, J. G., Kessinger, A., Lynch, J. C., Pavletic, Z. S. & Joshi, S. S., Dec 1 2000, In : Journal of Hematotherapy and Stem Cell Research. 9, 6, p. 971-981 11 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Stem Cell Transplantation
Blood Cells
Stem Cells
Cytokines

Heterogeneity of the stem and progenitor cell compartments and efficiency of blood stem/ progenitor cell harvests in autologous and allogeneic stem cell donors

Sharp, J. G., Petersen, K. & Kessinger, A., Dec 1 2000, In : Blood. 96, 11 PART II, p. 319b

Research output: Contribution to journalArticle

Stem cells
Chemotherapy
Blood Cells
Blood
Stem Cells